High GATA2 expression is a poor prognostic marker in pediatric acute myeloid leukemia

scientific article published on July 11, 2012

High GATA2 expression is a poor prognostic marker in pediatric acute myeloid leukemia is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1182/BLOOD-2011-12-397083
P8608Fatcat IDrelease_ztcwijkq7jdkpb2pjxntmcd4rm
P953full work available at URLhttp://ashpublications.org/blood/article-pdf/120/10/2064/1357117/zh803612002064.pdf
http://www.bloodjournal.org/content/bloodjournal/120/10/2064.full.pdf
P698PubMed publication ID22786876
P5875ResearchGate publication ID229075190

P50authorMarry M. van den Heuvel-EibrinkQ71498972
Jan TrkaQ88547666
Vincent H J van der VeldenQ89748267
Dirk ReinhardtQ91648795
P2093author name stringAndre Baruchel
Valérie de Haas
Maaike Luesink
C. Michel Zwaan
Joop H. Jansen
Bert A. van der Reijden
Iris H. I M. Hollink
Jan B. M. Boezeman
Ruth H. J N. Knops
P2860cites workNegative cross-talk between hematopoietic regulators: GATA proteins repress PU.1Q24671782
Redirecting differentiation of hematopoietic progenitors by a transcription factor, GATA-2Q28509425
Notch signaling requires GATA-2 to inhibit myelopoiesis from embryonic stem cells and primary hemopoietic progenitorsQ28591446
An early haematopoietic defect in mice lacking the transcription factor GATA-2Q28593072
Exome sequencing identifies GATA-2 mutation as the cause of dendritic cell, monocyte, B and NK lymphoid deficiency.Q30368393
High GATA-2 expression inhibits human hematopoietic stem and progenitor cell function by effects on cell cycleQ33402840
GATA-2 and GATA-2/ER display opposing activities in the development and differentiation of blood progenitorsQ34089261
Mutations in GATA2 are associated with the autosomal dominant and sporadic monocytopenia and mycobacterial infection (MonoMAC) syndrome.Q34192317
Differential expression and functional role of GATA-2, NF-E2, and GATA-1 in normal adult hematopoiesisQ34219129
Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemiaQ34313643
Ectopic expression of a conditional GATA-2/estrogen receptor chimera arrests erythroid differentiation in a hormone-dependent manner.Q34365985
Evaluation of gene expression signatures predictive of cytogenetic and molecular subtypes of pediatric acute myeloid leukemiaQ34542996
Characterization of CEBPA mutations and promoter hypermethylation in pediatric acute myeloid leukemiaQ34612599
Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemiaQ34627568
Biology, risk stratification, and therapy of pediatric acute leukemias: an updateQ34764504
Leukemic mutations in the methylation-associated genes DNMT3A and IDH2 are rare events in pediatric AML: a report from the Children's Oncology GroupQ35046171
Wilms' tumours: about tumour suppressor genes, an oncogene and a chameleon geneQ35095712
Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemiaQ35249294
Integrative analysis of type-I and type-II aberrations underscores the genetic heterogeneity of pediatric acute myeloid leukemiaQ35265916
Loss-of-function germline GATA2 mutations in patients with MDS/AML or MonoMAC syndrome and primary lymphedema reveal a key role for GATA2 in the lymphatic vasculatureQ35750366
Germ-line GATA2 p.THR354MET mutation in familial myelodysplastic syndrome with acquired monosomy 7 and ASXL1 mutation demonstrating rapid onset and poor survival.Q36006394
Gain-of-function mutation of GATA-2 in acute myeloid transformation of chronic myeloid leukemiaQ36883073
Pediatric acute myeloid leukemia: towards high-quality cure of all patientsQ37007119
Graded repression of PU.1/Sfpi1 gene transcription by GATA factors regulates hematopoietic cell fateQ37291657
GATA-2 reinforces megakaryocyte development in the absence of GATA-1Q37334070
Assessment of minimal residual disease in acute myeloid leukemiaQ37784128
The role of the GATA2 transcription factor in normal and malignant hematopoiesisQ37878679
The transcriptional program of terminal granulocytic differentiationQ38334911
EVI1 overexpression in distinct subtypes of pediatric acute myeloid leukemiaQ38345216
Mononuclear cells contaminating acute lymphoblastic leukaemic samples tested for cellular drug resistance using the methyl-thiazol-tetrazolium assayQ42032841
Notch1 inhibits differentiation of hematopoietic cells by sustaining GATA-2 expressionQ43806498
Abnormal WT1 expression in the CD34-negative compartment in myelodysplastic bone marrowQ44117292
Overexpression of GATA2 predicts an adverse prognosis for patients with acute myeloid leukemia and it is associated with distinct molecular abnormalities.Q44666362
Differential gene expression in human hematopoietic stem cells specified toward erythroid, megakaryocytic, and granulocytic lineageQ50894639
GATA-2 L359 V mutation is exclusively associated with CML progression but not other hematological malignancies and GATA-2 P250A is a novel single nucleotide polymorphismQ51756149
Low frequency of MLL-partial tandem duplications in paediatric acute myeloid leukaemia using MLPA as a novel DNA screenings technique.Q54436758
Real-time quantitative polymerase chain reaction detection of minimal residual disease by standardized WT1 assay to enhance risk stratification in acute myeloid leukemia: a European LeukemiaNet study.Q54465378
High WT1 expression after induction therapy predicts high risk of relapse and death in pediatric acute myeloid leukemia.Q54611165
Mutations in GATA2 cause primary lymphedema associated with a predisposition to acute myeloid leukemia (Emberger syndrome)Q55671562
High BRE expression in pediatric MLL-rearranged AML is associated with favorable outcomeQ58492940
Clinical significance of Gata-1, Gata-2, EKLF, and c-MPL expression in acute myeloid leukemiaQ60602807
Hematologic malignanciesQ74523586
Feasibility of using the combined MDS-EVI1/EVI1 gene expression as an alternative molecular marker in acute myeloid leukemia: a report of four casesQ80784426
Marked genetic heterogeneity in familial myelodysplasia/acute myeloid leukaemiaQ83990685
No prognostic impact of the WT1 gene single nucleotide polymorphism rs16754 in pediatric acute myeloid leukemiaQ84579865
Clinical significance of flowcytometric minimal residual disease detection in pediatric acute myeloid leukemia patients treated according to the DCOG ANLL97/MRC AML12 protocolQ84612087
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectgene expressionQ26972
leukemiaQ29496
P304page(s)2064-2075
P577publication date2012-07-11
P1433published inBloodQ885070
P1476titleHigh GATA2 expression is a poor prognostic marker in pediatric acute myeloid leukemia
P478volume120

Reverse relations

cites work (P2860)
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