Genome-wide screen reveals WNT11, a non-canonical WNT gene, as a direct target of ETS transcription factor ERG

scientific article published on January 17, 2011

Genome-wide screen reveals WNT11, a non-canonical WNT gene, as a direct target of ETS transcription factor ERG is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/ONC.2010.582
P953full work available online athttps://refubium.fu-berlin.de/bitstream/fub188/4096/1/Dissertation_LHMochmann.pdf
https://www.nature.com/articles/onc2010582
https://www.nature.com/articles/onc2010582.pdf
P698PubMed publication ID21242973

P2093author name stringE. Thiel
K. Neumann
J. Bock
A. Bohne
C. Schlee
C. D. Baldus
J. Ortiz-Tánchez
L. H. Mochmann
W. K. Hofmann
P2860cites workWnt-11 promotes neuroendocrine-like differentiation, survival and migration of prostate cancer cellsQ24302096
Insights from genomic profiling of transcription factorsQ24611607
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Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer.Q27824849
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resourcesQ27860739
A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERGQ28252253
The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cellsQ28281239
Clinical outcome of de novo acute myeloid leukaemia patients with normal cytogenetics is affected by molecular genetic alterations: a concise reviewQ28301344
Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family-mediated transcriptional activation of TGFbeta2Q28507487
ETS2 and ERG promote megakaryopoiesis and synergize with alterations in GATA-1 to immortalize hematopoietic progenitor cellsQ28754852
Transcription factor Erg regulates angiogenesis and endothelial apoptosis through VE-cadherinQ28771711
A chromatin landmark and transcription initiation at most promoters in human cellsQ29547180
Wnt signalling in stem cells and cancerQ29547862
Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitorQ29614622
GSK3beta is involved in JNK2-mediated beta-catenin inhibitionQ33493071
Genome-wide analysis of ETS-family DNA-binding in vitro and in vivoQ34000149
Silencing of bidirectional promoters by DNA methylation in tumorigenesisQ34527442
Transcription factor ERG and joint and articular cartilage formation during mouse limb and spine skeletogenesis.Q36183609
Fusion in the ETS gene family and prostate cancerQ36882701
A causal role for ERG in neoplastic transformation of prostate epithelium.Q36883091
Mechanisms of transcription factor deregulation in lymphoid cell transformationQ36970219
Acute myeloid leukemia with complex karyotypes and abnormal chromosome 21: Amplification discloses overexpression of APP, ETS2, and ERG genesQ37095280
Dysregulated gene expression networks in human acute myelogenous leukemia stem cellsQ37097180
Glycogen synthase kinase 3beta (GSK3beta) in tumorigenesis and cancer chemotherapyQ37163149
Major flowering time gene, flowering locus C, regulates seed germination in Arabidopsis thalianaQ37261698
Noncanonical Wnt11 signaling and cardiomyogenic differentiationQ37397996
Wnt/Fz signaling and the cytoskeleton: potential roles in tumorigenesis.Q37443849
Novel estrogen receptor-alpha binding sites and estradiol target genes identified by chromatin immunoprecipitation cloning in breast cancerQ38301651
Overexpression of the ETS-related gene, ERG, predicts a worse outcome in acute myeloid leukemia with normal karyotype: a Cancer and Leukemia Group B studyQ38319029
FZD4 as a mediator of ERG oncogene-induced WNT signaling and epithelial-to-mesenchymal transition in human prostate cancer cells.Q39666997
The role of the ETS factor erg in zebrafish vasculogenesisQ39770261
Epigenetic control of differential expression of specific ERG isoforms in acute T-lymphoblastic leukemia.Q39901673
p38 mitogen-activated protein kinase regulates canonical Wnt-beta-catenin signaling by inactivation of GSK3betaQ39926291
Inhibition of GSK-3beta promotes survival and proliferation of megakaryocytic cells through a beta-catenin-independent pathwayQ39937926
Genome-wide identification of aberrantly methylated promoter associated CpG islands in acute lymphocytic leukemia.Q39975102
Glycogen synthase kinase-3beta inhibition preserves hematopoietic stem cell activity and inhibits leukemic cell growthQ40005252
Epigenetic regulation of Wnt-signaling pathway in acute lymphoblastic leukemiaQ40200349
Analysis of Wnt gene expression in prostate cancer: mutual inhibition by WNT11 and the androgen receptorQ40497254
Analysis of the megakaryocyte glycoprotein IX promoter identifies positive and negative regulatory domains and functional GATA and Ets sitesQ41176566
wnt3a but not wnt11 supports self-renewal of embryonic stem cellsQ42801784
The proto-oncogene ERG in megakaryoblastic leukemiasQ46685673
ERG is a megakaryocytic oncogene.Q47677556
High expression of the ETS transcription factor ERG predicts adverse outcome in acute T-lymphoblastic leukemia in adultsQ52930719
The ETS-domain transcription factor familyQ77199453
Beta-catenin signaling contributes to stemness and regulates early differentiation in murine embryonic stem cellsQ81470072
P433issue17
P407language of work or nameEnglishQ1860
P921main subjectgenomicsQ222046
P304page(s)2044-2056
P577publication date2011-01-17
P1433published inOncogeneQ1568657
P1476titleGenome-wide screen reveals WNT11, a non-canonical WNT gene, as a direct target of ETS transcription factor ERG
P478volume30

Reverse relations

cites work (P2860)
Q38050656B-lineage transcription factors and cooperating gene lesions required for leukemia development
Q87690487Clinical significance of Wnt-11 and squamous cell carcinoma antigen expression in cervical cancer
Q36395611ERG and FLI1 binding sites demarcate targets for aberrant epigenetic regulation by AML1-ETO in acute myeloid leukemia
Q38457400ERG induces a mesenchymal-like state associated with chemoresistance in leukemia cells
Q28484833ERG transcriptional networks in primary acute leukemia cells implicate a role for ERG in deregulated kinase signaling
Q40028950Emergence of ETS transcription factors as diagnostic tools and therapeutic targets in prostate cancer
Q42719018FAT1 expression and mutations in adult acute lymphoblastic leukemia.
Q37710265Filamin A interacting protein 1-like inhibits WNT signaling and MMP expression to suppress cancer cell invasion and metastasis
Q47117864Functional expression of Tim-3 on blasts and clinical impact of its ligand galectin-9 in myelodysplastic syndromes
Q89702981Knockdown of eukaryotic translation initiation factor 3 subunit B inhibits cell proliferation and migration and promotes apoptosis by downregulating WNT signaling pathway in acute myeloid leukemia
Q26829833Molecular mechanisms of ETS transcription factor-mediated tumorigenesis
Q53590128Nature and nurture: a case of transcending haematological pre-malignancies in a pair of monozygotic twins adding possible clues on the pathogenesis of B-cell proliferations.
Q35685920Oncogenic activation of ERG: A predominant mechanism in prostate cancer
Q38913781Perturbations of heart development and function in cardiomyocytes from human embryonic stem cells with trisomy 21.
Q55166646Role of Wnt11 during Osteogenic Differentiation of Human Mesenchymal Stem Cells on Microstructured Titanium Surfaces.
Q42436743Strong expression of the neuronal transcription factor FOXP2 is linked to an increased risk of early PSA recurrence in ERG fusion-negative cancers
Q34939997The endothelial transcription factor ERG promotes vascular stability and growth through Wnt/β-catenin signaling
Q39799555Wnt/ß-Catenin: A New Therapeutic Approach to Acute Myeloid Leukemia
Q88649525Wnt11 alters integrin and cadherin expression by ovarian cancer spheroids and inhibits tumorigenesis and metastasis
Q37859092Wnt11 in 2011 – the regulation and function of a non‐canonical Wnt
Q50442588ZO-1 expression is suppressed by GM-CSF via miR-96/ERG in brain microvascular endothelial cells
Q38096240miRNA and TMPRSS2-ERG do not mind their own business in prostate cancer cells

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