Transmembrane domains 1 and 2 of the latent membrane protein 1 of Epstein-Barr virus contain a lipid raft targeting signal and play a critical role in cytostasis

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Transmembrane domains 1 and 2 of the latent membrane protein 1 of Epstein-Barr virus contain a lipid raft targeting signal and play a critical role in cytostasis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.77.6.3749-3758.2003
P932PMC publication ID149527
P698PubMed publication ID12610149
P5875ResearchGate publication ID10879997

P2093author name stringTimothy R Geiger
Jennifer M Martin
William F Coffin
P2860cites workEpstein-Barr virus latent membrane protein-1 (LMP1) C-terminus activation region 2 (CTAR2) maps to the far C-terminus and requires oligomerisation for NF-kappaB activationQ45759578
High Concentration of the EBV Latent Membrane Protein 1 in Glycosphingolipid-Rich Complexes from both Epithelial and Lymphoid CellsQ56917409
Crystallographic analysis of CD40 recognition and signaling by human TRAF2Q24675068
Structural basis for self-association and receptor recognition of human TRAF2Q27617947
The platelet-derived growth factor beta receptor as a target of the bovine papillomavirus E5 proteinQ33180948
The CD40-TRAF6 axis controls affinity maturation and the generation of long-lived plasma cellsQ33711057
A model for persistent infection with Epstein-Barr virus: the stealth virus of human B cellsQ33756928
Latent membrane protein 1 of Epstein-Barr virus interacts with JAK3 and activates STAT proteinsQ33891012
DNA sequence and expression of the B95-8 Epstein-Barr virus genome.Q34245077
Latent membrane protein 1 of Epstein-Barr virus mimics a constitutively active receptor molecule.Q34250209
Epstein-Barr virus latent-infection membrane proteins are palmitoylated and raft-associated: protein 1 binds to the cytoskeleton through TNF receptor cytoplasmic factorsQ35291650
Stimulation of NF-kappa B-mediated transcription by mutant derivatives of the latent membrane protein of Epstein-Barr virusQ35838888
Transformation by the oncogenic latent membrane protein correlates with its rapid turnover, membrane localization, and cytoskeletal associationQ36695348
The transforming domain alone of the latent membrane protein of Epstein-Barr virus is toxic to cells when expressed at high levelsQ36827992
Orientation and patching of the latent infection membrane protein encoded by Epstein-Barr virusQ36861507
An intricate route to immortalityQ38267805
The late lytic LMP-1 protein of Epstein-Barr virus can negatively regulate LMP-1 signalingQ39589143
Latent membrane protein 1 of Epstein-Barr virus inhibits as well as stimulates gene expressionQ39593467
CD40 and LMP-1 both signal from lipid rafts but LMP-1 assembles a distinct, more efficient signaling complexQ39645275
LMP-1's transmembrane domains encode multiple functions required for LMP-1's efficient signalingQ39685776
Characterization of LMP-1's association with TRAF1, TRAF2, and TRAF3.Q39879963
Cellular responses to murine CD40 in a mouse B cell line may be TRAF dependent or independentQ40761285
The cytoplasmic amino-terminus of the Latent Membrane Protein-1 of Epstein-Barr Virus: relationship between transmembrane orientation and effector functions of the carboxy-terminus and transmembrane domainQ40782239
The amino-terminus and membrane-spanning domains of LMP-1 inhibit cell proliferationQ40893186
Activation of the cJun N-terminal kinase (JNK) pathway by the Epstein-Barr virus-encoded latent membrane protein 1 (LMP1).Q41044165
A fusion of the EBV latent membrane protein-1 (LMP1) transmembrane domains to the CD40 cytoplasmic domain is similar to LMP1 in constitutive activation of epidermal growth factor receptor expression, nuclear factor-kappa B, and stress-activated protQ41046589
Early detection of the lytic LMP-1 protein in EBV-infected B-cells suggests its presence in the virionQ41098892
The latent membrane protein oncoprotein resembles growth factor receptors in the properties of its turnoverQ41132484
Cytostatic effect of Epstein-Barr virus latent membrane protein-1 analyzed using tetracycline-regulated expression in B cell linesQ41172143
Epstein-Barr virus: LMP1 masquerades as an active receptorQ41725733
Signal transduction from the Epstein-Barr virus LMP-1 transforming proteinQ45755742
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectmembrane raftQ424178
transmembrane proteinQ424204
Epstein–Barr virusQ6900
membrane proteinQ423042
P304page(s)3749-3758
P577publication date2003-03-01
P1433published inJournal of VirologyQ1251128
P1476titleTransmembrane domains 1 and 2 of the latent membrane protein 1 of Epstein-Barr virus contain a lipid raft targeting signal and play a critical role in cytostasis
P478volume77

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cites work (P2860)
Q40117245A membrane leucine heptad contributes to trafficking, signaling, and transformation by latent membrane protein 1.
Q40591623A novel dominant-negative mutant form of Epstein-Barr virus latent membrane protein-1 (LMP1) selectively and differentially impairs LMP1 and TNF signaling pathways
Q39939099Association of dengue virus NS1 protein with lipid rafts
Q33649035Augmented latent membrane protein 1 expression from Epstein-Barr virus episomes with minimal terminal repeats
Q24537608BS69, a specific adaptor in the latent membrane protein 1-mediated c-Jun N-terminal kinase pathway
Q37307520Cross-regulation between herpesviruses and the TNF superfamily members
Q34270437Epstein-Barr virus-encoded LMP1 interacts with FGD4 to activate Cdc42 and thereby promote migration of nasopharyngeal carcinoma cells
Q35634286Epstein-barr virus latent membrane protein 2B (LMP2B) modulates LMP2A activity
Q37587096High molecular weight complex analysis of Epstein-Barr virus Latent Membrane Protein 1 (LMP-1): structural insights into LMP-1's homo-oligomerization and lipid raft association
Q40595025High physiological levels of LMP1 result in phosphorylation of eIF2 alpha in Epstein-Barr virus-infected cells
Q43125086Identification of a lysine-rich region of Fas as a raft nanodomain targeting signal necessary for Fas-mediated cell death.
Q34092709In nasopharyngeal carcinoma cells, Epstein-Barr virus LMP1 interacts with galectin 9 in membrane raft elements resistant to simvastatin.
Q40629419Interaction of Epstein-Barr virus latent membrane protein 1 with SCFHOS/beta-TrCP E3 ubiquitin ligase regulates extent of NF-kappaB activation.
Q35052575LMP1 association with CD63 in endosomes and secretion via exosomes limits constitutive NF-κB activation
Q35139273LMP1 transmembrane domain 1 and 2 (TM1-2) FWLY mediates intermolecular interactions with TM3-6 to activate NF-kappaB
Q39777437LMP1, a viral relative of the TNF receptor family, signals principally from intracellular compartments
Q35122447Latent infection membrane protein transmembrane FWLY is critical for intermolecular interaction, raft localization, and signaling
Q36659985Lipid rafts, detergent-resistant membranes, and raft targeting signals
Q35375389Multi-Tox: application of the ToxR-transcriptional reporter assay to the study of multi-pass protein transmembrane domain oligomerization
Q39605257Multiple cytosolic and transmembrane determinants are required for the trafficking of SCAMP1 via an ER-Golgi-TGN-PM pathway
Q24300115PRA1 promotes the intracellular trafficking and NF-kappaB signaling of EBV latent membrane protein 1
Q34917410Reovirus FAST protein transmembrane domains function in a modular, primary sequence-independent manner to mediate cell-cell membrane fusion.
Q40323227TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB.
Q27318720Targeting of pseudorabies virus structural proteins to axons requires association of the viral Us9 protein with lipid rafts
Q40305675The Epstein-Barr virus oncoprotein LMP1 inhibits the activity of viral or cellular promoters without inducing cytostasis
Q39321358The Epstein-Barr virus-encoded LMP-1 oncoprotein negatively affects Tyk2 phosphorylation and interferon signaling in human B cells
Q38597238The Latent Membrane Protein 1 (LMP1).
Q57169059Transmembrane Domains Mediate Intra- and Extracellular Trafficking of Epstein-Barr Virus Latent Membrane Protein 1
Q35333205Transmembrane peptides used to investigate the homo-oligomeric interface and binding hotspot of latent membrane protein 1.

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