LMP-1's transmembrane domains encode multiple functions required for LMP-1's efficient signaling

scientific article published on November 2002

LMP-1's transmembrane domains encode multiple functions required for LMP-1's efficient signaling is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.76.22.11551-11560.2002
P932PMC publication ID136760
P698PubMed publication ID12388716

P50authorKathleen A WorringerQ47696475
P2093author name stringBill Sugden
Ajamete Kaykas
P2860cites workA heptad motif of leucine residues found in membrane proteins can drive self-assembly of artificial transmembrane segmentsQ74638043
Recruitment of CD40 and tumor necrosis factor receptor-associated factors 2 and 3 to membrane microdomains during CD40 signalingQ22253441
Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinasesQ24515076
Tumor necrosis factor receptor associated factor 2 is a mediator of NF-kappa B activation by latent infection membrane protein 1, the Epstein-Barr virus transforming proteinQ24599252
The Epstein-Barr virus oncogene product latent membrane protein 1 engages the tumor necrosis factor receptor-associated death domain protein to mediate B lymphocyte growth transformation and activate NF-kappaBQ24646694
Epstein-Barr virus latent membrane protein 2A (LMP2A) employs the SLP-65 signaling moduleQ24675538
Inhibition of receptor internalization by monodansylcadaverine selectively blocks p55 tumor necrosis factor receptor death domain signalingQ28140492
Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chainQ28142613
Monitoring protein-protein interactions in intact eukaryotic cells by beta-galactosidase complementationQ28244717
TRAF6 is a critical mediator of signal transduction by the viral oncogene latent membrane protein 1Q28361340
Characteristics of a human cell line transformed by DNA from human adenovirus type 5Q29547863
Role of the TRAF binding site and NF-kappaB activation in Epstein-Barr virus latent membrane protein 1-induced cell gene expressionQ33784729
Epstein-Barr virus latent membrane protein-1 triggers AP-1 activity via the c-Jun N-terminal kinase cascadeQ33887684
Epstein-Barr virus-mediated B-cell proliferation is dependent upon latent membrane protein 1, which simulates an activated CD40 receptorQ33888498
Latent membrane protein 1 of Epstein-Barr virus interacts with JAK3 and activates STAT proteinsQ33891012
A domain in TNF receptors that mediates ligand-independent receptor assembly and signalingQ33907802
Latent membrane protein 1 of Epstein-Barr virus mimics a constitutively active receptor molecule.Q34250209
Stimulation of NF-kappa B-mediated transcription by mutant derivatives of the latent membrane protein of Epstein-Barr virusQ35838888
Deletion of DNA encoding the first five transmembrane domains of Epstein-Barr virus latent membrane proteins 2A and 2B.Q36651589
Transformation by the oncogenic latent membrane protein correlates with its rapid turnover, membrane localization, and cytoskeletal associationQ36695348
A second Epstein-Barr virus membrane protein (LMP2) is expressed in latent infection and colocalizes with LMP1.Q36806077
Induction of the transcription factors NF-kappa B, AP-1 and NF-AT during B cell stimulation through the CD40 receptorQ38299456
Latent membrane protein 1 of Epstein-Barr virus inhibits as well as stimulates gene expressionQ39593467
CD40 and LMP-1 both signal from lipid rafts but LMP-1 assembles a distinct, more efficient signaling complexQ39645275
Characterization of LMP-1's association with TRAF1, TRAF2, and TRAF3.Q39879963
CD40 signaling in human dendritic cells is initiated within membrane raftsQ40430095
Activation of the cJun N-terminal kinase (JNK) pathway by the Epstein-Barr virus-encoded latent membrane protein 1 (LMP1).Q41044165
A fusion of the EBV latent membrane protein-1 (LMP1) transmembrane domains to the CD40 cytoplasmic domain is similar to LMP1 in constitutive activation of epidermal growth factor receptor expression, nuclear factor-kappa B, and stress-activated protQ41046589
The latent membrane protein oncoprotein resembles growth factor receptors in the properties of its turnoverQ41132484
Cross-linking CD40 on B cells rapidly activates nuclear factor-kappa B.Q41429303
Long-Term Human B Cell Lines Dependent on Interleukin-4 and antibody to CD40Q41700086
Mimicry of CD40 signals by Epstein-Barr virus LMP1 in B lymphocyte responsesQ45746898
Epstein-Barr virus latent membrane protein-1 (LMP1) C-terminus activation region 2 (CTAR2) maps to the far C-terminus and requires oligomerisation for NF-kappaB activationQ45759578
Receptor-specific induction of individual AP-1 components in B lymphocytesQ71682510
Localization of the major NF-kappaB-activating site and the sole TRAF3 binding site of LMP-1 defines two distinct signaling motifsQ73555510
Polyubiquitination of the epidermal growth factor receptor occurs at the plasma membrane upon ligand-induced activationQ73731460
Induction of STAT protein signaling through the CD40 receptor in B lymphocytes: distinct STAT activation following surface Ig and CD40 receptor engagementQ73900277
P4510describes a project that usesImageQuantQ112270642
P433issue22
P407language of work or nameEnglishQ1860
P921main subjecttransmembrane proteinQ424204
P304page(s)11551-11560
P577publication date2002-11-01
P1433published inJournal of VirologyQ1251128
P1476titleLMP-1's transmembrane domains encode multiple functions required for LMP-1's efficient signaling
P478volume76

Reverse relations

cites work (P2860)
Q40117245A membrane leucine heptad contributes to trafficking, signaling, and transformation by latent membrane protein 1.
Q38427527Characterization of the latent membrane protein 1 signaling complex of Epstein-Barr virus in the membrane of mammalian cells with bimolecular fluorescence complementation
Q35634286Epstein-barr virus latent membrane protein 2B (LMP2B) modulates LMP2A activity
Q40595025High physiological levels of LMP1 result in phosphorylation of eIF2 alpha in Epstein-Barr virus-infected cells
Q34092709In nasopharyngeal carcinoma cells, Epstein-Barr virus LMP1 interacts with galectin 9 in membrane raft elements resistant to simvastatin.
Q40629419Interaction of Epstein-Barr virus latent membrane protein 1 with SCFHOS/beta-TrCP E3 ubiquitin ligase regulates extent of NF-kappaB activation.
Q34717145LMP1 strain variants: biological and molecular properties.
Q35139273LMP1 transmembrane domain 1 and 2 (TM1-2) FWLY mediates intermolecular interactions with TM3-6 to activate NF-kappaB
Q35122447Latent infection membrane protein transmembrane FWLY is critical for intermolecular interaction, raft localization, and signaling
Q45146068Latent membrane protein 1 of Epstein-Barr virus coordinately regulates proliferation with control of apoptosis.
Q34352790NF-κB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1
Q37575613Role of the Epstein-Barr virus-encoded latent membrane protein-1, LMP1, in the pathogenesis of nasopharyngeal carcinoma
Q40061524The latent membrane protein 1 (LMP1) encoded by Epstein-Barr virus induces expression of the putative oncogene Bcl-3 through activation of the nuclear factor-kappaB.
Q40044863The latent membrane protein 1 oncogene modifies B-cell physiology by regulating autophagy
Q36327896The viral oncoprotein LMP1 exploits TRADD for signaling by masking its apoptotic activity
Q57169059Transmembrane Domains Mediate Intra- and Extracellular Trafficking of Epstein-Barr Virus Latent Membrane Protein 1
Q39732619Transmembrane domains 1 and 2 of the latent membrane protein 1 of Epstein-Barr virus contain a lipid raft targeting signal and play a critical role in cytostasis
Q35333205Transmembrane peptides used to investigate the homo-oligomeric interface and binding hotspot of latent membrane protein 1.