Neutralization of the human immunodeficiency virus type 1 primary isolate JR-FL by human monoclonal antibodies correlates with antibody binding to the oligomeric form of the envelope glycoprotein complex

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Neutralization of the human immunodeficiency virus type 1 primary isolate JR-FL by human monoclonal antibodies correlates with antibody binding to the oligomeric form of the envelope glycoprotein complex is …
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scholarly articleQ13442814

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P356DOI10.1128/JVI.71.4.2779-2785.1997
P932PMC publication ID191401
P698PubMed publication ID9060632

P2093author name stringA Trkola
J M Binley
J P Moore
J E Robinson
T R Fouts
P2860cites workGenotypic and phenotypic characterization of HIV-1 patients with primary infectionQ22242245
Identification of a major co-receptor for primary isolates of HIV-1Q22251282
A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactorsQ28118386
The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolatesQ28282895
CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1Q28646859
HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5Q29616094
Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibodyQ29618366
Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1Q29619512
Vpr is required for efficient replication of human immunodeficiency virus type-1 in mononuclear phagocytesQ29619514
High concentrations of recombinant soluble CD4 are required to neutralize primary human immunodeficiency virus type 1 isolatesQ33760671
Human monoclonal antibody that recognizes the V3 region of human immunodeficiency virus gp120 and neutralizes the human T-lymphotropic virus type IIIMN strainQ33880904
Discontinuous, conserved neutralization epitopes overlapping the CD4-binding region of human immunodeficiency virus type 1 gp120 envelope glycoproteinQ33937274
Production of site-selected neutralizing human monoclonal antibodies against the third variable domain of the human immunodeficiency virus type 1 envelope glycoproteinQ34097650
Human anti-V2 monoclonal antibody that neutralizes primary but not laboratory isolates of human immunodeficiency virus type 1Q34292765
Principal neutralizing domain of the human immunodeficiency virus type 1 envelope proteinQ34301897
Adaptation to persistent growth in the H9 cell line renders a primary isolate of human immunodeficiency virus type 1 sensitive to neutralization by vaccine seraQ35828529
A human monoclonal antibody to a complex epitope in the V3 region of gp120 of human immunodeficiency virus type 1 has broad reactivity within and outside clade B.Q35828898
Enhanced sensitivity to neutralizing antibodies in a variant of equine infectious anemia virus is linked to amino acid substitutions in the surface unit envelope glycoproteinQ35833979
Serotyping of primary human immunodeficiency virus type 1 isolates from diverse geographic locations by flow cytometry.Q35839973
Replicative function and neutralization sensitivity of envelope glycoproteins from primary and T-cell line-passaged human immunodeficiency virus type 1 isolates.Q35841780
Involvement of the V1/V2 variable loop structure in the exposure of human immunodeficiency virus type 1 gp120 epitopes induced by receptor bindingQ35845976
Cross-clade neutralization of primary isolates of human immunodeficiency virus type 1 by human monoclonal antibodies and tetrameric CD4-IgG.Q35849408
Antibody cross-competition analysis of the human immunodeficiency virus type 1 gp120 exterior envelope glycoprotein.Q35857331
The high efficiency, human B cell immortalizing heteromyeloma CB-F7. Production of human monoclonal antibodies to human immunodeficiency virusQ42817327
Chimeric viruses expressing primary envelope glycoproteins of human immunodeficiency virus type I show increased sensitivity to neutralization by human sera.Q45770199
Characterization of recombinant gp120 and gp160 from HIV-1: binding to monoclonal antibodies and soluble CD4.Q52449889
A trimeric structural domain of the HIV-1 transmembrane glycoproteinQ54155492
Dual infection of the central nervous system by AIDS viruses with distinct cellular tropisms.Q55487007
Back to primary schoolQ60075598
Simple methods for monitoring HIV-1 and HIV-2 gp120 binding to soluble CD4 by enzyme-linked immunosorbent assay: HIV-2 has a 25-fold lower affinity than HIV-1 for soluble CD4Q68515930
A resting cell assay for improved detection of antibody-mediated neutralization of HIV type 1 primary isolatesQ71185106
Expression and Characterization of CD4-IgG2, a Novel Heterotetramer That Neutralizes Primary HIV Type 1 IsolatesQ71783840
Enhancement of infectivity of a non-syncytium inducing HIV-1 by sCD4 and by human antibodies that neutralize syncytium inducing HIV-1Q72417361
Mechanisms of human immunodeficiency virus Type 1 (HIV-1) neutralization: irreversible inactivation of infectivity by anti-HIV-1 antibodyQ35866030
Increased envelope spike density and stability are not required for the neutralization resistance of primary human immunodeficiency virusesQ35868205
Antibody-mediated neutralization of primary isolates of human immunodeficiency virus type 1 in peripheral blood mononuclear cells is not affected by the initial activation state of the cellsQ35879840
Human immunodeficiency virus type 1 neutralization is determined by epitope exposure on the gp120 oligomerQ36365085
Neutralizing antibodies to human immunodeficiency virus type-1 gp120 induce envelope glycoprotein subunit dissociation.Q36366296
Probing the structure of the human immunodeficiency virus surface glycoprotein gp120 with a panel of monoclonal antibodiesQ36620408
Recognition properties of a panel of human recombinant Fab fragments to the CD4 binding site of gp120 that show differing abilities to neutralize human immunodeficiency virus type 1.Q36623941
Increase in soluble CD4 binding to and CD4-induced dissociation of gp120 from virions correlates with infectivity of human immunodeficiency virus type 1.Q36627098
Neutralization sensitivity of human immunodeficiency virus type 1 is determined in part by the cell in which the virus is propagated.Q36628256
Cryptic nature of envelope V3 region epitopes protects primary monocytotropic human immunodeficiency virus type 1 from antibody neutralizationQ36635390
Antibodies to discontinuous or conformationally sensitive epitopes on the gp120 glycoprotein of human immunodeficiency virus type 1 are highly prevalent in sera of infected humansQ36641374
Characterization of conserved human immunodeficiency virus type 1 gp120 neutralization epitopes exposed upon gp120-CD4 bindingQ36649958
Probing the structure of the V2 domain of human immunodeficiency virus type 1 surface glycoprotein gp120 with a panel of eight monoclonal antibodies: human immune response to the V1 and V2 domainsQ36653730
Native but not denatured recombinant human immunodeficiency virus type 1 gp120 generates broad-spectrum neutralizing antibodies in baboonsQ36655953
Virions of primary human immunodeficiency virus type 1 isolates resistant to soluble CD4 (sCD4) neutralization differ in sCD4 binding and glycoprotein gp120 retention from sCD4-sensitive isolatesQ36656036
Neutralization of diverse human immunodeficiency virus type 1 variants by an anti-V3 human monoclonal antibodyQ36687562
Changes in both gp120 and gp41 can account for increased growth potential and expanded host range of human immunodeficiency virus type 1Q36699051
V3 variability can influence the ability of an antibody to neutralize or enhance infection by diverse strains of human immunodeficiency virus type 1Q36711168
Characterization of a discontinuous human immunodeficiency virus type 1 gp120 epitope recognized by a broadly reactive neutralizing human monoclonal antibodyQ36821885
Evidence for non-V3-specific neutralizing antibodies that interfere with gp120/CD4 binding in human immunodeficiency virus 1-infected humansQ37548597
Envelope proteins from clinical isolates of human immunodeficiency virus type 1 that are refractory to neutralization by soluble CD4 possess high affinity for the CD4 receptorQ37588188
Another discontinuous epitope on glycoprotein gp120 that is important in human immunodeficiency virus type 1 neutralization is identified by a monoclonal antibodyQ37603996
Macrophage-tropic and T-cell line-adapted chimeric strains of human immunodeficiency virus type 1 differ in their susceptibilities to neutralization by soluble CD4 at different temperatures.Q39313957
HIV-1 tropism for mononuclear phagocytes can be determined by regions of gp120 outside the CD4-binding domainQ39313963
Structural modulations of the envelope gp120 glycoprotein of human immunodeficiency virus type 1 upon oligomerization and differential V3 loop epitope exposure of isolates displaying distinct tropism upon virion-soluble receptor bindingQ39485924
CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5.Q39605077
Primary isolates of human immunodeficiency virus type 1 are relatively resistant to neutralization by monoclonal antibodies to gp120, and their neutralization is not predicted by studies with monomeric gp120.Q39868309
Quantitative model of antibody- and soluble CD4-mediated neutralization of primary isolates and T-cell line-adapted strains of human immunodeficiency virus type 1.Q39874632
Serum neutralization of feline immunodeficiency virus is markedly dependent on passage history of the virus and host system.Q40038277
Conformational epitope on gp120 important in CD4 binding and human immunodeficiency virus type 1 neutralization identified by a human monoclonal antibodyQ40062738
Candidate AIDS vaccinesQ40416583
Toward an understanding of the correlates of protective immunity to HIV infectionQ40941051
HIV-1 neutralization: the consequences of viral adaptation to growth on transformed T cells.Q41120023
CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5.Q41151327
Neutralization of SIVmac239/17E in lymphocyte cultures involves virus strain-specific linear and conformational epitopes encoded by different regions of the env gene including the "V3" domainQ41179656
Antigenic determinants on HIV-1 envelope glycoproteins: a dickens of a time with oligomer twistQ41179665
Increase in sensitivity to soluble CD4 by primary HIV type 1 isolates after passage through C8166 cells: association with sequence differences in the first constant (C1) region of glycoprotein 120.Q41364323
Adaptation of two primary human immunodeficiency virus type 1 isolates to growth in transformed T cell lines correlates with alterations in the responses of their envelope glycoproteins to soluble CD4.Q41550657
Cooperativity of neutralizing antibodies directed against the V3 and CD4 binding regions of the human immunodeficiency virus gp120 envelope glycoproteinQ41645847
Neutralization of Divergent HIV-1 Isolates by Conformation-Dependent Human Antibodies to Gp120Q42129803
Characterization of murine monoclonal antibodies to HIV-1 induced by synthetic peptidesQ42649550
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectvirologyQ7215
antibodyQ79460
monoclonal antibodyQ422248
P304page(s)2779-2785
P577publication date1997-04-01
P1433published inJournal of VirologyQ1251128
P1476titleNeutralization of the human immunodeficiency virus type 1 primary isolate JR-FL by human monoclonal antibodies correlates with antibody binding to the oligomeric form of the envelope glycoprotein complex
P478volume71

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