Directional motility induced by epidermal growth factor requires Cdc42.

scientific article published on July 2003

Directional motility induced by epidermal growth factor requires Cdc42. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0014-4827(03)00119-8
P698PubMed publication ID12799181

P50authorAlan WellsQ38324974
Simon C WatkinsQ87981821
P2093author name stringAkihiro Iwabu
Jeffrey Chou
Nancy A Burke
P2860cites workWiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerizationQ24309118
Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASPQ24318478
Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformationQ24515205
Stimulation of phospholipase C-beta2 by the Rho GTPases Cdc42Hs and Rac1.Q24533367
Leukotriene D4 induces association of active RhoA with phospholipase C-gamma1 in intestinal epithelial cellsQ24534194
Vav2 activates Rac1, Cdc42, and RhoA downstream from growth factor receptors but not beta1 integrinsQ24551376
The Arp2/3 complex mediates actin polymerization induced by the small GTP-binding protein Cdc42Q24647927
Analysis of receptor signaling pathways by mass spectrometry: identification of vav-2 as a substrate of the epidermal and platelet-derived growth factor receptorsQ24649799
Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI bindingQ24674800
The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factorsQ27860467
Distribution of gelsolin and phosphoinositol 4,5-bisphosphate in lamellipodia during EGF-induced motilityQ40738595
Cdc42 controls secretory and endocytic transport to the basolateral plasma membrane of MDCK cellsQ40918582
Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting.Q41063499
Regulation of chemotaxis by the platelet-derived growth factor receptor-betaQ41488423
PDGF stimulation of inositol phospholipid hydrolysis requires PLC-gamma 1 phosphorylation on tyrosine residues 783 and 1254.Q41684625
Ligand-induced transformation by a noninternalizing epidermal growth factor receptorQ41743656
Phosphorylation of Phospholipase Cγ1 on Tyrosine Residue 783 by Platelet-Derived Growth Factor Regulates Reorganization of the CytoskeletonQ42826925
EGF-dependent translocation of green fluorescent protein-tagged PLC-gamma1 to the plasma membrane and endosomes.Q52543260
Specific Requirement for the p85-p110α Phosphatidylinositol 3-Kinase during Epidermal Growth Factor-stimulated Actin Nucleation in Breast Cancer CellsQ57371843
Focal adhesion kinase and phospholipase C gamma involvement in adhesion and migration of human hepatic stellate cellsQ73047920
The Ca2+/Calmodulin-dependent Kinase Type IV Is Involved in the CD5-mediated Signaling Pathway in Human T LymphocytesQ73935081
Epidermal growth factor receptor-mediated motility in fibroblastsQ77701735
Cell migration: a physically integrated molecular processQ27860682
The small GTP-binding protein rac regulates growth factor-induced membrane rufflingQ27861063
Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodiaQ27861126
A protein interaction map for cell polarity development.Q27934870
Activation of phospholipase D1 by Cdc42 requires the Rho insert regionQ28140512
Membrane-targeting is critical for the phosphorylation of Vav2 by activated EGF receptorQ28214047
Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complexQ28293934
Faciogenital dysplasia protein (FGD1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPasesQ28301106
Specificity and promiscuity in phosphoinositide binding by pleckstrin homology domainsQ28584046
The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assemblyQ28609843
Vav2 is an activator of Cdc42, Rac1, and RhoAQ28610652
Stimulation of phospholipase C-gamma 1 membrane association by epidermal growth factorQ28610780
Role of Substrates and Products of PI 3-kinase in Regulating Activation of Rac-Related Guanosine Triphosphatases by VavQ28646540
Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphateQ28647599
Rho GTPases control polarity, protrusion, and adhesion during cell movementQ29614244
The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblastsQ29614253
The mechanism involved in the regulation of phospholipase Cgamma1 activity in cell migration.Q30165214
Major transcript variants of VAV3, a new member of the VAV family of guanine nucleotide exchange factorsQ30175227
Shaping up for shipping out: PLCgamma signaling of morphology changes in EGF-stimulated fibroblast migrationQ33796988
Vav1 regulates phospholipase cgamma activation and calcium responses in mast cells.Q33968323
Insulin-like growth factor-I and platelet-derived growth factor-BB induce directed migration of human arterial smooth muscle cells via signaling pathways that are distinct from those of proliferationQ34133504
Biophysical integration of effects of epidermal growth factor and fibronectin on fibroblast migrationQ34170512
Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42Q34284892
Variants of 3T3 cells lacking mitogenic response to epidermal growth factorQ35051611
Filopodia of spreading 3T3 cells. Do they have a substrate-exploring function?Q36197893
Cell movement elicited by epidermal growth factor receptor requires kinase and autophosphorylation but is separable from mitogenesisQ36233701
Epidermal growth factor receptor-mediated cell motility: phospholipase C activity is required, but mitogen-activated protein kinase activity is not sufficient for induced cell movementQ36234800
A role for gelsolin in actuating epidermal growth factor receptor-mediated cell motilityQ36237218
Corequirement of Specific Phosphoinositides and Small GTP-binding Protein Cdc42 in Inducing Actin Assembly in Xenopus Egg ExtractsQ36255219
A role for Cdc42 in macrophage chemotaxisQ36264673
Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxisQ36322960
Cdc42 and Rac stimulate exocytosis of secretory granules by activating the IP(3)/calcium pathway in RBL-2H3 mast cellsQ36327471
Mutational analysis of CDC42Sc, a Saccharomyces cerevisiae gene that encodes a putative GTP-binding protein involved in the control of cell polarityQ36724820
Development of cell polarity in budding yeastQ37342343
P433issue1
P407language of work or nameEnglishQ1860
P1104number of pages10
P304page(s)47-56
P577publication date2003-07-01
P1433published inExperimental Cell ResearchQ1524289
P1476titleDirectional motility induced by epidermal growth factor requires Cdc42.
P478volume287

Reverse relations

cites work (P2860)
Q24306906Akt binds to and phosphorylates phospholipase C-gamma1 in response to epidermal growth factor
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Q40595058Epidermal growth factor induces fibroblast contractility and motility via a protein kinase C delta-dependent pathway
Q47974787ErbB Receptors and Cancer
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Q24317376Invasion of breast cancer cells into collagen matrix requires TGF-α and Cdc42 signaling
Q30777752Live imaging of wound inflammation in Drosophila embryos reveals key roles for small GTPases during in vivo cell migration
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Q33593984Phosphorylation of alpha-actinin 4 upon epidermal growth factor exposure regulates its interaction with actin
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Q34407341Protein kinase Cgamma regulates myosin IIB phosphorylation, cellular localization, and filament assembly
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Q27304834Subcellular optogenetic activation of Cdc42 controls local and distal signaling to drive immune cell migration
Q30491338Unbalancing the phosphatidylinositol-4,5-bisphosphate-cofilin interaction impairs cell steering
Q30497113m-Calpain activation is regulated by its membrane localization and by its binding to phosphatidylinositol 4,5-bisphosphate.
Q35551725β3 integrin-EGF receptor cross-talk activates p190RhoGAP in mouse mammary gland epithelial cells.

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