Human mammary epithelial cells exhibit a differential p53-mediated response following exposure to ionizing radiation or UV light

scientific article published on October 1999

Human mammary epithelial cells exhibit a differential p53-mediated response following exposure to ionizing radiation or UV light is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1014452648
P356DOI10.1038/SJ.ONC.1202977
P698PubMed publication ID10523860
P5875ResearchGate publication ID12776412

P2093author name stringTlsty TD
Leadon SA
Hess SM
Meyer KM
P2860cites workActivation of the ATM kinase by ionizing radiation and phosphorylation of p53Q24311891
p53 modulation of TFIIH–associated nucleotide excision repair activityQ24336880
UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse CellsQ24609948
Checkpoints: controls that ensure the order of cell cycle eventsQ28131705
Enhanced phosphorylation of p53 by ATM in response to DNA damageQ28609838
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasiaQ29615437
Cell cycle control and cancerQ29617536
Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV resistanceQ33934051
Immortalization of distinct human mammary epithelial cell types by human papilloma virus 16 E6 or E7.Q34368179
Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3Q35101216
DNA damage induces phosphorylation of the amino terminus of p53Q35199554
Functional activation of p53 via phosphorylation following DNA damage by UV but not gamma radiationQ35973184
Ubiquitination of p53 and p21 is differentially affected by ionizing and UV radiationQ36564865
Physical and functional interaction between wild-type p53 and mdm2 proteinsQ36646112
DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathwaysQ36647845
Accumulation of p53 in a mutant cell line defective in the ubiquitin pathwayQ36648425
Preferential repair of ionizing radiation-induced damage in the transcribed strand of an active human gene is defective in Cockayne syndromeQ36658207
Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.Q36665942
p53 cellular tumor antigen: analysis of mRNA levels in normal adult tissues, embryos, and tumorsQ36895398
Two Distinct Mechanisms Regulate the Levels of a Cellular Tumor Antigen, p53Q36980764
Wild-type p53 is a cell cycle checkpoint determinant following irradiationQ37152060
Ultraviolet radiation, but not gamma radiation or etoposide-induced DNA damage, results in the phosphorylation of the murine p53 protein at serine-389Q37413761
Induction of transformation and continuous cell lines from normal human mammary epithelial cells after exposure to benzo[a]pyreneQ37684502
Regulation of the specific DNA binding function of p53Q38324290
Ataxia-telangiectasia: an inherited disorder of ionizing-radiation sensitivity in man. Progress in the elucidation of the underlying biochemical defectQ39761489
Mutation of the casein kinase II phosphorylation site abolishes the anti-proliferative activity of p53.Q40535104
Primary structure polymorphism at amino acid residue 72 of human p53.Q40658642
p53 mutations in human immortalized epithelial cell linesQ41554898
Expression and stability of p53 protein in normal human mammary epithelial cellsQ41554910
A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage.Q45985375
A variation in the structure of the protein-coding region of the human p53 geneQ48312738
Differential disruption of genomic integrity and cell cycle regulation in normal human fibroblasts by the HPV oncoproteins.Q52512094
G1 arrest and cell-cycle-dependent clastogenesis in UV-irradiated human fibroblasts.Q54223365
Isolation and growth of human mammary epithelial cellsQ107101532
P433issue42
P407language of work or nameEnglishQ1860
P304page(s)5795-5805
P577publication date1999-10-01
P1433published inOncogeneQ1568657
P1476titleHuman mammary epithelial cells exhibit a differential p53-mediated response following exposure to ionizing radiation or UV light
P478volume18

Reverse relations

cites work (P2860)
Q40597504Cell death in irradiated prostate epithelial cells: role of apoptotic and clonogenic cell kill.
Q53207019Contrasting DNA damage checkpoint responses in epithelium of the human seminal vesicle and prostate.
Q33776331Contribution of p53 to metastasis
Q33997846Dial 9-1-1 for p53: mechanisms of p53 activation by cellular stress
Q36823692Dissecting cellular responses to irradiation via targeted disruptions of the ATM-CHK1-PP2A circuit
Q35138074Epigenetic and transcriptional determinants of the human breast
Q42476896Exploring a minimal two-component p53 model
Q39422548FISH-based analysis of 10- and 25-kV soft X-ray-induced DNA damage in 184A1 human mammary epithelial cells
Q35249104Gene expression pattern of insect fat body cells from in vitro challenge to cell line establishment
Q46704393Histologically normal human mammary epithelia with silenced p16(INK4a) overexpress COX-2, promoting a premalignant program
Q34334869Loss of chromosomal integrity in human mammary epithelial cells subsequent to escape from senescence
Q38023979Maintenance of genomic integrity after DNA double strand breaks in the human prostate and seminal vesicle epithelium: the best and the worst
Q53437770Multiple molecular mechanisms contribute to radiation sensitivity in mantle cell lymphoma.
Q46069224Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes
Q34552889Oncogenic functions of tumour suppressor p21(Waf1/Cip1/Sdi1): association with cell senescence and tumour-promoting activities of stromal fibroblasts
Q34324237Overexpression of c-Myc alters G(1)/S arrest following ionizing radiation
Q44513266Phosphorylation site interdependence of human p53 post-translational modifications in response to stress
Q40011883Replication of an E1B 55-kilodalton protein-deficient adenovirus (ONYX-015) is restored by gain-of-function rather than loss-of-function p53 mutants
Q40750476Study of the G2/M cell cycle checkpoint in irradiated mammary epithelial cells overexpressing Cul-4A gene
Q79635149The p53/p21 DNA damage-signaling pathway is defective in most meningioma cells

Search more.