Spinal opioid analgesia: how critical is the regulation of substance P signaling?

scientific article published on November 1999

Spinal opioid analgesia: how critical is the regulation of substance P signaling? is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1523/JNEUROSCI.19-21-09642.1999
P932PMC publication ID6782904
P698PubMed publication ID10531466

P2093author name stringS Marchand
A I Basbaum
P W Mantyh
C Abbadie
J A Trafton
P2860cites workPrimary afferent tachykinins are required to experience moderate to intense painQ28506575
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Characterization of antibodies to the rat substance P (NK-1) receptor and to a chimeric substance P receptor expressed in mammalian cellsQ38311745
Opiate analgesics inhibit substance P release from rat trigeminal nucleusQ39156657
Can chronic pain be suppressed despite purported tolerance to narcotic analgesia?Q39253603
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Upregulation, release and axonal transport of substance P and calcitonin gene-related peptide in adjuvant inflammation and regulatory function of nerve growth factorQ40491049
Opioidergic control of the spinal release of neuropeptides. Possible significance for the analgesic effects of opioidsQ40590296
Opioid modulation of capsaicin-evoked release of substance P from rat spinal cord in vivoQ41258524
Characterization of receptors using cyanine 3-labeled neuropeptidesQ41406522
Substance P release in the dorsal horn assessed by receptor internalization: NMDA receptors counteract a tonic inhibition by GABA(B) receptorsQ41610524
The dual nature of the tachykinin NK1 receptor.Q41633157
Analgesic doses of morphine do not reduce noxious stimulus-evoked release of immunoreactive neurokinins in the dorsal horn of the spinal cat.Q42463170
Spinal cord substance P receptor immunoreactivity increases in both inflammatory and nerve injury models of persistent painQ43917106
Double in situ hybridization study on coexistence of mu-, delta- and kappa-opioid receptor mRNAs with preprotachykinin A mRNA in the rat dorsal root gangliaQ44333074
Activation of kappa opioid receptors by U50488H and morphine enhances the release of substance P from rat trigeminal nucleus slicesQ44334354
Mu, delta, and kappa opioid receptor mRNA expression in the rat CNS: an in situ hybridization studyQ44336066
Comparison of the antinociceptive and motor effects of intrathecal opioid agonists in the rat.Q44336403
Opposite effects of delta and mu opioid receptor agonists on the in vitro release of substance P-like material from the rat spinal cordQ44339346
Kappa-opioid receptor modulation of the release of substance P in the dorsal hornQ44342095
Delta-Opioid receptor modulation of the release of substance P-like immunoreactivity in the dorsal horn of the rat following mechanical or thermal noxious stimulationQ44344151
Localization and regulation of the delta-opioid receptor in dorsal root ganglia and spinal cord of the rat and monkey: evidence for association with the membrane of large dense-core vesiclesQ44347921
Morphological characterization of substance P receptor‐immunoreactive neurons in the rat spinal cord and trigeminal nucleus caudalisQ46090686
Differential effects of morphine on noxious stimulus-evoked fos-like immunoreactivity in subpopulations of spinoparabrachial neurons.Q46149436
Inflammation increases the distribution of dorsal horn neurons that internalize the neurokinin-1 receptor in response to noxious and non-noxious stimulation.Q46304913
NMDA-receptor regulation of substance P release from primary afferent nociceptorsQ46378238
Mechanisms of desensitization and resensitization of G protein-coupled neurokinin1 and neurokinin2 receptors.Q46588266
Neurokinin 1 receptor internalization in spinal cord slices induced by dorsal root stimulation is mediated by NMDA receptors.Q46662825
Effects of systemic morphine on lamina I spinothalamic tract neurons in the cat.Q48174849
Actions of opioids on primate spinothalamic tract neuronsQ48308407
Effects of iontophoresed opioids on physiologically characterized laminae I and II dorsal horn neurons in the cat spinal cordQ48860166
Inflammatory pain hypersensitivity mediated by phenotypic switch in myelinated primary sensory neurons.Q52198922
Intrathecal morphine inhibits substance P release from mammalian spinal cord in vivoQ59061346
Lamina-specific effects of morphine and naloxone in dorsal horn of rat spinal cord in vitroQ67885730
Met-enkephalin and morphine but not dynorphin inhibit noxious stimuli-induced release of substance P from rabbit dorsal horn in situQ68938614
Cutaneous stimuli releasing immunoreactive substance P in the dorsal horn of the catQ69078129
Demonstration of rat preprotachykinin A mRNA in the rat trigeminal ganglion by in situ hybridization histochemistryQ69102569
The analgesic effects of morphine, but not those of the enkephalinase inhibitor thiorphan, are enhanced in arthritic ratsQ70905045
Monoarthritis in the rat knee induces bilateral and time-dependent changes in substance P and calcitonin gene-related peptide immunoreactivity in the spinal cordQ71610040
Substance P elevates intracellular calcium in both neurons and glial cells from the dorsal horn of the spinal cordQ71665671
Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulationQ71696623
The proportion of CGRP-immunoreactive and SP-mRNA containing dorsal root ganglion cells is increased by a unilateral inflammation of the ankle joint of the ratQ72099729
Spinoparabrachial tract neurons showing substance P receptor-like immunoreactivity in the lumbar spinal cord of the ratQ72346996
Alterations in Uptake and Release Rates for GABA, Glutamate, and Glutamine During Biochemical Maturation of Highly Purified Cultures of Cerebral Cortical Neurons, a GABAergic PreparationQ72573203
Inflammation-induced upregulation of NK1 receptor mRNA in dorsal horn neuronesQ72610367
The use of antiavidin antibody and avidin-biotin-peroxidase complex in immunoperoxidase technicsQ72640463
Intrathecal substance P elicits a caudally-directed biting and scratching behavior in miceQ72640892
Effects of morphine on noxious stimuli-induced release of substance P from rabbit dorsal hornQ72723436
Lamina-specific alteration of C-fibre evoked activity by morphine in the dorsal horn of the rat spinal cordQ72907051
P433issue21
P407language of work or nameEnglishQ1860
P304page(s)9642-9653
P577publication date1999-11-01
P1433published inJournal of NeuroscienceQ1709864
P1476titleSpinal opioid analgesia: how critical is the regulation of substance P signaling?
P478volume19

Reverse relations

cites work (P2860)
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