Mechanisms of μ-opioid receptor inhibition of NMDA receptor-induced substance P release in the rat spinal cord

scientific article published on 14 October 2017

Mechanisms of μ-opioid receptor inhibition of NMDA receptor-induced substance P release in the rat spinal cord is …
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scholarly articleQ13442814

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P356DOI10.1016/J.NEUROPHARM.2017.10.014
P932PMC publication ID5726399
P698PubMed publication ID29042318

P50authorJuan Carlos MarvizónQ57571543
P2093author name stringWenling Chen
James A McRoberts
Helena S Ennes
P2860cites workSpinal substance P receptor expression and internalization in acute, short-term, and long-term inflammatory pain statesQ78166434
Primary afferent NMDA receptors increase dorsal horn excitation and mediate opiate tolerance in neonatal ratsQ79362825
Acute inflammation induces segmental, bilateral, supraspinally mediated opioid release in the rat spinal cord, as measured by mu-opioid receptor internalizationQ28578470
Differential actions of PKA and PKC in the regulation of glutamate release by group III mGluRs in the entorhinal cortex.Q31841458
Mechanisms of inward-rectifier K+ channel inhibition by tertiapin-Q.Q33881318
Inverse, protean, and ligand-selective agonism: matters of receptor conformationQ33938998
BDNF released during neuropathic pain potentiates NMDA receptors in primary afferent terminalsQ34005579
Src family kinases mediate the inhibition of substance P release in the rat spinal cord by μ-opioid receptors and GABA(B) receptors, but not α2 adrenergic receptorsQ34142913
Spinal G-protein-gated potassium channels contribute in a dose-dependent manner to the analgesic effect of mu- and delta- but not kappa-opioids.Q34409452
Alternative splicing controls G protein-dependent inhibition of N-type calcium channels in nociceptorsQ34523190
Why the Schild method is better than Schild realisedQ34714817
Evidence for presynaptic N-methyl-D-aspartate autoreceptors in the spinal cord dorsal hornQ35702669
Ca2+ channels as integrators of G protein-mediated signaling in neuronsQ35842956
Latent sensitization: a model for stress-sensitive chronic painQ35939954
Comparing analgesia and mu-opioid receptor internalization produced by intrathecal enkephalin: requirement for peptidase inhibitionQ36155156
Regulation of NMDA receptor Ca2+ signalling and synaptic plasticityQ36408077
Sustained Suppression of Hyperalgesia during Latent Sensitization by μ-, δ-, and κ-opioid receptors and α2A Adrenergic Receptors: Role of Constitutive ActivityQ36431999
Noxious mechanical stimulation evokes the segmental release of opioid peptides that induce mu-opioid receptor internalization in the presence of peptidase inhibitorsQ36538158
Sex-dependent differences in the activity and modulation of N-methyl-d-aspartic acid receptors in rat dorsal root ganglia neuronsQ36597159
Opioid receptor-coupled second messenger systemsQ37179761
NMDA-receptor regulation of substance P release from primary afferent nociceptorsQ46378238
Activation of spinal d1/d5 receptors induces late-phase LTP of C-fiber-evoked field potentials in rat spinal dorsal horn.Q46437060
Neurokinin 1 receptor internalization in spinal cord slices induced by dorsal root stimulation is mediated by NMDA receptors.Q46662825
Experimental colitis modulates the functional properties of NMDA receptors in dorsal root ganglia neuronsQ46693180
Expression of mRNAs encoding full-length and truncated TrkB receptors in rat dorsal root ganglia and spinal cord following peripheral inflammationQ48097724
Expression of mRNAs for neurotrophin receptors in the dorsal root ganglion and spinal cord during development and following peripheral or central axotomyQ48321978
Chronic catheterization of the spinal subarachnoid spaceQ48344815
Roles of intracellular cAMP and protein kinase A in the actions of dopamine and neurotensin on midbrain dopamine neuronsQ48478385
Spinal monoamine and opiate systems partly mediate the antinociceptive effects produced by glutamate at brainstem sitesQ48602338
Effect of NMDA NR2B antagonist on neuropathic pain in two spinal cord injury modelsQ48712867
Bortezomib induces neuropathic pain through protein kinase C-mediated activation of presynaptic NMDA receptors in the spinal cordQ48737325
Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptorsQ49132765
The induction and maintenance of central sensitization is dependent on N -methyl-d-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity statesQ52237708
G protein-coupled inwardly rectifying potassium channels in dorsal root ganglion neurons.Q54400031
Endogenous activation of presynaptic NMDA receptors enhances glutamate release from the primary afferents in the spinal dorsal horn in a rat model of neuropathic pain.Q54453373
Intrathecal morphine inhibits substance P release from mammalian spinal cord in vivoQ59061346
Intracellular calibration of the fluorescent calcium indicator Fura-2Q68817958
Lumbar catheterization of the spinal subarachnoid space in the ratQ71346801
Inhibition of calcium channels in rat central and peripheral neurons by omega-conotoxin MVIICQ71483859
Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulationQ71696623
Long-term potentiation and long-term depression of primary afferent neurotransmission in the rat spinal cordQ72640836
Long-term potentiation induced by theta frequency stimulation is regulated by a protein phosphatase-1-operated gateQ73119640
Localization of N-methyl-D-aspartate NR2B subunits on primary sensory neurons that give rise to small-caliber sciatic nerve fibers in ratsQ73289187
Dynorphin-(1-8) inhibits the release of substance P-like immunoreactivity in the spinal cord of rats following a noxious mechanical stimulusQ73292044
Noxious cutaneous thermal stimuli induce a graded release of endogenous substance P in the spinal cord: imaging peptide action in vivoQ73507903
Spinal N-methyl-D-aspartate receptors and nociception-evoked release of primary afferent substance P.Q37314774
Phosphorylation of Ser1166 on GluN2B by PKA is critical to synaptic NMDA receptor function and Ca2+ signaling in spinesQ37479508
Truncated TrkB: beyond a dominant negative receptorQ37985103
Direct association of Mu-opioid and NMDA glutamate receptors supports their cross-regulation: molecular implications for opioid tolerance.Q38037679
Omega-conotoxins as experimental tools and therapeutics in pain managementQ38087443
Oxidation of protein tyrosine phosphatases as a pharmaceutical mechanism of action: a study using 4-hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dioneQ38345436
Constitutive μ-opioid receptor activity leads to long-term endogenous analgesia and dependenceQ39220347
NMDA receptors in primary afferents require phosphorylation by Src family kinases to induce substance P release in the rat spinal cordQ39576351
The mu-opioid receptor and the NMDA receptor associate in PAG neurons: implications in pain control.Q39904357
Characterisation of N-methyl-D-aspartate receptor-specific [(3)H]Ifenprodil binding to recombinant human NR1a/NR2B receptors compared with native receptors in rodent brain membranesQ40842221
Differential distribution of alpha2A and alpha2C adrenergic receptor immunoreactivity in the rat spinal cord.Q41023728
mu-Opioid receptor internalization: opiate drugs have differential effects on a conserved endocytic mechanism in vitro and in the mammalian brainQ41054132
Down-regulation of mu-opioid receptor by full but not partial agonists is independent of G protein couplingQ41082537
Signal transduction mediated by the truncated trkB receptor isoforms, trkB.T1 and trkB.T2.Q41116074
Functional analysis of cloned opioid receptors in transfected cell lines.Q41153532
Characterization of antisera specific to NK1, NK2, and NK3 neurokinin receptors and their utilization to localize receptors in the rat gastrointestinal tract.Q41156993
Opioid modulation of capsaicin-evoked release of substance P from rat spinal cord in vivoQ41258524
Internalization of mu-opioid receptors in rat spinal cord slicesQ41684135
Spinal opioid analgesia: how critical is the regulation of substance P signaling?Q41697764
Omega-conotoxin GVIA-resistant neurotransmitter release from postganglionic sympathetic nerves in the guinea-pig vas deferens and its modulation by presynaptic receptorsQ41807817
NMDA receptor activation modulates evoked release of substance P from rat spinal cordQ41868145
The K(+) channel GIRK2 is both necessary and sufficient for peripheral opioid-mediated analgesiaQ41923805
Substance P release and neurokinin 1 receptor activation in the rat spinal cord increase with the firing frequency of C-fibers.Q41924456
Constitutively active μ-opioid receptorsQ42841719
Inhibition of N-methyl-D-aspartate- and kainic acid-induced neurotransmitter release by omega-conotoxin GVIA.Q42847446
Upregulation of substance P in low-threshold myelinated afferents is not required for tactile allodynia in the chronic constriction injury and spinal nerve ligation models.Q42913997
Inhibition of long-term potentiation by valproic acid through modulation of cyclic AMP.Q43225500
Effect of peptidases on the ability of exogenous and endogenous neurokinins to produce neurokinin 1 receptor internalization in the rat spinal cordQ43263146
Role of peripheral N-methyl-D-aspartate (NMDA) receptors in visceral nociception in ratsQ43619434
Spinal NK-1 receptor-expressing neurons and descending pathways support fentanyl-induced pain hypersensitivity in a rat model of postoperative pain.Q43690504
Two N-methyl-D-aspartate receptors in rat dorsal root ganglia with different subunit composition and localizationQ43959884
The role of ketamine in preventing fentanyl-induced hyperalgesia and subsequent acute morphine toleranceQ43969879
Glutamate induces a depolarization of adult rat dorsal root ganglion neurons that is mediated predominantly by NMDA receptorsQ44081052
mu-Opioid receptor activation reduces multiple components of high-threshold calcium current in rat sensory neurons.Q44333031
Mu- and kappa-opioid receptors selectively reduce the same transient components of high-threshold calcium current in rat dorsal root ganglion sensory neurons.Q44336799
NMDAR-nNOS generated zinc recruits PKCgamma to the HINT1-RGS17 complex bound to the C terminus of Mu-opioid receptors.Q44339601
Novel peptidic mu opioid antagonists: pharmacologic characterization in vitro and in vivoQ44340965
Kappa-opioid receptor modulation of the release of substance P in the dorsal hornQ44342095
Delta-Opioid receptor modulation of the release of substance P-like immunoreactivity in the dorsal horn of the rat following mechanical or thermal noxious stimulationQ44344151
Inhibition by spinal mu- and delta-opioid agonists of afferent-evoked substance P release.Q44348612
The histidine triad nucleotide-binding protein 1 supports mu-opioid receptor-glutamate NMDA receptor cross-regulationQ44348688
Mu-opioid and GABA(B) receptors modulate different types of Ca2+ currents in rat nodose ganglion neuronsQ44349152
Multiple targets of μ-opioid receptor-mediated presynaptic inhibition at primary afferent Aδ- and C-fibers.Q44349203
Delayed postoperative latent pain sensitization revealed by the systemic administration of opioid antagonists in miceQ44349380
Opioid-activated postsynaptic, inward rectifying potassium currents in whole cell recordings in substantia gelatinosa neuronsQ44350931
Relationship between capsaicin-evoked substance P release and neurokinin 1 receptor internalization in the rat spinal cord.Q44406479
Neurokinin release produced by capsaicin acting on the central terminals and axons of primary afferents: relationship with n-methyl-d-aspartate and gabab receptorsQ44624456
Presynaptic NMDA receptors modulate glutamate release from primary sensory neurons in rat spinal cord dorsal horn.Q44804059
Electrophysiological characterization of N-methyl-D-aspartate receptors in rat dorsal root ganglia neuronsQ44906078
Gene knockdown with intrathecal siRNA of NMDA receptor NR2B subunit reduces formalin-induced nociception in the rat.Q45095142
GABA(A) receptor facilitation of neurokinin release from primary afferent terminals in the rat spinal cordQ45226068
Ketamine improves the management of exaggerated postoperative pain observed in perioperative fentanyl-treated ratsQ45245132
Inflammation increases the distribution of dorsal horn neurons that internalize the neurokinin-1 receptor in response to noxious and non-noxious stimulation.Q46304913
P921main subjectsubstance PQ411041
P1104number of pages14
P304page(s)255-268
P577publication date2017-10-14
P1433published inNeuropharmacologyQ15332439
P1476titleMechanisms of μ-opioid receptor inhibition of NMDA receptor-induced substance P release in the rat spinal cord
P478volume128

Reverse relations

cites work (P2860)
Q53821408Mu-opioid receptors in nociceptive afferents produce a sustained suppression of hyperalgesia in chronic pain.
Q49714100Peripheral Mu-Opioid receptors Attenuate the Responses of Group III and IV Afferents to Contraction in Rats with Simulated Peripheral Artery Disease.

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