Substance P release and neurokinin 1 receptor activation in the rat spinal cord increase with the firing frequency of C-fibers.

scientific article published on 29 March 2009

Substance P release and neurokinin 1 receptor activation in the rat spinal cord increase with the firing frequency of C-fibers. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.NEUROSCIENCE.2009.03.058
P932PMC publication ID2692762
P698PubMed publication ID19336248
P5875ResearchGate publication ID24248114

P50authorDavid W AdelsonQ59198600
P2093author name stringG Zhang
W Kim
L Lao
J C G Marvizón
P2860cites workAltered nociception, analgesia and aggression in mice lacking the receptor for substance PQ24322842
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Glutamate and substance P coexist in primary afferent terminals in the superficial laminae of spinal cordQ33658035
Neuropeptides in morphologically and functionally identified primary afferent neurons in dorsal root ganglia: substance P, CGRP and somatostatin.Q40940886
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Substance P release in the dorsal horn assessed by receptor internalization: NMDA receptors counteract a tonic inhibition by GABA(B) receptorsQ41610524
Spinal opioid analgesia: how critical is the regulation of substance P signaling?Q41697764
Dorsal horn neurons firing at high frequency, but not primary afferents, release opioid peptides that produce micro-opioid receptor internalization in the rat spinal cord.Q43114642
Effect of peptidases on the ability of exogenous and endogenous neurokinins to produce neurokinin 1 receptor internalization in the rat spinal cordQ43263146
Presynaptic regulation of spinal cord tachykinin signaling via GABA(B) but not GABA(A) receptor activationQ43557132
Brain-derived neurotrophic factor is released in the dorsal horn by distinctive patterns of afferent fiber stimulation.Q43638939
Projection neurons in lamina I of rat spinal cord with the neurokinin 1 receptor are selectively innervated by substance p-containing afferents and respond to noxious stimulation.Q43999186
Inhibition by spinal mu- and delta-opioid agonists of afferent-evoked substance P release.Q44348612
Relationship between capsaicin-evoked substance P release and neurokinin 1 receptor internalization in the rat spinal cord.Q44406479
Neurokinin release produced by capsaicin acting on the central terminals and axons of primary afferents: relationship with n-methyl-d-aspartate and gabab receptorsQ44624456
Volatile anesthetics excite mammalian nociceptor afferents recorded in vitro.Q44637567
Differential contribution of substance P and neurokinin A to spinal cord neurokinin-1 receptor signaling in the rat.Q45027502
Changes in axonal impulse conduction correlate with sensory modality in primary afferent fibers in the rat.Q45158281
GABA(A) receptor facilitation of neurokinin release from primary afferent terminals in the rat spinal cordQ45226068
Morphological characterization of substance P receptor‐immunoreactive neurons in the rat spinal cord and trigeminal nucleus caudalisQ46090686
Warm-Sensitive Afferent Splanchnic C-Fiber Units In VitroQ46259968
Inflammation increases the distribution of dorsal horn neurons that internalize the neurokinin-1 receptor in response to noxious and non-noxious stimulation.Q46304913
Neurokinin 1 receptor internalization in spinal cord slices induced by dorsal root stimulation is mediated by NMDA receptors.Q46662825
Release of substance P from the enteric nervous system: direct quantitation and characterizationQ46909547
Formalin-evoked activity in identified primary afferent fibers: systemic lidocaine suppresses phase-2 activityQ46914865
Activation of spinal N-methyl-D-aspartate or neurokinin receptors induces long-term potentiation of spinal C-fibre-evoked potentialsQ47715644
Primary sensory neurones: Neurofilament, neuropeptides and conduction velocityQ48391775
Functional consequences of coexistence of classical and peptide neurotransmittersQ48420164
Nerve growth factor treatment increases brain-derived neurotrophic factor selectively in TrkA-expressing dorsal root ganglion cells and in their central terminations within the spinal cordQ48617112
Electrophysiological properties of subpopulations of rat dorsal root ganglion neurons in vitro.Q51742857
Long-term potentiation of C-fiber-evoked potentials in the rat spinal dorsal horn is prevented by spinal N-methyl-D-aspartic acid receptor blockage.Q52053090
Temporal pattern dependence of neuronal peptide transmitter release: models and experiments.Q52073796
C-fiber excitability in the cat.Q54074721
Characterization of Long-Term Potentiation of C-Fiber–Evoked Potentials in Spinal Dorsal Horn of Adult Rat: Essential Role of NK1 and NK2 ReceptorsQ57767792
Excitability characteristics of the A- and C-fibers in a peripheral nerveQ67435205
Release of substance P from the cat spinal cordQ69022182
Cell type and conduction velocity of rat primary sensory neurons with substance P-like immunoreactivityQ69062076
In vitro and in vivo release of neurokinin A-like immunoreactivity from rat substantia nigraQ69929485
H2O2 sensitivity of afferent splanchnic C fiber units in vitroQ71604372
Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulationQ71696623
The spinal contribution of substance P to the generation and maintenance of inflammatory hyperalgesia in the ratQ71733165
Tachykinins Potentiate N‐Methyl‐D‐Aspartate Responses in Acutely Isolated Neurons from the Dorsal HornQ72070701
Release of neuropeptide Y in response to splanchnic nerve stimulation in the conscious calfQ72596198
Long-term potentiation and long-term depression of primary afferent neurotransmission in the rat spinal cordQ72640836
Mechanical and heat sensitization of cutaneous nociceptors after peripheral inflammation in the ratQ73182010
Noxious cutaneous thermal stimuli induce a graded release of endogenous substance P in the spinal cord: imaging peptide action in vivoQ73507903
Neurokinin 1 receptor expression by neurons in laminae I, III and IV of the rat spinal dorsal horn that project to the brainstemQ73537433
Low-frequency stimulation of afferent Adelta-fibers induces long-term depression at primary afferent synapses with substantia gelatinosa neurons in the ratQ73542551
Stimulation of the sympathetic perimesenteric arterial nerves releases neuropeptide Y potentiating the vasomotor activity of noradrenaline: involvement of neuropeptide Y-Y1 receptorsQ73664247
Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptorQ73763175
Dependence of transient and residual calcium dynamics on action-potential patterning during neuropeptide secretionQ74339114
Time-course of the internalization and recycling of neurokinin 1 receptors in rat dorsal horn neuronsQ74430664
Primary afferent fibers that contribute to increased substance P receptor internalization in the spinal cord after injuryQ74620741
Nonmedullated fibres in the saphenous nerve which signal touchQ74751313
Spinal substance P receptor expression and internalization in acute, short-term, and long-term inflammatory pain statesQ78166434
Activation of lamina I spinal cord neurons that express the substance P receptor in visceral nociception and hyperalgesiaQ79301287
Neurokinin-1 receptors on lumbar spinothalamic neurons in the ratQ95825658
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)538-553
P577publication date2009-03-29
P1433published inNeuroscienceQ15708571
P1476titleSubstance P release and neurokinin 1 receptor activation in the rat spinal cord increase with the firing frequency of C-fibers
P478volume161

Reverse relations

cites work (P2860)
Q50246060A Pilot Study Investigating Clinical Responses and Biological Pathways of Azelastine/Fluticasone in Nonallergic Vasomotor Rhinitis before and after Cold Dry Air Provocation.
Q34650932Acute colitis induces neurokinin 1 receptor internalization in the rat lumbosacral spinal cord
Q34005579BDNF released during neuropathic pain potentiates NMDA receptors in primary afferent terminals
Q33803774Cannabinoid CB1 receptor facilitation of substance P release in the rat spinal cord, measured as neurokinin 1 receptor internalization
Q48284583De novo expression of neurokinin-1 receptors by spinoparabrachial lamina I pyramidal neurons following a peripheral nerve lesion
Q34151474Frequency-dependent release of substance P mediates heterosynaptic potentiation of glutamatergic synaptic responses in the rat visual thalamus
Q49830597Imaging of electrical activity in small diameter fibers of the murine peripheral nerve with virally-delivered GCaMP6f
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Q44015807Inhibition of CaV2.3 channels by NK1 receptors is sensitive to membrane cholesterol but insensitive to caveolin-1.
Q93213096Intracellular emetic signaling cascades by which the selective neurokinin type 1 receptor (NK1R) agonist GR73632 evokes vomiting in the least shrew (Cryptotis parva)
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Q53821408Mu-opioid receptors in nociceptive afferents produce a sustained suppression of hyperalgesia in chronic pain.
Q39576351NMDA receptors in primary afferents require phosphorylation by Src family kinases to induce substance P release in the rat spinal cord
Q34142913Src family kinases mediate the inhibition of substance P release in the rat spinal cord by μ-opioid receptors and GABA(B) receptors, but not α2 adrenergic receptors
Q34459218Substance P induces the reversible formation of varicosities in the dendrites of rat brainstem neurons
Q37251613Systemic morphine treatment induces changes in firing patterns and responses of nociceptive afferent fibers in mouse glabrous skin
Q37721910μ-Opioid receptor inhibition of substance P release from primary afferents disappears in neuropathic pain but not inflammatory pain

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