Energetics of Inhibition: Insights with a Computational Model of the Human GABAergic Neuron–Astrocyte Cellular Complex

scientific article published on July 28, 2010

Energetics of Inhibition: Insights with a Computational Model of the Human GABAergic Neuron–Astrocyte Cellular Complex is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/JCBFM.2010.107
P8608Fatcat IDrelease_ne5yp6qznjea5gvivq3zryc45i
P953full work available at URLhttps://journals.sagepub.com/doi/pdf/10.1038/jcbfm.2010.107
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20664615/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20664615/pdf/?tool=EBI
https://europepmc.org/articles/PMC3023929
https://europepmc.org/articles/PMC3023929?pdf=render
https://doi.org/10.1038/jcbfm.2010.107
http://journals.sagepub.com/doi/pdf/10.1038/jcbfm.2010.107
http://journals.sagepub.com/doi/full-xml/10.1038/jcbfm.2010.107
P932PMC publication ID3023929
P698PubMed publication ID20664615
P5875ResearchGate publication ID45389553

P50authorErkki SomersaloQ63865092
Daniela CalvettiQ63865093
Rossana OcchipintiQ102396351
P2860cites workNeuronal pyruvate carboxylation supports formation of transmitter glutamateQ73419643
Mitochondrial transport proteins of the brainQ81230750
The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer.Q27863346
Carboxylation and anaplerosis in neurons and gliaQ30654572
Compartmentation of Glutamine, Glutamate, and GABA Metabolism in Neurons and Astrocytes: Functional ImplicationsQ30882878
Energetic basis of brain activity: implications for neuroimaging.Q30946727
The contribution of GABA to glutamate/glutamine cycling and energy metabolism in the rat cortex in vivoQ33936559
GABA uptake into astrocytes is not associated with significant metabolic cost: Implications for brain imaging of inhibitory transmissionQ33973012
Phosphate-activated glutaminase and mitochondrial glutamine transport in the brainQ34074260
Oxidative and nonoxidative metabolism of excited neurons and astrocytesQ34504180
In vivo 13C NMR measurements of cerebral glutamine synthesis as evidence for glutamate-glutamine cyclingQ36055611
Neuronal-glial glucose oxidation and glutamatergic-GABAergic function.Q36366441
Determination of the rate of the glutamate/glutamine cycle in the human brain by in vivo 13C NMR.Q36418950
Astrocytes as the glucose shunt for glutamatergic neurons at high activity: an in silico studyQ37190449
Use of randomized sampling for analysis of metabolic networksQ37305068
Glutamine Synthetase: Glial Localization in BrainQ39138188
Bayesian flux balance analysis applied to a skeletal muscle metabolic model.Q39776363
The regulation of glutamate metabolism by tricarboxylic acid-cycle activity in rat brain mitochondriaQ41827657
A simulation study of brain compartments. Metabolism of glutamate and related substances in mouse brainQ41872028
Metabolica: a statistical research tool for analyzing metabolic networksQ42925318
Glutamine is the major precursor for GABA synthesis in rat neocortex in vivo following acute GABA-transaminase inhibitionQ43794066
Elucidation of the quantitative significance of pyruvate carboxylation in cultured cerebellar neurons and astrocytesQ43825322
Demonstration of neuron-glia transfer of precursors for GABA biosynthesis in a co-culture system of dissociated mouse cerebral cortexQ46424902
Statistical analysis of metabolic pathways of brain metabolism at steady state.Q48228638
Direct demonstration by [13C]NMR spectroscopy that glutamine from astrocytes is a precursor for GABA synthesis in neuronsQ48387362
Quantification of cortical GABA-glutamine cycling rate using in vivo magnetic resonance signal of [2-13C]GABA derived from glia-specific substrate [2-13C]acetateQ48390467
Metabolism of lactate in cultured GABAergic neurons studied by 13C nuclear magnetic resonance spectroscopyQ48564331
Glutamine transport in cerebellar granule cells in cultureQ48706122
Pyruvate carboxylase activity in primary cultures of astrocytes and neuronsQ48719469
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectcomputational modelQ1122506
astrocyteQ502961
neurological modelsQ73501278
P304page(s)1834-1846
P577publication date2010-07-28
P1433published inJournal of Cerebral Blood Flow & MetabolismQ14663525
P1476titleEnergetics of inhibition: insights with a computational model of the human GABAergic neuron-astrocyte cellular complex
Energetics of Inhibition: Insights with a Computational Model of the Human GABAergic Neuron–Astrocyte Cellular Complex
P478volume30

Reverse relations

cites work (P2860)
Q34207469A neuron-glia interaction involving GABA transaminase contributes to sleep loss in sleepless mutants
Q30452931Brain Lactate Metabolism: The Discoveries and the Controversies
Q92043375Computational singular perturbation analysis of brain lactate metabolism
Q48681715Cytosolic Ca2+ regulates the energization of isolated brain mitochondria by formation of pyruvate through the malate–aspartate shuttle
Q34219179Ménage à Trois: The Role of Neurotransmitters in the Energy Metabolism of Astrocytes, Glutamatergic, and GABAergic Neurons
Q41820259Quantitative in silico Analysis of Neurotransmitter Pathways Under Steady State Conditions
Q38045780The metabolism of neurons and astrocytes through mathematical models.
Q48768537Uncertainty quantification in flux balance analysis of spatially lumped and distributed models of neuron-astrocyte metabolism.

Search more.