HPV 5 and 8 E6 expression reduces ATM protein levels and attenuates LINE-1 retrotransposition.

scientific article published on 23 May 2013

HPV 5 and 8 E6 expression reduces ATM protein levels and attenuates LINE-1 retrotransposition. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.VIROL.2013.04.022
P932PMC publication ID3873879
P698PubMed publication ID23706308
P5875ResearchGate publication ID236937484

P50authorPrescott DeiningerQ42533877
Zachary J FaberQ59543632
Denise GallowayQ91250425
P2093author name stringHeather L Howie
Stephen L Gasior
Nicholas A Wallace
P2860cites workInitial sequencing and analysis of the human genomeQ21045365
A role for ATR in the DNA damage-induced phosphorylation of p53Q22008733
ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathwayQ22253899
Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor proteinQ24311317
The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53Q24317677
Mdm2 promotes the rapid degradation of p53Q24322597
Degradation of tyrosine phosphatase PTPN3 (PTPH1) by association with oncogenic human papillomavirus E6 proteinsQ24336493
Multi-PDZ domain protein MUPP1 is a cellular target for both adenovirus E4-ORF1 and high-risk papillomavirus type 18 E6 oncoproteinsQ24527216
p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damageQ24530584
Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligaseQ24551145
UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse CellsQ24609948
Interactions of the PDZ-protein MAGI-1 with adenovirus E4-ORF1 and high-risk papillomavirus E6 oncoproteinsQ24622878
Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor proteinQ24654803
Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitroQ24656275
Retrotransposition-Competent Human LINE-1 Induces Apoptosis in Cancer Cells With Intactp53Q24805857
Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domainQ27860534
Human L1 retrotransposon encodes a conserved endonuclease required for retrotranspositionQ28114795
Association of CBP/p300 acetylase and thymine DNA glycosylase links DNA repair and transcriptionQ28203698
The many substrates and functions of ATMQ28205055
Convergence of the fanconi anemia and ataxia telangiectasia signaling pathwaysQ28207549
DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2Q28254119
Reverse transcription of R2Bm RNA is primed by a nick at the chromosomal target site: A mechanism for non-LTR retrotranspositionQ28297748
Human papillomaviruses activate the ATM DNA damage pathway for viral genome amplification upon differentiationQ28476215
Enhanced phosphorylation of p53 by ATM in response to DNA damageQ28609838
Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaksQ28609912
The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53Q29547773
Improved retroviral vectors for gene transfer and expressionQ29614384
DNA damage activates p53 through a phosphorylation-acetylation cascadeQ29616294
High frequency retrotransposition in cultured mammalian cellsQ29618259
Participation of p53 protein in the cellular response to DNA damageQ29618319
Biology of mammalian L1 retrotransposonsQ29618630
Sequence patterns indicate an enzymatic involvement in integration of mammalian retroposonsQ30004188
Inhibition of Bak-induced apoptosis by HPV-18 E6.Q33292381
Human papillomavirus (HPV) E6 interactions with Bak are conserved amongst E6 proteins from high and low risk HPV typesQ33292386
Papillomaviruses in human cancersQ33790611
Beta-HPV 5 and 8 E6 promote p300 degradation by blocking AKT/p300 associationQ34013630
Classification of papillomaviruses (PVs) based on 189 PV types and proposal of taxonomic amendmentsQ34021545
The human LINE-1 retrotransposon creates DNA double-strand breaks.Q34061457
HPV 5 and 8 E6 abrogate ATR activity resulting in increased persistence of UVB induced DNA damageQ34341388
Human papillomavirus infection and skin cancer risk in organ transplant recipientsQ34582477
Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmanninQ34663629
ERCC1/XPF limits L1 retrotranspositionQ34768580
Multiple signaling pathways involving ATM.Q35132643
Human papillomaviruses and skin cancerQ35237486
Ataxia telangiectasia mutated (ATM) modulates long interspersed element-1 (L1) retrotransposition in human neural stem cellsQ35650901
A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18Q35937193
Kinase-dead ATM protein causes genomic instability and early embryonic lethality in miceQ36145724
Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damageQ36275074
HPV-associated skin disease.Q36346158
A novel ATM-dependent pathway regulates protein phosphatase 1 in response to DNA damageQ36540326
RNA template requirements for target DNA-primed reverse transcription by the R2 retrotransposable elementQ36552964
Fragments of ATM which have dominant-negative or complementing activityQ36567594
Human papillomaviruses and non-melanoma skin cancer: basic virology and clinical manifestationsQ36878737
L1 mobile element expression causes multiple types of toxicity.Q37139954
The human papillomavirus E7 oncoproteinQ37325199
Papillomavirus E6 proteinsQ37350446
Genital human papillomavirus infections: current and prospective therapiesQ37983044
Feedback inhibition of L1 and alu retrotransposition through altered double strand break repair kinetics.Q38273264
Skin human papillomavirus type 38 alters p53 functions by accumulation of deltaNp73.Q38317007
Repair of UV-induced thymine dimers is compromised in cells expressing the E6 protein from human papillomaviruses types 5 and 18.Q38795632
Vanillins--a novel family of DNA-PK inhibitorsQ39936122
The ability of human papillomavirus E6 proteins to target p53 for degradation in vivo correlates with their ability to abrogate actinomycin D-induced growth arrest.Q40041446
Artemis links ATM to G2/M checkpoint recovery via regulation of Cdk1-cyclin B.Q40180257
Repair processes in radiation biology.Q40194509
The role of the ubiquitin ligase E6-AP in human papillomavirus E6-mediated degradation of PDZ domain-containing proteinsQ40211890
Characteristics of the lesions and risk of malignant conversion associated with the type of human papillomavirus involved in epidermodysplasia verruciformisQ40216033
The E6 protein of the cutaneous human papillomavirus type 8 can stimulate the viral early and late promoters by distinct mechanismsQ40243112
Genome instability in ataxia telangiectasia (A-T) families: camptothecin-induced damage to replicating DNA discriminates between obligate A-T heterozygotes, A-T homozygotes and controlsQ40374436
A double-strand break repair defect in ATM-deficient cells contributes to radiosensitivityQ40595505
Phosphorylation of p53 at serine 37 is important for transcriptional activity and regulation in response to DNA damageQ40601283
High spontaneous intrachromosomal recombination rates in ataxia-telangiectasiaQ41552717
Analysis of 5' junctions of human LINE-1 and Alu retrotransposons suggests an alternative model for 5'-end attachment requiring microhomology-mediated end-joiningQ42844670
Human papillomavirus infection of the cervix: relative risk associations of 15 common anogenital typesQ44918470
DNA repair mediated by endonuclease-independent LINE-1 retrotranspositionQ48304886
Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine.Q52536369
Carcinogenicity of human papillomavirusesQ58296516
Ataxia telangiectasia: a human mutation with abnormal radiation sensitivityQ59066708
Clinical Observation, Virologic Studies, and Treatment Trials in Patients with Epidermodysplasia Verruciformis, a Disease Induced by Specific Human PapillomavirusesQ70219286
Dispersal process associated with the L1 family of interspersed repetitive DNA sequencesQ70652228
DNA damage induced p53 mediated transcription is inhibited by human papillomavirus type 18 E6Q72728896
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)69-79
P577publication date2013-05-23
P1433published inVirologyQ7934867
P1476titleHPV 5 and 8 E6 expression reduces ATM protein levels and attenuates LINE-1 retrotransposition
P478volume443

Reverse relations

cites work (P2860)
Q33574854A team of heterochromatin factors collaborates with small RNA pathways to combat repetitive elements and germline stress
Q42112805Beta human papillomavirus E6 expression inhibits stabilization of p53 and increases tolerance of genomic instability
Q37619334Cutaneous HPV8 and MmuPV1 E6 Proteins Target the NOTCH and TGF-β Tumor Suppressors to Inhibit Differentiation and Sustain Keratinocyte Proliferation.
Q37724792DNA damage response is hijacked by human papillomaviruses to complete their life cycle
Q57922398Epidemiology and biology of cutaneous human papillomavirus
Q26742086Guardian of the Human Genome: Host Defense Mechanisms against LINE-1 Retrotransposition
Q59355027HIV-1 Vpr and p21 restrict LINE-1 mobility
Q38645976High Risk Alpha Papillomavirus Oncogenes Impair the Homologous Recombination Pathway
Q38240647Human Beta-papillomavirus infection and keratinocyte carcinomas
Q58699202Human papillomavirus and genome instability: from productive infection to cancer
Q37241711Human papillomaviruses: research priorities for the next decade
Q36597230LINE retrotransposition and host DNA repair machinery
Q45393476Loss of Genome Fidelity: Beta HPVs and the DNA Damage Response
Q38177526Manipulation of cellular DNA damage repair machinery facilitates propagation of human papillomaviruses
Q26750825Post-Transcriptional Control of LINE-1 Retrotransposition by Cellular Host Factors in Somatic Cells
Q26741496Restricting retrotransposons: a review
Q64092342The Protein Tyrosine Phosphatase H1 PTPH1 Supports Proliferation of Keratinocytes and is a Target of the Human Papillomavirus Type 8 E6 Oncogene
Q37194605The importance of L1 ORF2p cryptic sequence to ORF2p fragment-mediated cytotoxicity
Q33553561The transmembrane channel-like protein family and human papillomaviruses: Insights into epidermodysplasia verruciformis and progression to squamous cell carcinoma
Q35585348β-HPV 5 and 8 E6 disrupt homology dependent double strand break repair by attenuating BRCA1 and BRCA2 expression and foci formation

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