PLK1-mediated phosphorylation of WDR62/MCPH2 ensures proper mitotic spindle orientation

scientific article published on 26 August 2017

PLK1-mediated phosphorylation of WDR62/MCPH2 ensures proper mitotic spindle orientation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/HMG/DDX330
P698PubMed publication ID28973348

P50authorTakashi YamamotoQ46522287
Tatsuo MiyamotoQ50621962
Shinya MatsuuraQ59304325
Hideshi KawakamiQ71016675
Hiroyuki MorinoQ75186077
P2093author name stringHirofumi Ohashi
Kenji Shimizu
Akihiro Fukumitsu
Kosuke Hosoba
Silvia Natsuko Akutsu
Yoshinori Masatsuna
P2860cites workEfficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9.Q48789186
Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20Q24291673
Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformationsQ24296941
Dishevelled, a Wnt signalling component, is involved in mitotic progression in cooperation with Plk1Q24299033
Mutations in WDR62, encoding a centrosome-associated protein, cause microcephaly with simplified gyri and abnormal cortical architectureQ24301645
WDR62 is associated with the spindle pole and is mutated in human microcephalyQ24301673
Microcephaly-associated protein WDR62 regulates neurogenesis through JNK1 in the developing neocortexQ24317320
A mutation in the low voltage-gated calcium channel CACNA1G alters the physiological properties of the channel, causing spinocerebellar ataxiaQ28116910
Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitorsQ28594217
Centrioles, centrosomes, and cilia in health and diseaseQ29615173
MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progressionQ30537786
Identification of a consensus motif for Plk (Polo-like kinase) phosphorylation reveals Myt1 as a Plk1 substrate.Q34195806
Opposing roles for JNK and Aurora A in regulating the association of WDR62 with spindle microtubules.Q35029169
Regulation of NDR1 activity by PLK1 ensures proper spindle orientation in mitosisQ35701372
Mitotic spindle (DIS)orientation and DISease: cause or consequence?Q36486600
WD40-repeat protein 62 is a JNK-phosphorylated spindle pole protein required for spindle maintenance and timely mitotic progressionQ36497538
Aurora A phosphorylation of WD40-repeat protein 62 in mitotic spindle regulation.Q37091944
Genetic causes of microcephaly and lessons for neuronal developmentQ37158051
The Microtubule-Depolymerizing Activity of a Mitotic Kinesin Protein KIF2A Drives Primary Cilia Disassembly Coupled with Cell Proliferation.Q37398735
TALEN-mediated single-base-pair editing identification of an intergenic mutation upstream of BUB1B as causative of PCS (MVA) syndrome.Q37543719
Disruptions in asymmetric centrosome inheritance and WDR62-Aurora kinase B interactions in primary microcephalyQ37685924
What next-generation sequencing (NGS) technology has enabled us to learn about primary autosomal recessive microcephaly (MCPH).Q38518978
Nonsense-mediated mRNA decay: an intricate machinery that shapes transcriptomesQ38591386
ASPM and CITK regulate spindle orientation by affecting the dynamics of astral microtubules.Q38750052
Regulation of mitotic spindle orientation: an integrated view.Q38901748
Insufficiency of BUBR1, a mitotic spindle checkpoint regulator, causes impaired ciliogenesis in vertebrates.Q39578797
PLK1-dependent activation of LRRK1 regulates spindle orientation by phosphorylating CDK5RAP2.Q41569146
Microcephaly Proteins Wdr62 and Aspm Define a Mother Centriole Complex Regulating Centriole Biogenesis, Apical Complex, and Cell FateQ41921410
The Microcephaly-Associated Protein Wdr62/CG7337 Is Required to Maintain Centrosome Asymmetry in Drosophila NeuroblastsQ41926666
Neuroepithelial progenitors undergo LGN-dependent planar divisions to maintain self-renewability during mammalian neurogenesis.Q42522587
P433issue22
P304page(s)4429-4440
P577publication date2017-08-26
P1433published inHuman Molecular GeneticsQ2720965
P1476titlePLK1-mediated phosphorylation of WDR62/MCPH2 ensures proper mitotic spindle orientation
P478volume26

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cites work (P2860)
Q90060993Control of Intestinal Cell Fate by Dynamic Mitotic Spindle Repositioning Influences Epithelial Homeostasis and Longevity
Q91941027Endoplasmic reticulum and Golgi stress in microcephaly
Q55273319Exploration of genetic basis underlying individual differences in radiosensitivity within human populations using genome editing technology.
Q61810522Expression of polo-like kinase 1 in pre-implantation stage murine somatic cell nuclear transfer embryos
Q92733484Modeling microcephaly with cerebral organoids reveals a WDR62-CEP170-KIF2A pathway promoting cilium disassembly in neural progenitors
Q64981854Novel compound heterozygous mutations in WDR62 gene leading to developmental delay and Primary Microcephaly in Saudi Family.
Q59136612Plk1 regulates spindle orientation by phosphorylating NuMA in human cells
Q58555874Regulating a key mitotic regulator, Polo-like Kinase 1 (PLK1)
Q89978236The Yin and Yang of Autosomal Recessive Primary Microcephaly Genes: Insights from Neurogenesis and Carcinogenesis

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