WD40-repeat protein 62 is a JNK-phosphorylated spindle pole protein required for spindle maintenance and timely mitotic progression

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WD40-repeat protein 62 is a JNK-phosphorylated spindle pole protein required for spindle maintenance and timely mitotic progression is …
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scholarly articleQ13442814

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P356DOI10.1242/JCS.107326
P932PMC publication ID3533392
P698PubMed publication ID22899712
P5875ResearchGate publication ID230686132

P50authorD C NgQ73004117
Marie A BogoyevitchQ40538361
Julian Ik-Tsen HengQ47502691
P2093author name stringYan Y Yip
Yvonne Y C Yeap
Kevin R Ngoei
Teresa T Zhao
Zhengdong Qu
P2860cites workWhole-exome sequencing identifies recessive WDR62 mutations in severe brain malformationsQ24296941
CDK5RAP2 is a pericentriolar protein that functions in centrosomal attachment of the gamma-tubulin ring complexQ24298634
Mutations in WDR62, encoding a centrosome-associated protein, cause microcephaly with simplified gyri and abnormal cortical architectureQ24301645
WDR62 is associated with the spindle pole and is mutated in human microcephalyQ24301673
The Plk1 target Kizuna stabilizes mitotic centrosomes to ensure spindle bipolarityQ24303592
Human ASPM participates in spindle organisation, spindle orientation and cytokinesisQ24305282
STIL is required for centriole duplication in human cellsQ24305503
Cep72 regulates the localization of key centrosomal proteins and proper bipolar spindle formationQ24338704
Plk1-dependent recruitment of gamma-tubulin complexes to mitotic centrosomes involves multiple PCM componentsQ24338881
Aspm specifically maintains symmetric proliferative divisions of neuroepithelial cellsQ24550947
A quantitative atlas of mitotic phosphorylationQ24646817
Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screenQ28146108
CDK5RAP2 regulates centriole engagement and cohesion in miceQ28505755
Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germlineQ28586392
Cdk5rap2 interacts with pericentrin to maintain the neural progenitor pool in the developing neocortexQ28587633
Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitorsQ28594217
Control of mitosis by changes in the subcellular location of cyclin-B1-Cdk1 and Cdc25CQ28611955
Centrioles, centrosomes, and cilia in health and diseaseQ29615173
Polo-like kinases and the orchestration of cell divisionQ29616759
The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain developmentQ48219557
JNK2 participates in spindle assembly during mouse oocyte meiotic maturationQ48682249
Microcephalin encodes a centrosomal protein.Q53636512
Phosphate-binding tag, a new tool to visualize phosphorylated proteinsQ29617792
WD40 proteins propel cellular networks.Q30156873
JNK-mediated phosphorylation of Cdc25C regulates cell cycle entry and G(2)/M DNA damage checkpoint.Q30432395
Primary microcephaly: do all roads lead to Rome?Q33629131
CDK5RAP2 functions in centrosome to spindle pole attachment and DNA damage responseQ33788443
Spindle pole organization in Drosophila S2 cells by dynein, abnormal spindle protein (Asp), and KLP10A.Q33877027
Spindle assembly in animal cells.Q34019352
NuMA after 30 years: the matrix revisited.Q34097270
c-Jun N-terminal kinase phosphorylation of stathmin confers protection against cellular stressQ34121410
Cep152 interacts with Plk4 and is required for centriole duplication.Q34317054
The Plk1-dependent phosphoproteome of the early mitotic spindleQ34454981
GCP-WD is a gamma-tubulin targeting factor required for centrosomal and chromatin-mediated microtubule nucleationQ34479608
Neurogenin 2 controls cortical neuron migration through regulation of Rnd2.Q34806146
Role of JNK in tumor developmentQ35122697
Many fingers on the mitotic trigger: post-translational regulation of the Cdc25C phosphatase.Q35601099
A primary microcephaly protein complex forms a ring around parental centrioles.Q35822248
Cdk5rap2 exposes the centrosomal root of microcephaly syndromesQ36021561
A truncating mutation of CEP135 causes primary microcephaly and disturbed centrosomal functionQ36036561
Mitogen-activated protein kinases in cell-cycle controlQ36294744
Aurora-A: the maker and breaker of spindle polesQ36917445
Mitosis-specific anchoring of gamma tubulin complexes by pericentrin controls spindle organization and mitotic entryQ37031680
Requirements for NuMA in maintenance and establishment of mammalian spindle poles.Q37202371
Centrosome function in cancer: guilty or innocent?Q37537868
Neural stem cells: the need for a proper orientationQ37764155
Interplay between Cdh1 and JNK activity during the cell cycleQ39687769
A novel c-Jun N-terminal kinase (JNK)-binding protein WDR62 is recruited to stress granules and mediates a nonclassical JNK activation.Q39775444
Basal c-Jun N-terminal kinases promote mitotic progression through histone H3 phosphorylationQ40015646
Asterless is a centriolar protein required for centrosome function and embryo development in DrosophilaQ42520198
Docking interactions of the JNK scaffold protein WDR62.Q42533944
Opposing actions of extracellular signal-regulated kinase (ERK) and signal transducer and activator of transcription 3 (STAT3) in regulating microtubule stabilization during cardiac hypertrophy.Q42571258
Compression regulates mitotic spindle length by a mechanochemical switch at the polesQ43076243
Cell cycle regulation of c-Jun N-terminal kinase activity at the centrosomesQ43799495
Characterization of a novel JNK (c-Jun N-terminal kinase) inhibitory peptideQ44764096
Roles of polo-like kinase 1 in the assembly of functional mitotic spindlesQ45086018
Centriolar SAS-5 is required for centrosome duplication in C. elegansQ47069336
P4510describes a project that usesImageJQ1659584
P433issuePt 21
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
P304page(s)5096-5109
P577publication date2012-08-16
P1433published inJournal of Cell ScienceQ1524177
P1476titleWD40-repeat protein 62 is a JNK-phosphorylated spindle pole protein required for spindle maintenance and timely mitotic progression
P478volume125

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cites work (P2860)
Q27323861A CEP215-HSET complex links centrosomes with spindle poles and drives centrosome clustering in cancer
Q35321786A novel single base pair duplication in WDR62 causes primary microcephaly
Q34479346Abnormal centrosome and spindle morphology in a patient with autosomal recessive primary microcephaly type 2 due to compound heterozygous WDR62 gene mutation
Q37091944Aurora A phosphorylation of WD40-repeat protein 62 in mitotic spindle regulation.
Q41961976B-Myb switches from Cyclin/Cdk-dependent to Jnk- and p38 kinase-dependent phosphorylation and associates with SC35 bodies after UV stress
Q52972875Centrosomes and mitotic spindle poles: a recent liaison?
Q90060993Control of Intestinal Cell Fate by Dynamic Mitotic Spindle Repositioning Influences Epithelial Homeostasis and Longevity
Q37685924Disruptions in asymmetric centrosome inheritance and WDR62-Aurora kinase B interactions in primary microcephaly
Q28655454Growth and folding of the mammalian cerebral cortex: from molecules to malformations
Q41463207Identification and analysis of a novel dimerization domain shared by various members of c-Jun N-terminal kinase (JNK) scaffold proteins
Q26741279JNK Signaling: Regulation and Functions Based on Complex Protein-Protein Partnerships
Q41661088Kinases Involved in Both Autophagy and Mitosis.
Q90634984MEKK3 coordinates with FBW7 to regulate WDR62 stability and neurogenesis
Q41921410Microcephaly Proteins Wdr62 and Aspm Define a Mother Centriole Complex Regulating Centriole Biogenesis, Apical Complex, and Cell Fate
Q41930126Microcephaly disease gene Wdr62 regulates mitotic progression of embryonic neural stem cells and brain size
Q30556376Microcephaly models in the developing zebrafish retinal neuroepithelium point to an underlying defect in metaphase progression.
Q24317320Microcephaly-associated protein WDR62 regulates neurogenesis through JNK1 in the developing neocortex
Q36486600Mitotic spindle (DIS)orientation and DISease: cause or consequence?
Q38303675Molecular and cellular basis of autosomal recessive primary microcephaly
Q28975782Mutations in MAPKBP1 Cause Juvenile or Late-Onset Cilia-Independent Nephronophthisis
Q37694637Novel mutations c.28G>T (p.Ala10Ser) and c.189G>T (p.Glu63Asp) in WDR62 associated with early onset acanthosis and hyperkeratosis in a patient with autosomal recessive microcephaly type 2.
Q41927089Novel splice-site mutation in WDR62 revealed by whole-exome sequencing in a Sudanese family with primary microcephaly
Q28910450Nucleoporin Nup62 maintains centrosome homeostasis
Q35029169Opposing roles for JNK and Aurora A in regulating the association of WDR62 with spindle microtubules.
Q41918159PLK1-mediated phosphorylation of WDR62/MCPH2 ensures proper mitotic spindle orientation
Q49571261Same but different: pleiotropy in centrosome-related microcephaly
Q56232646Severe presentation of WDR62 mutation: is there a role for modifying genetic factors?
Q37603210Signaling regulates activity of DHCR24, the final enzyme in cholesterol synthesis
Q33959953Small organelle, big responsibility: the role of centrosomes in development and disease
Q57252972The Genetics of Brain Malformations
Q41918329The Role of WD40-Repeat Protein 62 (MCPH2) in Brain Growth: Diverse Molecular and Cellular Mechanisms Required for Cortical Development.
Q39448573The function of sperm-associated antigen 6 in neuronal proliferation and differentiation
Q41037948WDR62 Regulates Early Neural and Glial Progenitor Specification of Human Pluripotent Stem Cells.
Q91970878WDR62 is a novel participator in spindle migration and asymmetric cytokinesis during mouse oocyte meiotic maturation
Q64911797WDR62 mediates TNFα-dependent JNK activation via TRAF2-MLK3 axis.
Q38712957WDR62 overexpression is associated with a poor prognosis in patients with lung adenocarcinoma

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