scholarly article | Q13442814 |
P50 | author | Erich Gulbins | Q37611826 |
Ildikó Szabó | Q40971068 | ||
Luigi Leanza | Q61163903 | ||
P2093 | author name string | K George Chandy | |
Mario Zoratti | |||
Nicola Sassi | |||
Brian Henry | |||
P2860 | cites work | Clofazimine inhibits human Kv1.3 potassium channel by perturbing calcium oscillation in T lymphocytes | Q21143901 |
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Deficiency in apoptotic effectors Bax and Bak reveals an autophagic cell death pathway initiated by photodamage to the endoplasmic reticulum | Q28254691 | ||
Purification, characterization, and biosynthesis of margatoxin, a component of Centruroides margaritatus venom that selectively inhibits voltage-dependent potassium channels | Q28261952 | ||
Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of effector memory T cells in autoimmune diseases | Q28267180 | ||
Tyrosine phosphorylation-dependent suppression of a voltage-gated K+ channel in T lymphocytes upon Fas stimulation | Q28284440 | ||
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A novel potassium channel in lymphocyte mitochondria | Q28301096 | ||
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BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis | Q29620466 | ||
Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis | Q33854131 | ||
Kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulators | Q34322193 | ||
In vitro and in vivo activity of SKI-606, a novel Src-Abl inhibitor, against imatinib-resistant Bcr-Abl+ neoplastic cells | Q34582817 | ||
ROS stress in cancer cells and therapeutic implications | Q35781703 | ||
bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis | Q36040551 | ||
Molecular proximity of Kv1.3 voltage-gated potassium channels and beta(1)-integrins on the plasma membrane of melanoma cells: effects of cell adherence and channel blockers | Q36558200 | ||
Pharmacokinetics, toxicity, and functional studies of the selective Kv1.3 channel blocker 5-(4-phenoxybutoxy)psoralen in rhesus macaques | Q36666549 | ||
Mutational inactivation of the proapoptotic gene BAX confers selective advantage during tumor clonal evolution | Q37264027 | ||
Targeting ion channels in cancer: a novel frontier in antineoplastic therapy | Q37370358 | ||
The functional network of ion channels in T lymphocytes | Q37597609 | ||
Interaction of mitochondrial potassium channels with the permeability transition pore | Q37663104 | ||
Contribution of voltage-gated potassium channels to the regulation of apoptosis. | Q37681686 | ||
Functional up-regulation of HERG K+ channels in neoplastic hematopoietic cells | Q38291180 | ||
Anti-proliferative effect of Kv1.3 blockers in A549 human lung adenocarcinoma in vitro and in vivo | Q39630130 | ||
Activation of guanine-β-D-arabinofuranoside and deoxyguanosine to triphosphates by a common pathway blocks T lymphoblasts at different checkpoints. | Q39684234 | ||
Role of Kv1.3 mitochondrial potassium channel in apoptotic signalling in lymphocytes. | Q39746194 | ||
An investigation of the occurrence and properties of the mitochondrial intermediate-conductance Ca2+-activated K+ channel mtKCa3.1. | Q39758627 | ||
Kv1.3 voltage-gated K(+) channel subunit as a potential diagnostic marker and therapeutic target for breast cancer | Q39807311 | ||
Superoxide dismutase activity of normal murine liver, regenerating liver, and H6 hepatoma | Q40166932 | ||
Role of endoplasmic reticulum depletion and multidomain proapoptotic BAX and BAK proteins in shaping cell death after hypericin-mediated photodynamic therapy | Q40321304 | ||
Expression of delayed rectifier potassium channels and their possible roles in proliferation of human gastric cancer cells | Q40356565 | ||
Regression of Novikoff rat hepatocellular carcinoma following locoregional administration of a novel formulation of clofazimine in lipiodol. | Q40572288 | ||
Kv1.3 is the exclusive voltage-gated K+ channel of platelets and megakaryocytes: roles in membrane potential, Ca2+ signalling and platelet count | Q40762411 | ||
A role for mitochondrial Bak in apoptotic response to anticancer drugs | Q40793451 | ||
Calcium-activated potassium channels sustain calcium signaling in T lymphocytes. Selective blockers and manipulated channel expression levels | Q40816569 | ||
Endogenous voltage-gated potassium channels in human embryonic kidney (HEK293) cells | Q41033148 | ||
Alpha-tocopherol antagonizes the multidrug-resistance-reversal activity of cyclosporin A, verapamil, GF120918, clofazimine and B669. | Q41035921 | ||
Clofazimine alters the energy metabolism and inhibits the growth rate of a human lung-cancer cell line in vitro and in vivo | Q41480954 | ||
The riminophenazine agents clofazimine and B669 inhibit the proliferation of cancer cell lines in vitro by phospholipase A2-mediated oxidative and nonoxidative mechanisms | Q41578794 | ||
Free radical stress in chronic lymphocytic leukemia cells and its role in cellular sensitivity to ROS-generating anticancer agents | Q42435827 | ||
Single-point mutations of a lysine residue change function of Bax and Bcl-xL expressed in Bax- and Bak-less mouse embryonic fibroblasts: novel insights into the molecular mechanisms of Bax-induced apoptosis. | Q42790829 | ||
Kv1.1 and Kv1.3 channels contribute to the degeneration of retinal ganglion cells after optic nerve transection in vivo | Q43288452 | ||
Differential involvement of Bax and Bak in TRAIL-mediated apoptosis of leukemic T cells | Q43902939 | ||
Tumor-cell resistance to death receptor--induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax. | Q43903493 | ||
Voltage-gated potassium ion channels in colon cancer. | Q44094664 | ||
Activity of potassium channel-blockers in breast cancer. | Q44554023 | ||
Expression of CuZn- and Mn-superoxide dismutase in human colorectal neoplasms. | Q45229108 | ||
A phase II evaluation of clofazimine plus doxorubicin in advanced, unresectable primary hepatocellular carcinoma | Q46199288 | ||
Deregulation of 2 potassium channels in pancreas adenocarcinomas: implication of KV1.3 gene promoter methylation. | Q47734211 | ||
Expression of voltage-gated potassium channels Kv1.3 and Kv1.5 in human gliomas | Q47773428 | ||
Identification of a voltage-gated potassium channel in gerbil hippocampal mitochondria. | Q48156276 | ||
Voltage-dependent potassium channels Kv1.3 and Kv1.5 in human cancer | Q48373384 | ||
The mitochondrial effects of novel apoptogenic molecules generated by psoralen photolysis as a crucial mechanism in PUVA therapy | Q58176158 | ||
Superoxide generation by the respiratory chain of tumor mitochondria | Q69808847 | ||
A phase II study of oral clofazimine in unresectable and metastatic hepatocellular carcinoma | Q74467049 | ||
Reduced Kv1.3 potassium channel expression in human prostate cancer | Q80423725 | ||
P433 | issue | 7 | |
P304 | page(s) | 577-593 | |
P577 | publication date | 2012-04-11 | |
P1433 | published in | EMBO Molecular Medicine | Q15817279 |
P1476 | title | Inhibitors of mitochondrial Kv1.3 channels induce Bax/Bak-independent death of cancer cells | |
P478 | volume | 4 |
Q34411580 | 13-acetoxysarcocrassolide induces apoptosis on human gastric carcinoma cells through mitochondria-related apoptotic pathways: p38/JNK activation and PI3K/AKT suppression |
Q53361782 | 17-Demethoxy-reblastatin, an Hsp90 inhibitor, induces mitochondria-mediated apoptosis through downregulation of Mcl-1 in human hepatocellular carcinoma cells. |
Q61813958 | Cancer-Associated Intermediate Conductance Ca-Activated K⁺ Channel K3.1 |
Q44961848 | Catastrophic inflammatory death of monocytes and macrophages by overtaking of a critical dose of endocytosed synthetic amorphous silica nanoparticles/serum protein complexes. |
Q44188484 | Clofazimine, Psora-4 and PAP-1, inhibitors of the potassium channel Kv1.3, as a new and selective therapeutic strategy in chronic lymphocytic leukemia. |
Q92494358 | Contribution of Mitochondrial Ion Channels to Chemo-Resistance in Cancer Cells |
Q37465356 | Cytotoxicity of 11-epi-Sinulariolide Acetate Isolated from Cultured Soft Corals on HA22T Cells through the Endoplasmic Reticulum Stress Pathway and Mitochondrial Dysfunction |
Q38126397 | Domain structure and function of matrix metalloprotease 23 (MMP23): role in potassium channel trafficking |
Q43189326 | Early effects of the antineoplastic agent salinomycin on mitochondrial function. |
Q92859002 | Expression and function of Kv1.3 channel in malignant T cells in Sézary syndrome |
Q34544160 | Fluorescent system based on bacterial expression of hybrid KcsA channels designed for Kv1.3 ligand screening and study. |
Q57812368 | Gas Signaling Molecules and Mitochondrial Potassium Channels |
Q51067064 | Guide to the Pharmacology of Mitochondrial Potassium Channels. |
Q38358175 | Hitting the Bull's-Eye in Metastatic Cancers-NSAIDs Elevate ROS in Mitochondria, Inducing Malignant Cell Death. |
Q38862322 | Impact of intracellular ion channels on cancer development and progression |
Q36482384 | Induction of apoptosis by sinulariolide from soft coral through mitochondrial-related and p38MAPK pathways on human bladder carcinoma cells |
Q41787828 | Inhibition of Kv1.3 Channels in Human Jurkat T Cells by Xanthohumol and Isoxanthohumol. |
Q27008995 | Intracellular ion channels and cancer |
Q64084189 | Ion Channels: New Actors Playing in Chemotherapeutic Resistance |
Q27005947 | Ion channels and apoptosis in cancer |
Q54958641 | Kv1.3 activity perturbs the homeostatic properties of astrocytes in glioma. |
Q39306627 | Kv1.3 channels facilitate the connection between metabolism and blood flow in the heart |
Q92351177 | Leprosy drug clofazimine activates peroxisome proliferator-activated receptor-γ and synergizes with imatinib to inhibit chronic myeloid leukemia cells |
Q61447663 | Memantine potentiates cytarabine-induced cell death of acute leukemia correlating with inhibition of K1.3 potassium channels, AKT and ERK1/2 signaling |
Q35682293 | Mitochondrial Ion Channels in Cancer Transformation |
Q36913999 | Mitochondrial Ultrastructure and Glucose Signaling Pathways Attributed to the Kv1.3 Ion Channel |
Q38201407 | Mitochondrial channels: ion fluxes and more |
Q38182357 | Mitochondrial ion channels as oncological targets |
Q49727278 | Mitochondrial pathway-mediated apoptosis is associated with erlotinib-induced cytotoxicity in hepatic cells |
Q38262884 | Mitochondrial potassium channels as pharmacological target for cardioprotective drugs. |
Q36905804 | N-(3-oxo-acyl) homoserine lactone inhibits tumor growth independent of Bcl-2 proteins |
Q55041671 | Novel Mitochondria-Targeted Furocoumarin Derivatives as Possible Anti-Cancer Agents. |
Q35608067 | Nuclear localization and functional characteristics of voltage-gated potassium channel Kv1.3. |
Q46605772 | Phycocyanin prevents methylglyoxal-induced mitochondrial-dependent apoptosis in INS-1 cells by Nrf2. |
Q36210906 | Prognostic significance of the TREK-1 K2P potassium channels in prostate cancer |
Q60933032 | Proteomics identification of radiation-induced changes of membrane proteins in the rat model of arteriovenous malformation in pursuit of targets for brain AVM molecular therapy |
Q48176860 | Psora-4, a Kv1.3 Blocker, Enhances Differentiation and Maturation in Neural Progenitor Cells. |
Q42369746 | Regulation of Proliferation by a Mitochondrial Potassium Channel in Pancreatic Ductal Adenocarcinoma Cells |
Q38947652 | Silencing the KCNK9 potassium channel (TASK-3) gene disturbs mitochondrial function, causes mitochondrial depolarization, and induces apoptosis of human melanoma cells |
Q42700967 | State-dependent blocking mechanism of Kv 1.3 channels by the antimycobacterial drug clofazimine. |
Q41484523 | Targeting Kv1.3 channels to reduce white matter pathology after traumatic brain injury |
Q57175954 | Targeting Mitochondrial Ion Channels to Fight Cancer |
Q38985342 | The Kv1.3 potassium channel is localized to the cis-Golgi and Kv1.6 is localized to the endoplasmic reticulum in rat astrocytes |
Q36146320 | The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology. |
Q39044112 | The Roles of Mitochondrial Cation Channels Under Physiological Conditions and in Cancer. |
Q37511746 | The evidence of HeLa cell apoptosis induced with tetraethylammonium using proteomics and various analytical methods |
Q38278265 | The mitochondrial permeability transition pore and its adaptive responses in tumor cells |
Q38171243 | The roles of K(+) channels in cancer |
Q38153378 | The voltage-dependent K(+) channels Kv1.3 and Kv1.5 in human cancer. |
Q38658556 | The voltage-gated potassium channel Kv1.3 is a promising multitherapeutic target against human pathologies. |
Q40970883 | Tumor-reducing effect of the clinically used drug clofazimine in a SCID mouse model of pancreatic ductal adenocarcinoma |
Q90706493 | Voltage-Gated Potassium Channel Kv1.3 as a Target in Therapy of Cancer |
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Q37225299 | Voltage-gated potassium channel Kv1.3 is highly expressed in human osteosarcoma and promotes osteosarcoma growth |