Inhibitors of mitochondrial Kv1.3 channels induce Bax/Bak-independent death of cancer cells

scientific article published on 11 April 2012

Inhibitors of mitochondrial Kv1.3 channels induce Bax/Bak-independent death of cancer cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/EMMM.201200235
P932PMC publication ID3407946
P698PubMed publication ID22496117
P5875ResearchGate publication ID223977390

P50authorErich GulbinsQ37611826
Ildikó SzabóQ40971068
Luigi LeanzaQ61163903
P2093author name stringK George Chandy
Mario Zoratti
Nicola Sassi
Brian Henry
P2860cites workClofazimine inhibits human Kv1.3 potassium channel by perturbing calcium oscillation in T lymphocytesQ21143901
Hematopoietic malignancies demonstrate loss-of-function mutations of BAXQ24321995
Mitochondrial potassium channel Kv1.3 mediates Bax-induced apoptosis in lymphocytesQ24652512
Distinct types of diffuse large B-cell lymphoma identified by gene expression profilingQ27860529
Deficiency in apoptotic effectors Bax and Bak reveals an autophagic cell death pathway initiated by photodamage to the endoplasmic reticulumQ28254691
Purification, characterization, and biosynthesis of margatoxin, a component of Centruroides margaritatus venom that selectively inhibits voltage-dependent potassium channelsQ28261952
Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of effector memory T cells in autoimmune diseasesQ28267180
Tyrosine phosphorylation-dependent suppression of a voltage-gated K+ channel in T lymphocytes upon Fas stimulationQ28284440
International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channelsQ28289179
A novel potassium channel in lymphocyte mitochondriaQ28301096
Methods in mammalian autophagy researchQ29547276
Production of large amounts of hydrogen peroxide by human tumor cellsQ29617080
BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosisQ29620466
Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosisQ33854131
Kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulatorsQ34322193
In vitro and in vivo activity of SKI-606, a novel Src-Abl inhibitor, against imatinib-resistant Bcr-Abl+ neoplastic cellsQ34582817
ROS stress in cancer cells and therapeutic implicationsQ35781703
bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosisQ36040551
Molecular proximity of Kv1.3 voltage-gated potassium channels and beta(1)-integrins on the plasma membrane of melanoma cells: effects of cell adherence and channel blockersQ36558200
Pharmacokinetics, toxicity, and functional studies of the selective Kv1.3 channel blocker 5-(4-phenoxybutoxy)psoralen in rhesus macaquesQ36666549
Mutational inactivation of the proapoptotic gene BAX confers selective advantage during tumor clonal evolutionQ37264027
Targeting ion channels in cancer: a novel frontier in antineoplastic therapyQ37370358
The functional network of ion channels in T lymphocytesQ37597609
Interaction of mitochondrial potassium channels with the permeability transition poreQ37663104
Contribution of voltage-gated potassium channels to the regulation of apoptosis.Q37681686
Functional up-regulation of HERG K+ channels in neoplastic hematopoietic cellsQ38291180
Anti-proliferative effect of Kv1.3 blockers in A549 human lung adenocarcinoma in vitro and in vivoQ39630130
Activation of guanine-β-D-arabinofuranoside and deoxyguanosine to triphosphates by a common pathway blocks T lymphoblasts at different checkpoints.Q39684234
Role of Kv1.3 mitochondrial potassium channel in apoptotic signalling in lymphocytes.Q39746194
An investigation of the occurrence and properties of the mitochondrial intermediate-conductance Ca2+-activated K+ channel mtKCa3.1.Q39758627
Kv1.3 voltage-gated K(+) channel subunit as a potential diagnostic marker and therapeutic target for breast cancerQ39807311
Superoxide dismutase activity of normal murine liver, regenerating liver, and H6 hepatomaQ40166932
Role of endoplasmic reticulum depletion and multidomain proapoptotic BAX and BAK proteins in shaping cell death after hypericin-mediated photodynamic therapyQ40321304
Expression of delayed rectifier potassium channels and their possible roles in proliferation of human gastric cancer cellsQ40356565
Regression of Novikoff rat hepatocellular carcinoma following locoregional administration of a novel formulation of clofazimine in lipiodol.Q40572288
Kv1.3 is the exclusive voltage-gated K+ channel of platelets and megakaryocytes: roles in membrane potential, Ca2+ signalling and platelet countQ40762411
A role for mitochondrial Bak in apoptotic response to anticancer drugsQ40793451
Calcium-activated potassium channels sustain calcium signaling in T lymphocytes. Selective blockers and manipulated channel expression levelsQ40816569
Endogenous voltage-gated potassium channels in human embryonic kidney (HEK293) cellsQ41033148
Alpha-tocopherol antagonizes the multidrug-resistance-reversal activity of cyclosporin A, verapamil, GF120918, clofazimine and B669.Q41035921
Clofazimine alters the energy metabolism and inhibits the growth rate of a human lung-cancer cell line in vitro and in vivoQ41480954
The riminophenazine agents clofazimine and B669 inhibit the proliferation of cancer cell lines in vitro by phospholipase A2-mediated oxidative and nonoxidative mechanismsQ41578794
Free radical stress in chronic lymphocytic leukemia cells and its role in cellular sensitivity to ROS-generating anticancer agentsQ42435827
Single-point mutations of a lysine residue change function of Bax and Bcl-xL expressed in Bax- and Bak-less mouse embryonic fibroblasts: novel insights into the molecular mechanisms of Bax-induced apoptosis.Q42790829
Kv1.1 and Kv1.3 channels contribute to the degeneration of retinal ganglion cells after optic nerve transection in vivoQ43288452
Differential involvement of Bax and Bak in TRAIL-mediated apoptosis of leukemic T cellsQ43902939
Tumor-cell resistance to death receptor--induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax.Q43903493
Voltage-gated potassium ion channels in colon cancer.Q44094664
Activity of potassium channel-blockers in breast cancer.Q44554023
Expression of CuZn- and Mn-superoxide dismutase in human colorectal neoplasms.Q45229108
A phase II evaluation of clofazimine plus doxorubicin in advanced, unresectable primary hepatocellular carcinomaQ46199288
Deregulation of 2 potassium channels in pancreas adenocarcinomas: implication of KV1.3 gene promoter methylation.Q47734211
Expression of voltage-gated potassium channels Kv1.3 and Kv1.5 in human gliomasQ47773428
Identification of a voltage-gated potassium channel in gerbil hippocampal mitochondria.Q48156276
Voltage-dependent potassium channels Kv1.3 and Kv1.5 in human cancerQ48373384
The mitochondrial effects of novel apoptogenic molecules generated by psoralen photolysis as a crucial mechanism in PUVA therapyQ58176158
Superoxide generation by the respiratory chain of tumor mitochondriaQ69808847
A phase II study of oral clofazimine in unresectable and metastatic hepatocellular carcinomaQ74467049
Reduced Kv1.3 potassium channel expression in human prostate cancerQ80423725
P433issue7
P304page(s)577-593
P577publication date2012-04-11
P1433published inEMBO Molecular MedicineQ15817279
P1476titleInhibitors of mitochondrial Kv1.3 channels induce Bax/Bak-independent death of cancer cells
P478volume4

Reverse relations

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