Enhanced sensitivity to oxidative stress in cultured embryonic cells from transgenic mice deficient in metallothionein I and II genes

scientific article

Enhanced sensitivity to oxidative stress in cultured embryonic cells from transgenic mice deficient in metallothionein I and II genes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.270.10.5506
P698PubMed publication ID7890668
P5875ResearchGate publication ID15307897

P2093author name stringLazo JS
Kondo Y
Choo KH
Pitt BR
Dellapiazza D
Michalska AE
P2860cites workQuantitative studies of the growth of mouse embryo cells in culture and their development into established linesQ24683034
P433issue10
P407language of work or nameEnglishQ1860
P304page(s)5506-5510
P577publication date1995-03-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleEnhanced sensitivity to oxidative stress in cultured embryonic cells from transgenic mice deficient in metallothionein I and II genes
P478volume270

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cites work (P2860)
Q64121990A Novel Synthetic Compound, Bismuth Zinc Citrate, Could Potentially Reduce Cisplatin-Induced Toxicity Without Compromising the Anticancer Effect Through Enhanced Expression of Antioxidant Protein
Q36369639A mediator role for metallothionein in tumor necrosis factor-induced lethal shock.
Q36426320Activation of metallothionein transcription by 4-hydroxynonenal
Q38349963Activation of the chicken metallothionein promoter by metals and oxidative stress in cultured cells and transgenic mice
Q33865538Alteration of iron homeostasis following chronic exposure to manganese in rats
Q43755784Altered inflammatory response and increased neurodegeneration in metallothionein I+II deficient mice during experimental autoimmune encephalomyelitis.
Q34635317Analysis of the effects of overexpression of metallothionein-I in transgenic mice on the reproductive toxicology of cadmium
Q44505502Antioxidant property of metallothionein in fasted mice
Q44649352Antioxidant status in the liver of hypertensive and metallothionein-deficient mice
Q48184013Apocynin Alleviates Renal Ischemia/Reperfusion Injury Through Regulating the Level of Zinc and Metallothionen.
Q42486812Astrocyte cultures from transgenic mice to study the role of metallothionein in cytotoxicity of tert-butyl hydroperoxide
Q48293159Astrocyte-targeted expression of IL-6 protects the CNS against a focal brain injury
Q48257398CNS wound healing is severely depressed in metallothionein I- and II-deficient mice.
Q28369889Cadmium-mediated activation of the metal response element in human neuroblastoma cells lacking functional metal response element-binding transcription factor-1
Q58027874Changes of metallothionein i + ii proteins in the brain after l-methyl-4-phenylpyridinium administration in mice
Q73009411Characterization of the MTF-1 transcription factor from zebrafish and trout cells
Q36855382Chemical synthesis and biological activity of a novel fluorescent etoposide derivative
Q42528965Chinese hamster cells expressing antisense to metallothionein become spontaneous mutators
Q53390269Chronic arsenic exposure impairs macrophage functions in the exposed individuals.
Q43505756Chronic combined exposure to cadmium and arsenic exacerbates nephrotoxicity, particularly in metallothionein-I/II null mice
Q43883983Clofibric acid down-regulation of metallothionein IIA in HepG2 human hepatoma cells
Q50501929Cloning and sequencing of cDNAs encoding for a novel copper-specific metallothionein and two cadmium-inducible metallothioneins from the blue crab Callinectes sapidus.
Q36017985Crambescin C1 Exerts a Cytoprotective Effect on HepG2 Cells through Metallothionein Induction
Q73614054Cytoprotection by metallothionein against gastroduodenal mucosal injury caused by ethanol in mice
Q38308882Cytotoxicity of nitric oxide is alleviated by zinc-mediated expression of antioxidant genes
Q58027841Differential expression of metallothioneins in the CNS of mice with experimental autoimmune encephalomyelitis
Q47985470Dimethyl sulfoxide, but not acidosis-induced metallothionein mRNA expression in neonatal rat primary astrocyte cultures is inhibited by the bioflavonoid, quercetin
Q34180578Early life inorganic lead exposure induces testicular teratoma and renal and urinary bladder preneoplasia in adult metallothionein-knockout mice but not in wild type mice
Q43996972Effects of mercury vapor inhalation on reactive oxygen species and antioxidant enzymes in rat brain and kidney are minimal
Q24314859Embryonic lethality and liver degeneration in mice lacking the metal-responsive transcriptional activator MTF-1.
Q31430351Enhanced seizures and hippocampal neurodegeneration following kainic acid-induced seizures in metallothionein-I + II-deficient mice
Q42492464Functional heterogeneity in the zinc fingers of metalloregulatory protein metal response element-binding transcription factor-1.
Q48047734GUS expression in Arabidopsis directed by 5' regions of the pea metallothionein-like gene PsMTA.
Q45015203Identification and characterization of metallothionein-1 and -2 gene expression in the context of (+/-)3,4-methylenedioxymethamphetamine-induced toxicity to brain dopaminergic neurons.
Q38312638Identification and expression analysis of leptin-regulated immediate early response and late target genes
Q33817242Identification of ATF-7 and the insulin signaling pathway in the regulation of metallothionein in C. elegans suggests roles in aging and reactive oxygen species
Q42475092Increased radiation-induced apoptosis in mouse thymus in the absence of metallothionein
Q24296947Induction of human metallothionein 1G promoter by VEGF and heavy metals: differential involvement of E2F and metal transcription factors
Q34940584Induction of metallothionein as an adaptive mechanism affecting the magnitude and progression of toxicological injury
Q33706904Induction of metallothionein by stress and its molecular mechanisms.
Q48595546Induction of metallothionein in astrocytes and microglia in the spinal cord from the myelin-deficient jimpy mouse
Q33886007Induction, regulation, degradation, and biological significance of mammalian metallothioneins.
Q39529176Influenza virus infection induces metallothionein gene expression in the mouse liver and lung by overlapping but distinct molecular mechanisms
Q31966807Interleukin-6 deficiency reduces the brain inflammatory response and increases oxidative stress and neurodegeneration after kainic acid-induced seizures.
Q40862353Involvement of differential metallothionein expression in free radical sensitivity of RTG-2 and CHSE-214 cells
Q47925633Involvement of oxidative stress in paraquat-induced metallothionein synthesis under glutathione depletion
Q73818775MPTP decreases MT-I mRNA in mouse striatum
Q37222939Mercury-induced cognitive impairment in metallothionein-1/2 null mice
Q42163275Metallothionein 1+2 protect the CNS during neuroglial degeneration induced by 6-aminonicotinamide
Q36068166Metallothionein and the biology of aging
Q36561727Metallothionein blocks oxidative DNA damage in vitro.
Q28387251Metallothionein blocks oxidative DNA damage induced by acute inorganic arsenic exposure
Q36793817Metallothionein in the central nervous system: Roles in protection, regeneration and cognition
Q73042679Metallothionein inducers protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity in mice
Q36456735Metallothionein induction in response to restraint stress. Transcriptional control, adaptation to stress, and role of glucocorticoid
Q48101500Metallothionein-I and -II knock-out mice are not more sensitive than control mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity
Q48363883Metallothionein-I overexpression decreases brain pathology in transgenic mice with astrocyte-targeted expression of interleukin-6.
Q31395518Metallothionein-III prevents glutamate and nitric oxide neurotoxicity in primary cultures of cerebellar neurons.
Q36699961Metallothionein-induced zinc partitioning exacerbates hyperoxic acute lung injury.
Q35554899Metallothionein: A Multifunctional Protein from Toxicity to Cancer
Q28655612Metallothioneins, unconventional proteins from unconventional animals: a long journey from nematodes to mammals
Q41680456Molecular analyses of metallothionein gene regulation.
Q36280705Monitoring metal ion flux in reactions of metallothionein and drug-modified metallothionein by electrospray mass spectrometry.
Q32065043Multiple isoforms of metallothionein are expressed in the porcine liver
Q28509018Nitric oxide-induced changes in intracellular zinc homeostasis are mediated by metallothionein/thionein
Q35679481Obesity and hyperleptinemia in metallothionein (-I and -II) null mice
Q40240291On the role of the two extracytoplasmic substrate-binding domains in the ABC transporter OpuA
Q28204847Overexpression of human metallothionein-III prevents hydrogen peroxide-induced oxidative stress in human fibroblasts
Q37465531Overexpression of the large subunit of the protein Ku suppresses metallothionein-I induction by heavy metals
Q43983979Oxidative stress and metallothionein expression in the liver of rats with severe thermal injury
Q51570233Paracetamol hepatotoxicity in metallothionein-null mice.
Q37045664Paraquat poisonings: mechanisms of lung toxicity, clinical features, and treatment
Q39725591Participation of upstream stimulator factor (USF) in cadmium-induction of the mouse metallothionein-I gene
Q37303879Potential role of alpha-synuclein and metallothionein in lead-induced inclusion body formation
Q41782383Primary structures of decapod crustacean metallothioneins with special emphasis on freshwater and semi-terrestrial species
Q73465697Protective effect of metallothionein to ras DNA damage induced by hydrogen peroxide and ferric ion-nitrilotriacetic acid
Q44560107Protective role of zinc-metallothionein (Zn-MT) in iron nitrilotriacetate (Fe-NTA)-induced renal oxidative damage
Q39383441Proteomic High Affinity Zn2+ Trafficking: Where Does Metallothionein Fit in?
Q56240158RETRACTED: Metallothionein I+II expression and their role in experimental autoimmune encephalomyelitis
Q34805998Reactive oxygen species in the regulation of synaptic plasticity and memory
Q37885826Redox biochemistry of mammalian metallothioneins
Q28377912Regulation of metallothionein gene expression by oxidative stress and metal ions
Q38322296Regulatory role of metallothionein in NF-kappaB activation
Q40022171Reversible activation of mouse metal response element-binding transcription factor 1 DNA binding involves zinc interaction with the zinc finger domain
Q48639050Role of Glucocorticoids on Rat Brain Metallothionein-I and -III Response to Stress.
Q36383664Role of MTL-1, MTL-2, and CDR-1 in mediating cadmium sensitivity in Caenorhabditis elegans
Q44722705Role of astrocytes in pathogenesis of ischemic brain injury
Q39524858Role of metallothionein against oxidative stress in the mussel Mytilus galloprovincialis
Q45200572Role of metallothionein in antigen-related airway inflammation
Q37157872Role of metallothionein in nitric oxide signaling as revealed by a green fluorescent fusion protein
Q34317904Roles of the metallothionein family of proteins in the central nervous system
Q63363233Specificity of the Metallothionein-1 Response by Cadmium-Exposed Normal Human Urothelial Cells
Q41022833Spontaneous mutagenesis in mammalian cells is caused mainly by oxidative events and can be blocked by antioxidants and metallothionein
Q42481666Suppression of metallothionein gene expression in a rat hepatoma because of promoter-specific DNA methylation
Q40427854Targeting the mouse genome: a compendium of knockouts (part II)
Q41050800The DNA binding activity of metal response element-binding transcription factor-1 is activated in vivo and in vitro by zinc, but not by other transition metals
Q26766916The Functions of Metallothionein and ZIP and ZnT Transporters: An Overview and Perspective
Q64797268The absence of reactive astrocytosis is indicative of a unique inflammatory process in Parkinson's disease
Q62604444The effects of cadmium exposure on the cytology and function of primary cultures from rainbow trout
Q35788855The metallothionein-null phenotype is associated with heightened sensitivity to lead toxicity and an inability to form inclusion bodies
Q47785517The protein thiol metallothionein as an antioxidant and protectant against antineoplastic drugs
Q74342099Tolerance to cadmium hepatotoxicity by metallothionein and zinc: in vivo and in vitro studies with MT-null mice
Q48640156Transgenic expression of interleukin 6 in the central nervous system regulates brain metallothionein-I and -III expression in mice
Q73503952Using MT(-/-) mice to study metallothionein and oxidative stress
Q26823615Zinc and the modulation of redox homeostasis
Q42512775Zinc resistance impairs sensitivity to oxidative stress in HeLa cells: protection through metallothioneins expression
Q35232889Zn-responsive proteome profiling and time-dependent expression of proteins regulated by MTF-1 in A549 cells