Cutting edge: critical role for mesothelial cells in necrosis-induced inflammation through the recognition of IL-1 alpha released from dying cells

scientific article published on December 2008

Cutting edge: critical role for mesothelial cells in necrosis-induced inflammation through the recognition of IL-1 alpha released from dying cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.4049/JIMMUNOL.181.12.8194
P932PMC publication ID2762646
P698PubMed publication ID19050234
P5875ResearchGate publication ID23563271

P50authorTatjana EigenbrodQ63980847
P2093author name stringGabriel Núñez
Jong-Hwan Park
Yoichiro Iwakura
Jürgen Harder
P2860cites workThe epistatic interrelationships of IL-1, IL-1 receptor antagonist, and the type I IL-1 receptor.Q52118355
Effect of cytokines on polymorphonuclear neutrophil infiltration in the mouse. Prostaglandin- and leukotriene-independent induction of infiltration by IL-1 and tumor necrosis factor.Q53520461
Nod1/RICK and TLR signaling regulate chemokine and antimicrobial innate immune responses in mesothelial cells.Q53567983
Pannexin-1-Mediated Recognition of Bacterial Molecules Activates the Cryopyrin Inflammasome Independent of Toll-like Receptor SignalingQ57080628
Quantitative Determination of IL-1α-Induced IL-8 mRNA Levels in Cultured Human Keratinocytes, Dermal Fibroblasts, Endothelial Cells, and MonocytesQ58466364
Human peritoneal mesothelial cells produce many cytokines (granulocyte colony-stimulating factor [CSF], granulocyte-monocyte-CSF, macrophage-CSF, interleukin-1 [IL-1], and IL-6) and are activated and stimulated to grow by IL-1Q67802477
The expression and modulation of IL-1 alpha in murine keratinocytesQ68092034
IL-1alpha responds to necrotic cell deathQ80584710
Pathogen recognition and innate immunityQ27861084
Release of chromatin protein HMGB1 by necrotic cells triggers inflammationQ28131815
Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complexQ28588629
Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophagesQ28594887
DAMPs, PAMPs and alarmins: all we need to know about dangerQ29547535
NOD-LRR proteins: role in host-microbial interactions and inflammatory diseaseQ34426050
MyD88 as a bottle neck in Toll/IL-1 signalingQ35017555
Alarmins: chemotactic activators of immune responsesQ36162859
Production of mice deficient in genes for interleukin (IL)-1alpha, IL-1beta, IL-1alpha/beta, and IL-1 receptor antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretionQ36400734
The orphan mouse receptor interleukin (IL)-8R beta binds N51. Structure-function analysis using N51/IL-8 chimeric moleculesQ38297803
Identification of a key pathway required for the sterile inflammatory response triggered by dying cellsQ40119160
HMGB1 signals through toll-like receptor (TLR) 4 and TLR2.Q40249835
Interleukin 1alpha-induced NFkappaB activation and chemokine mRNA stabilization diverge at IRAK1Q40446721
An essential role of the NF-kappa B/Toll-like receptor pathway in induction of inflammatory and tissue-repair gene expression by necrotic cellsQ40801344
Cytokine-stimulated human mesothelial cells produce chemotactic activity for neutrophils including NAP-1/IL-8Q41082248
CXCR2 regulates respiratory syncytial virus-induced airway hyperreactivity and mucus overproductionQ45728854
CXC-chemokines KC and macrophage inflammatory protein-2 (MIP-2) synergistically induce leukocyte recruitment to the central nervous system in ratsQ48418178
Different patterns of interleukin-1alpha and interleukin-1beta expression in organs of normal young and old mice.Q48630118
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectinflammationQ101991
P304page(s)8194-8198
P577publication date2008-12-01
P1433published inJournal of ImmunologyQ3521441
P1476titleCutting edge: critical role for mesothelial cells in necrosis-induced inflammation through the recognition of IL-1 alpha released from dying cells
P478volume181

Reverse relations

cites work (P2860)
Q92092731AIM2 inflammasome-derived IL-1β induces postoperative ileus in mice
Q57598527Activation of the NLRP3 inflammasome byMycobacterium tuberculosisis uncoupled from susceptibility to active tuberculosis
Q38077755Alarmins in tendinopathy: unravelling new mechanisms in a common disease
Q33770758Anti-inflammatory Effects of Oct4/Sox2-overexpressing Human Adipose Tissue-derived Mesenchymal Stem Cells
Q28387699Asbestos and erionite prime and activate the NLRP3 inflammasome that stimulates autocrine cytokine release in human mesothelial cells
Q92697835Caspase-11-dependent IL-1α release boosts Th17 immunity against Paracoccidioides brasiliensis
Q37900518Cellular and molecular choreography of neutrophil recruitment to sites of sterile inflammation
Q92689501Compartmentalized profiling of amniotic fluid cytokines in women with preterm labor
Q42568942Cutting edge: nitrogen bisphosphonate-induced inflammation is dependent upon mast cells and IL-1.
Q37143403Cytosolic flagellin-induced lysosomal pathway regulates inflammasome-dependent and -independent macrophage responses
Q38025082Danger signals activating the immune response after trauma
Q30279070Dealing with Danger in the CNS: The Response of the Immune System to Injury
Q37870827Death and inflammation following somatic cell transplantation
Q35821070Degradable polyethylenimine derivate coupled to a bifunctional peptide R13 as a new gene-delivery vector
Q38112683Different Members of the IL-1 Family Come Out in Different Ways: DAMPs vs. Cytokines?
Q24646390Differential release of chromatin-bound IL-1alpha discriminates between necrotic and apoptotic cell death by the ability to induce sterile inflammation
Q37676926Disease-associated functions of IL-33: the new kid in the IL-1 family
Q92971145Divergent Roles for the IL-1 Family in Gastrointestinal Homeostasis and Inflammation
Q36238562Effects of Exposure to Ozone on the Ocular Surface in an Experimental Model of Allergic Conjunctivitis
Q38270705Endothelial barrier dysfunction in septic shock
Q35043172Endovascular laser–tissue interactions and biological responses in relation to endovenous laser therapy
Q24598045Epigenetics of colorectal cancer
Q35225843Evaluation of the contribution of multiple DAMPs and DAMP receptors in cell death-induced sterile inflammatory responses.
Q36372845Evidence of perturbations of the cytokine network in preterm labor
Q47285901Function and regulation of IL-1α in inflammatory diseases and cancer
Q42185747Granzyme B-dependent proteolysis acts as a switch to enhance the proinflammatory activity of IL-1α.
Q38939435HMGB1, IL-1α, IL-33 and S100 proteins: dual-function alarmins
Q60044041Human NK cells adapt their immune response towards increasing multiplicities of infection of Aspergillus fumigatus
Q36304279IL-1 family cytokines trigger sterile inflammatory disease
Q38847946IL-1α Gene Deletion Protects Oligodendrocytes after Spinal Cord Injury through Upregulation of the Survival Factor Tox3.
Q39274974IL-1α modulates neutrophil recruitment in chronic inflammation induced by hydrocarbon oil
Q49650563IL-1α promotes pathogenic immature myeloid cells and IL-1β favors protective mature myeloid cells during acute lung infection.
Q83790505IL-33-activated dendritic cells are critical for allergic airway inflammation
Q39729219Identification of the cellular sensor that stimulates the inflammatory response to sterile cell death.
Q38261586Immune cells in experimental acute kidney injury
Q34311701Immunogenic cell death and DAMPs in cancer therapy
Q92835955Immunogenic cell death in cancer therapy: Present and emerging inducers
Q39178654Immunogenic cell death: can it be exploited in PhotoDynamic Therapy for cancer?
Q38255959Immunogenicity of necrotic cell death.
Q37950925Impaired clearance of apoptotic cells in germinal centers: implications for loss of B cell tolerance and induction of autoimmunity
Q36895048Inflammation in alcoholic liver disease
Q38187172Inflammatory triggers of acute rejection of organ allografts.
Q36088759Inhibition of NF-κB in Tumor Cells Exacerbates Immune Cell Activation Following Photodynamic Therapy
Q89683476Inhibitory Role of TRIP-Br1/XIAP in Necroptosis under Nutrient/Serum Starvation
Q35205885Innate and adaptive immune responses to cell death.
Q37494902Interleukin 1α and the inflammatory process
Q24606766Interleukin-1 in the pathogenesis and treatment of inflammatory diseases
Q41901427Interleukin-1 receptor-mediated inflammation impairs the heat shock response of human mesothelial cells.
Q38439111Interleukin-1α and brain inflammation
Q36585708Interleukin-33 in the human placenta
Q28392777Interplay of innate and adaptive immunity in metal-induced hypersensitivity
Q28591187Intracellular interleukin-1 receptor 2 binding prevents cleavage and activity of interleukin-1α, controlling necrosis-induced sterile inflammation
Q37437339Intralesional rose bengal in melanoma elicits tumor immunity via activation of dendritic cells by the release of high mobility group box 1
Q37482664Intratumoral Immunization by p19Arf and Interferon-β Gene Transfer in a Heterotopic Mouse Model of Lung Carcinoma
Q35535851Lack of interleukin-1α or interleukin-1β inhibits transformation of steatosis to steatohepatitis and liver fibrosis in hypercholesterolemic mice
Q35581200Lipopolysaccharide Induces Alveolar Macrophage Necrosis via CD14 and the P2X7 Receptor Leading to Interleukin-1α Release
Q40201540Macrophage-derived IL-1α promotes sterile inflammation in a mouse model of acetaminophen hepatotoxicity.
Q38008374Mast Cells Respond to Cell Injury through the Recognition of IL-33.
Q51306137Mechanisms of cell uptake, inflammatory potential and protein corona effects with gold nanoparticles.
Q27025291Medical therapies with adult stem/progenitor cells (MSCs): a backward journey from dramatic results in vivo to the cellular and molecular explanations
Q35665181Mesenchymal stem/stromal cells (MSCs): role as guardians of inflammation
Q30533230Metamorphosis of mesothelial cells with active horizontal motility in tissue culture
Q28260209MicroRNA29a regulates IL-33-mediated tissue remodelling in tendon disease
Q35760849Microbiota-induced IL-1β, but not IL-6, is critical for the development of steady-state TH17 cells in the intestine
Q39277467Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases.
Q34088856Molecular mechanisms of late apoptotic/necrotic cell clearance
Q28388472MyD88 dependence of beryllium-induced dendritic cell trafficking and CD4⁺ T-cell priming
Q36382191NADPH oxidase controls neutrophilic response to sterile inflammation in mice by regulating the IL-1α/G-CSF axis.
Q39142554NF-κB as a Therapeutic Target in Inflammatory-Associated Bone Diseases
Q38579499Necroinflammation in Kidney Disease
Q35862108Necrosis-Induced Sterile Inflammation Mediated by Interleukin-1α in Retinal Pigment Epithelial Cells
Q37959327Neutrophils and intravascular immunity in the liver during infection and sterile inflammation
Q37415404New insights into mechanisms controlling the NLRP3 inflammasome and its role in lung disease
Q44330404Non-redundant properties of IL-1α and IL-1β during acute colon inflammation in mice
Q42233586Nuclear retention of IL-1 alpha by necrotic cells: a mechanism to dampen sterile inflammation
Q44846869Octacalcium phosphate crystals induce inflammation in vivo through interleukin-1 but independent of the NLRP3 inflammasome in mice
Q35856645P2X7R activation drives distinct IL-1 responses in dendritic cells compared to macrophages
Q36802436PGE2 induced in and released by dying cells functions as an inhibitory DAMP
Q37730606Physiological consequences of programmed necrosis, an alternative form of cell demise
Q93358519Post-stroke inflammation-target or tool for therapy?
Q38135408Processes of sterile inflammation.
Q38560502Redox distress and genetic defects conspire in systemic autoinflammatory diseases
Q52720171Regulation of Tumor Progression by Programmed Necrosis.
Q36213462Relationship between -889 C/T polymorphism in interleukin-1A gene and risk of chronic periodontitis: Evidence from a meta-analysis with new published findings.
Q40369818Release of interleukin-1α or interleukin-1β depends on mechanism of cell death
Q90245610Role of Damage Associated Molecular Pattern Molecules (DAMPs) in Aneurysmal Subarachnoid Hemorrhage (aSAH)
Q35091107Role of IL-1 receptor-associated kinase-M (IRAK-M) in priming of immune and inflammatory responses by nitrogen bisphosphonates
Q36873728Sterile inflammation in acetaminophen-induced liver injury is mediated by Cot/tpl2.
Q35651080Sterile inflammation of endothelial cell-derived apoptotic bodies is mediated by interleukin-1α
Q29620014Sterile inflammation: sensing and reacting to damage
Q35210606TLR-2 and TLR-9 are sensors of apoptosis in a mouse model of doxorubicin-induced acute inflammation
Q24651453The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1
Q28080249The NLRP3 inflammasome in pathogenic particle and fibre-associated lung inflammation and diseases
Q38948602The Role of Interleukin-1 in Inflammatory and Malignant Human Skin Diseases and the Rationale for Targeting Interleukin-1 Alpha
Q40151249The Role of the Immune System Beyond the Fight Against Infection.
Q37800776The biological paths of IL-1 family members IL-18 and IL-33
Q91595744The clearance of dead cells by efferocytosis
Q37715704The enigmatic processing and secretion of interleukin-33.
Q35669042The epithelial danger signal IL-1α is a potent activator of fibroblasts and reactivator of intestinal inflammation.
Q50221142The expression of matrix metalloproteinases and their inhibitors in corneal fibroblasts by alarmins from necrotic corneal epithelial cells
Q43072756The extracellular release of DNA and HMGB1 from Jurkat T cells during in vitro necrotic cell death
Q29617049The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis
Q37716003The sterile inflammatory response
Q36233768The transcription of the alarmin cytokine interleukin-1 alpha is controlled by hypoxia inducible factors 1 and 2 alpha in hypoxic cells
Q40905712Toll/IL-1 domain-containing adaptor inducing IFN-β (TRIF) mediates innate immune responses in murine peritoneal mesothelial cells through TLR3 and TLR4 stimulation
Q36829387Uric acid as a danger signal in gout and its comorbidities
Q35022269Various forms of tissue damage and danger signals following hematopoietic stem-cell transplantation
Q57039643[EXPRESS] Mouse mast cells and mast cell proteases do not play a significant role in acute tissue injury pain induced by formalin

Search more.