Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue.

scientific article published on 22 June 2009

Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.00192-09
P932PMC publication ID2725728
P698PubMed publication ID19546236

P50authorNils HalbergQ42323130
Sean P DineenQ53473792
Philipp E. SchererQ60572448
Ingrid Wernstedt AsterholmQ81886906
P2093author name stringAlan D Attie
Rolf A Brekken
Ulysses J Magalang
Zhao V Wang
Shira Landskroner-Eiger
Maria E Trujillo
Tayeba Khan
Shariq Sherwani
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A central role for JNK in obesity and insulin resistanceQ29619778
Glucose uptake and perfusion in subcutaneous and visceral adipose tissue during insulin stimulation in nonobese and obese humansQ30710925
THE DIFFERENTIATION OF WHITE ADIPOSE CELLS. AN ELECTRON MICROSCOPE STUDYQ33191419
Adipose tissue mass can be regulated through the vasculatureQ34075818
Tissue oxygenation in obese and non-obese patients during laparoscopyQ34314256
Reversal of obesity by targeted ablation of adipose tissueQ34319543
Angiogenesis inhibitor, TNP-470, prevents diet-induced and genetic obesity in miceQ34322120
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Obesity decreases perioperative tissue oxygenationQ34435120
A pericellular collagenase directs the 3-dimensional development of white adipose tissueQ34522343
Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1alphaQ35081587
Obesity-associated improvements in metabolic profile through expansion of adipose tissueQ35945161
The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alphaQ36095810
The pinocytic rate of activated macrophagesQ36358570
A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibilityQ36586611
Localization and activity of lysyl oxidase within nuclei of fibrogenic cellsQ36709638
Hypoxia and cancerQ37008506
Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI.Q37110569
Obesity in C57BL/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration.Q38297857
Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese miceQ38299555
Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulationQ38303256
Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight lossQ38323163
Hypoxic induction of Ctgf is directly mediated by Hif-1.Q38337618
Regulation of elastin promoter by lysyl oxidase and growth factors: cross control of lysyl oxidase on TGF-beta1 effectsQ40152221
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Connective tissue growth factor inhibits adipocyte differentiationQ42811047
Fibronectin modulation of cell shape and lipogenic gene expression in 3T3-adipocytesQ42820082
A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated circulating adiponectin and improved insulin sensitivityQ42834758
Impaired postprandial adipose tissue blood flow response is related to aspects of insulin sensitivityQ44080998
Life with oxygenQ45345070
Relationship between adipocyte size and adipokine expression and secretionQ47310274
Subcutaneous abdominal adipose tissue blood flow: variation within and between subjects and relationship to obesity.Q51578283
Angiogenic role of LYVE-1-positive macrophages in adipose tissue.Q51995490
Lysyl Oxidase Activates the Transcription Activity of Human Collagene III PromoterQ58620548
Postprandial substrate deposition in human forearm and adipose tissues in vivoQ68482968
Low oxygen tension increases mRNA levels of alpha 1 (I) procollagen in human dermal fibroblastsQ72572385
Hypoxia promotes fibrogenesis in human renal fibroblastsQ73293210
Cancer: looking outside the genomeQ74046042
The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acidQ79111319
Hypoxia-induced increase in the production of extracellular matrix proteins in systemic sclerosisQ80123824
Adipocyte death, adipose tissue remodeling, and obesity complicationsQ81234708
P4510describes a project that usesImageJQ1659584
P433issue16
P407language of work or nameEnglishQ1860
P921main subjecthypoxiaQ105688
insulin resistanceQ1053470
preproinsulinQ7240673
P304page(s)4467-4483
P577publication date2009-06-22
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleHypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue
P478volume29

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Q90581137Sirt1 activator induces proangiogenic genes in preadipocytes to rescue insulin resistance in diet-induced obese mice
Q35953485Stearic acid induces proinflammatory cytokine production partly through activation of lactate-HIF1α pathway in chondrocytes
Q37440982Sudden decrease in physical activity evokes adipocyte hyperplasia in 70- to 77-day-old rats but not 49- to 56-day-old rats
Q33602989Switch from stress response to homeobox transcription factors in adipose tissue after profound fat loss
Q36702510Systemic ghrelin administration alters serum biomarkers of angiogenesis in diet-induced obese mice
Q38081407Systems biology of adipose tissue metabolism: regulation of growth, signaling and inflammation
Q38660731Systems-level organization of non-alcoholic fatty liver disease progression network.
Q39614320THP-1 Macrophages and SGBS Adipocytes - A New Human in vitro Model System of Inflamed Adipose Tissue
Q49958603Targeted disruption of the iNOS gene improves adipose tissue inflammation and fibrosis in leptin-deficient ob/ob mice: role of tenascin C.
Q46792366Targeting HIF-1α/PDK1 Axis by Dichloroacetate (DCA) Suppresses Bleomycin-induced Pulmonary Fibrosis
Q39370856Targeting Hypoxia Inducible Factors-1α As a Novel Therapy in Fibrosis
Q38852204Targeting adipose tissue in the treatment of obesity-associated diabetes
Q51755304Telmisartan Does Not Improve Lymph Node or Adipose Tissue Fibrosis More Than Continued ART Alone.
Q36591198Tenomodulin promotes human adipocyte differentiation and beneficial visceral adipose tissue expansion
Q89664945The Adipocyte Acquires a Fibroblast-Like Transcriptional Signature in Response to a High Fat Diet
Q35916550The Association Between Subcutaneous Fat Density and the Propensity to Store Fat Viscerally
Q41023080The Central Role of Biometals Maintains Oxidative Balance in the Context of Metabolic and Neurodegenerative Disorders.
Q58694047The Effect of Chronic Inflammation and Oxidative and Endoplasmic Reticulum Stress in the Course of Metabolic Syndrome and Its Therapy
Q36547176The Human Microcirculation: Regulation of Flow and Beyond
Q38410928The Hypoxia-Inducible Factor Pathway in Adipocytes: The Role of HIF-2 in Adipose Inflammation and Hypertrophic Cardiomyopathy
Q51807137The Immune System in Obesity: Developing Paradigms Amidst Inconvenient Truths.
Q29616026The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
Q42532363The PPARγ-FGF1 axis: an unexpected mediator of adipose tissue homeostasis.
Q46355679The Pathogenesis of Obesity-Associated Adipose Tissue Inflammation
Q60921563The Role of Berberine in the Prevention of HIF-1 Activation to Alleviate Adipose Tissue Fibrosis in High-Fat-Diet-Induced Obese Mice
Q37974553The adaptive immune system as a fundamental regulator of adipose tissue inflammation and insulin resistance
Q28084054The cell biology of fat expansion
Q44450039The consumption of n-3 polyunsaturated fatty acids differentially modulates gene expression of peroxisome proliferator-activated receptor alpha and gamma and hypoxia-inducible factor 1 alpha in subcutaneous adipose tissue of obese adolescents
Q28505719The density of extracellular matrix proteins regulates inflammation and insulin signaling in adipocytes
Q35499600The differential role of Hif1β/Arnt and the hypoxic response in adipose function, fibrosis, and inflammation
Q35812133The extracellular matrix and insulin resistance
Q48181172The hypoxic tumour microenvironment
Q27001164The immune system's involvement in obesity-driven type 2 diabetes
Q35757181The limited storage capacity of gonadal adipose tissue directs the development of metabolic disorders in male C57Bl/6J mice
Q35687138The lysyl oxidase inhibitor β-aminopropionitrile reduces body weight gain and improves the metabolic profile in diet-induced obesity in rats
Q93345358The many secret lives of adipocytes: implications for diabetes
Q38078880The microcirculation in adipose tissue inflammation.
Q43727416The nuclear receptors NUR77, NURR1 and NOR1 in obesity and during fat loss
Q64082822The obese adipose tissue microenvironment in cancer development and progression
Q49430910The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis
Q47146555The pathological role of vascular aging in cardio-metabolic disorder.
Q37104149The relationship between inflammatory markers, angiogenesis, and obesity
Q37610766The relationship between serum hypoxia-inducible factor 1α and coronary artery calcification in asymptomatic type 2 diabetic patients
Q57030139The role of adipose tissue in cardiovascular health and disease
Q36569619The role of adipose tissue in insulin resistance in women of African ancestry
Q38209671The role of epigenetics in the fibrotic processes associated with glaucoma.
Q57060192The role of hypoxia-inducible factors in metabolic diseases
Q41762813The role of metformin and resveratrol in the prevention of hypoxia-inducible factor 1α accumulation and fibrosis in hypoxic adipose tissue
Q35572938Thromboxane synthase deficiency improves insulin action and attenuates adipose tissue fibrosis.
Q89662533Through fat and thin - a journey with the adipose tissues
Q34402691Time-course microarrays reveal early activation of the immune transcriptome and adipokine dysregulation leads to fibrosis in visceral adipose depots during diet-induced obesity
Q41051062Trail (TNF-related apoptosis-inducing ligand) induces an inflammatory response in human adipocytes
Q34713714Transcriptional control of adipose lipid handling by IRF4
Q26774389Transcriptome and Molecular Endocrinology Aspects of Epicardial Adipose Tissue in Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Observational Studies
Q35903355Transgenic expression and genetic variation of Lmf1 affect LPL activity in mice and humans
Q64941221Transient Overexpression of Vascular Endothelial Growth Factor A in Adipose Tissue Promotes Energy Expenditure via Activation of the Sympathetic Nervous System.
Q55339039Treatment of Dimpling from Cellulite.
Q26752583Type 2 Diabetes in Non-Alcoholic Fatty Liver Disease and Hepatitis C Virus Infection--Liver: The "Musketeer" in the Spotlight
Q33701881Unique transcriptomic signature of omental adipose tissue in Ossabaw swine: a model of childhood obesity
Q58091922VCE-004.8, A Multitarget Cannabinoquinone, Attenuates Adipogenesis and Prevents Diet-Induced Obesity
Q35106315Vascular biology of metabolic syndrome
Q37022876Vascular endothelial growth factor is important for brown adipose tissue development and maintenance.
Q37726638Vascular rarefaction mediates whitening of brown fat in obesity.
Q89827527Viscoelastic characterization of diabetic and non-diabetic human adipose tissue
Q41112264Vitamin D controls resistance artery function through regulation of perivascular adipose tissue hypoxia and inflammation.
Q33684984What causes the insulin resistance underlying obesity?
Q37601812What we talk about when we talk about fat.
Q34062979miR-210 promotes IPF fibroblast proliferation in response to hypoxia
Q47624355miR-27 impairs the adipogenic lineage commitment via targeting lysyl oxidase
Q34899647microRNA-122 regulates hypoxia-inducible factor-1 and vimentin in hepatocytes and correlates with fibrosis in diet-induced steatohepatitis
Q92217601β Cell Hypoxia-Inducible Factor-1α Is Required for the Prevention of Type 1 Diabetes

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