| scholarly article | Q13442814 |
| P356 | DOI | 10.1158/0008-5472.CAN-07-1320 |
| P698 | PubMed publication ID | 17909001 |
| P50 | author | Markus Dagnell | Q50904262 |
| Dimitra Dafou | Q55135144 | ||
| Heidi Fiegl | Q57252461 | ||
| Mohammadreza Zali | Q57466904 | ||
| Martin Widschwendter | Q71025350 | ||
| P2093 | author name string | Charles Spruck | |
| Dahui Sun | |||
| Olle Sangfelt | |||
| Steven I Reed | |||
| Johan Hansson | |||
| Hans Nordgren | |||
| Sophia Apostolidou | |||
| Fredrik Petersson | |||
| Dan Grander | |||
| Martin Corcoran | |||
| Christian Marth | |||
| Elisabeth Mueller-Holzner | |||
| Per Sangfelt | |||
| Natalie von der Lehr | |||
| Shahab Akhoondi | |||
| Diana Cepeda | |||
| Alena Maljukova | |||
| Babak Noori Nayer | |||
| Kathleen Klotz | |||
| Sepideh Zabihi Nejad | |||
| Susanne Egyhazi | |||
| P433 | issue | 19 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 9006-9012 | |
| P577 | publication date | 2007-10-01 | |
| P1433 | published in | Cancer Research | Q326097 |
| P1476 | title | FBXW7/hCDC4 is a general tumor suppressor in human cancer | |
| P478 | volume | 67 |
| Q50045908 | A complex molecular switch directs stress-induced cyclin C nuclear release through SCFGrr1-mediated degradation of Med13. |
| Q93197932 | A patent review of the ubiquitin ligase system: 2015-2018 |
| Q33698641 | A programmable method for massively parallel targeted sequencing |
| Q92686162 | Activation of hedgehog signaling associates with early disease progression in chronic lymphocytic leukemia |
| Q33746155 | Alcohol-dysregulated microRNAs in hepatitis B virus-related hepatocellular carcinoma. |
| Q34163470 | Allele-specific deletions in mouse tumors identify Fbxw7 as germline modifier of tumor susceptibility |
| Q37160444 | Altered subcellular localization of tumor-specific cyclin E isoforms affects cyclin-dependent kinase 2 complex formation and proteasomal regulation. |
| Q28485395 | An evolutionarily conserved synthetic lethal interaction network identifies FEN1 as a broad-spectrum target for anticancer therapeutic development |
| Q52720960 | Animal models of cholangiocarcinoma. |
| Q45940002 | B-cell receptor configuration and mutational analysis of patients with chronic lymphocytic leukaemia and trisomy 12 reveal recurrent molecular abnormalities. |
| Q35677900 | C/EBP-β-activated microRNA-223 promotes tumour growth through targeting RASA1 in human colorectal cancer |
| Q41262162 | CDC4/FBXW7 and the 'just enough' model of tumourigenesis |
| Q38740975 | Cadherin-6 is a putative tumor suppressor and target of epigenetically dysregulated miR-429 in cholangiocarcinoma |
| Q54942210 | Chromatin-Bound Cullin-Ring Ligases: Regulatory Roles in DNA Replication and Potential Targeting for Cancer Therapy. |
| Q60958618 | Clinical Significance of CUB and Sushi Multiple Domains 1 Inactivation in Head and Neck Squamous Cell Carcinoma |
| Q36304519 | Clinicopathological and Targeted Exome Gene Features of a Patient with Metastatic Acinic Cell Carcinoma of the Parotid Gland Harboring an ARID2 Nonsense Mutation and CDKN2A/B Deletion |
| Q51919937 | Complex regulation of cell-cycle inhibitors by Fbxw7 in mouse embryonic fibroblasts. |
| Q64238834 | Comprehensive Investigation of miRNome Identifies Novel Candidate miRNA-mRNA Interactions Implicated in T-Cell Acute Lymphoblastic Leukemia |
| Q28606437 | Comprehensive assessment of cancer missense mutation clustering in protein structures |
| Q24647543 | Control of cell growth by the SCF and APC/C ubiquitin ligases |
| Q36699782 | Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7 |
| Q37096504 | Copy number variation of E3 ubiquitin ligase genes in peripheral blood leukocyte and colorectal cancer |
| Q28251481 | DLEU2, frequently deleted in malignancy, functions as a critical host gene of the cell cycle inhibitory microRNAs miR-15a and miR-16-1 |
| Q33816178 | DNA methylation profiling in doxorubicin treated primary locally advanced breast tumours identifies novel genes associated with survival and treatment response |
| Q91208644 | DUBs, Hypoxia, and Cancer |
| Q95839654 | Decreased expression of FBXW7 by ERK1/2 activation in drug-resistant cancer cells confers transcriptional activation of MDR1 by suppression of ubiquitin degradation of HSF1 |
| Q42205041 | Decreased expression of FBXW7 is correlated with poor prognosis in patients with esophageal squamous cell carcinoma |
| Q36291421 | Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint. |
| Q41899199 | Differential regulation of FBXW7 isoforms by various stress stimuli |
| Q38989123 | Direct phosphorylation events involved in HIF-α regulation: the role of GSK-3β. |
| Q37122075 | Diverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells |
| Q99583847 | Downregulation of miR-182-5p inhibits the proliferation and invasion of triple-negative breast cancer cells through regulating TLR4/NF-κB pathway activity by targeting FBXW7 |
| Q91451295 | Downregulation of specific FBXW7 isoforms with differential effects in T-cell lymphoblastic lymphoma |
| Q28086796 | Dysregulation of ubiquitin ligases in cancer |
| Q37701681 | EglN2 contributes to triple negative breast tumorigenesis by functioning as a substrate for the FBW7 tumor suppressor |
| Q38596749 | Emerging roles for the FBXW7 ubiquitin ligase in leukemia and beyond |
| Q33604979 | Enhancing mTOR-targeted cancer therapy |
| Q48130306 | Establishment and analysis of a novel mouse line carrying a conditional knockin allele of a cancer-specific FBXW7 mutation |
| Q38130013 | Evading apoptosis in cancer |
| Q36344621 | Evaluating the prognostic significance of FBXW7 expression level in human breast cancer by a meta-analysis of transcriptional profiles |
| Q53171497 | Evaluation of Fbxw7 expression and its correlation with the expression of c-Myc, cyclin E and p53 in human hepatocellular carcinoma. |
| Q36689094 | Expression profiling reveals transcriptional regulation by Fbxw7/mTOR pathway in radiation-induced mouse thymic lymphomas |
| Q39108673 | F-box and WD repeat domain-containing-7 (Fbxw7) protein targets endoplasmic reticulum-anchored osteogenic and chondrogenic transcriptional factors for degradation. |
| Q35056718 | F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner |
| Q90746433 | F-box proteins and cancer: an update from functional and regulatory mechanism to therapeutic clinical prospects |
| Q55253244 | F-box proteins involved in cancer-associated drug resistance. |
| Q24313524 | FAM83D promotes cell proliferation and motility by downregulating tumor suppressor gene FBXW7 |
| Q90480385 | FBW7 in hematological tumors |
| Q39009700 | FBW7 increases chemosensitivity in hepatocellular carcinoma cells through suppression of epithelial-mesenchymal transition |
| Q38920285 | FBW7 increases drug sensitivity to cisplatin in human nasopharyngeal carcinoma by downregulating the expression of multidrug resistance-associated protein |
| Q43235785 | FBW7 increases the chemosensitivity of pancreatic cancer cells to gemcitabine through upregulation of ENT1. |
| Q41667106 | FBW7 regulates DNA interstrand cross-link repair by modulating FAAP20 degradation |
| Q28391884 | FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma |
| Q29616127 | FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation |
| Q27010419 | FBW7-mediated ubiquitination and degradation of KLF5 |
| Q89423009 | FBXL14 abolishes breast cancer progression by targeting CDCP1 for proteasomal degradation |
| Q57788900 | FBXO17 promotes cell proliferation through activation of Akt in lung adenocarcinoma cells |
| Q47991876 | FBXO4 inhibits lung cancer cell survival by targeting Mcl-1 for degradation |
| Q36261318 | FBXW12, a novel F box protein-encoding gene, is deleted or methylated in some cases of epithelial ovarian cancer |
| Q90347521 | FBXW4 Is Highly Expressed and Associated With Poor Survival in Acute Myeloid Leukemia |
| Q38272804 | FBXW7 Facilitates Nonhomologous End-Joining via K63-Linked Polyubiquitylation of XRCC4. |
| Q37754789 | FBXW7 Mutants and NOTCH1 in Cancer |
| Q35138854 | FBXW7 acts as an independent prognostic marker and inhibits tumor growth in human osteosarcoma. |
| Q35828658 | FBXW7 and USP7 regulate CCDC6 turnover during the cell cycle and affect cancer drugs susceptibility in NSCLC. |
| Q52720407 | FBXW7 deletion contributes to lung tumor development and confers resistance to gefitinib therapy. |
| Q47601708 | FBXW7 expression affects the response to chemoradiotherapy and overall survival among patients with oral squamous cell carcinoma: A single-center retrospective study. |
| Q64244621 | FBXW7 in Cancer: What Has Been Unraveled Thus Far? |
| Q36426514 | FBXW7 is involved in Aurora B degradation. |
| Q37375225 | FBXW7 is involved in the acquisition of the malignant phenotype in epithelial ovarian tumors |
| Q33889158 | FBXW7 missense mutation: a novel negative prognostic factor in metastatic colorectal adenocarcinoma. |
| Q35463880 | FBXW7 modulates cellular stress response and metastatic potential through HSF1 post-translational modification |
| Q57287778 | FBXW7 modulates malignant potential and cisplatin-induced apoptosis in cholangiocarcinoma via NOTCH1 and MCL1 |
| Q33845217 | FBXW7 mutations in melanoma and a new therapeutic paradigm |
| Q27852932 | FBXW7 mutations in patients with advanced cancers: clinical and molecular characteristics and outcomes with mTOR inhibitors |
| Q28590336 | FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development |
| Q36004642 | FBXW7 negatively regulates ENO1 expression and function in colorectal cancer |
| Q38854407 | FBXW7 overexpression suppresses renal cancer cell proliferation and induces apoptosis |
| Q48094154 | FBXW7 regulates DISC1 stability via the ubiquitin-proteosome system |
| Q35742526 | FBXW7 suppresses epithelial-mesenchymal transition, stemness and metastatic potential of cholangiocarcinoma cells |
| Q39904718 | FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression |
| Q92023426 | FBXW7-mediated stability regulation of signal transducer and activator of transcription 2 in melanoma formation |
| Q58797685 | FBXW7: a critical tumor suppressor of human cancers |
| Q41837475 | Fbw7 and p53 cooperatively suppress advanced and chromosomally unstable intestinal cancer |
| Q37388879 | Fbw7 dimerization determines the specificity and robustness of substrate degradation. |
| Q37576259 | Fbw7 regulates apoptosis in activated B-cell like diffuse large B-cell lymphoma by targeting Stat3 for ubiquitylation and degradation |
| Q36506569 | Fbw7α and Fbw7γ collaborate to shuttle cyclin E1 into the nucleolus for multiubiquitylation |
| Q90325570 | Fbxl17 is rearranged in breast cancer and loss of its activity leads to increased global O-GlcNAcylation |
| Q37352098 | Fbxw7 Deletion Accelerates KrasG12D-Driven Pancreatic Tumorigenesis via Yap Accumulation |
| Q26765153 | Fbxw7 Tumor Suppressor: A Vital Regulator Contributes to Human Tumorigenesis |
| Q33779516 | Fbxw7 haploinsufficiency loses its protection against DNA damage and accelerates MNU-induced gastric carcinogenesis |
| Q33673983 | Fbxw7 is an independent prognostic marker and induces apoptosis and growth arrest by regulating YAP abundance in hepatocellular carcinoma. |
| Q36116425 | Fbxw7 regulates Notch to control specification of neural precursors for oligodendrocyte fate |
| Q24310626 | Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver |
| Q49477276 | Fbxw7 regulates renal cell carcinoma migration and invasion via suppression of the epithelial-mesenchymal transition |
| Q35919057 | Fbxw7α- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma |
| Q51533864 | Fbxw7β, E3 ubiquitin ligase, negative regulation of primary myoblast differentiation, proliferation and migration. |
| Q27004534 | From fly wings to targeted cancer therapies: a centennial for notch signaling |
| Q98159045 | Function and regulation of F-box/WD repeat-containing protein 7 |
| Q35959502 | GSK-3β regulates cell growth, migration, and angiogenesis via Fbw7 and USP28-dependent degradation of HIF-1α |
| Q34084819 | Gene dysregulations driven by somatic copy number aberrations-biological and clinical implications in colon tumors: a paper from the 2009 William Beaumont Hospital Symposium on Molecular Pathology |
| Q38989186 | Genetic mutations in human rectal cancers detected by targeted sequencing |
| Q91362422 | Genome-wide CRISPR Screen to Identify Genes that Suppress Transformation in the Presence of Endogenous KrasG12D |
| Q34079545 | Genome-wide approaches to systematically identify substrates of the ubiquitin-proteasome pathway |
| Q52717015 | Haploid genetic screens identify genetic vulnerabilities to microtubule-targeting agents. |
| Q92876951 | High Frequency of KRAS Codon 146 and FBXW7 Mutations in Thai Patients with Stage II-III Colon Cancer |
| Q90216786 | Hsa_circ_RNA_0011780 Represses the Proliferation and Metastasis of Non-Small Cell Lung Cancer by Decreasing FBXW7 via Targeting miR-544a |
| Q55298059 | Identification and targeting of an FGFR fusion in a pediatric thalamic "central oligodendroglioma". |
| Q34393919 | Identification of molecular pathway aberrations in uterine serous carcinoma by genome-wide analyses. |
| Q43429196 | In the wrong place at the wrong time: does cyclin mislocalization drive oncogenic transformation? |
| Q34613635 | Inactivation of FBXW7/hCDC4-β expression by promoter hypermethylation is associated with favorable prognosis in primary breast cancer |
| Q38860405 | Increased incidence of FBXW7 and POLE proofreading domain mutations in young adult colorectal cancers. |
| Q36334266 | Induction of cell senescence by targeting to Cullin-RING Ligases (CRLs) for effective cancer therapy |
| Q93372382 | Integrated Genomic, Epigenomic, and Expression Analyses of Ovarian Cancer Cell Lines |
| Q28658581 | Investigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines |
| Q92816840 | Involvement of E3 Ligases and Deubiquitinases in the Control of HIF-α Subunit Abundance |
| Q24656740 | Isoform- and cell cycle-dependent substrate degradation by the Fbw7 ubiquitin ligase |
| Q55638343 | Isolation of T cell receptors targeting recurrent neoantigens in hematological malignancies. |
| Q39070009 | KRAS Mutation as a Potential Prognostic Biomarker of Biliary Tract Cancers |
| Q37282490 | Less frequently mutated genes in colorectal cancer: evidences from next-generation sequencing of 653 routine cases |
| Q54980998 | LncRNA MT1JP functions as a ceRNA in regulating FBXW7 through competitively binding to miR-92a-3p in gastric cancer. |
| Q42274998 | Loss of FBXW7 and accumulation of MCL1 and PLK1 promote paclitaxel resistance in breast cancer |
| Q52881675 | Loss of FBXW7 is related to the susceptibility and poor prognosis of cervical squamous carcinoma. |
| Q54976764 | Loss of USP28-mediated BRAF degradation drives resistance to RAF cancer therapies. |
| Q92644997 | Low expression of the ubiquitin ligase FBXW7 correlates with poor prognosis of patients with colorectal cancer |
| Q38625813 | Lysine-52 stabilizes the MYC oncoprotein through an SCF(Fbxw7)-independent mechanism |
| Q33836755 | MYC Deregulation in Primary Human Cancers. |
| Q39406924 | MYC Modulation around the CDK2/p27/SKP2 Axis |
| Q38193043 | MYC degradation |
| Q35550234 | MYC is a critical target of FBXW7 |
| Q34992987 | MYC, FBXW7 and TP53 copy number variation and expression in gastric cancer |
| Q59072385 | Mammalian MYC Proteins and Cancer |
| Q24631164 | Massive genomic rearrangement acquired in a single catastrophic event during cancer development |
| Q37307464 | Mechanisms and function of substrate recruitment by F-box proteins. |
| Q34364753 | Merkel cell polyomavirus small T antigen controls viral replication and oncoprotein expression by targeting the cellular ubiquitin ligase SCFFbw7. |
| Q54089797 | MiR-182 promotes cell proliferation by suppressing FBXW7 and FBXW11 in non-small cell lung cancer. |
| Q37215547 | MiR-182 promotes proliferation and invasion and elevates the HIF-1α-VEGF-A axis in breast cancer cells by targeting FBXW7 |
| Q92158393 | MiR-195-5p Promotes Cardiomyocyte Hypertrophy by Targeting MFN2 and FBXW7 |
| Q42779463 | MiR-27a-3p promotes esophageal cancer cell proliferation via F-box and WD repeat domain-containing 7 (FBXW7) suppression |
| Q38577492 | MicroRNA regulation of F-box proteins and its role in cancer. |
| Q39407479 | MicroRNA-223 functions as an oncogene in human gastric cancer by targeting FBXW7/hCdc4. |
| Q34991208 | MicroRNA-27a distinguishes glioblastoma multiforme from diffuse and anaplastic astrocytomas and has prognostic value |
| Q37607744 | MicroRNA-32 promotes cell proliferation, migration and suppresses apoptosis in breast cancer cells by targeting FBXW7 |
| Q39483070 | Mixed Mesonephric Adenocarcinoma and High-grade Neuroendocrine Carcinoma of the Uterine Cervix: Case Description of a Previously Unreported Entity With Insights Into Its Molecular Pathogenesis |
| Q41037621 | Molecular Characterization of Somatic Alterations in Dukes' B and C Colorectal Cancers by Targeted Sequencing |
| Q82521439 | Molecular Genetics of Colorectal Cancer |
| Q59329900 | Molecular characterization of sessile serrated adenoma/polyps with dysplasia/carcinoma based on immunohistochemistry, next-generation sequencing, and microsatellite instability testing: a case series study |
| Q47603972 | Molecular mechanisms driving cholangiocarcinoma invasiveness: an overview. |
| Q37802059 | Molecular pathogenesis and targeted therapies for NOTCH1-induced T-cell acute lymphoblastic leukemia |
| Q36436413 | Molecular pathways: turning proteasomal protein degradation into a unique treatment approach |
| Q37525272 | Molecular spectrum of KRAS, NRAS, BRAF, PIK3CA, TP53, and APC somatic gene mutations in Arab patients with colorectal cancer: determination of frequency and distribution pattern. |
| Q45848384 | Moving forward with actionable therapeutic targets and opportunities in endometrial cancer: NCI clinical trials planning meeting report on identifying key genes and molecular pathways for targeted endometrial cancer trials |
| Q34482351 | Multiple novel alternative splicing forms of FBXW7α have a translational modulatory function and show specific alteration in human cancer |
| Q36074577 | Negative regulation of the stability and tumor suppressor function of Fbw7 by the Pin1 prolyl isomerase |
| Q92539066 | Neoantigens in Hematological Malignancies-Ultimate Targets for Immunotherapy? |
| Q51032285 | Next-Generation Sequencing. |
| Q98771864 | Non-BRAF Mutant Melanoma: Molecular Features and Therapeutical Implications |
| Q92405733 | Notch Signaling Activation as a Hallmark for Triple-Negative Breast Cancer Subtype |
| Q37867484 | Notch signalling in solid tumours: a little bit of everything but not all the time |
| Q51952187 | Notch-dependent cell cycle arrest and apoptosis in mouse embryonic fibroblasts lacking Fbxw7. |
| Q47807782 | Novel Role of FBXW7 Circular RNA in Repressing Glioma Tumorigenesis |
| Q35034604 | Novel genes associated with colorectal cancer are revealed by high resolution cytogenetic analysis in a patient specific manner |
| Q34742737 | Nucleolar targeting of the fbw7 ubiquitin ligase by a pseudosubstrate and glycogen synthase kinase 3. |
| Q36958575 | Oncogenic NOTCH1 control of MYC and PI3K: challenges and opportunities for anti-NOTCH1 therapy in T-cell acute lymphoblastic leukemias and lymphomas |
| Q46223004 | Opposing functions of Fbxw7 in keratinocyte growth, differentiation and skin tumorigenesis mediated through negative regulation of c-Myc and Notch |
| Q33782728 | PP2A-B55β antagonizes cyclin E1 proteolysis and promotes its dysregulation in cancer. |
| Q62654663 | Pan-cancer transcriptional signatures predictive of oncogenic mutations reveal that Fbw7 regulates cancer cell oxidative metabolism |
| Q36489494 | Pharmacodynamic and genomic markers associated with response to the XPO1/CRM1 inhibitor selinexor (KPT-330): A report from the pediatric preclinical testing program. |
| Q52374099 | Physiological functions of FBW7 in cancer and metabolism. |
| Q37181702 | Pin1-Nanog expression in human glioma is correlated with advanced tumor progression |
| Q38776694 | Poor prognosis in cholangiocarcinoma patients with low FBXW7 expression is improved by chemotherapy |
| Q39199650 | Prognostic significance of Fbw7 in human melanoma and its role in cell migration |
| Q59337413 | Prognostic significance of tumor genotypes and CD8+ infiltrates in stage I-III colorectal cancer |
| Q57809308 | Prognostic values of F-box members in breast cancer: an online database analysis and literature review |
| Q35160414 | Proteomic screen reveals Fbw7 as a modulator of the NF-κB pathway. |
| Q38614200 | RNAi screen reveals synthetic lethality between cyclin G-associated kinase and FBXW7 by inducing aberrant mitoses |
| Q34255775 | RORα suppresses breast tumor invasion by inducing SEMA3F expression |
| Q38828721 | Recent advances in SCF ubiquitin ligase complex: Clinical implications |
| Q53285198 | Reduced expression of ubiquitin ligase FBXW7 mRNA is associated with poor prognosis in breast cancer patients. |
| Q39152605 | Regulation of APC(Cdh1) E3 ligase activity by the Fbw7/cyclin E signaling axis contributes to the tumor suppressor function of Fbw7. |
| Q39980994 | Regulation of BRAF protein stability by a negative feedback loop involving the MEK-ERK pathway but not the FBXW7 tumour suppressor. |
| Q92106577 | Regulation of Cell Cycle Entry and Exit: A Single Cell Perspective |
| Q37707515 | Regulation of stem cell function by protein ubiquitylation |
| Q42918132 | Regulation of the tumour suppressor Fbw7α by PKC-dependent phosphorylation and cancer-associated mutations. |
| Q58420563 | Research Highlights |
| Q34809227 | Retracted: Recombinant Human Adenovirus-p53 Injection Induced Apoptosis in Hepatocellular Carcinoma Cell Lines Mediated by p53-Fbxw7 Pathway, Which Controls c-Myc and Cyclin E |
| Q24632684 | Rictor regulates FBXW7-dependent c-Myc and cyclin E degradation in colorectal cancer cells |
| Q37388126 | Role of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases in skin cancer |
| Q35012352 | Roles of F-box proteins in cancer |
| Q38267996 | SCF ubiquitin ligase-targeted therapies. |
| Q38065012 | SCF-mediated degradation of p100 (NF-κB2): mechanisms and relevance in multiple myeloma |
| Q38102567 | SCFs in the new millennium |
| Q52369784 | SCFβ-TRCP E3 ubiquitin ligase targets the tumor suppressor ZNRF3 for ubiquitination and degradation. |
| Q36421768 | SEL-10/Fbw7-dependent negative feedback regulation of LIN-45/Braf signaling in C. elegans via a conserved phosphodegron |
| Q38834625 | SPOP regulates prostate epithelial cell proliferation and promotes ubiquitination and turnover of c-MYC oncoprotein |
| Q42535880 | Self-renewal versus transformation: Fbxw7 deletion leads to stem cell activation and leukemogenesis |
| Q35692037 | Sequential mutations in Notch1, Fbxw7, and Tp53 in radiation-induced mouse thymic lymphomas |
| Q37753018 | Signaling by NOTCH1 in Cancer |
| Q89594338 | Skp, Cullin, F-box (SCF)-Met30 and SCF-Cdc4-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A for Chromosomal Stability in Budding Yeast |
| Q36802418 | Sleeping Beauty transposon mutagenesis identifies genes that cooperate with mutant Smad4 in gastric cancer development |
| Q36600976 | Small molecule therapeutics targeting F-box proteins in cancer |
| Q99710913 | Stat2 stability regulation: an intersection between immunity and carcinogenesis |
| Q37437735 | Subtype-specific FBXW7 mutation and MYCN copy number gain in Wilms' tumor. |
| Q36009016 | Systematic Functional Interrogation of Rare Cancer Variants Identifies Oncogenic Alleles |
| Q46036182 | TP53, PIK3CA, FBXW7 and KRAS Mutations in Esophageal Cancer Identified by Targeted Sequencing. |
| Q91329830 | TRIP13 promotes the cell proliferation, migration and invasion of glioblastoma through the FBXW7/c-MYC axis |
| Q36739319 | Temporal mTOR inhibition protects Fbxw7-deficient mice from radiation-induced tumor development. |
| Q36811486 | Temsirolimus therapy in a patient with lung adenocarcinoma harboring an FBXW7 mutation |
| Q38178032 | The Complex Relationship between Liver Cancer and the Cell Cycle: A Story of Multiple Regulations. |
| Q48403231 | The F-box protein FBXL18 promotes glioma progression by promoting K63-linked ubiquitination of Akt. |
| Q47757165 | The FOXA2 transcription factor is frequently somatically mutated in uterine carcinosarcomas and carcinomas. |
| Q36029051 | The Fbw7 and betaTRCP E3 ubiquitin ligases and their roles in tumorigenesis |
| Q33897957 | The Fbw7/human CDC4 tumor suppressor targets proproliferative factor KLF5 for ubiquitination and degradation through multiple phosphodegron motifs |
| Q92667854 | The MAP3K13-TRIM25-FBXW7α axis affects c-Myc protein stability and tumor development |
| Q36592394 | The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator |
| Q64236096 | The WD40 domain of FBXW7 is a poly(ADP-ribose)-binding domain that mediates the early DNA damage response |
| Q42396446 | The cyclin E regulator cullin 3 prevents mouse hepatic progenitor cells from becoming tumor-initiating cells |
| Q24307181 | The glomuvenous malformation protein Glomulin binds Rbx1 and regulates cullin RING ligase-mediated turnover of Fbw7 |
| Q41991904 | The hormone-bound vitamin D receptor enhances the FBW7-dependent turnover of NF-κB subunits. |
| Q28072910 | The more the messier: centrosome amplification as a novel biomarker for personalized treatment of colorectal cancers |
| Q41352872 | The phosphorylation-dependent regulation of nuclear SREBP1 during mitosis links lipid metabolism and cell growth. |
| Q38779048 | The pseudophosphatase STYX targets the F-box of FBXW7 and inhibits SCFFBXW7 function. |
| Q38608745 | The role of cullin proteins in gastric cancer |
| Q38962587 | The sensitivity of gastric cancer to trastuzumab is regulated by the miR-223/FBXW7 pathway |
| Q41545354 | The stability of Fbw7α in M-phase requires its phosphorylation by PKC. |
| Q35999467 | The two faces of FBW7 in cancer drug resistance. |
| Q24296476 | The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability |
| Q89837985 | The ubiquitin ligase FBXW7 targets the centriolar assembly protein HsSAS-6 for degradation and thereby regulates centriole duplication |
| Q50525986 | The ubiquitin ligase SCFFBXW7α promotes GATA3 degradation. |
| Q36836053 | The ubiquitous nature of cancer: the role of the SCF(Fbw7) complex in development and transformation |
| Q60926326 | Therapeutic Inhibition of Myc in Cancer. Structural Bases and Computer-Aided Drug Discovery Approaches |
| Q34488856 | Tumor suppression by the Fbw7 ubiquitin ligase: mechanisms and opportunities |
| Q51598778 | Tumor suppressor Fbxw7 antagonizes WNT signaling by targeting β-catenin for degradation in pancreatic cancer. |
| Q36025441 | Tumor suppressor functions of FBW7 in cancer development and progression |
| Q34503492 | Ubiquitin becomes ubiquitous in cancer: emerging roles of ubiquitin ligases and deubiquitinases in tumorigenesis and as therapeutic targets |
| Q46609299 | Ubiquitin ligases in oncogenic transformation and cancer therapy |
| Q38229325 | Ubiquitination involved enzymes and cancer |
| Q39565343 | Upregulation of miR-27a contributes to the malignant transformation of human bronchial epithelial cells induced by SV40 small T antigen |
| Q37291631 | WT1 mutations in T-ALL |
| Q33853093 | Whole exome sequence analysis of serous borderline tumors of the ovary |
| Q37585215 | c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells |
| Q37588068 | miR‑223‑3p regulates cell growth and apoptosis via FBXW7 suggesting an oncogenic role in human testicular germ cell tumors |
| Q51646235 | β-Catenin activation in fundic gland polyps, gastric cancer and colonic polyps in families afflicted by 'gastric adenocarcinoma and proximal polyposis of the stomach' (GAPPS). |
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