| review article | Q7318358 |
| scholarly article | Q13442814 |
| P356 | DOI | 10.1042/CS20160718 |
| P698 | PubMed publication ID | 29203722 |
| P50 | author | Yan Li | Q85967901 |
| P2093 | author name string | Xiaobo Zhou | |
| Michael H Cho | |||
| P2860 | cites work | A gene expression signature of emphysema-related lung destruction and its reversal by the tripeptide GHK | Q21183967 |
| Cutis laxa arising from frameshift mutations in exon 30 of the elastin gene (ELN) | Q22008606 | ||
| Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease | Q22299313 | ||
| FTO Obesity Variant Circuitry and Adipocyte Browning in Humans | Q22305008 | ||
| The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling | Q24308827 | ||
| An elastin gene mutation producing abnormal tropoelastin and abnormal elastic fibres in a patient with autosomal dominant cutis laxa | Q24314373 | ||
| Genome-wide meta-analyses identify multiple loci associated with smoking behavior | Q24597886 | ||
| RNA-guided human genome engineering via Cas9 | Q24598394 | ||
| Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly. | Q24608988 | ||
| Multiplex genome engineering using CRISPR/Cas systems | Q24609428 | ||
| Five years of GWAS discovery | Q24610574 | ||
| Genome-wide association study identifies five loci associated with lung function | Q24629653 | ||
| Wnt/beta-catenin signaling: components, mechanisms, and diseases | Q24630938 | ||
| From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus | Q24633183 | ||
| Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function | Q24633262 | ||
| Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers | Q36742577 | ||
| Pulmonary arterial enlargement and acute exacerbations of COPD | Q36950168 | ||
| Exome Sequencing Analysis in Severe, Early-Onset Chronic Obstructive Pulmonary Disease | Q37013121 | ||
| Hedgehog signaling in neonatal and adult lung. | Q37056427 | ||
| β-catenin in the alveolar epithelium protects from lung fibrosis after intratracheal bleomycin | Q37070081 | ||
| Wnt signaling in lung organogenesis | Q37080180 | ||
| Temporal and Spatial Expression of Transforming Growth Factor-β after Airway Remodeling to Tobacco Smoke in Rats | Q37088311 | ||
| Exome Array Analysis Identifies a Common Variant in IL27 Associated with Chronic Obstructive Pulmonary Disease | Q37125510 | ||
| Genes associated with polymorphic variants predicting lung function are differentially expressed during human lung development. | Q37138826 | ||
| Notch-dependent differentiation of adult airway basal stem cells | Q37186787 | ||
| Analysis of exonic elastin variants in severe, early-onset chronic obstructive pulmonary disease | Q37211184 | ||
| Aging and induced senescence as factors in the pathogenesis of lung emphysema | Q37212594 | ||
| A Chronic Obstructive Pulmonary Disease Susceptibility Gene, FAM13A, Regulates Protein Stability of β-Catenin | Q37213583 | ||
| Association between Functional Small Airway Disease and FEV1 Decline in Chronic Obstructive Pulmonary Disease | Q37213599 | ||
| A functional mutation in the terminal exon of elastin in severe, early-onset chronic obstructive pulmonary disease | Q37273940 | ||
| Patterns of Growth and Decline in Lung Function in Persistent Childhood Asthma | Q37274181 | ||
| Increasing Generality and Power of Rare-Variant Tests by Utilizing Extended Pedigrees | Q37342111 | ||
| Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene | Q37373901 | ||
| Conditional stabilization of beta-catenin expands the pool of lung stem cells | Q37412788 | ||
| Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema | Q44360463 | ||
| Endogenous lung regeneration: potential and limitations | Q46210244 | ||
| Genetic Control of Fatty Acid β-Oxidation in Chronic Obstructive Pulmonary Disease | Q46417648 | ||
| Serum leptin and skeletal differences between obese and non-obese patients with chronic obstructive pulmonary disease | Q47163438 | ||
| Differentiation of Human Pluripotent Stem Cells into Functional Lung Alveolar Epithelial Cells. | Q47719385 | ||
| Inhibition of Wnt/β-catenin signaling promotes engraftment of mesenchymal stem cells to repair lung injury | Q47946445 | ||
| Reduced Frizzled Receptor 4 Expression Prevents WNT/β-Catenin-driven Alveolar Lung Repair in Chronic Obstructive Pulmonary Disease. | Q47963089 | ||
| Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report. GOLD Executive Summary | Q47984024 | ||
| Lung-Function Trajectories Leading to Chronic Obstructive Pulmonary Disease. | Q50440978 | ||
| Respiratory disorders: Ironing out smoking-related airway disease. | Q51541110 | ||
| Impaired distal airway development in mice lacking elastin. | Q52165576 | ||
| Mapping of a major genetic modifier of embryonic lethality in TGF beta 1 knockout mice. | Q52196601 | ||
| Genetic epidemiology of severe, early-onset chronic obstructive pulmonary disease. Risk to relatives for airflow obstruction and chronic bronchitis. | Q52241091 | ||
| Large, Diverse Population Cohorts of hiPSCs and Derived Hepatocyte-like Cells Reveal Functional Genetic Variation at Blood Lipid-Associated Loci. | Q52427399 | ||
| WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis | Q24650922 | ||
| Increased metalloproteinase activity, oxidant production, and emphysema in surfactant protein D gene-inactivated mice | Q24681813 | ||
| Trends in Next-Generation Sequencing and a New Era for Whole Genome Sequencing | Q28066705 | ||
| Capture Hi-C identifies a novel causal gene, IL20RA, in the pan-autoimmune genetic susceptibility region 6q23 | Q28109583 | ||
| Mechanisms and functions of Hedgehog signalling across the metazoa | Q28235875 | ||
| Obesity-associated variants within FTO form long-range functional connections with IRX3 | Q28236283 | ||
| Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes | Q28272915 | ||
| Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke-induced pulmonary injury and emphysema | Q28397712 | ||
| Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis | Q28505771 | ||
| Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung | Q28508085 | ||
| Improved imputation of low-frequency and rare variants using the UK10K haplotype reference panel | Q28607364 | ||
| BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis | Q28607483 | ||
| A gene-based association method for mapping traits using reference transcriptome data | Q28608356 | ||
| Bayesian test for colocalisation between pairs of genetic association studies using summary statistics | Q28660129 | ||
| Genetics of sputum gene expression in chronic obstructive pulmonary disease | Q28740314 | ||
| Loss-of-function mutations in the RNA biogenesis factor NAF1 predispose to pulmonary fibrosis-emphysema | Q28771473 | ||
| Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis | Q29416987 | ||
| Wnt signalling in stem cells and cancer | Q29547862 | ||
| Systematic localization of common disease-associated variation in regulatory DNA | Q29614895 | ||
| Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary | Q29614970 | ||
| Exome sequencing as a tool for Mendelian disease gene discovery | Q29615382 | ||
| Telomerase mutations in families with idiopathic pulmonary fibrosis | Q29615671 | ||
| The nature of small-airway obstruction in chronic obstructive pulmonary disease | Q29618682 | ||
| Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis | Q30274832 | ||
| Alveolar epithelial cell chemokine expression triggered by antigen-specific cytolytic CD8(+) T cell recognition | Q30306117 | ||
| Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction | Q30420166 | ||
| Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. | Q30427183 | ||
| Signaling network of lipids as a comprehensive scaffold for omics data integration in sputum of COPD patients | Q30983000 | ||
| Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary disease | Q33373335 | ||
| A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. | Q33419815 | ||
| A genome-wide association study of pulmonary function measures in the Framingham Heart Study | Q33419839 | ||
| Whole exome re-sequencing implicates CCDC38 and cilia structure and function in resistance to smoking related airflow obstruction. | Q33553057 | ||
| Variants in FAM13A are associated with chronic obstructive pulmonary disease | Q33687879 | ||
| Obesity, adipokines, and lung disease | Q33728020 | ||
| Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function | Q33830476 | ||
| Receptor for advanced glycation endproducts (RAGE) maintains pulmonary structure and regulates the response to cigarette smoke | Q33873927 | ||
| The Ser82 RAGE Variant Affects Lung Function and Serum RAGE in Smokers and sRAGE Production In Vitro | Q36166108 | ||
| Oxidative stress in pathogenesis of chronic obstructive pulmonary disease: cellular and molecular mechanisms | Q36207186 | ||
| Single-cell barcoding and sequencing using droplet microfluidics | Q36215738 | ||
| Functional interrogation of non-coding DNA through CRISPR genome editing | Q36306820 | ||
| Lung function associated gene Integrator Complex subunit 12 regulates protein synthesis pathways | Q36320879 | ||
| The emerging importance of autophagy in pulmonary diseases | Q36388052 | ||
| Single-cell chromatin accessibility reveals principles of regulatory variation | Q36389877 | ||
| Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation | Q36392496 | ||
| Role of apoptosis in the pathogenesis of COPD and pulmonary emphysema | Q36434963 | ||
| Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice | Q36547252 | ||
| Congenital cutis laxa with a dominant inheritance and early onset emphysema | Q36573905 | ||
| Dissecting direct and indirect genetic effects on chronic obstructive pulmonary disease (COPD) susceptibility. | Q36691602 | ||
| Genetic control of gene expression at novel and established chronic obstructive pulmonary disease loci | Q36724956 | ||
| Mutations in LTBP4 cause a syndrome of impaired pulmonary, gastrointestinal, genitourinary, musculoskeletal, and dermal development | Q37417872 | ||
| Hedgehog signalling: emerging evidence for non-canonical pathways | Q37462651 | ||
| Single-cell RNA sequencing identifies diverse roles of epithelial cells in idiopathic pulmonary fibrosis. | Q37469191 | ||
| Colocalization of GWAS and eQTL Signals Detects Target Genes | Q37480692 | ||
| Lung development: orchestrating the generation and regeneration of a complex organ | Q37507601 | ||
| Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps | Q37613798 | ||
| A common 16p11.2 inversion underlies the joint susceptibility to asthma and obesity | Q37634115 | ||
| Molecular determinants of lung development | Q37639254 | ||
| NOTCH1 is required for regeneration of Clara cells during repair of airway injury | Q37734267 | ||
| Autophagy in cigarette smoke-induced chronic obstructive pulmonary disease | Q37798027 | ||
| RAGE in tissue homeostasis, repair and regeneration. | Q38055993 | ||
| Leptin modulates innate and adaptive immune cell recruitment after cigarette smoke exposure in mice | Q38343887 | ||
| Hedgehog-interacting protein is a COPD susceptibility gene: the Rotterdam Study | Q38377093 | ||
| Oxidative damage and TGF-β differentially induce lung epithelial cell sonic hedgehog and tenascin-C expression: implications for the regulation of lung remodelling in idiopathic interstitial lung disease | Q38413953 | ||
| A Genetic Variant Associated with Five Vascular Diseases Is a Distal Regulator of Endothelin-1 Gene Expression. | Q38655393 | ||
| 10 Years of GWAS Discovery: Biology, Function, and Translation | Q38689236 | ||
| Fine-mapping inflammatory bowel disease loci to single-variant resolution | Q38704623 | ||
| Toll-like receptor 4 deficiency causes pulmonary emphysema. | Q38743977 | ||
| Genetic variants affecting cross-sectional lung function in adults show little or no effect on longitudinal lung function decline | Q38760182 | ||
| Genome Editing of Lineage Determinants in Human Pluripotent Stem Cells Reveals Mechanisms of Pancreatic Development and Diabetes | Q38773986 | ||
| Patient-Specific iPSC-Derived Endothelial Cells Uncover Pathways that Protect against Pulmonary Hypertension in BMPR2 Mutation Carriers | Q38778206 | ||
| Blockade of RAGE ameliorates elastase-induced emphysema development and progression via RAGE-DAMP signaling | Q38985841 | ||
| An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level. | Q39081873 | ||
| TGF-β₂ decreases baseline and IL-13-stimulated mucin production by primary human bronchial epithelial cells. | Q39224518 | ||
| Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets | Q39568339 | ||
| Blockade of the Wnt/β-catenin pathway attenuates bleomycin-induced pulmonary fibrosis | Q39611228 | ||
| Integrative functional genomics identifies an enhancer looping to the SOX9 gene disrupted by the 17q24.3 prostate cancer risk locus | Q39627440 | ||
| Activation of the WNT/β-catenin pathway attenuates experimental emphysema | Q39831271 | ||
| Resident cellular components of the human lung: current knowledge and goals for research on cell phenotyping and function. | Q40053427 | ||
| Discovery of stimulation-responsive immune enhancers with CRISPR activation. | Q40065009 | ||
| Open Chromatin Profiling in hiPSC-Derived Neurons Prioritizes Functional Noncoding Psychiatric Risk Variants and Highlights Neurodevelopmental Loci | Q40084576 | ||
| Local lung hypoxia determines epithelial fate decisions during alveolar regeneration. | Q40122514 | ||
| Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease | Q40253101 | ||
| Risk factors in chronic obstructive pulmonary disease (COPD) | Q40644528 | ||
| Familial prevalence of chronic obstructive pulmonary disease in a matched pair study | Q40656485 | ||
| Emergence of a stage-dependent human liver disease signature with directed differentiation of alpha-1 antitrypsin-deficient iPS cells | Q40843065 | ||
| Association of plasma adipokines with chronic obstructive pulmonary disease severity and progression | Q40902162 | ||
| Ferroptosis is an autophagic cell death process | Q41162188 | ||
| A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration. | Q42143150 | ||
| Analyzing CRISPR genome-editing experiments with CRISPResso | Q42551389 | ||
| Cigarette smoke disrupts the integrity of airway adherens junctions through the aberrant interaction of p120-catenin with the cytoplasmic tail of MUC1. | Q42734887 | ||
| Epithelial repair mechanisms in the lung | Q33916933 | ||
| Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD | Q34117623 | ||
| Advanced glycation end products and its receptor (RAGE) are increased in patients with COPD. | Q34152095 | ||
| Massively parallel functional dissection of mammalian enhancers in vivo | Q34174436 | ||
| Integrative genomics of chronic obstructive pulmonary disease. | Q34232677 | ||
| Identification of a chronic obstructive pulmonary disease genetic determinant that regulates HHIP. | Q34238083 | ||
| Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema | Q34279364 | ||
| The electrophoretic α1-globulin pattern of serum in α1-antitrypsin deficiency. 1963. | Q34335215 | ||
| The association of plasma biomarkers with computed tomography-assessed emphysema phenotypes | Q34346490 | ||
| Haploinsufficiency of Hedgehog interacting protein causes increased emphysema induced by cigarette smoke through network rewiring | Q34466780 | ||
| Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases | Q34478075 | ||
| Hhip haploinsufficiency sensitizes mice to age-related emphysema | Q34534888 | ||
| Refining susceptibility loci of chronic obstructive pulmonary disease with lung eqtls | Q34922245 | ||
| Polymorphisms in surfactant protein-D are associated with chronic obstructive pulmonary disease. | Q34985449 | ||
| Clinical practice. Alpha1-antitrypsin deficiency | Q34988812 | ||
| Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury | Q35032592 | ||
| Telomerase mutations in smokers with severe emphysema. | Q35056698 | ||
| Blue journal conference. Aging and susceptibility to lung disease | Q35153456 | ||
| The receptor for advanced glycation end products (RAGE) contributes to the progression of emphysema in mice | Q35190905 | ||
| Exome sequencing links mutations in PARN and RTEL1 with familial pulmonary fibrosis and telomere shortening | Q35554660 | ||
| Chronic obstructive pulmonary disease: molecular and cellularmechanisms | Q35569962 | ||
| Obesity and extent of emphysema depicted at CT. | Q35648257 | ||
| The support of human genetic evidence for approved drug indications | Q35677036 | ||
| Evaluating the Performance of Fine-Mapping Strategies at Common Variant GWAS Loci | Q35787851 | ||
| A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. | Q35816887 | ||
| SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice | Q36005375 | ||
| Systematic Functional Dissection of Common Genetic Variation Affecting Red Blood Cell Traits | Q36040307 | ||
| Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function | Q36099476 | ||
| Leptin, adiponectin and pulmonary diseases | Q36101219 | ||
| Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD. | Q36105702 | ||
| Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank | Q36123192 | ||
| Pathogenesis of chronic obstructive pulmonary disease | Q36129048 | ||
| CRISPR-Cas9-mediated gene knockout in primary human airway epithelial cells reveals a proinflammatory role for MUC18. | Q36143201 | ||
| P433 | issue | 24 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 2847-2863 | |
| P577 | publication date | 2017-12-04 | |
| P1433 | published in | Clinical Science | Q372419 |
| P1476 | title | What do polymorphisms tell us about the mechanisms of COPD? | |
| P478 | volume | 131 |
| Q92253691 | Airway epithelial cell differentiation relies on deficient Hedgehog signalling in COPD |
| Q90332541 | Effects of Chronic Nicotine Inhalation on Systemic and Pulmonary Blood Pressure and Right Ventricular Remodeling in Mice |
| Q64250312 | FKBP5 rs4713916: A Potential Genetic Predictor of Interindividual Different Response to Inhaled Corticosteroids in Patients with Chronic Obstructive Pulmonary Disease in a Real-Life Setting |
Search more.