Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells

scientific article published in April 2005

Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/NM0405-367
P698PubMed publication ID15812508
P5875ResearchGate publication ID7922935

P50authorMassimiliano GnecchiQ43088906
Fulvio MorelloQ56951654
P2093author name stringLunan Zhang
Victor J Dzau
Richard E Pratt
Huamei He
Olin D Liang
Joanne S Ingwall
Luis G Melo
Nicolas Noiseux
Hui Mu
P2860cites workRegeneration of ischemic cardiac muscle and vascular endothelium by adult stem cellsQ24672061
Bone marrow cells regenerate infarcted myocardiumQ28210640
Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiationQ33202256
Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heartQ64379356
31P nuclear magnetic resonance spectroscopic imaging of regions of remodeled myocardium in the infarcted rat heartQ70787324
Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted heartsQ73791469
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectmesenchymal stem cellQ1922379
P304page(s)367-368
P577publication date2005-04-01
P1433published inNature MedicineQ1633234
P1476titleParacrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells
P478volume11

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Q51775681Human umbilical cord blood mononuclear cells decrease fibrosis and increase cardiac function in cardiomyopathy.
Q36659304Hyaluronan enhances bone marrow cell therapy for myocardial repair after infarction
Q42242902Hypoxia Pre-Conditioned Embryonic Mesenchymal Stem Cell Secretome Reduces IL-10 Production by Peripheral Blood Mononuclear Cells
Q42773071Hypoxia-pretreated human MSCs attenuate acute kidney injury through enhanced angiogenic and antioxidative capacities
Q60048546Hypoxic Preconditioned Mesenchymal Stromal Cell Therapy in a Rat Model of Renal Ischemia-reperfusion Injury: Development of Optimal Protocol to Potentiate Therapeutic Efficacy
Q30539770Hypoxic conditioning enhances the angiogenic paracrine activity of human adipose-derived stem cells.
Q24603371Hypoxic preconditioning results in increased motility and improved therapeutic potential of human mesenchymal stem cells
Q33972581IL-15: a novel prosurvival signaling pathway in cardiomyocytes.
Q52731378Imaging cellular pharmacokinetics of 18F-FDG and 6-NBDG uptake by inflammatory and stem cells.
Q30494736Imaging survival and function of transplanted cardiac resident stem cells
Q36703067Immune regulation by mesenchymal stem cells: two sides to the coin
Q37606564Immune regulatory cells in umbilical cord blood: T regulatory cells and mesenchymal stromal cells
Q27004487Immunobiology of mesenchymal stem cells
Q36174278Immunomodulation of activated hepatic stellate cells by mesenchymal stem cells
Q94503661Immunomodulatory Effect of Adipose-Derived Stem Cells: The Cutting Edge of Clinical Application
Q51714776Impact of different bone marrow cell preparations on left ventricular remodelling after experimental myocardial infarction.
Q42284739Impact of mesenchymal stem cells' secretome on glioblastoma pathophysiology
Q46685771Improved anti-apoptotic and anti-remodeling potency of bone marrow mesenchymal stem cells by anoxic pre-conditioning in diabetic cardiomyopathy
Q54423753Improved function and myocardial repair of infarcted heart by intracoronary injection of mesenchymal stem cell-derived growth factors.
Q34753654Improved survival of mesenchymal stromal cell after hypoxia preconditioning: Role of oxidative stress
Q91737517Improved therapeutic potential of MSCs by genetic modification
Q35163294Improvement of cardiac function by placenta-derived mesenchymal stem cells does not require permanent engraftment and is independent of the insulin signaling pathway
Q35687572Improving the Post-Stroke Therapeutic Potency of Mesenchymal Multipotent Stromal Cells by Cocultivation With Cortical Neurons: The Role of Crosstalk Between Cells
Q35855818In vitro and in vivo effects of bone marrow stem cells on cardiac structure and function.
Q91878243In vivo priming of human mesenchymal stem cells with hepatocyte growth factor-engineered mesenchymal stem cells promotes therapeutic potential for cardiac repair
Q38726132Individual evaluation of cardiac marker expression and self-beating during cardiac differentiation of P19CL6 cells on different culture substrates.
Q48752307Individualized stem cell therapy
Q39548257Induced pluripotent stem (iPS) cells repair and regenerate infarcted myocardium
Q90053560Induced pluripotent stem cell-derived tenocyte-like cells promote the regeneration of injured tendons in mice
Q34454918Induced pluripotent stem cells without c-Myc ameliorate retinal oxidative damage via paracrine effects and reduced oxidative stress in rats
Q49617810Injectable co-gels of collagen and decellularized vascular matrix improve MSC-based therapy for acute kidney injury
Q50937837Injection of basic fibroblast growth factor together with adipose-derived stem cell transplantation: improved cardiac remodeling and function in myocardial infarction.
Q33433387Injection of bone marrow cell extract into infarcted hearts results in functional improvement comparable to intact cell therapy
Q27338187Intra-myocardial injection of both growth factors and heart derived Sca-1+/CD31- cells attenuates post-MI LV remodeling more than does cell transplantation alone: neither intervention enhances functionally significant cardiomyocyte regeneration
Q37766197Intramyocardial navigation and mapping for stem cell delivery.
Q90727813Intraportally delivered stem cell spheroids localize in the liver and protect hepatocytes against GalN/LPS-induced fulminant hepatic toxicity
Q42659946Is biological repair of heart on the horizon?
Q27322292Ischemic preconditioning potentiates the protective effect of stem cells through secretion of exosomes by targeting Mecp2 via miR-22
Q51313309Isolation and Characterization of Exosome from Human Embryonic Stem Cell-Derived C-Myc-Immortalized Mesenchymal Stem Cells.
Q58226894Isolation and Characterization of Extracellular Vesicles in Stem Cell-Related Studies
Q50053575Isolation and characterization of mesenchymal stem cells from human fetus heart
Q36691627Isolation and expansion of resident cardiac progenitor cells.
Q27010386Kallikrein-kinin in stem cell therapy
Q46754972Lactate modulates gene expression in human mesenchymal stem cells
Q51468945Laminin α2-secreting fibroblasts enhance the therapeutic effect of skeletal myoblast sheets.
Q33611657Learning from Mother Nature: Innovative Tools to Boost Endogenous Repair of Critical or Difficult-to-Heal Large Tissue Defects
Q36111569Lipopolysaccharide treatment induces genome-wide pre-mRNA splicing pattern changes in mouse bone marrow stromal stem cells
Q91939151Lipopolysaccharides Improve Mesenchymal Stem Cell-Mediated Cardioprotection by MyD88 and stat3 Signaling in a Mouse Model of Cardiac Ischemia/Reperfusion Injury
Q36108438Liver epithelial cells proliferate under hypoxia and protect the liver from ischemic injury via expression of HIF-1 alpha target genes
Q37355668Local activation or implantation of cardiac progenitor cells rescues scarred infarcted myocardium improving cardiac function
Q30573375Local injection of autologous bone marrow cells to regenerate muscle in patients with traumatic brachial plexus injury: a pilot study.
Q37562012Locally delivered growth factor enhances the angiogenic efficacy of adipose-derived stromal cells transplanted to ischemic limbs
Q42039222Long Term Study of Protective Mechanisms of Human Adipose Derived Mesenchymal Stem Cells on Cisplatin Induced Kidney injury in Sprague-Dawley Rats
Q37175477Long-term functional improvement and gene expression changes after bone marrow-derived multipotent progenitor cell transplantation in myocardial infarction
Q37471408Long-term superior performance of a stem cell/hepatocyte device for the treatment of acute liver failure
Q37421053MEK, p38, and PI-3K mediate cross talk between EGFR and TNFR in enhancing hepatocyte growth factor production from human mesenchymal stem cells.
Q34370097MSC microvesicles for the treatment of lung disease: a new paradigm for cell-free therapy
Q34962330MSCs transplantation with application of G-CSF reduces apoptosis or increases VEGF in rabbit model of myocardial infarction
Q51201458Magnetic targeting of human mesenchymal stem cells with internalized superparamagnetic iron oxide nanoparticles.
Q35030040Malignant tumor formation after transplantation of short-term cultured bone marrow mesenchymal stem cells in experimental myocardial infarction and diabetic neuropathy.
Q53576712Mechanisms of action of mesenchymal stem cells in cardiac repair: potential influences on the cardiac stem cell niche.
Q42918845Mechanisms of cell therapy for clinical investigations: an urgent need for large-animal models
Q28079649Mechanisms of mesenchymal stem/stromal cell function
Q40274980Melatonin facilitates adipose-derived mesenchymal stem cells to repair the murine infarcted heart via the SIRT1 signaling pathway
Q88952347Mesenchymal Stem Cell Paracrine Factors in Vascular Repair and Regeneration
Q39223572Mesenchymal Stem Cell Therapy for the Treatment of Heart Failure Caused by Ischemic or Non-ischemic Cardiomyopathy: Immunosuppression and Its Implications
Q57823788Mesenchymal Stem Cell-Mediated Autophagy Inhibition
Q34763616Mesenchymal Stem Cells Ameliorate Atherosclerotic Lesions via Restoring Endothelial Function
Q36074040Mesenchymal Stem Cells Improve Heart Rate Variability and Baroreflex Sensitivity in Rats with Chronic Heart Failure
Q42945928Mesenchymal Stem Cells and Cardiomyocytes Interplay to Prevent Myocardial Hypertrophy
Q47146529Mesenchymal Stem Cells in Cardiology
Q39419410Mesenchymal Stem/Stromal Cell-Derived Extracellular Vesicles and Their Potential as Novel Immunomodulatory Therapeutic Agents
Q60046871Mesenchymal Stromal Cell Secretome: Influencing Therapeutic Potential by Cellular Pre-conditioning
Q91899785Mesenchymal Stromal Cell-Based Bone Regeneration Therapies: From Cell Transplantation and Tissue Engineering to Therapeutic Secretomes and Extracellular Vesicles
Q39781977Mesenchymal Stromal Cell-Derived Extracellular Vesicles Protect the Fetal Brain After Hypoxia-Ischemia
Q91695791Mesenchymal Stromal Cells Anno 2019: Dawn of the Therapeutic Era? Concise Review
Q57110619Mesenchymal Stromal Cells Based Therapy in Systemic Sclerosis: Rational and Challenges
Q57805266Mesenchymal stem cell adhesion to cardiac microvascular endothelium: activators and mechanisms
Q37900300Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease
Q39297520Mesenchymal stem cell secreted platelet derived growth factor exerts a pro-migratory effect on resident Cardiac Atrial appendage Stem Cells
Q24651962Mesenchymal stem cell secretes microparticles enriched in pre-microRNAs
Q38004307Mesenchymal stem cell therapy for heart disease.
Q35889077Mesenchymal stem cell-based therapy: a new paradigm in regenerative medicine
Q43070723Mesenchymal stem cell-derived IL-10 and recovery from infarction: a third pitch for the chord
Q38670442Mesenchymal stem cell-derived exosomes as a new therapeutic strategy for liver diseases
Q90116025Mesenchymal stem cell-derived exosomes do not promote the proliferation of cancer cells in vitro
Q59336133Mesenchymal stem cell-derived extracellular vesicles affect disease outcomes via transfer of microRNAs
Q44124588Mesenchymal stem cell-derived molecules directly modulate hepatocellular death and regeneration in vitro and in vivo
Q33300346Mesenchymal stem cell-derived molecules reverse fulminant hepatic failure
Q33765470Mesenchymal stem cell: present challenges and prospective cellular cardiomyoplasty approaches for myocardial regeneration
Q58136326Mesenchymal stem cells
Q26753086Mesenchymal stem cells (MSCs) as skeletal therapeutics - an update
Q61448396Mesenchymal stem cells alleviate the early brain injury of subarachnoid hemorrhage partly by suppression of Notch1-dependent neuroinflammation: involvement of Botch
Q35862434Mesenchymal stem cells and cardiac repair.
Q37982370Mesenchymal stem cells and cardiovascular disease: a bench to bedside roadmap
Q38816740Mesenchymal stem cells and vascular regeneration.
Q34349428Mesenchymal stem cells as therapeutics and vehicles for gene and drug delivery
Q44774171Mesenchymal stem cells attenuate cardiac fibroblast proliferation and collagen synthesis through paracrine actions
Q28566510Mesenchymal stem cells attenuate peritoneal injury through secretion of TSG-6
Q36901349Mesenchymal stem cells for the treatment of heart failure.
Q38214090Mesenchymal stem cells for treatment of myocardial infarction.
Q90412540Mesenchymal stem cells from different sources and their derived exosomes: A pre-clinical perspective
Q35009828Mesenchymal stem cells improve wound healing in vivo via early activation of matrix metalloproteinase-9 and vascular endothelial growth factor
Q37169180Mesenchymal stem cells in cancer
Q37142817Mesenchymal stem cells in tissue repair
Q44592644Mesenchymal stem cells overexpressing Akt dramatically repair infarcted myocardium and improve cardiac function despite infrequent cellular fusion or differentiation
Q39298884Mesenchymal stem cells overexpressing GCP-2 improve heart function through enhanced angiogenic properties in a myocardial infarction model
Q37376894Mesenchymal stem cells protect podocytes from apoptosis induced by high glucose via secretion of epithelial growth factor
Q34053510Mesenchymal stem cells restore frataxin expression and increase hydrogen peroxide scavenging enzymes in Friedreich ataxia fibroblasts
Q26799013Mesenchymal stem cells secretome as a modulator of the neurogenic niche: basic insights and therapeutic opportunities
Q90175439Mesenchymal stem cells secretome: current trends and future challenges
Q85022401Mesenchymal stem cells stimulate protective genetic reprogramming of injured cardiac ventricular myocytes
Q98291527Mesenchymal stem cells to treat liver diseases
Q34157101Mesenchymal stem cells, not conditioned medium, contribute to kidney repair after ischemia-reperfusion injury
Q37762880Mesenchymal stem cells: Mechanisms of immunomodulation and homing
Q37724579Mesenchymal stem cells: a new strategy for immunosuppression and tissue repair
Q26865070Mesenchymal stem cells: biology, pathophysiology, translational findings, and therapeutic implications for cardiac disease
Q47694971Mesenchymal stromal cell phenotype is not influenced by confluence during culture expansion
Q38014753Mesenchymal stromal cells (MSCs): science and f(r)iction
Q48684091Mesenchymal stromal cells rescue cortical neurons from apoptotic cell death in an in vitro model of cerebral ischemia
Q38499617Mesenchymal stromal cells to halt the progression of type 1 diabetes?
Q92514773Methods for loading therapeutics into extracellular vesicles and generating extracellular vesicles mimetic-nanovesicles
Q41984743MiR-155 inhibits cell migration of human cardiomyocyte progenitor cells (hCMPCs) via targeting of MMP-16.
Q28116144MicroRNA-155 prevents necrotic cell death in human cardiomyocyte progenitor cells via targeting RIP1
Q35003611Microencapsulated stem cells for tissue repairing: implications in cell-based myocardial therapy
Q35754348Microfluidic Single-Cell Analysis of Transplanted Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes After Acute Myocardial Infarction
Q38184460Microvesicles and exosomes for intracardiac communication
Q37686479Microvesicles as mediators of tissue regeneration
Q92523675Mircrining the injured heart with stem cell-derived exosomes: an emerging strategy of cell-free therapy
Q99726354Mitochondrial donation in translational medicine; from imagination to reality
Q30476644Mitochondrial transfer between cells can rescue aerobic respiration
Q30836161Mitochondrial transfer of mesenchymal stem cells effectively protects corneal epithelial cells from mitochondrial damage
Q52605943Modularized Extracellular Vesicles: The Dawn of Prospective Personalized and Precision Medicine.
Q42462379Modulation of hepatic mitochondrial energy efficiency with age.
Q36480080Molecular aspects of ischemic heart disease: ischemia/reperfusion-induced genetic changes and potential applications of gene and RNA interference therapy
Q37808269Molecular physiology of cardiac regeneration
Q35176487Mononuclear cell secretome protects from experimental autoimmune myocarditis
Q37678413More insight into mesenchymal stem cells and their effects inside the body
Q33722504Multimodal Delivery of Isogenic Mesenchymal Stem Cells Yields Synergistic Protection from Retinal Degeneration and Vision Loss
Q51069965Multiple paracrine factors secreted by mesenchymal stem cells contribute to angiogenesis.
Q42853310Multipotent human stromal cells improve cardiac function after myocardial infarction in mice without long-term engraftment
Q42407370Multipotent stem cells in cardiac regenerative therapy
Q35843862Murine bone marrow stromal progenitor cells elicit an in vivo cellular and humoral alloimmune response
Q36659319Muscle-derived stem cell sheets support pump function and prevent cardiac arrhythmias in a model of chronic myocardial infarction.
Q37352442Muscular dystrophy therapy by nonautologous mesenchymal stem cells: muscle regeneration without immunosuppression and inflammation
Q24314350Myeloid-derived growth factor (C19orf10) mediates cardiac repair following myocardial infarction
Q36908289Myocardial AKT: the omnipresent nexus
Q42015303Myocardial injection with GSK-3β-overexpressing bone marrow-derived mesenchymal stem cells attenuates cardiac dysfunction after myocardial infarction.
Q36247746Myocardial regenerative properties of macrophage populations and stem cells.
Q33635730Myocardial survival signaling in response to stem cell transplantation
Q33746524Myocardial transfection of hypoxia-inducible factor-1α and co-transplantation of mesenchymal stem cells enhance cardiac repair in rats with experimental myocardial infarction
Q35665230N-cadherin determines individual variations in the therapeutic efficacy of human umbilical cord blood-derived mesenchymal stem cells in a rat model of myocardial infarction
Q38235920Nanoparticles and stem cells - has targeted therapy for aneurysms finally arrived?
Q46984458Nanotubular crosstalk with distressed cardiomyocytes stimulates the paracrine repair function of mesenchymal stem cells.
Q96136503Nanovesicles derived from iron oxide nanoparticles-incorporated mesenchymal stem cells for cardiac repair
Q96127279Native and bioengineered extracellular vesicles for cardiovascular therapeutics
Q38155429Natural history of mesenchymal stem cells, from vessel walls to culture vessels.
Q34245510Netrin-1 ameliorates myocardial infarction-induced myocardial injury: mechanisms of action in rats and diabetic mice
Q30361288New Delivery Systems of Stem Cells for Vascular Regeneration in Ischemia
Q38129057Non-invasive in-vivo imaging of stem cells after transplantation in cardiovascular tissue
Q37907966Noninvasive stem cell tracking
Q47713030Notch activation enhances lineage commitment and protective signaling in cardiac progenitor cells.
Q91715702Novel Evidence of the Increase in Angiogenic Factor Plasma Levels after Lineage-Negative Stem/Progenitor Cell Intracoronary Infusion in Patients with Acute Myocardial Infarction
Q37792416Novel Therapies in Childhood Heart Failure: Today and Tomorrow
Q21999280Novel mechanism for mesenchymal stem cells in attenuating peritoneal adhesion: accumulating in the lung and secreting tumor necrosis factor α-stimulating gene-6
Q50848438Optimization of Mesenchymal Stem Cells to Increase Their Therapeutic Potential.
Q93069246Optimization of Timing and Times for Administration of Atorvastatin-Pretreated Mesenchymal Stem Cells in a Preclinical Model of Acute Myocardial Infarction
Q38005087Optimization of the cardiovascular therapeutic properties of mesenchymal stromal/stem cells-taking the next step.
Q79438588Optimizing adult mesenchymal stem cells for heart repair
Q37786701Optimizing stem cell function for the treatment of ischemic heart disease
Q38982831Optimizing stem cells for cardiac repair: Current status and new frontiers in regenerative cardiology
Q42175191Ox-LDL modifies the behaviour of bone marrow stem cells and impairs their endothelial differentiation via inhibition of Akt phosphorylation
Q27318224Paracrine Factors from Irradiated Peripheral Blood Mononuclear Cells Improve Skin Regeneration and Angiogenesis in a Porcine Burn Model
Q46362410Paracrine Mechanisms of Mesenchymal Stem Cells in Tissue Repair
Q42541819Paracrine effects of TLR4-polarised mesenchymal stromal cells are mediated by extracellular vesicles
Q34700487Paracrine effects of bone marrow soup restore organ function, regeneration, and repair in salivary glands damaged by irradiation
Q39068025Paracrine factors of human mesenchymal stem cells increase wound closure and reduce reactive oxygen species production in a traumatic brain injury in vitro model
Q29620571Paracrine mechanisms in adult stem cell signaling and therapy
Q38107063Paracrine mechanisms of mesenchymal stem cell-based therapy: current status and perspectives.
Q34494230Paracrine mechanisms of stem cell reparative and regenerative actions in the heart
Q36547431Paracrine release from nonviral engineered adipose-derived stem cells promotes endothelial cell survival and migration in vitro
Q38136924Patching the heart: cardiac repair from within and outside
Q28071643Peripheral blood mononuclear cell secretome for tissue repair
Q37467729Perspectives on Trypanosoma cruzi-induced heart disease (Chagas disease).
Q35242096Phenotypic and functional characterization of human bone marrow stromal cells in hollow-fibre bioreactors
Q58093950Pilot Production of Mesenchymal Stem/Stromal Freeze-Dried Secretome for Cell-Free Regenerative Nanomedicine: A Validated GMP-Compliant Process
Q37404197Platelet rich plasma clot releasate preconditioning induced PI3K/AKT/NFκB signaling enhances survival and regenerative function of rat bone marrow mesenchymal stem cells in hostile microenvironments
Q51003781Platelet-derived growth factor-BB enhances MSC-mediated cardioprotection via suppression of miR-320 expression.
Q36855438Pluripotent stem cells for cardiac regeneration: overview of recent advances & emerging trends
Q34791203Points to Consider in Designing Mesenchymal Stem Cell-Based Clinical Trials
Q33994997Postinfarct intramyocardial injection of mesenchymal stem cells pretreated with TGF-alpha improves acute myocardial function.
Q45215541Potent endothelial progenitor cell-conditioned media-related anti-apoptotic, cardiotrophic, and pro-angiogenic effects post-myocardial infarction are mediated by insulin-like growth factor-1.
Q92394640Potential Clinical Applications of Stem Cells in Regenerative Medicine
Q38160455Potential and clinical utility of stem cells in cardiovascular disease.
Q42727547Potential of mesenchymal stem cells in the repair of tubular injury
Q88219970Preclinical Studies of Stem Cell Therapy for Heart Disease
Q55564081Preconditioning in regenerative medicine.
Q93366161Preconditioning strategies for improving the survival rate and paracrine ability of mesenchymal stem cells in acute kidney injury
Q93066172Priming with erythropoietin enhances cell survival and angiogenic effect of mesenchymal stem cell implantation in rat limb ischemia
Q34245487Production of de novo cardiomyocytes: human pluripotent stem cell differentiation and direct reprogramming
Q42499130Progenitor cell secretory products exert additive renoprotective effects when combined with ace inhibitors in experimental CKD.
Q35296718Progenitor cell therapy in a porcine acute myocardial infarction model induces cardiac hypertrophy, mediated by paracrine secretion of cardiotrophic factors including TGFbeta1.
Q36108608Progenitor/stem cell transplantation for repair of myocardial infarction: Hype or hope?
Q27001064Progenitors for the corneal endothelium and trabecular meshwork: a potential source for personalized stem cell therapy in corneal endothelial diseases and glaucoma
Q36327823Progress and prospects: cell based regenerative therapy for cardiovascular disease.
Q33858319Proinflammatory stem cell signaling in cardiac ischemia
Q35224444Prolonged hypoxia induces monocarboxylate transporter-4 expression in mesenchymal stem cells resulting in a secretome that is deleterious to cardiovascular repair
Q46728724Protective Effect of Intravitreal Administration of Exosomes Derived from Mesenchymal Stem Cells on Retinal Ischemia.
Q33489764Protective paracrine effect of mesenchymal stem cells on cardiomyocytes
Q34978109Protein signaling networks from single cell fluctuations and information theory profiling
Q91760354Proteomic analysis of the secretome of adipose tissue-derived murine mesenchymal cells overexpressing telomerase and myocardin
Q89719762Purity Determines the Effect of Extracellular Vesicles Derived from Mesenchymal Stromal Cells
Q40238928REPAIR-AMI: stem cells for acute myocardial infarction
Q37807086REVIEW: Stem Cell Therapy in Cardiovascular Disorders
Q37167471Rap1-mediated nuclear factor-kappaB (NF-κB) activity regulates the paracrine capacity of mesenchymal stem cells in heart repair following infarction
Q92578413Rapamycin-Preactivated Autophagy Enhances Survival and Differentiation of Mesenchymal Stem Cells After Transplantation into Infarcted Myocardium
Q64991457Re-Defining Stem Cell-Cardiomyocyte Interactions: Focusing on the Paracrine Effector Approach.
Q39076891Re-Engineering Extracellular Vesicles as Smart Nanoscale Therapeutics.
Q35459559Re-modelling 'hostile' milieu of diseased myocardium via paracrine function of transplanted cells or relaxin
Q38874116Rebuilding the Damaged Heart: Mesenchymal Stem Cells, Cell-Based Therapy, and Engineered Heart Tissue.
Q35070251Rebuilding the damaged heart: the potential of cytokines and growth factors in the treatment of ischemic heart disease
Q52657125Recent Progress in Stem Cell Modification for Cardiac Regeneration.
Q36083407Recent Progress on Chemical Biology of Pluripotent Stem Cell Self-renewal, Reprogramming and Cardiomyogenesis
Q26739985Recent Stem Cell Advances: Cord Blood and Induced Pluripotent Stem Cell for Cardiac Regeneration- a Review
Q52782743Recovery of renal function after administration of adipose-tissue-derived stromal vascular fraction in rat model of acute kidney injury induced by ischemia/reperfusion injury.
Q33764626Reduction of Na/K-ATPase affects cardiac remodeling and increases c-kit cell abundance in partial nephrectomized mice.
Q27687840Regenerating functional heart tissue for myocardial repair
Q64065918Regenerative Cardiovascular Therapies: Stem Cells and Beyond
Q38075104Regenerative medicine for the treatment of heart disease
Q37821376Regenerative therapies in electrophysiology and pacing: introducing the next steps
Q38174769Regenerative therapy for cardiovascular disease
Q35050037Relative roles of direct regeneration versus paracrine effects of human cardiosphere-derived cells transplanted into infarcted mice.
Q37104058Repairing damaged myocardium: evaluating cells used for cardiac regeneration
Q36278420Repeated treatment with bone marrow cell secretory products maintains long-term renoprotection in experimental chronic kidney disease: a placebo-controlled trial
Q92405265Reproducibility of GMP-compliant production of therapeutic stressed peripheral blood mononuclear cell-derived secretomes, a novel class of biological medicinal products
Q26800082Reprogramming and transdifferentiation for cardiovascular development and regenerative medicine: where do we stand?
Q38269487Rethinking regenerative medicine: a macrophage-centered approach
Q37766134Review of stem cell-based therapy for the treatment of cardiovascular disease
Q37976449Revisiting cardiovascular regeneration with bone marrow-derived angiogenic and vasculogenic cells
Q36294424Role of host tissues for sustained humoral effects after endothelial progenitor cell transplantation into the ischemic heart
Q41940674Role of paracrine factors in stem and progenitor cell mediated cardiac repair and tissue fibrosis
Q54561835S6K inhibition renders cardiac protection against myocardial infarction through PDK1 phosphorylation of Akt.
Q92618217SDF-1α promotes repair of myocardial ischemic necrosis zones in rats
Q35009602SDF-1α secreted by human CD133-derived multipotent stromal cells promotes neural progenitor cell survival through CXCR7
Q30563310SLIT3-ROBO4 activation promotes vascular network formation in human engineered tissue and angiogenesis in vivo
Q30428262Safety and efficacy of bone marrow-derived autologous CD133+ stem cell therapy
Q28587325Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair
Q37260268Secreted frizzled related protein 2 protects cells from apoptosis by blocking the effect of canonical Wnt3a
Q48602794Secretome of Aggregated Embryonic Stem Cell-Derived Mesenchymal Stem Cell Modulates the Release of Inflammatory Factors in Lipopolysaccharide-Induced Peripheral Blood Mononuclear Cells
Q36233665Secretome of apoptotic peripheral blood cells (APOSEC) attenuates microvascular obstruction in a porcine closed chest reperfused acute myocardial infarction model: role of platelet aggregation and vasodilation
Q21133599Secretome of peripheral blood mononuclear cells enhances wound healing
Q37035997Serum-deprived human multipotent mesenchymal stromal cells (MSCs) are highly angiogenic
Q33892777Simvastatin augments the efficacy of therapeutic angiogenesis induced by bone marrow-derived mesenchymal stem cells in a murine model of hindlimb ischemia
Q37054555Skeletal myoblasts and cardiac repair
Q30273656Sonic Hedgehog gene delivery to the rodent heart promotes angiogenesis via iNOS/netrin-1/PKC pathway
Q38798555Stem Cell Extracellular Vesicles: Extended Messages of Regeneration
Q39124190Stem Cell Technology in Cardiac Regeneration: A Pluripotent Stem Cell Promise
Q38992231Stem Cell Therapy for Myocardial Infarction 2001-2013 Revisited
Q28069300Stem Cell Therapy for the Heart: Blind Alley or Magic Bullet?
Q85240790Stem and progenitor cell-based therapy approaches: current developments on treatment of acute myocardial infarction and chronic ischemic cardiomyopathy
Q35462023Stem cell conditioned culture media attenuated albumin-induced epithelial-mesenchymal transition in renal tubular cells
Q36494604Stem cell conditioned medium improves acute lung injury in mice: in vivo evidence for stem cell paracrine action
Q37545373Stem cell death and survival in heart regeneration and repair
Q37045472Stem cell differentiation: cardiac repair
Q35002029Stem cell factor gene transfer improves cardiac function after myocardial infarction in swine
Q33708216Stem cell paracrine actions and tissue regeneration
Q26740531Stem cell procedures in arthroscopic surgery
Q38098219Stem cell stimulation of endogenous myocyte regeneration
Q37087315Stem cell therapies in cardiovascular disease A "realistic" appraisal.
Q37827158Stem cell therapy for cardiac disease.
Q37544884Stem cell therapy for cardiac repair: benefits and barriers
Q26827498Stem cell therapy for incontinence: where are we now? What is the realistic potential?
Q38761212Stem cell therapy for ischemic heart diseases
Q36368239Stem cell transplantation for the treatment of myocardial infarction
Q37166081Stem cell use for cardiac diseases as of 2008.
Q37900227Stem cell-based cardiac tissue engineering
Q28071466Stem cell-derived exosomes as a therapeutic tool for cardiovascular disease
Q37766151Stem cells and cardiac repair: a critical analysis
Q37991771Stem cells and regenerative medicine - future perspectives
Q37688435Stem cells for myocardial repair with use of a transarterial catheter
Q36446920Stem cells for the ischaemic heart
Q37766200Stem cells in the infarcted heart
Q57767168Stem-Cell-Based Therapies for Vascular Regeneration in Peripheral Artery Diseases
Q37164041Stem-cell-based therapy and lessons from the heart
Q28068007Strategies and Challenges to Myocardial Replacement Therapy
Q34795299Strategies for cardiac regeneration and repair
Q38938850Strategies for functional bioscaffold-based skeletal muscle reconstruction
Q37162061Strategies to promote donor cell survival: combining preconditioning approach with stem cell transplantation
Q37318040Stretching the limits: stem cells in regeneration science
Q94545341Substance P Improves Renal Ischemia Reperfusion Injury Through Modulating Immune Response
Q53258151Sustained IGF-1 Secretion by Adipose-Derived Stem Cells Improves Infarcted Heart Function.
Q52724942Sustained Release of Endothelial Progenitor Cell-Derived Extracellular Vesicles from Shear-Thinning Hydrogels Improves Angiogenesis and Promotes Function after Myocardial Infarction.
Q41996348Synergism of matrix stiffness and vascular endothelial growth factor on mesenchymal stem cells for vascular endothelial regeneration
Q45856327Synergistic effect of combined intramyocardial CD34+ cells and VEGF2 gene therapy after MI.
Q34784627TGF-β2 treatment enhances cytoprotective factors released from embryonic stem cells and inhibits apoptosis in infarcted myocardium
Q33769592TLR4 inhibits mesenchymal stem cell (MSC) STAT3 activation and thereby exerts deleterious effects on MSC-mediated cardioprotection
Q37089726Tackling heart failure in the twenty-first century
Q38697049Taking a bite out of spinal cord injury: do dental stem cells have the teeth for it?
Q36642702Targeting angiogenesis versus myogenesis with cardiac cell therapy
Q37220758Targeting human CD34+ hematopoietic stem cells with anti-CD45 x anti-myosin light-chain bispecific antibody preserves cardiac function in myocardial infarction
Q41248205Telocytes - a Hope for Cardiac Repair after Myocardial Infarction
Q35558497Terminal differentiation is not a major determinant for the success of stem cell therapy - cross-talk between muscle-derived stem cells and host cells
Q46718093Testing the Paracrine Properties of Human Mesenchymal Stem Cells Using Conditioned Medium.
Q26769042The Evolution of the Stem Cell Theory for Heart Failure
Q40988293The Healing Effect of Conditioned Media and Bone Marrow-Derived Stem Cells in Laryngotracheal Stenosis: A Comparison in Experimental Dog Model
Q92128776The Immunomodulatory Functions of Mesenchymal Stromal/Stem Cells Mediated via Paracrine Activity
Q41553531The Impact of Confluence on Bone Marrow Mesenchymal Stem (BMMSC) Proliferation and Osteogenic Differentiation
Q58719281The Importance of Biophysical and Biochemical Stimuli in Dynamic Skeletal Muscle Models
Q36995514The Necessity of a Systematic Approach for the Use of MSCs in the Clinical Setting
Q27004398The Regenerative Role of the Fetal and Adult Stem Cell Secretome
Q28080565The Role of MicroRNAs in Cardiac Stem Cells
Q64925846The Therapeutic Potential of Stem Cells for Bronchopulmonary Dysplasia: "It's About Time" or "Not so Fast" ?
Q48653172The Use of Biocompatible Alginate Scaffolds Covalently Modified with Cyclic RGDfK Peptides to Improve Survival of Transplanted Cells and Angiogenesis in Damaged Myocardium
Q37293743The antiapoptotic effect of mesenchymal stem cell transplantation on ischemic myocardium is enhanced by anoxic preconditioning
Q36836344The birth of 'regenerative pharmacology': a clinical perspective
Q98291533The clinical application of mesenchymal stem cells in liver disease: the current situation and potential future
Q41864818The effects of adenoviral transfection of the keratinocyte growth factor gene on epidermal stem cells: an in vitro study
Q28570440The effects of mesenchymal stem cells on c-kit up-regulation and cell-cycle re-entry of neonatal cardiomyocytes are mediated by activation of insulin-like growth factor 1 receptor
Q35584038The effects of secretion factors from umbilical cord derived mesenchymal stem cells on osteogenic differentiation of mesenchymal stem cells.
Q40348066The future of cell therapy for acute myocardial infarction
Q36850913The hepatocyte growth factor-expressing character is required for mesenchymal stem cells to protect the lung injured by lipopolysaccharide in vivo
Q44113705The importance of understanding the molecular mechanism of stem cell-induced cardiac tissue repair
Q34257083The influence of autologous bone marrow stem cell transplantation on matrix metalloproteinases in patients treated for acute ST-elevation myocardial infarction
Q37766123The paracrine effect: pivotal mechanism in cell-based cardiac repair
Q90115342The proangiogenic effects of extracellular vesicles secreted by dental pulp stem cells derived from periodontally compromised teeth
Q37594948The role of bioactive lipids in stem cell mobilization and homing: novel therapeutics for myocardial ischemia
Q35861681The role of immunosuppression of mesenchymal stem cells in tissue repair and tumor growth
Q37306210The role of progenitor cells in the development of intimal hyperplasia
Q37067647The role of stem cells in the post-MI patient
Q38274270The role of tissue engineering and biomaterials in cardiac regenerative medicine
Q36897375The therapeutic potential of mesenchymal stem cells. Cell- & tissue-based therapy
Q36740266The use of scaffold-free cell sheet technique to refine mesenchymal stromal cell-based therapy for heart failure.
Q59807954Therapeutic Effect of Human Umbilical Cord Mesenchymal Stem Cells at Various Passages on Acute Liver Failure in Rats
Q47935765Therapeutic Effects of Mesenchymal Stem Cell-Derived Exosomes in Cardiovascular Disease
Q64062508Therapeutic Potential of Extracellular Vesicles for the Treatment of Nerve Disorders
Q47763374Therapeutic Potential of Hematopoietic Stem Cell-Derived Exosomes in Cardiovascular Disease.
Q35823993Therapeutic Potential of Stem Cells from Human Exfoliated Deciduous Teeth in Models of Acute Kidney Injury
Q38841567Therapeutic angiogenesis: angiogenic growth factors for ischemic heart disease
Q95360896Therapeutic applications of adipose-derived stem cells in cardiovascular disease
Q41933891Therapeutic effects of human STRO-3-selected mesenchymal precursor cells and their soluble factors in experimental myocardial ischemia.
Q36395705Therapeutic effects of late outgrowth endothelial progenitor cells or mesenchymal stem cells derived from human umbilical cord blood on infarct repair
Q26779938Therapeutic potential of CAR-T cell-derived exosomes: a cell-free modality for targeted cancer therapy
Q36909360Therapeutic potential of adult progenitor cells in cardiovascular disease
Q94663995Therapeutic potential of lipids obtained from γ-irradiated PBMCs in dendritic cell-mediated skin inflammation
Q38031213Therapeutic potential of mesenchymal stem cell-derived microvesicles.
Q38857237Tissue Engineering Strategies for Myocardial Regeneration: Acellular Versus Cellular Scaffolds?
Q38167702Tissue engineering and regenerative medicine approaches to enhance the functional response to skeletal muscle injury
Q33537670Tissue-engineered vascular grafts transform into mature blood vessels via an inflammation-mediated process of vascular remodeling
Q33840741Toll-like receptor 2 mediates mesenchymal stem cell-associated myocardial recovery and VEGF production following acute ischemia-reperfusion injury
Q64082706Toxicological testing of allogeneic secretome derived from peripheral mononuclear cells (APOSEC): a novel cell-free therapeutic agent in skin disease
Q35665292Tracking fusion of human mesenchymal stem cells after transplantation to the heart
Q27438164Transcriptional and functional profiling of human embryonic stem cell-derived cardiomyocytes
Q26774565Translational research of adult stem cell therapy
Q49875736Transplantation of Allogeneic Pericytes Improves Myocardial Vascularization and Reduces Interstitial Fibrosis in a Swine Model of Reperfused Acute Myocardial Infarction.
Q50637278Transplantation of adipose derived stromal cells is associated with functional improvement in a rat model of chronic myocardial infarction.
Q51842282Transplantation of adipose tissue mesenchymal cells conjugated with VEGF-releasing microcarriers promotes repair in murine myocardial infarction.
Q36294602Transplantation of cord blood mesenchymal stem cells as spheroids enhances vascularization
Q36757074Transplantation of human pericyte progenitor cells improves the repair of infarcted heart through activation of an angiogenic program involving micro-RNA-132
Q51105200Transplantation of mesenchymal stem cells attenuates myocardial injury and dysfunction in a rat model of acute myocarditis.
Q46139780Transplantation of mesenchymal stem cells improves atrioventricular conduction in a rat model of complete atrioventricular block
Q47848637Transplantation of mesenchymal stem cells overexpressing IL10 attenuates cardiac impairments in rats with myocardial infarction
Q44828167Transplantation with survivin-engineered mesenchymal stem cells results in better prognosis in a rat model of myocardial infarction
Q52886470Treatment of dilated cardiomyopathy in rabbits with mesenchymal stem cell transplantation and platelet-rich plasma.
Q39772665Treatment of pulmonary arterial hypertension with circulating angiogenic cells
Q35731055Treatment with hESC-Derived Myocardial Precursors Improves Cardiac Function after a Myocardial Infarction
Q92096728Triple-marker cardiac MRI detects sequential tissue changes of healing myocardium after a hydrogel-based therapy
Q37512338Trophic actions of bone marrow-derived mesenchymal stromal cells for muscle repair/regeneration
Q43166311Unraveling the mechanistic basis of mesenchymal stem cell activity in the heart
Q27003127Use of mesenchymal stem cells for therapy of cardiac disease
Q35114758VEGF/SDF-1 promotes cardiac stem cell mobilization and myocardial repair in the infarcted heart
Q28567683VEGFR1/CXCR4-positive progenitor cells modulate local inflammation and augment tissue perfusion by a SDF-1-dependent mechanism
Q37451512Vascular stem cells-potential for clinical application
Q37824871Very small embryonic-like stem cells: biology and therapeutic potential for heart repair
Q43203972What is the oncologic risk of stem cell treatment for heart disease?
Q55069122[Prediction of the molecular response to pertubations from single cell measurements].
Q41370575microRNA and Cardiac Regeneration.
Q91596421microRNA-21-5p dysregulation in exosomes derived from heart failure patients impairs regenerative potential
Q34163289shRNA-mediated decreases in c-Met levels affect the differentiation potential of human mesenchymal stem cells and reduce their capacity for tissue repair

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