Norisoboldine, a natural AhR agonist, promotes Treg differentiation and attenuates colitis via targeting glycolysis and subsequent NAD+/SIRT1/SUV39H1/H3K9me3 signaling pathway

scientific article published on 15 February 2018

Norisoboldine, a natural AhR agonist, promotes Treg differentiation and attenuates colitis via targeting glycolysis and subsequent NAD+/SIRT1/SUV39H1/H3K9me3 signaling pathway is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41419-018-0297-3
P932PMC publication ID5833367
P698PubMed publication ID29449535

P2093author name stringKai Wang
Ling Yang
Qi Lv
Yue Dai
Zhifeng Wei
Simiao Qiao
Yirong Xin
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Histone/protein deacetylases control Foxp3 expression and the heat shock response of T-regulatory cells.Q35300659
Hypoxia and the pharmaceutical diclofenac influence the circadian responses of three-spined stickleback.Q35476148
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E3 Ubiquitin Ligase VHL Regulates Hypoxia-Inducible Factor-1α to Maintain Regulatory T Cell Stability and Suppressive Capacity.Q35837701
Norisoboldine, an Anti-Arthritis Alkaloid Isolated from Radix Linderae, Attenuates Osteoclast Differentiation and Inflammatory Bone Erosion in an Aryl Hydrocarbon Receptor-Dependent MannerQ35891351
Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosaQ36339991
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Interaction with Suv39H1 is critical for Snail-mediated E-cadherin repression in breast cancer.Q36989015
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3-bromopyruvate ameliorate autoimmune arthritis by modulating Th17/Treg cell differentiation and suppressing dendritic cell activation.Q37635070
Inflammatory hypoxia induces syndecan-2 expression through IL-1β-mediated FOXO3a activation in colonic epitheliaQ38407202
Assessment of selected media supplements to improve F/HN lentiviral vector production yields.Q38693642
Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammationQ38997053
Role of the histone H3 lysine 9 methyltransferase Suv39 h1 in maintaining Epsteinn-Barr virus latency in B95-8 cellsQ39019130
miRNAs in B Cell Development and Lymphomagenesis.Q39426666
Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis.Q40176806
The aryl hydrocarbon receptor/microRNA-212/132 axis in T cells regulates IL-10 production to maintain intestinal homeostasisQ41089665
Nucleus accumbens-associated protein-1 promotes glycolysis and survival of hypoxic tumor cells via the HDAC4-HIF-1α axis.Q41193919
Impact of nucleic acid and methylated H3K9 binding activities of Suv39h1 on its heterochromatin assemblyQ41201442
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Three novel acetylation sites in the Foxp3 transcription factor regulate the suppressive activity of regulatory T cellsQ42196147
Norisoboldine ameliorates collagen-induced arthritis through regulating the balance between Th17 and regulatory T cells in gut-associated lymphoid tissuesQ42703257
Stabilization of Suv39H1 by SirT1 is part of oxidative stress response and ensures genome protectionQ42811651
Norisoboldine ameliorates DSS-induced ulcerative colitis in mice through induction of regulatory T cells in colonsQ44926236
Prior PCB exposure suppresses hypoxia-induced up-regulation of glycolytic enzymes in Fundulus heteroclitusQ45157700
G9a drives hypoxia-mediated gene repression for breast cancer cell survival and tumorigenesisQ47217251
Transcriptional inhibition of TCDD-mediated induction of cytochrome P450 1A1 and alteration of protein expression in a zebrafish hepatic cell line following the administration of TCDD and Cd2.Q47437257
CT45A1 siRNA silencing suppresses the proliferation, metastasis and invasion of lung cancer cells by downregulating the ERK/CREB signaling pathwayQ47811348
SIRT1 antagonizes liver fibrosis by blocking hepatic stellate cell activation in mice.Q47880064
Quantification of Lactate Dehydrogenase for Cell Viability Testing Using Cell Lines and Primary Cultured AstrocytesQ47899878
Glycolytic Enzymes Coalesce in G Bodies under Hypoxic StressQ48024704
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue3
P304page(s)258
P577publication date2018-02-15
P1433published inCell Death and DiseaseQ2197222
P1476titleNorisoboldine, a natural AhR agonist, promotes Treg differentiation and attenuates colitis via targeting glycolysis and subsequent NAD+/SIRT1/SUV39H1/H3K9me3 signaling pathway
P478volume9

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cites work (P2860)
Q64086620Activation of aryl hydrocarbon receptor signaling by a novel agonist ameliorates autoimmune encephalomyelitis
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Q57181197Metabolic regulation of innate and adaptive lymphocyte effector responses
Q64119258Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease
Q92511963Systematic understanding of the mechanism and effects of Arctigenin attenuates inflammation in dextran sulfate sodium-induced acute colitis through suppression of NLRP3 inflammasome by SIRT1
Q58612537The Aryl Hydrocarbon Receptor: Connecting Immunity to the Microenvironment
Q60920837The Role of the Aryl Hydrocarbon Receptor (AHR) in Immune and Inflammatory Diseases

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