Deltex1 antagonizes HIF-1α and sustains the stability of regulatory T cells in vivo

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Deltex1 antagonizes HIF-1α and sustains the stability of regulatory T cells in vivo is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2015NatCo...6.6353H
P356DOI10.1038/NCOMMS7353
P932PMC publication ID4346631
P698PubMed publication ID25695215
P5875ResearchGate publication ID272516796

P50authorMing-Zong LaiQ72049141
Si-Tse JiangQ46508631
P2093author name stringTzu-Sheng Hsu
Wan-Chen Hsieh
Wen-Hsien Liu
Huey-Wen Hsiao
Ting-Fang Chou
Yu-Jung Wu
P2860cites workFOXP3 controls regulatory T cell function through cooperation with NFATQ24298179
Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteinsQ24310048
Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1Q24336199
Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeatsQ24337414
Human T regulatory cell therapy: take a billion or so and call me in the morningQ24656069
Regulatory cells and transplantation toleranceQ26865816
Hypoxia-inducible factors in physiology and medicineQ27013770
Th17 and regulatory T cells in mediating and restraining inflammationQ27687428
Control of regulatory T cell development by the transcription factor Foxp3Q27860489
Foxp3 programs the development and function of CD4+CD25+ regulatory T cellsQ27860714
The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3Q28118511
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseasesQ28131652
Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesisQ28588058
Mechanisms of foxp3+ T regulatory cell-mediated suppressionQ29615842
Regulatory T cells and immune toleranceQ29616864
Molecular antagonism and plasticity of regulatory and inflammatory T cell programsQ29619478
Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acidQ29619479
Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infectionQ33624096
Deltex regulates T-cell activation by targeted degradation of active MEKK1.Q33823429
Rapid temporal control of Foxp3 protein degradation by sirtuin-1.Q33886284
Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cellsQ33979948
The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation.Q34041946
Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity.Q34049065
Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells.Q50968365
The plasticity and stability of regulatory T cellsQ50987847
Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3.Q51997055
Drosophila deltex mediates suppressor of Hairless-independent and late-endosomal activation of Notch signaling.Q52086514
Use of I region-restricted, antigen-specific T cell hybridomas to produce idiotypically specific anti-receptor antibodiesQ52829697
CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells.Q54139898
Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expressionQ59048389
Interleukin-1beta and tumor necrosis factor-alpha stimulate DNA binding of hypoxia-inducible factor-1Q78225117
Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?Q83125659
Deltex1 is a target of the transcription factor NFAT that promotes T cell anergyQ84207047
CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptorQ34116317
Role of LAG-3 in regulatory T cells.Q34358935
Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunityQ34596060
Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi CellsQ35117509
Synergy between the ESCRT-III complex and Deltex defines a ligand-independent Notch signalQ35621031
Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion into effector-like T cellsQ35992433
An N-terminal mutation of the Foxp3 transcription factor alleviates arthritis but exacerbates diabetesQ36067669
Mechanisms of suppression by suppressor T cellsQ36078047
STAT3 transcription factor promotes instability of nTreg cells and limits generation of iTreg cells during acute murine graft-versus-host disease.Q36231545
Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosaQ36339991
Regulatory T cells, tumour immunity and immunotherapyQ36430144
Itch expression by Treg cells controls Th2 inflammatory responses.Q37259247
Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivoQ37312884
Epigenetic mechanisms of regulation of Foxp3 expressionQ37412329
Therapeutic approaches to allergy and autoimmunity based on FoxP3+ regulatory T-cell activation and expansionQ37434891
Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor?Q37493607
Foxp3+ regulatory T cells: differentiation, specification, subphenotypesQ37523266
Hypoxia and hypoxia-inducible factors as regulators of T cell development, differentiation, and function.Q37573701
Biological functions of regulatory T cellsQ37961178
CD4(+)Foxp3(+) regulatory T cell therapy in transplantationQ37968576
Development and maintenance of regulatory T cellsQ38092234
Regulatory T cells in cancer immunotherapyQ38177627
Hypoxia-inducible factor regulates survival of antigen receptor-driven T cellsQ38347067
Control of immune responses by antigen-specific regulatory T cells expressing the folate receptor.Q40110921
Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth.Q40861131
Stability of the regulatory T cell lineage in vivo.Q42060265
Resistance to CD4+CD25+ regulatory T cells and TGF-beta in Cbl-b-/- miceQ44240372
Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritisQ44688981
Animal models of airway sensitization.Q46629985
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P304page(s)6353
P577publication date2015-02-19
P1433published inNature CommunicationsQ573880
P1476titleDeltex1 antagonizes HIF-1α and sustains the stability of regulatory T cells in vivo
P478volume6

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cites work (P2860)
Q26749571A Metabolic Immune Checkpoint: Adenosine in Tumor Microenvironment
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Q42336333Deltex-1 mutations predict poor survival in diffuse large B-cell lymphoma
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Q64083937HIF-1α Is a Metabolic Switch between Glycolytic-Driven Migration and Oxidative Phosphorylation-Driven Immunosuppression of Tregs in Glioblastoma
Q100464172HIF-2α is indispensable for regulatory T cell function
Q36237075Hypoxia-inducible factors in T lymphocyte differentiation and function. A Review in the Theme: Cellular Responses to Hypoxia
Q28081650Hypoxia-inducible factors regulate T cell metabolism and function
Q33673786IL-1β induced HIF-1α inhibits the differentiation of human FOXP3+ T cells.
Q50217787Metabolic Regulation of T Cell Immunity
Q92614781MicroRNA 182 promotes T helper 1 cell by repressing hypoxia induced factor 1 alpha in experimental autoimmune encephalomyelitis
Q49959240Norisoboldine, a natural AhR agonist, promotes Treg differentiation and attenuates colitis via targeting glycolysis and subsequent NAD+/SIRT1/SUV39H1/H3K9me3 signaling pathway
Q37689449Nutrient and Metabolic Sensing in T Cell Responses
Q64067672Rbpj expression in regulatory T cells is critical for restraining T2 responses
Q100694982Regulatory t cell metabolism at the intersection between autoimmune diseases and cancer
Q92511099Systemic silencing of PHD2 causes reversible immune regulatory dysfunction
Q26863525Ubiquitin-dependent regulation of Foxp3 and Treg function
Q48158098c-FLIP is a target of the E3 ligase deltex1 in gastric cancer.

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