Michael A. Geeves

researcher

Michael A. Geeves is …
instance of (P31):
humanQ5

External links are
P8446Gateway to Research person ID101C0D19-FEE1-435A-8E3B-51CB5E1E7A61
P496ORCID iD0000-0002-9364-8898
P1153Scopus author ID7006458343

P69educated atUniversity of BristolQ459506
University of BirminghamQ223429
P108employerUniversity of KentQ1516684
University of CaliforniaQ184478
Max Planck Institute for Molecular GeneticsQ1721667
P734family nameGeevesQ27631735
GeevesQ27631735
GeevesQ27631735
P735given nameMichaelQ4927524
MichaelQ4927524
P106occupationresearcherQ1650915
P21sex or gendermaleQ6581097

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author (P50)
Q3928365113 Cryoenzymology: The study of enzyme catalysis at subzero temperatures
Q43001941A kinetic model of the co-operative binding of calcium and ADP to scallop (Argopecten irradians) heavy meromyosin
Q92764676A micro-volume adaptation of a stopped-flow system; use with μg quantities of muscle proteins
Q74229259A modulatory role for the troponin T tail domain in thin filament regulation
Q58798735A novel live-cell imaging system reveals a reversible hydrostatic pressure impact on cell-cycle progression
Q24534408A novel pressure-jump apparatus for the microvolume analysis of protein-ligand and protein-protein interactions: its application to nucleotide binding to skeletal-muscle and smooth-muscle myosin subfragment-1
Q71971068A novel stopped-flow method for measuring the affinity of actin for myosin head fragments using microgram quantities of protein
Q35589202A systematic nomenclature for mammalian tropomyosin isoforms
Q36083020A variable domain near the ATP-binding site in Drosophila muscle myosin is part of the communication pathway between the nucleotide and actin-binding sites.
Q43574547ADP binding induces an asymmetry between the heads of unphosphorylated myosin.
Q69780324ATP-induced dissociation of rabbit skeletal actomyosin subfragment 1. Characterization of an isomerization of the ternary acto-S1-ATP complex
Q50687915Acetylation regulates tropomyosin function in the fission yeast Schizosaccharomyces pombe.
Q121177104Acetylation stabilises calmodulin‐regulated calcium signalling
Q52573197Actin residue glu(93) is identified as an amino acid affecting myosin binding.
Q73838653Actin-tropomyosin activation of myosin subfragment 1 ATPase and thin filament cooperativity. The role of tropomyosin flexibility and end-to-end interactions
Q34129446Actomyosin kinetics and in vitro motility of wild-type Drosophila actin and the effects of two mutations in the Act88F gene.
Q42372196Actomyosin kinetics of pure fast and slow rat myosin isoforms studied by in vitro motility assay approach.
Q36007515Adenosine diphosphate and strain sensitivity in myosin motors.
Q121177154Alpha and beta myosin isoforms and human atrial and ventricular contraction
Q98575250Alternative N-terminal regions of Drosophila myosin heavy chain II regulate communication of the purine binding loop with the essential light chain
Q35059426Alternative exon 9-encoded relay domains affect more than one communication pathway in the Drosophila myosin head
Q27674286An enzyme-trap approach allows isolation of intermediates in cobalamin biosynthesis
Q42386692Analysis of biophysical and functional consequences of tropomyosin-fluorescent protein fusions.
Q52306811Bisphosphorylation of cardiac troponin I modulates the Ca(2+)-dependent binding of myosin subfragment S1 to reconstituted thin filaments.
Q30481688Calcium sensitivity of the cross-bridge cycle of Myo1c, the adaptation motor in the inner ear
Q45173722Changes in Mg2+ ion concentration and heavy chain phosphorylation regulate the motor activity of a class I myosin
Q44020719Changes in catalytic activity and association state of pyruvate carboxylase which are dependent on enzyme concentration.
Q38326456Characterization of the cardiac holotroponin complex reconstituted from native cardiac troponin T and recombinant I and C.
Q54014357Characterization of the equilibrium between blocked and closed states of muscle thin filaments.
Q33484633Contractile activation and force generation in skinned rabbit muscle fibres: effects of hydrostatic pressure.
Q42119619Contractility parameters of human β-cardiac myosin with the hypertrophic cardiomyopathy mutation R403Q show loss of motor function.
Q33922832Cooperative [Ca²+]-dependent regulation of the rate of myosin binding to actin: solution data and the tropomyosin chain model.
Q42267863Cooperative regulation of myosin-S1 binding to actin filaments by a continuous flexible Tm-Tn chain
Q34181116Cooperative regulation of myosin-actin interactions by a continuous flexible chain I: actin-tropomyosin systems.
Q34181121Cooperative regulation of myosin-actin interactions by a continuous flexible chain II: actin-tropomyosin-troponin and regulation by calcium.
Q42690203Cooperativity and switching within the three-state model of muscle regulation.
Q40126797Cooperativity between the two heads of rabbit skeletal muscle heavy meromyosin in binding to actin.
Q34562133Cooperativity in the Ca2+ regulation of muscle contraction.
Q42783964Cross-talk, cross-bridges, and calcium activation of cardiac contraction.
Q98171250Cryo-EM and Molecular Docking Shows Myosin Loop 4 Contacts Actin and Tropomyosin on Thin Filaments
Q41967903Cryptococcus neoformans senses CO2 through the carbonic anhydrase Can2 and the adenylyl cyclase Cac1
Q41192724Crystallization and preliminary X-ray crystallographic analysis of full-length yeast tropomyosin 2 from Saccharomyces cerevisiae.
Q58491146Dictyostelium discoideumMyosin II: Characterization of Functional Myosin Motor Fragments†
Q46917024Dictyostelium myosin-IE is a fast molecular motor involved in phagocytosis
Q42690345Differential regulation of the actomyosin interaction by skeletal and cardiac troponin isoforms.
Q58491140Differential scanning calorimetric study of the thermal unfolding of the motor domain fragments of Dictyostelium discoideum myosin II
Q43759055Differing ADP release rates from myosin heavy chain isoforms define the shortening velocity of skeletal muscle fibers.
Q73037295Diffusional barrier crossing in a two-state protein folding reaction
Q52318721Dilated cardiomyopathy myosin mutants have reduced force-generating capacity.
Q118055774Distinct effects of two hearing loss–associated mutations in the sarcomeric myosin MYH7b
Q52576029Drosophila ACT88F indirect flight muscle-specific actin is not N-terminally acetylated: a mutation in N-terminal processing affects actin function.
Q37371692Drug effect unveils inter-head cooperativity and strain-dependent ADP release in fast skeletal actomyosin
Q93519366Dynamic interaction between actin and myosin subfragment 1 in the presence of ADP
Q42606576Dynamics of the muscle thin filament regulatory switch: the size of the cooperative unit.
Q33941983Dynamics of tropomyosin in muscle fibers as monitored by saturation transfer EPR of bi-functional probe.
Q121177152Effect of Myosin Isoforms on Cardiac Muscle Twitch of Mice, Rats and Humans
Q121177149Effects of Hydrostatic-Pressure on Muscle Contraction: A Look Back on Some Experimental Findings
Q71971060Effects of hydrostatic pressure on fatiguing frog muscle fibres
Q43005989Effects of pressure on equatorial x-ray fiber diffraction from skeletal muscle fibers.
Q34188103Effects of two familial hypertrophic cardiomyopathy mutations in alpha-tropomyosin, Asp175Asn and Glu180Gly, on the thermal unfolding of actin-bound tropomyosin
Q36937943Erratum to: Identification of functional differences between recombinant human α and β cardiac myosin motors.
Q93190721Evidence of functional deficits at the single muscle fiber level in experimentally-induced renal insufficiency
Q121177151Exploring the super-relaxed state of myosin in myofibrils from fast-twitch, slow-twitch, and cardiac muscle
Q42722057FAD binding, cobinamide binding and active site communication in the corrin reductase (CobR)
Q37126952Fast pressure jumps can perturb calcium and magnesium binding to troponin C F29W
Q73165952Force generation upon hydrostatic pressure release in tetanized intact frog muscle fibres
Q52568686Functional and biophysical analyses of the class XIV Toxoplasma gondii myosin D.
Q36898618Functional homodimers and heterodimers of recombinant smooth muscle tropomyosin
Q93112689High-speed imaging of glutamate release with genetically encoded sensors
Q36032815Identification of functional differences between recombinant human α and β cardiac myosin motors
Q32872095In vitro formation and characterization of the skeletal muscle α·β tropomyosin heterodimers
Q74104012Inhibition of actin-myosin subfragment 1 ATPase activity by troponin I and IC: relationship to the thin filament states of muscle
Q74252125Interaction of actin and ADP with the head domain of smooth muscle myosin: implications for strain-dependent ADP release in smooth muscle
Q43002735Interactions of the two heads of scallop (Argopecten irradians) heavy meromyosin with actin: influence of calcium and nucleotides
Q34182309Ionic interactions play a role in the regulatory mechanism of scallop heavy meromyosin.
Q44761193Isolation and kinetic characterisation of myosin and myosin S1 from the Drosophila indirect flight muscles.
Q24535798KIF1D is a fast non-processive kinesin that demonstrates novel K-loop-dependent mechanochemistry.
Q58491137Kinetic Analysis ofDictyostelium discoideumMyosin Motor Domains with Glycine-to-Alanine Mutations in the Reactive Thiol Region†
Q73712699Kinetic analyses of a truncated mammalian myosin I suggest a novel isomerization event preceding nucleotide binding
Q44594103Kinetic analysis of Drosophila muscle myosin isoforms suggests a novel mode of mechanochemical coupling
Q40792968Kinetic analysis of the slow skeletal myosin MHC-1 isoform from bovine masseter muscle
Q79167129Kinetic and mechanistic basis of the nonprocessive Kinesin-3 motor NcKin3
Q36542676Kinetic characterization of a cytoplasmic myosin motor domain expressed in Dictyostelium discoideum.
Q38288079Kinetic characterization of the catalytic domain of Dictyostelium discoideum myosin.
Q59663138Kinetics of acto-S1 interaction as a guide to a model for the crossbridge cycle
Q45114735Kinetics of an enzyme-catalyzed reaction measured by electrospray ionization mass spectrometry using a simple rapid mixing attachment.
Q71715239Kinetics of nucleotide binding to pyruvate carboxylase
Q45226232Kinetics of the interaction of 2'(3')-O-(N-methylanthraniloyl)-ATP with myosin subfragment 1 and actomyosin subfragment 1: Characterization of two acto.cntdot.S1.cntdot.ADP complexes
Q36562803Looking at long molecules in solution: what happens when they are subjected to Couette flow?
Q46568454Loop 1 of transducer region in mammalian class I myosin, Myo1b, modulates actin affinity, ATPase activity, and nucleotide access.
Q74540838Loop I can modulate ADP affinity, ATPase activity, and motility of different scallop myosins. Transient kinetic analysis of S1 isoforms
Q64235498Measurement of Myofilament-Localized Calcium Dynamics in Adult Cardiomyocytes and the Effect of Hypertrophic Cardiomyopathy Mutations
Q70533616Mechanism of adenosine 5'-triphosphate cleavage by myosin: studies with oxygen-18-labeled adenosine 5'-triphosphate
Q48019624Mechanism, regulation, and functional properties of Dictyostelium myosin-1B.
Q90696298Mg2+ -free ATP regulates the processivity of native cytoplasmic dynein
Q74599218Microsecond folding of the cold shock protein measured by a pressure-jump technique
Q38905575Modeling the Actin.myosin ATPase Cross-Bridge Cycle for Skeletal and Cardiac Muscle Myosin Isoforms.
Q28575899Modification of loop 1 affects the nucleotide binding properties of Myo1c, the adaptation motor in the inner ear
Q58491145Modulation of Actin Affinity and Actomyosin Adenosine Triphosphatase by Charge Changes in the Myosin Motor Domain†
Q104694412Modulation of post-powerstroke dynamics in myosin II by 2'-deoxy-ADP
Q48320291Modulators of actin-myosin dissociation: basis for muscle type functional differences during fatigue
Q90857341Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin
Q36144111Molecular mechanism of actomyosin-based motility.
Q54488142More Can Mean Less, or: Simplifying Sometimes Requires Ideas to Be More Complicated.
Q121177155Multiscale modeling of twitch contractions in cardiac trabeculae
Q58491097Mutations in the relay loop region result in dominant-negative inhibition of myosin II function in Dictyostelium
Q40398998Mutations in the relay loop region result in dominant-negative inhibition of myosin II function in Dictyostelium
Q24610102Myo1c is designed for the adaptation response in the inner ear
Q34459239Myo1c mutations associated with hearing loss cause defects in the interaction with nucleotide and actin.
Q26770575Myosin isoforms and the mechanochemical cross-bridge cycle
Q90466801Myosin motor domains carrying mutations implicated in early or late onset hypertrophic cardiomyopathy have similar properties
Q92858875Nebulin and titin modulate cross-bridge cycling and length-dependent calcium sensitivity
Q31854490Overexpression of human cardiac troponin in Escherichia coli: its purification and characterization.
Q39234683Phosphorylation of Ser283 enhances the stiffness of the tropomyosin head-to-tail overlap domain
Q38119858Polymorphism in tropomyosin structure and function
Q69680088Pressure sensitivity of active tension in glycerinated rabbit psoas muscle fibres: effects of ADP and phosphate
Q71586048Pressure-induced changes in the isometric contractions of single intact frog muscle fibres at low temperatures
Q44657400Probing nucleotide dissociation from myosin in vitro using microgram quantities of myosin.
Q42118754Production of amino-terminally acetylated recombinant proteins in E. coli
Q72529664Protein-bound adenosine 5'-triphosphate: properties of a key intermediate of the magnesium-dependent subfragment 1 adenosinetriphosphatase from rabbit skeletal muscle
Q48718220Proteins: from chemical to physiological mechanism.
Q28236967Rapid folding of the prion protein captured by pressure-jump
Q38237246Rapid reaction kinetic techniques.
Q43199021Resolution and uniqueness of estimated parameters of a model of thin filament regulation in solution.
Q35610635Reversible movement of switch 1 loop of myosin determines actin interaction
Q38803218Review: The ATPase mechanism of myosin and actomyosin.
Q54295386Role of the head-to-tail overlap region in smooth and skeletal muscle beta-tropomyosin.
Q53929131Role of the salt-bridge between switch-1 and switch-2 of Dictyostelium myosin.
Q80162383Role of tropomyosin isoforms in the calcium sensitivity of striated muscle thin filaments
Q80195387Selective perturbation of the myosin recovery stroke by point mutations at the base of the lever arm affects ATP hydrolysis and phosphate release
Q70782795Separation and characterization of the two functional regions of troponin involved in muscle thin filament regulation
Q37946073Shaking the myosin family tree: biochemical kinetics defines four types of myosin motor
Q121177150Single-molecule imaging reveals how mavacamten and PKA modulate ATP turnover in skeletal muscle myofibrils
Q58491123Stabilization of the Actomyosin Complex by Negative Charges on Myosin†
Q42540953Strain-dependent cross-bridge cycle for muscle.
Q42540958Strain-dependent cross-bridge cycle for muscle. II. Steady-state behavior.
Q43863354Stretching the lever-arm theory.
Q27671754Structural Basis for the Allosteric Interference of Myosin Function by Reactive Thiol Region Mutations G680A and G680V
Q33953597Structural mechanism of muscle contraction.
Q28623694Substrate specificity of human nucleoside-diphosphate kinase revealed by transient kinetic analysis
Q121177105TORC2 dependent phosphorylation modulates calcium regulation of fission yeast myosin
Q83227757TORC2-Gad8-dependent myosin phosphorylation modulates regulation by calcium
Q33784412Targeted amino-terminal acetylation of recombinant proteins in E. coli
Q47406906Temperature manifold for a stopped-flow machine to allow measurements from -10 to +40°C.
Q47591174Temperature sensitive point mutations in fission yeast tropomyosin have long range effects on the stability and function of the actin-tropomyosin copolymer
Q69911341Tension responses to increased hydrostatic pressure in glycerinated rabbit psoas muscle fibres
Q92459947The ATPase cycle of human muscle myosin II isoforms: Adaptation of a single mechanochemical cycle for different physiological roles
Q35836060The Hill model for binding myosin S1 to regulated actin is not equivalent to the McKillop-Geeves model
Q36876238The Most Prevalent Freeman-Sheldon Syndrome Mutations in the Embryonic Myosin Motor Share Functional Defects
Q30381592The Relay/Converter Interface Influences Hydrolysis of ATP by Skeletal Muscle Myosin II.
Q73578570The XXVIII European Muscle conference. York, UK, 4-7 September 1999
Q82731170The XXXVII European muscle conference: Oxford September 2008
Q35257399The actomyosin ATPase: a two-state system
Q28247638The core FH2 domain of diaphanous-related formins is an elongated actin binding protein that inhibits polymerization
Q69890965The dynamics of the interaction between myosin subfragment 1 and pyrene-labelled thin filaments, from rabbit skeletal muscle
Q67904532The effect of hydrostatic pressure on the interaction of actomyosin subfragment 1 with nucleotides
Q36143822The flexibility of two tropomyosin mutants, D175N and E180G, that cause hypertrophic cardiomyopathy
Q30356929The hypertrophic cardiomyopathy myosin mutation R453C alters ATP binding and hydrolysis of human cardiac β-myosin
Q72725586The influence of 2,3-butanedione 2-monoxime (BDM) on the interaction between actin and myosin in solution and in skinned muscle fibres
Q71824990The limiting rate of the ATP-mediated dissociation of actin from rabbit skeletal muscle myosin subfragment 1
Q90388612The mechanism of thin filament regulation: Models in conflict?
Q36288552The molecular mechanism of muscle contraction.
Q38205172The myosin-activated thin filament regulatory state, M⁻-open: a link to hypertrophic cardiomyopathy (HCM).
Q42101523The regulation of myosin binding to actin filaments by Lethocerus troponin.
Q39656476The role of three-state docking of myosin S1 with actin in force generation.
Q79386309The slow skeletal muscle isoform of myosin shows kinetic features common to smooth and non-muscle myosins
Q30352527The superfast human extraocular myosin is kinetically distinct from the fast skeletal IIa, IIb, and IId isoforms.
Q77797693The use of fast kinetic systems for the study of ng-microgram quantities of purified muscle proteins
Q52722149The use of pressure perturbations to investigate the interaction of rabbit muscle myosin subfragment 1 with actin in the presence of MgADP.
Q37457012Three-dimensional stochastic model of actin-myosin binding in the sarcomere lattice.
Q46472537Towards a unified theory of muscle contraction. I: foundations.
Q31050066Toxoplasma gondii myosin A and its light chain: a fast, single-headed, plus-end-directed motor
Q38458847Tropomyosin and actin isoforms modulate the localization of tropomyosin strands on actin filaments.
Q75366742Tropomyosin exon 6b is troponin-specific and required for correct acto-myosin regulation
Q36207989Tuning the calcium sensitivity of cardiac muscle
Q35150221Two Drosophila myosin transducer mutants with distinct cardiomyopathies have divergent ADP and actin affinities
Q38439597Ultra short yeast tropomyosins show novel myosin regulation
Q55396849Ultrafast glutamate sensors resolve high-frequency release at Schaffer collateral synapses.
Q38950646Upregulation of cardiomyocyte ribonucleotide reductase increases intracellular 2 deoxy-ATP, contractility, and relaxation.
Q38237248Use of pyrene-labelled actin to probe actin-myosin interactions: kinetic and equilibrium studies.
Q43116209Using fluorescent myosin to directly visualize cooperative activation of thin filaments
Q39316212What kinesin does at roadblocks: the coordination mechanism for molecular walking
Q46833542What limits the velocity of fast-skeletal muscle contraction in mammals?
Q43092360α-Tropomyosin with a D175N or E180G mutation in only one chain differs from tropomyosin with mutations in both chains

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