Beta1 integrin mediated adhesion increases Bim protein degradation and contributes to drug resistance in leukaemia cells.

scientific article published in January 2007

Beta1 integrin mediated adhesion increases Bim protein degradation and contributes to drug resistance in leukaemia cells. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/J.1365-2141.2006.06435.X
P698PubMed publication ID17233818
P5875ResearchGate publication ID6568587

P2093author name stringW S Dalton
L A Hazlehurst
R F Argilagos
P2860cites workProapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunityQ28138855
The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complexQ28141249
Gene structure alternative splicing, and chromosomal localization of pro-apoptotic Bcl-2 relative BimQ28201672
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cellsQ28277030
Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cellsQ28505374
G1/S cell cycle arrest provides anoikis resistance through Erk-mediated Bim suppressionQ33836907
Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: a mechanism for small cell lung cancer growth and drug resistance in vivoQ34503877
Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteinsQ34612753
Differential role of beta(1C) and beta(1A) integrin cytoplasmic variants in modulating focal adhesion kinase, protein kinase B/AKT, and Ras/Mitogen-activated protein kinase pathwaysQ34729632
Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells.Q40462629
Roles of Bim in apoptosis of normal and Bcr-Abl-expressing hematopoietic progenitorsQ40540288
Extracellular signal-regulated kinases 1/2 are serum-stimulated "Bim(EL) kinases" that bind to the BH3-only protein Bim(EL) causing its phosphorylation and turnoverQ40606380
Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function.Q40626751
Cell adhesion-mediated drug resistance (CAM-DR) protects the K562 chronic myelogenous leukemia cell line from apoptosis induced by BCR/ABL inhibition, cytotoxic drugs, and gamma-irradiationQ40789146
BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo.Q41837676
Integrin-mediated activation of MEK and mitogen-activated protein kinase is independent of Ras [corrected].Q42810800
Integrin signaling inhibits paclitaxel-induced apoptosis in breast cancer cellsQ43722430
Reduction in drug-induced DNA double-strand breaks associated with beta1 integrin-mediated adhesion correlates with drug resistance in U937 cellsQ43727826
Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikisQ44502162
Low-level expression of proapoptotic Bcl-2-interacting mediator in leukemic cells in patients with chronic myeloid leukemia: role of BCR/ABL, characterization of underlying signaling pathways, and reexpression by novel pharmacologic compounds.Q46757499
Adhesion to fibronectin via beta1 integrins regulates p27kip1 levels and contributes to cell adhesion mediated drug resistance (CAM-DR).Q52540929
Remodeling of the extracellular matrix through overexpression of collagen VI contributes to cisplatin resistance in ovarian cancer cells.Q52826677
Adhesion-mediated intracellular redistribution of c-Fas-associated death domain-like IL-1-converting enzyme-like inhibitory protein-long confers resistance to CD95-induced apoptosis in hematopoietic cancer cell lines.Q53978532
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectleukemiaQ29496
drug resistanceQ12147416
P304page(s)269-275
P577publication date2007-01-01
P1433published inBritish Journal of HaematologyQ4970200
P1476titleBeta1 integrin mediated adhesion increases Bim protein degradation and contributes to drug resistance in leukaemia cells.
P478volume136

Reverse relations

cites work (P2860)
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