Novel events in the molecular regulation of muscle mass in critically ill patients.

scientific article

Novel events in the molecular regulation of muscle mass in critically ill patients. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1113/JPHYSIOL.2011.206193
P932PMC publication ID3171892
P698PubMed publication ID21669975
P5875ResearchGate publication ID51216158

P50authorPaul L. GreenhaffQ43153720
P2093author name stringRavi P Mahajan
Despina Constantin
Justine McCullough
P2860cites workDysregulation of mitochondrial dynamics and the muscle transcriptome in ICU patients suffering from sepsis induced multiple organ failureQ21144214
Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wastingQ22008491
Myostatin mutation associated with gross muscle hypertrophy in a childQ24297666
Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube sizeQ24314330
Mutations in the proteolytic enzyme calpain 3 cause limb-girdle muscular dystrophy type 2AQ24314667
Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophyQ24555065
Regulation of myostatin activity and muscle growthQ24555817
Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathwaysQ28346530
Identification of cathepsin L as a differentially expressed message associated with skeletal muscle wastingQ28363312
Identification of Ubiquitin Ligases Required for Skeletal Muscle AtrophyQ28582211
Suppression of body fat accumulation in myostatin-deficient miceQ28586697
The effect of exercise on muscle glycogen and electrolytes in normalsQ72799003
Sepsis upregulates the gene expression of multiple ubiquitin ligases in skeletal muscleQ73208228
Longitudinal changes of biochemical parameters in muscle during critical illnessQ73515746
Glutamine appearance rate in plasma is not increased after gastrointestinal surgery in humansQ73825796
Tissue protein synthesis rates in critically ill patientsQ74037665
Muscle fibre atrophy in critically ill patients is associated with the loss of myosin filaments and the presence of lysosomal enzymes and ubiquitinQ77793916
Mechanism responsible for inactivation of skeletal muscle pyruvate dehydrogenase complex in starvation and diabetesQ78060401
Impact of surgical trauma on human skeletal muscle protein synthesisQ80482024
Respiratory weakness is associated with limb weakness and delayed weaning in critical illnessQ81251477
APACHE II: a severity of disease classification systemQ29547729
Intensive insulin therapy in critically ill patientsQ29618795
Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophyQ29619282
Myostatin, insulin-like growth factor-1, and leukemia inhibitory factor mRNAs are upregulated in chronic human disuse muscle atrophy.Q33951825
Paresis acquired in the intensive care unit: a prospective multicenter studyQ34163357
What do we really know about the ubiquitin-proteasome pathway in muscle atrophy?Q34343580
Muscle function in critically ill patientsQ34354969
Impact of intensive insulin therapy on neuromuscular complications and ventilator dependency in the medical intensive care unitQ34586285
Regulation of muscle protein synthesis during sepsis and inflammationQ34628735
Glycogen synthase kinase-3beta: a novel regulator of cardiac hypertrophy and development.Q34662451
Insulin resistance and hyperglycemia in critical illness: role of insulin in glycemic controlQ35651338
Regulation of muscle mass by myostatinQ35912777
Calpains in muscle wasting.Q36241898
Acute alcohol intoxication increases atrogin-1 and MuRF1 mRNA without increasing proteolysis in skeletal muscleQ36647885
Calpain activity and muscle wasting in sepsisQ36956035
Myostatin inhibits IGF-I-induced myotube hypertrophy through Akt.Q37421047
Caspase and calpain activation both contribute to sepsis-induced diaphragmatic weaknessQ37422187
Intensive care unit-acquired weakness: risk factors and preventionQ37666324
Structure to function: muscle failure in critically ill patients.Q37801761
Insulin-like growth factor-1 (IGF-1) inversely regulates atrophy-induced genes via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathwayQ40490374
Regulation of eIF-4E BP1 phosphorylation by mTOR.Q41087062
Protein Turnover, Synthesis and Breakdown before and after Recovery from Protein-Energy MalnutritionQ41347955
Disassociation between the effects of amino acids and insulin on signaling, ubiquitin ligases, and protein turnover in human muscleQ42532366
Tumor necrosis factor-{alpha} decreases Akt protein levels in 3T3-L1 adipocytes via the caspase-dependent ubiquitination of Akt.Q42817477
Altered protein kinetics in vivo after single-limb burn injuryQ42848334
Necrotizing myopathy in critically-ill patientsQ44440526
Disuse atrophy and exercise rehabilitation in humans profoundly affects the expression of genes associated with the regulation of skeletal muscle mass.Q44844832
A potential role for Akt/FOXO signalling in both protein loss and the impairment of muscle carbohydrate oxidation during sepsis in rodent skeletal muscle.Q46346112
Down-regulation of Akt/mammalian target of rapamycin signaling pathway in response to myostatin overexpression in skeletal muscleQ46359311
Acquired weakness, handgrip strength, and mortality in critically ill patientsQ48433888
Myostatin induces cachexia by activating the ubiquitin proteolytic system through an NF-kappaB-independent, FoxO1-dependent mechanismQ51805331
Presence and severity of intensive care unit-acquired paresis at time of awakening are associated with increased intensive care unit and hospital mortalityQ51809075
Metabolism in peripheral tissues in cancer patients.Q54542943
Prevalence of the metabolic syndrome in patients with coronary heart disease, cerebrovascular disease, peripheral arterial disease or abdominal aortic aneurysmQ57790468
Human Septic Myopathy: Induction of Cyclooxygenase, Heme Oxygenase and Activation of the Ubiquitin Proteolytic PathwayQ59650782
PPARdelta agonism induces a change in fuel metabolism and activation of an atrophy programme, but does not impair mitochondrial function in rat skeletal muscleQ60730463
Cathepsin B and D activity in human skeletal muscle in disease statesQ67249528
A descriptive study of skeletal muscle metabolism in critically ill patients: free amino acids, energy-rich phosphates, protein, nucleic acids, fat, water, and electrolytesQ71032735
Activation of the ATP-ubiquitin-proteasome pathway in skeletal muscle of cachectic rats bearing a hepatomaQ71694941
The local and systemic effects of minor injury on muscle protein synthesis in the ratQ71801541
P433issuePt 15
P407language of work or nameEnglishQ1860
P921main subjectpatientQ181600
P1104number of pages13
P304page(s)3883-3895
P577publication date2011-06-13
P1433published inJournal of PhysiologyQ7743612
P1476titleNovel events in the molecular regulation of muscle mass in critically ill patients.
P478volume589

Reverse relations

cites work (P2860)
Q82985578A step towards underpinning the molecular signalling events regulating muscle protein loss in critically ill patients
Q37300631Association of the K153R polymorphism in the myostatin gene and extreme longevity
Q84770286Attack of the catabolic pathways: muscle wasting in the ICU
Q38887437Control of skeletal muscle atrophy in response to disuse: clinical/preclinical contentions and fallacies of evidence
Q42330082Deletion of Nlrp3 protects from inflammation-induced skeletal muscle atrophy
Q33778791Disruption of genes encoding eIF4E binding proteins-1 and -2 does not alter basal or sepsis-induced changes in skeletal muscle protein synthesis in male or female mice
Q33951567Downregulation of E3 ubiquitin ligases and mitophagy-related genes in skeletal muscle of physically inactive, frail older women: a cross-sectional comparison.
Q46415736Effects of corticosteroids in the development of limb muscle weakness in a porcine intensive care unit model
Q34449998Exercise attenuates the major hallmarks of aging
Q35206436Fasting increases human skeletal muscle net phenylalanine release and this is associated with decreased mTOR signaling
Q35697448Feeding critically ill patients the right 'whey': thinking outside of the box. A personal view
Q35135414Increased expression of GDF-15 may mediate ICU-acquired weakness by down-regulating muscle microRNAs
Q47219696Inflammation-mediated muscle metabolic dysregulation local and remote to the site of major abdominal surgery.
Q37618599Intensive care unit acquired weakness in children: Critical illness polyneuropathy and myopathy
Q38064396Intensive care unit-acquired weakness: clinical phenotypes and molecular mechanisms.
Q54197697Lean mass, muscle strength and gene expression in community dwelling older men: findings from the Hertfordshire Sarcopenia Study (HSS).
Q41056751Ligand-induced rapid skeletal muscle atrophy in HSA-Fv2E-PERK transgenic mice
Q51534149Mechanisms of Chronic Muscle Wasting and Dysfunction After an Intensive Care Unit Stay: A Pilot Study
Q38730157Muscle carnitine availability plays a central role in regulating fuel metabolism in the rodent
Q51045283Neuromuscular electrical stimulation prevents muscle wasting in critically ill comatose patients.
Q57580357Nutritional Approaches to Treating Sarcopenia
Q51305299Pharmacological activation of the pyruvate dehydrogenase complex reduces statin-mediated upregulation of FOXO gene targets and protects against statin myopathy in rodents.
Q34896090Pre-Operative nutrition In Neck of femur Trial (POINT)--carbohydrate loading in patients with fragility hip fracture: study protocol for a randomised controlled trial
Q38779281Proceedings of the 2016 Clinical Nutrition Week Research Workshop-The Optimal Dose of Protein Provided to Critically Ill Patients
Q37175505Proteins regulating cap-dependent translation are downregulated during total knee arthroplasty
Q40409557Recoverable, Record-High Lactic Acidosis in a Patient with Glycogen Storage Disease Type 1: A Mixed Type A and Type B Lactate Disorder
Q37138209Regulation of muscle protein synthesis and the effects of catabolic states
Q36905257Ribosome biogenesis: emerging evidence for a central role in the regulation of skeletal muscle mass.
Q36829863Serum creatinine level, a surrogate of muscle mass, predicts mortality in critically ill patients
Q37094172Short-term bed rest increases TLR4 and IL-6 expression in skeletal muscle of older adults
Q47715759Skeletal Muscle Dysfunction in Idiopathic Pulmonary Arterial Hypertension
Q38640357Skeletal Muscle Ultrasound in Critical Care: A Tool in Need of Translation.
Q54441161Skeletal muscle molecular responses to resistance training and dietary supplementation in COPD.
Q35174188Statin myalgia is not associated with reduced muscle strength, mass or protein turnover in older male volunteers, but is allied with a slowing of time to peak power output, insulin resistance and differential muscle mRNA expression.
Q36246665Targeting anabolic impairment in response to resistance exercise in older adults with mobility impairments: potential mechanisms and rehabilitation approaches.
Q34507052The E3 ubiquitin ligase TRIM62 and inflammation-induced skeletal muscle atrophy
Q34483183The Sick and the Weak: Neuropathies/Myopathies in the Critically Ill.
Q91897430The age-performance relationship in the general population and strategies to delay age related decline in performance
Q89397680The impact of immobilisation and inflammation on the regulation of muscle mass and insulin resistance: different routes to similar end-points
Q38239466The importance of dietary protein for muscle health in inactive, hospitalized older adults
Q64911038The metabolic and molecular mechanisms of hyperammonaemia- and hyperethanolaemia-induced protein catabolism in skeletal muscle cells.
Q39225991Weak by the machines: muscle motor protein dysfunction - a side effect of intensive care unit treatment