Abstract is: Jennifer Anne Doudna ForMemRS (/ˈdaʊdnə/; born February 19, 1964) is an American biochemist who has done pioneering work in CRISPR gene editing, and made other fundamental contributions in biochemistry and genetics. She received the 2020 Nobel Prize in Chemistry, with Emmanuelle Charpentier, "for the development of a method for genome editing." She is the Li Ka Shing Chancellor's Chair Professor in the Department of Chemistry and the Department of Molecular and Cell Biology at the University of California, Berkeley. She has been an investigator with the Howard Hughes Medical Institute since 1997. She graduated from Pomona College in 1985 and earned a Ph.D. from Harvard Medical School in 1989. Apart from her professorship at Berkeley, she is also president and chair of the board of the Innovative Genomics Institute, a faculty scientist at Lawrence Berkeley National Laboratory, a senior investigator at the Gladstone Institutes, and an adjunct professor of cellular and molecular pharmacology at the University of California, San Francisco (UCSF). In 2012, Doudna and Emmanuelle Charpentier were the first to propose that CRISPR-Cas9 (enzymes from bacteria that control microbial immunity) could be used for programmable editing of genomes, which has been called one of the most significant discoveries in the history of biology. Since then, Doudna has been a leading figure in what is referred to as the "CRISPR revolution" for her fundamental work and leadership in developing CRISPR-mediated genome editing. Her many other prestigious awards and fellowships include the 2000 Alan T. Waterman Award for her research on the structure as determined by X-ray crystallography of a ribozyme, and the 2015 Breakthrough Prize in Life Sciences for CRISPR-Cas9 genome editing technology, with Charpentier. She has been a co-recipient of the Gruber Prize in Genetics (2015), the Tang Prize (2016), the Canada Gairdner International Award (2016), and the Japan Prize (2017). She was named one of the Time 100 most influential people in 2015.
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| P512 | academic degree | Doctor of Philosophy | Q752297 |
| P1416 | affiliation | University of California, Berkeley | Q168756 |
| P6424 | affiliation string | University of California, Berkeley | |
| P166 | award received | Nobel Prize in Chemistry | Q44585 |
| Gruber Prize in Genetics | Q477467 | ||
| Wolf Prize in Medicine | Q540561 | ||
| Japan Prize | Q908745 | ||
| Massry Prize | Q1907790 | ||
| Albany Medical Center Prize | Q2637278 | ||
| Time 100 | Q604370 | ||
| Canada Gairdner International Award | Q1031994 | ||
| Princess of Asturias Award for Technical and Scientific Research | Q3320352 | ||
| L'Oréal-UNESCO Award For Women in Science | Q1786381 | ||
| Croonian Medal and Lecture | Q1192912 | ||
| Dickson Prize in Medicine | Q1210161 | ||
| Guggenheim Fellowship | Q1316544 | ||
| NAS Award in Chemical Sciences | Q905656 | ||
| Eli Lilly Award in Biological Chemistry | Q1328817 | ||
| National Inventors Hall of Fame | Q1366018 | ||
| Dr H.P. Heineken Prize for Biochemistry and Biophysics | Q1562531 | ||
| Breakthrough Prize in Life Sciences | Q5019489 | ||
| Tang Prize | Q10922924 | ||
| Foreign Member of the Royal Society | Q14906020 | ||
| John Scott Award | Q3332215 | ||
| Nierenberg Prize | Q3405093 | ||
| Alan T. Waterman Award | Q3607779 | ||
| Dr. Paul Janssen Award for Biomedical Research | Q5304319 | ||
| BBVA Foundation Frontiers of Knowledge Award | Q6085042 | ||
| Harvey Prize | Q1587906 | ||
| Gabbay Award | Q15811193 | ||
| William O. Baker Award for Initiatives in Research | Q6952555 | ||
| Pearl Meister Greengard Prize | Q7158133 | ||
| Clarivate Citation Laureates | Q7795894 | ||
| Warren Alpert Foundation Prize | Q7970020 | ||
| Paul Ehrlich and Ludwig Darmstaedter Prize | Q458338 | ||
| Beckman Young Investigators Award | Q18357228 | ||
| Kavli Prize in Nanoscience | Q18889779 | ||
| Lurie Prize in Biomedical Sciences | Q22080517 | ||
| Carl Sagan Prize for Science Popularization | Q25324264 | ||
| F. A. Cotton Medal | Q31836935 | ||
| Mildred Cohn Award in Biological Chemistry | Q59104907 | ||
| Fellow of the AACR Academy | Q61636373 | ||
| Murray Goodman Memorial Prize | Q85787109 | ||
| Vanderbilt Prize in Biomedical Science | Q100377523 | ||
| Packard Fellowship for Science and Engineering | Q113469875 | ||
| P1477 | birth name | Jennifer Anne Doudna | |
| P27 | country of citizenship | United States of America | Q30 |
| P184 | doctoral advisor | Jack Szostak | Q104600 |
| P185 | doctoral student | Akshay Tambe | Q102941359 |
| P69 | educated at | Harvard University | Q13371 |
| Hilo High School | Q5764322 | ||
| Pomona College | Q7227384 | ||
| P108 | employer | Yale University | Q49112 |
| University of California, San Francisco | Q1061104 | ||
| University of California, Berkeley | Q168756 | ||
| Howard Hughes Medical Institute | Q1512226 | ||
| P734 | family name | Doudna | Q37567647 |
| Doudna | Q37567647 | ||
| Doudna | Q37567647 | ||
| P101 | field of work | molecular biology | Q7202 |
| ribosome | Q42244 | ||
| biochemistry | Q7094 | ||
| Hepatitis C virus | Q708693 | ||
| transcription | Q177900 | ||
| X-ray crystallography | Q826582 | ||
| RNA interference | Q201993 | ||
| P735 | given name | Jennifer | Q4677161 |
| Jennifer | Q4677161 | ||
| Anne | Q564684 | ||
| Anne | Q564684 | ||
| P737 | influenced by | Jack Szostak | Q104600 |
| Thomas Cech | Q135180 | ||
| Corwin Hansch | Q5173502 | ||
| Sharon Panasenko | Q84426680 | ||
| P1412 | languages spoken, written or signed | English | Q1860 |
| P6104 | maintained by WikiProject | WikiProject Biography | Q4913761 |
| WikiProject Chemistry | Q8487234 | ||
| WikiProject Women scientists | Q14544312 | ||
| WikiProject California | Q15785976 | ||
| WikiProject Molecular Biology | Q88425552 | ||
| P463 | member of | Pontifical Academy of Sciences | Q938622 |
| Royal Society | Q123885 | ||
| National Academy of Medicine | Q4352382 | ||
| National Academy of Sciences | Q270794 | ||
| American Academy of Arts and Sciences | Q463303 | ||
| P1559 | name in native language | Jennifer Anne Doudna | |
| P106 | occupation | chemist | Q593644 |
| biochemist | Q2919046 | ||
| university teacher | Q1622272 | ||
| crystallographer | Q15142825 | ||
| molecular biologist | Q15839206 | ||
| P5008 | on focus list of Wikimedia project | WikiProject COVID-19 | Q87748614 |
| P1344 | participant in | World Economic Forum Annual Meeting 2015 | Q114717231 |
| World Economic Forum Annual Meeting 2016 | Q114717232 | ||
| P39 | position held | board of directors member | Q55168644 |
| P551 | residence | Hilo | Q216258 |
| P21 | sex or gender | female | Q6581072 |
| P26 | spouse | Jamie H. D. Cate | Q87623216 |
| P1066 | student of | Jack Szostak | Q104600 |
| P910 | topic's main category | Category:Jennifer Doudna | Q110268242 |
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| Q30371316 | An inhibitory activity in human cells restricts the function of an avian-like influenza virus polymerase. |
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| Q74599226 | Assembly of an exceptionally stable RNA tertiary interface in a group I ribozyme |
| Q92830534 | Author Correction: CasX enzymes comprise a distinct family of RNA-guided genome editors |
| Q95319659 | Author Correction: Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity |
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| Q36518348 | Autoinhibitory Interdomain Interactions and Subfamily-specific Extensions Redefine the Catalytic Core of the Human DEAD-box Protein DDX3. |
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| Q46244913 | CRISPR-Cpf1 mediates efficient homology-directed repair and temperature-controlled genome editing |
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| Q36366478 | Chemical biology at the crossroads of molecular structure and mechanism |
| Q56904560 | Chemical synthesis of oligoribonucleotides containing 2-aminopurine: substrates for the investigation of ribozyme function |
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| Q36879255 | Conformational control of DNA target cleavage by CRISPR-Cas9. |
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| Q58673100 | Contributors |
| Q64060426 | Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs |
| Q104486681 | Controlling and enhancing CRISPR systems |
| Q36290029 | Coordinated activities of human dicer domains in regulatory RNA processing |
| Q37691340 | Coordinated assembly of human translation initiation complexes by the hepatitis C virus internal ribosome entry site RNA. |
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| Q42365836 | Correction: RNA and DNA Targeting by a Reconstituted Thermus thermophilus Type III-A CRISPR-Cas System |
| Q55180928 | Correction: Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain. |
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| Q27667115 | Coupled 5′ Nucleotide Recognition and Processivity in Xrn1-Mediated mRNA Decay |
| Q56901067 | Creative catalysis: pieces of the RNA world jigsaw |
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| Q27765718 | Crystal structure of a hepatitis delta virus ribozyme |
| Q27638697 | Crystal structure of an RNA tertiary domain essential to HCV IRES-mediated translation initiation |
| Q112568172 | Crystal structure of an RNA/DNA strand exchange junction |
| Q24630978 | Crystal structure of the HCV IRES central domain reveals strategy for start-codon positioning |
| Q27621449 | Crystal structure of the ribonucleoprotein core of the signal recognition particle |
| Q45745245 | Crystallization and structure determination of a hepatitis delta virus ribozyme: use of the RNA-binding protein U1A as a crystallization module |
| Q35869456 | Crystallization of RNA and RNA-protein complexes |
| Q36492163 | Crystallization of ribozymes and small RNA motifs by a sparse matrix approach |
| Q27678649 | Csy4 relies on an unusual catalytic dyad to position and cleave CRISPR RNA |
| Q38282014 | Cutting it close: CRISPR-associated endoribonuclease structure and function |
| Q37418237 | DNA Targeting by a Minimal CRISPR RNA-Guided Cascade |
| Q98176043 | DNA capture by a CRISPR-Cas9-guided adenine base editor |
| Q112366768 | DNA interference states of the hypercompact CRISPR-CasΦ effector |
| Q33931841 | DNA interrogation by the CRISPR RNA-guided endonuclease Cas9. |
| Q33699328 | DNA recognition by an RNA-guided bacterial Argonaute |
| Q64118920 | Deciphering Off-Target Effects in CRISPR-Cas9 through Accelerated Molecular Dynamics |
| Q24311911 | Dicer-TRBP complex formation ensures accurate mammalian microRNA biogenesis |
| Q24339591 | Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing |
| Q27653299 | Direct Link between RACK1 Function and Localization at the Ribosome In Vivo |
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| Q58054275 | Disabling Cas9 by an anti-CRISPR DNA mimic |
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| Q34366815 | Distinct contributions of KH domains to substrate binding affinity of Drosophila P-element somatic inhibitor protein |
| Q40848247 | Distinct sites of phosphorothioate substitution interfere with folding and splicing of the Anabaena group I intron |
| Q42818252 | Dynamics of CRISPR-Cas9 genome interrogation in living cells |
| Q34551100 | Efficient genome editing in the mouse brain by local delivery of engineered Cas9 ribonucleoprotein complexes. |
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| Q35247829 | Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery |
| Q46347859 | Enhanced proofreading governs CRISPR-Cas9 targeting accuracy |
| Q37448762 | Enhancement of hepatitis C viral RNA abundance by precursor miR-122 molecules |
| Q73469271 | Establishing suitability of RNA preparations for crystallization. Determination of polydispersity |
| Q27680426 | Evolution of CRISPR RNA recognition and processing by Cas6 endonucleases |
| Q34317357 | Evolutionarily conserved roles of the dicer helicase domain in regulating RNA interference processing |
| Q34499475 | Foreign DNA capture during CRISPR-Cas adaptive immunity |
| Q58929523 | Foreign DNA capture during CRISPR–Cas adaptive immunity |
| Q33531761 | Functional overlap between eIF4G isoforms in Saccharomyces cerevisiae |
| Q34237617 | Functional reconstitution of human eukaryotic translation initiation factor 3 (eIF3). |
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| Q34487189 | Generation of knock-in primary human T cells using Cas9 ribonucleoproteins. |
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| Q28252298 | Genome editing. The new frontier of genome engineering with CRISPR-Cas9 |
| Q42670621 | Genome editing: the end of the beginning |
| Q34506451 | Genome-editing revolution: My whirlwind year with CRISPR. |
| Q105179581 | Genome-resolved metagenomics reveals site-specific diversity of episymbiotic CPR bacteria and DPANN archaea in groundwater ecosystems |
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| Q40053915 | Guide-bound structures of an RNA-targeting A-cleaving CRISPR-Cas13a enzyme. |
| Q40427585 | Hammerhead ribozyme structure: U-turn for RNA structural biology |
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| Q36369721 | High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding |
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| Q43207435 | Identification and analysis of U5 snRNA variants in Drosophila |
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| Q37144649 | Methods to crystallize RNA. |
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| Q107554526 | Molecular mechanism of off-target effects in CRISPR-Cas9 |
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| Q112280305 | Neutralizing immunity in vaccine breakthrough infections from the SARS-CoV-2 Omicron and Delta variants |
| Q34547817 | New CRISPR-Cas systems from uncultivated microbes. |
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| Q92686702 | Nontoxic nanopore electroporation for effective intracellular delivery of biological macromolecules |
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| Q36936033 | Nucleosome breathing and remodeling constrain CRISPR-Cas9 function |
| Q111271389 | Omicron mutations enhance infectivity and reduce antibody neutralization of SARS-CoV-2 virus-like particles |
| Q113281284 | Omicron mutations enhance infectivity and reduce antibody neutralization of SARS-CoV-2 virus-like particles |
| Q33812679 | Optimized high-throughput screen for hepatitis C virus translation inhibitors |
| Q50802843 | Paul Sigler (1934-2000). |
| Q46312368 | Perspective: Embryo editing needs scrutiny |
| Q95319654 | Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity |
| Q90199051 | Potent CRISPR-Cas9 inhibitors from Staphylococcus genomes |
| Q37194743 | Precise and heritable genome editing in evolutionarily diverse nematodes using TALENs and CRISPR/Cas9 to engineer insertions and deletions |
| Q80426636 | Preliminary X-ray diffraction studies of an RNA pseudoknot that inhibits HIV-1 reverse transcriptase |
| Q73469269 | Preparation of homogeneous ribozyme RNA for crystallization |
| Q34524602 | Profiling of engineering hotspots identifies an allosteric CRISPR-Cas9 switch |
| Q34676404 | Programmable RNA Tracking in Live Cells with CRISPR/Cas9. |
| Q34042210 | Programmable RNA recognition and cleavage by CRISPR/Cas9. |
| Q105179611 | Programmable RNA recognition using a CRISPR-associated Argonaute |
| Q52358392 | Programmable RNA recognition using a CRISPR-associated Argonaute. |
| Q58603906 | Programmed DNA destruction by miniature CRISPR-Cas14 enzymes |
| Q40594870 | Protecting genome integrity during CRISPR immune adaptation |
| Q37029425 | Quantitative studies of ribosome conformational dynamics |
| Q90468390 | RNA Binding and HEPN-Nuclease Activation Are Decoupled in CRISPR-Cas13a |
| Q47251389 | RNA Scanning of a Molecular Machine with a Built-in Ruler |
| Q46843134 | RNA Targeting by Functionally Orthogonal Type VI-A CRISPR-Cas Enzymes |
| Q36257710 | RNA and DNA Targeting by a Reconstituted Thermus thermophilus Type III-A CRISPR-Cas System |
| Q57250364 | RNA binding and HEPN nuclease activation are decoupled in CRISPR-Cas13a |
| Q28139993 | RNA folds: insights from recent crystal structures |
| Q46097857 | RNA processing enables predictable programming of gene expression |
| Q41560728 | RNA seeing double: close-packing of helices in RNA tertiary structure |
| Q34306843 | RNA structure, not sequence, determines the 5' splice-site specificity of a group I intron |
| Q41515759 | RNA structure: crystal clear? |
| Q28649354 | RNA targeting by the type III-A CRISPR-Cas Csm complex of Thermus thermophilus |
| Q30469007 | RNA tertiary structure mediation by adenosine platforms |
| Q39135511 | RNA-based recognition and targeting: sowing the seeds of specificity |
| Q59060299 | RNA-catalysed synthesis of complementary-strand RNA |
| Q48304493 | RNA-dependent RNA targeting by CRISPR-Cas9. |
| Q34080345 | RNA-guided assembly of Rev-RRE nuclear export complexes |
| Q35064344 | RNA-guided complex from a bacterial immune system enhances target recognition through seed sequence interactions |
| Q29614421 | RNA-guided genetic silencing systems in bacteria and archaea |
| Q46023389 | RNA-mediated interaction between the peptide-binding and GTPase domains of the signal recognition particle. |
| Q28044562 | RNA-programmed genome editing in human cells |
| Q36747563 | RNA-protein analysis using a conditional CRISPR nuclease |
| Q45974915 | RNA: primed for packing? |
| Q50705038 | RNAs regulate biology. |
| Q111271381 | Rapid assessment of SARS-CoV-2–evolved variants using virus-like particles |
| Q104563317 | Rapid detection of SARS-CoV-2 with Cas13 |
| Q34464381 | Rational design of a split-Cas9 enzyme complex |
| Q100951480 | Reactions to the National Academies/Royal Society Report on Heritable Human Genome Editing |
| Q37263726 | Real-time observation of DNA recognition and rejection by the RNA-guided endonuclease Cas9. |
| Q30409567 | Reassortment and mutation of the avian influenza virus polymerase PA subunit overcome species barriers |
| Q52431661 | Receptor-Mediated Delivery of CRISPR-Cas9 Endonuclease for Cell Type Specific Gene Editing. |
| Q39868137 | Reconsidering movement of eukaryotic mRNAs between polysomes and P bodies |
| Q37098853 | Reconstitution of selective HIV-1 RNA packaging in vitro by membrane-bound Gag assemblies |
| Q90990728 | Reply to Nathamgari et al.: Nanopore electroporation for intracellular delivery of biological macromolecules |
| Q29615784 | Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression |
| Q29031125 | Ribonuclease revisited: structural insights into ribonuclease III family enzymes |
| Q36116084 | Ribozyme catalysis: not different, just worse |
| Q28205184 | Ribozyme structures and mechanisms |
| Q34019400 | Ribozyme structures and mechanisms |
| Q38321076 | Ribozyme-catalyzed primer extension by trinucleotides: A model for the RNA-catalyzed replication of RNA |
| Q74776622 | Ribozymes: the hammerhead swings into action |
| Q36134036 | Ro's role in RNA reconnaissance |
| Q42012761 | SRP RNA provides the physiologically essential GTPase activation function in cotranslational protein targeting |
| Q27701410 | STRUCTURAL BIOLOGY. A Cas9-guide RNA complex preorganized for target DNA recognition |
| Q30463953 | Selection of an RNA molecule that mimics a major autoantigenic epitope of human insulin receptor |
| Q36316261 | Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain |
| Q30463736 | Self-assembly of a group I intron active site from its component tertiary structural domains. |
| Q27664403 | Sequence- and Structure-Specific RNA Processing by a CRISPR Endonuclease |
| Q36258984 | Single-Stranded DNA Cleavage by Divergent CRISPR-Cas9 Enzymes |
| Q100396199 | Site-Specific Bioconjugation through Enzyme-Catalyzed Tyrosine-Cysteine Bond Formation |
| Q93847128 | Site-Specific Generation of Protein-Protein Conjugates Using Native Amino Acids |
| Q73829770 | Solving large RNA structures by X-ray crystallography |
| Q91311481 | Spacer Acquisition Rates Determine the Immunological Diversity of the Type II CRISPR-Cas Immune Response |
| Q67953088 | Specificity for aminoacylation of an RNA helix: an unpaired, exocyclic amino group in the minor groove |
| Q27639511 | Specificity of RNA-RNA helix recognition |
| Q49964072 | Spotlight: A Conversation with Laura Kiessling and Jennifer Doudna |
| Q34413657 | Stereochemical course of catalysis by the Tetrahymena ribozyme |
| Q27664447 | Structural and Biochemical Studies of a Fluoroacetyl-CoA-Specific Thioesterase Reveal a Molecular Basis for Fluorine Selectivity |
| Q27630537 | Structural and energetic analysis of RNA recognition by a universally conserved protein from the signal recognition particle |
| Q27639690 | Structural and energetic analysis of metal ions essential to SRP signal recognition domain assembly |
| Q34584874 | Structural and mechanistic insights into hepatitis C viral translation initiation |
| Q83230233 | Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a |
| Q34175461 | Structural basis for CRISPR RNA-guided DNA recognition by Cascade |
| Q27655927 | Structural basis for DNase activity of a conserved protein implicated in CRISPR-mediated genome defense |
| Q28291591 | Structural basis for double-stranded RNA processing by Dicer |
| Q36092029 | Structural biology. Structures of the CRISPR-Cmr complex reveal mode of RNA target positioning |
| Q24298332 | Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry |
| Q43466402 | Structural determinants of RNA recognition and cleavage by Dicer |
| Q47809952 | Structural genomics of RNA. |
| Q33791962 | Structural insights into RNA interference |
| Q24324404 | Structural insights into RNA processing by the human RISC-loading complex |
| Q27638009 | Structural insights into group II intron catalysis and branch-site selection |
| Q27659139 | Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation |
| Q35799985 | Structural insights into the signal recognition particle |
| Q34472092 | Structural roles for human translation factor eIF3 in initiation of protein synthesis |
| Q27644035 | Structural roles of monovalent cations in the HDV ribozyme |
| Q33131259 | Structure and activity of the RNA-targeting Type III-B CRISPR-Cas complex of Thermus thermophilus |
| Q34635324 | Structure and function of the eukaryotic ribosome: the next frontier |
| Q46322369 | Structure of Dicer and mechanistic implications for RNAi |
| Q27678294 | Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity |
| Q34148968 | Structure-guided reprogramming of human cGAS dinucleotide linkage specificity |
| Q27681624 | Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation |
| Q27703932 | Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage |
| Q40114138 | Structures of the CRISPR genome integration complex |
| Q30587075 | Structures of the RNA-guided surveillance complex from a bacterial immune system |
| Q34422752 | Substrate-specific kinetics of Dicer-catalyzed RNA processing |
| Q36912488 | Substrate-specific structural rearrangements of human Dicer |
| Q36259528 | Surveillance and Processing of Foreign DNA by the Escherichia coli CRISPR-Cas System |
| Q59345201 | Systematic discovery of natural CRISPR-Cas12a inhibitors |
| Q36342240 | TRBP alters human precursor microRNA processing in vitro |
| Q91665478 | Target preference of Type III-A CRISPR-Cas complexes at the transcription bubble |
| Q33878793 | Targeted gene knock-in by homology-directed genome editing using Cas9 ribonucleoprotein and AAV donor delivery |
| Q115763562 | Targeting and Degradation of Viral DNA by the CRISPR-Cas System of Escherichia Coli |
| Q90813733 | Temperature-Responsive Competitive Inhibition of CRISPR-Cas9 |
| Q36697760 | Template-directed primer extension catalyzed by the Tetrahymena ribozyme |
| Q33718286 | Tertiary Motifs in RNA Structure and Folding |
| Q27666996 | The Crystal Structure of the Signal Recognition Particle in Complex with Its Receptor |
| Q34002207 | The HCV IRES pseudoknot positions the initiation codon on the 40S ribosomal subunit |
| Q73259438 | The P4-P6 domain directs higher order folding of the Tetrahymena ribozyme core |
| Q38314751 | The P5abc peripheral element facilitates preorganization of the tetrahymena group I ribozyme for catalysis |
| Q59737903 | The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders |
| Q30309627 | The chemical repertoire of natural ribozymes |
| Q42995296 | The hepatitis C virus internal ribosome entry site adopts an ion-dependent tertiary fold |
| Q24302384 | The j-subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40 S ribosomal subunits in vitro |
| Q74546400 | The parallel universe of RNA folding |
| Q27488440 | The pathway of hepatitis C virus mRNA recruitment to the human ribosome |
| Q89686956 | The promise and challenge of therapeutic genome editing |
| Q40824294 | The stem-loop binding protein forms a highly stable and specific complex with the 3' stem-loop of histone mRNAs |
| Q35561686 | The structural biology of CRISPR-Cas systems |
| Q28603873 | Tunable protein synthesis by transcript isoforms in human cells |
| Q28118899 | Two RNA-binding motifs in eIF3 direct HCV IRES-dependent translation |
| Q41558629 | Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection |
| Q34328215 | Unconventional miR-122 binding stabilizes the HCV genome by forming a trimolecular RNA structure |
| Q39715689 | Use of cis- and trans-ribozymes to remove 5' and 3' heterogeneities from milligrams of in vitro transcribed RNA. |
| Q38873147 | Voices of biotech |
| Q46308340 | Widespread Translational Remodeling during Human Neuronal Differentiation |
| Q37133172 | dsRNA with 5' overhangs contributes to endogenous and antiviral RNA silencing pathways in plants |
| Q28118876 | eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation |
| Q34641203 | eIF3j is located in the decoding center of the human 40S ribosomal subunit |
| Q35128519 | siRNA repositioning for guide strand selection by human Dicer complexes |
| Q122115536 | Prolomený kód života: Jennifer Doudnaová, genetické inženýrství a budoucnost lidstva |
| Q87714788 | A Conversation with Jennifer Doudna |
| Q34553023 | Biography of Jennifer A. Doudna |
| Q97523564 | Forum: CRISPR roundtable with Doudna and Liu |
| Q94948718 | Jennifer Doudna |
| Q88598296 | Jennifer Doudna: Tailoring the Genome |
| Q37173166 | QnAs with Jennifer Doudna |
| Q106008008 | The Code Breaker |
| Q102941359 | Akshay Tambe | doctoral advisor | P184 |
| Q104600 | Jack Szostak | doctoral student | P185 |
| Q87623216 | Jamie H. D. Cate | spouse | P26 |
| Q54621387 | Intellia Therapeutics | discoverer or inventor | P61 |
| Q458338 | Paul Ehrlich and Ludwig Darmstaedter Prize | winner | P1346 |
| Q110268242 | Category:Jennifer Doudna | category's main topic | P301 |
| Q333718 | Johnson & Johnson | board member | P3320 |
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