Facilitated Diffusion Mechanisms in DNA Base Excision Repair and Transcriptional Activation

scientific article published on 31 October 2018

Facilitated Diffusion Mechanisms in DNA Base Excision Repair and Transcriptional Activation is …
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P356DOI10.1021/ACS.CHEMREV.8B00513
P932PMC publication ID6504930
P698PubMed publication ID30379068

P50authorJames T StiversQ88361476
P2093author name stringAlexandre Esadze
P2860cites workhUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backupQ24303661
Post-replicative base excision repair in replication fociQ24534209
How do site-specific DNA-binding proteins find their targets?Q24563835
HMDB 3.0--The Human Metabolome Database in 2013Q24595162
Nuclear and mitochondrial forms of human uracil-DNA glycosylase are encoded by the same geneQ24633708
Macromolecular crowding and confinement: biochemical, biophysical, and potential physiological consequencesQ24644640
Molecular basis for discriminating between normal and damaged bases by the human alkyladenine glycosylase, AAGQ24669704
DNA glycosylases: in DNA repair and beyondQ26830166
What macromolecular crowding can do to a proteinQ27012942
Single-molecule visualization of RecQ helicase reveals DNA melting, nucleation, and assembly are required for processive DNA unwindingQ27318290
Crystal structure of Escherichia coli uracil DNA glycosylase and its complexes with uracil and glycerol: structure and glycosylase mechanism revisitedQ27617728
Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNAQ27621681
Structure of hybrid backbone methylphosphonate DNA heteroduplexes: effect of R and S stereochemistryQ27637290
Product-assisted catalysis in base-excision DNA repairQ27640521
Electrostatic guidance of glycosyl cation migration along the reaction coordinate of uracil DNA glycosylaseQ27642424
Enzymatic capture of an extrahelical thymine in the search for uracil in DNAQ27647377
Structural Basis for the Inhibition of Human Alkyladenine DNA Glycosylase (AAG) by 3,N4-Ethenocytosine-containing DNAQ27667051
Searching for DNA Lesions: Structural Evidence for Lower- and Higher-Affinity DNA Binding Conformations of Human Alkyladenine DNA GlycosylaseQ27676011
Structural basis of damage recognition by thymine DNA glycosylase: Key roles for N-terminal residuesQ27727975
Zif268 protein-DNA complex refined at 1.6 A: a model system for understanding zinc finger-DNA interactionsQ27733960
Cell cycle checkpoint in cancer: a therapeutically targetable double-edged swordQ28078268
Base Excision Repair, a Pathway Regulated by Posttranslational ModificationsQ28078441
3-methyladenine DNA glycosylases: structure, function, and biological importanceQ28141634
The influence of macromolecular crowding and macromolecular confinement on biochemical reactions in physiological mediaQ28209077
DNA translocation by human uracil DNA glycosylase: role of DNA phosphate chargeQ36774056
DNA translocation by human uracil DNA glycosylase: the case of single-stranded DNA and clustered uracilsQ36790722
Uracil DNA glycosylase uses DNA hopping and short-range sliding to trap extrahelical uracilsQ36825207
Global jumping and domain-specific intersegment transfer between DNA cognate sites of the multidomain transcription factor Oct-1.Q36893573
Extrahelical damaged base recognition by DNA glycosylase enzymesQ37000640
Isolating contributions from intersegmental transfer to DNA searching by alkyladenine DNA glycosylase.Q37112676
Base excision repairQ28288115
Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteinsQ28291920
Control of cell cycle transcription during G1 and S phasesQ28295030
Human alkyladenine DNA glycosylase employs a processive search for DNA damageQ28296242
A sequence in the N-terminal region of human uracil-DNA glycosylase with homology to XPA interacts with the C-terminal part of the 34-kDa subunit of replication protein AQ28304314
JASPAR: an open-access database for eukaryotic transcription factor binding profilesQ29614419
Base-excision repair of oxidative DNA damageQ29615373
A base-excision DNA-repair protein finds intrahelical lesion bases by fast sliding in contact with DNA.Q30477242
Nontarget DNA binding shapes the dynamic landscape for enzymatic recognition of DNA damageQ30488332
Visualizing helicases unwinding DNA at the single molecule levelQ30495681
Crowding and hydrodynamic interactions likely dominate in vivo macromolecular motionQ30497258
A benchmark for chromatin binding measurements in live cells.Q30524321
Visualizing protein movement on DNA at the single-molecule level using DNA curtainsQ30585002
Probing the target search of DNA-binding proteins in mammalian cells using TetR as model searcherQ30658188
Structural basis of human PCNA sliding on DNA.Q30834894
Kinetic mechanism of damage site recognition and uracil flipping by Escherichia coli uracil DNA glycosylaseQ31931744
Rates of base excision repair are not solely dependent on levels of initiating enzymesQ32128607
Microscopic viscosity and rotational diffusion of proteins in a macromolecular environmentQ33178223
Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA.Q33310273
Computational models for large-scale simulations of facilitated diffusionQ33556999
Specific cellular water dynamics observed in vivo by neutron scattering and NMR.Q33660348
Positive and negative impacts of nonspecific sites during target location by a sequence-specific DNA-binding protein: origin of the optimal search at physiological ionic strength.Q33791313
Hopping enables a DNA repair glycosylase to search both strands and bypass a bound protein.Q33819477
Single-molecule analysis of steroid receptor and cofactor action in living cells.Q33827904
Ultrafast redistribution of E. coli SSB along long single-stranded DNA via intersegment transferQ33895798
Nonspecifically bound proteins spin while diffusing along DNA.Q33929106
Sp1 and krüppel-like factor family of transcription factors in cell growth regulation and cancerQ33952921
Base excision repair of DNA in mammalian cellsQ33957142
Microscopic mechanism of DNA damage searching by hOGG1Q34044395
Phosphate backbone neutralization increases duplex DNA flexibility: a model for protein bindingQ34046682
Egr-1: is it always immediate and early?Q34076135
Measurement of the contributions of 1D and 3D pathways to the translocation of a protein along DNA.Q34091428
Absence of a simple code: how transcription factors read the genomeQ34111752
Macromolecular crowding: an important but neglected aspect of the intracellular environmentQ34141548
Facilitated diffusion with DNA coiling.Q37208544
Artemis is a negative regulator of p53 in response to oxidative stressQ37216943
DNA repair in mammalian cells: Base excision repair: the long and short of it.Q37372532
An end to 40 years of mistakes in DNA-protein association kinetics?Q37416158
The Role of Early Growth Response 1 (EGR1) in Brain Plasticity and Neuropsychiatric DisordersQ37681295
Detection of damaged DNA bases by DNA glycosylase enzymesQ37752315
Physics of protein–DNA interactions: mechanisms of facilitated target searchQ37813036
Intrinsically disordered regions as affinity tuners in protein-DNA interactionsQ37932415
Early growth response 1--a transcription factor in the crossfire of signal transduction cascadesQ37952759
Classes of fast and specific search mechanisms for proteins on DNA.Q38025896
Quantifying transcription factor kinetics: at work or at play?Q38136333
Characterization of nonspecific protein-DNA interactions by 1H paramagnetic relaxation enhancement.Q38335719
Crowding and confinement effects on protein diffusion in vivoQ38501075
Disordered N-Terminal Domain of Human Uracil DNA Glycosylase (hUNG2) Enhances DNA Translocation.Q38634601
Investigation of N-Terminal Phospho-Regulation of Uracil DNA Glycosylase Using Protein SemisynthesisQ38659891
Hide and seek: How do DNA glycosylases locate oxidatively damaged DNA bases amidst a sea of undamaged bases?Q39014392
Nuclear and mitochondrial splice forms of human uracil-DNA glycosylase contain a complex nuclear localisation signal and a strong classical mitochondrial localisation signal, respectivelyQ39725305
Kinetics of protein-nucleic acid interactions: use of salt effects to probe mechanisms of interactionQ39727763
Thermodynamic analysis of ion effects on the binding and conformational equilibria of proteins and nucleic acids: the roles of ion association or release, screening, and ion effects on water activityQ39750512
Diffusion-controlled macromolecular interactionsQ39821984
Kinetics of protein-DNA interaction: facilitated target location in sequence-dependent potentialQ40308402
One- and three-dimensional pathways for proteins to reach specific DNA sitesQ40388353
Obstacles may facilitate and direct DNA search by proteinsQ40495004
Timing facilitated site transfer of an enzyme on DNAQ40531695
The dynamics of eukaryotic replication initiation: origin specificity, licensing, and firing at the single-molecule level.Q40541137
Comparative Effects of Ions, Molecular Crowding, and Bulk DNA on the Damage Search Mechanisms of hOGG1 and hUNG.Q41299404
Live-cell p53 single-molecule binding is modulated by C-terminal acetylation and correlates with transcriptional activity.Q41488339
A dynamic mode of mitotic bookmarking by transcription factorsQ41809452
Electrostatic properties of complexes along a DNA glycosylase damage search pathwayQ41844655
Generalized facilitated diffusion model for DNA-binding proteins with search and recognition statesQ42171094
Common crowding agents have only a small effect on protein-protein interactionsQ42629355
Protein-protein association in polymer solutions: from dilute to semidilute to concentratedQ42826492
MEASUREMENT of Protein 53 Diffusion Coefficient in Live HeLa Cells Using Raster Image Correlation Spectroscopy (RICS).Q42847084
Search by proteins for their DNA target site: 2. The effect of DNA conformation on the dynamics of multidomain proteinsQ42999182
Macromolecular diffusion in crowded solutionsQ43006058
Direct visualization of a DNA glycosylase searching for damageQ43943026
An evolutionary analysis of the helix-hairpin-helix superfamily of DNA repair glycosylasesQ44495541
Proteolytic degradation of the nuclear isoform of uracil-DNA glycosylase occurs during the S phase of the cell cycleQ44844586
Stopped-flow fluorescence kinetic study of protein sliding and intersegment transfer in the target DNA search processQ44948975
p53 linear diffusion along DNA requires its C terminusQ45138454
Structures of end products resulting from lesion processing by a DNA glycosylase/lyaseQ45195481
Correlated cleavage of damaged DNA by bacterial and human 8-oxoguanine-DNA glycosylasesQ46450712
Measurement of nanoscale DNA translocation by uracil DNA glycosylase in human cellsQ47156991
Effect of crowding on protein-protein association rates: fundamental differences between low and high mass crowding agentsQ47736902
Putting p53 in ContextQ47833426
Backbone (1)H, (13)C and (15)N chemical shift assignment of full-length human uracil DNA glycosylase UNG2.Q47844295
The Disordered Linker in p53 Participates in Nonspecific Binding to and One-Dimensional Sliding along DNA Revealed by Single-Molecule Fluorescence MeasurementsQ47912513
A Requirement for the Immediate Early Gene zif268 in Reconsolidation of Recognition Memory after RetrievalQ48143332
Visualizing transcription factor dynamics in living cells.Q48148108
Single-particle trajectories reveal two-state diffusion-kinetics of hOGG1 proteins on DNA.Q50089806
The Human Transcription FactorsQ50098118
Spatial distribution of competing ions around DNA in solution.Q51543158
Regulation of DNA binding of p53 by its C-terminal domain.Q51624447
Activation of p53 Facilitates the Target Search in DNA by Enhancing the Target Recognition Probability.Q51707194
The effects of intersegmental transfers on target location by proteins.Q51856018
Diffusion-driven mechanisms of protein translocation on nucleic acids. 1. Models and theory.Q52732418
One-Dimensional Sliding of p53 Along DNA Is Accelerated in the Presence of Ca(2+) or Mg(2+) at Millimolar Concentrations.Q53190488
Dynamic interactions of p53 with DNA in solution by time-lapse atomic force microscopyQ57188522
Imaging dynamic and selective low-complexity domain interactions that control gene transcriptionQ57979132
Direct Observation of Enhanced Translocation of a Homeodomain between DNA Cognate Sites by NMR Exchange SpectroscopyQ58443617
Facilitated diffusion during catalysis by EcoRI endonuclease. Nonspecific interactions in EcoRI catalysisQ70105786
Salt dependence of the kinetics of the lac repressor-operator interaction: role of nonoperator deoxyribonucleic acid in the association reactionQ70174498
Egr-1-induced endothelial gene expression: a common theme in vascular injuryQ70990718
Protein sliding along DNA: dynamics and structural characterizationQ82851590
Dynamics of E. coli single stranded DNA binding (SSB) protein-DNA complexesQ88194032
NMR-based investigations into target DNA search processes of proteinsQ88647725
N-terminal domain of human uracil DNA glycosylase (hUNG2) promotes targeting to uracil sites adjacent to ssDNA-dsDNA junctionsQ89149291
Distinguishing Specific and Nonspecific Complexes of Alkyladenine DNA GlycosylaseQ89234745
Intrinsically disordered domain of tumor suppressor p53 facilitates target search by ultrafast transfer between different DNA strandsQ89475634
New Insights into the Role of DNA Shape on Its Recognition by p53 ProteinsQ90596330
Uracil in DNA--occurrence, consequences and repairQ34165028
A model for the mediation of processivity of DNA-targeting proteins by nonspecific binding: dependence on DNA length and presence of obstaclesQ34189290
Visualizing one-dimensional diffusion of eukaryotic DNA repair factors along a chromatin latticeQ34193203
DNA search efficiency is modulated by charge composition and distribution in the intrinsically disordered tailQ34397079
Structure of a repair enzyme interrogating undamaged DNA elucidates recognition of damaged DNA.Q34407601
Connecting the dots: the effects of macromolecular crowding on cell physiology.Q34454279
A single-molecule characterization of p53 search on DNAQ34490695
Probing transcription factor dynamics at the single-molecule level in a living cellQ34631575
The DNA binding activity of p53 displays reaction-diffusion kinetics.Q34680338
Interpreting protein/DNA interactions: distinguishing specific from non-specific and electrostatic from non-electrostatic componentsQ34779522
Effect of the thymidylate synthase inhibitors on dUTP and TTP pool levels and the activities of DNA repair glycosylases on uracil and 5-fluorouracil in DNA.Q34782000
Dynamics of uracil and 5-fluorouracil in DNA.Q34813962
Probing the DNA structural requirements for facilitated diffusion.Q35001072
Awakening guardian angels: drugging the p53 pathwayQ35014385
Intra- and intermolecular translocation of the bi-domain transcription factor Oct1 characterized by liquid crystal and paramagnetic NMR.Q35021954
A nucleobase lesion remodels the interaction of its normal neighbor in a DNA glycosylase complex.Q35108052
NMR structural and kinetic characterization of a homeodomain diffusing and hopping on nonspecific DNA.Q35108070
Protein self-diffusion in crowded solutionsQ35123303
A mechanistic perspective on the chemistry of DNA repair glycosylasesQ35171800
Exploring translocation of proteins on DNA by NMRQ35517617
Molecular crowding enhances facilitated diffusion of two human DNA glycosylasesQ35562174
Determining the Locations of Ions and Water around DNA from X-Ray Scattering MeasurementsQ35666406
Single Cell Assay for Molecular Diagnostics and Medicine: Monitoring Intracellular Concentrations of Macromolecules by Two-photon Fluorescence Lifetime ImagingQ35686254
Quantitative Aspects of Single Molecule MicroscopyQ35826411
Surf the post-translational modification network of p53 regulationQ35967111
Balancing between affinity and speed in target DNA search by zinc-finger proteins via modulation of dynamic conformational ensembleQ36079071
Dancing on DNA: kinetic aspects of search processes on DNAQ36110835
Enforced presentation of an extrahelical guanine to the lesion recognition pocket of human 8-oxoguanine glycosylase, hOGG1.Q36127010
Influence of quasi-specific sites on kinetics of target DNA search by a sequence-specific DNA-binding proteinQ36272461
Repair of Alkylation Damage in Eukaryotic Chromatin Depends on Searching Ability of Alkyladenine DNA GlycosylaseQ36496110
Evidence for a common mode of transcription factor interaction with chromatin as revealed by improved quantitative fluorescence recovery after photobleaching.Q36510561
Optical Methods to Study Protein-DNA Interactions in Vitro and in Living Cells at the Single-Molecule Level.Q36656166
Tumor suppressor p53 slides on DNA with low friction and high stabilityQ36717623
Spatial effects on the speed and reliability of protein-DNA searchQ36740092
P433issue23
P407language of work or nameEnglishQ1860
P304page(s)11298-11323
P577publication date2018-10-31
P1433published inChemical ReviewsQ900502
P1476titleFacilitated Diffusion Mechanisms in DNA Base Excision Repair and Transcriptional Activation
P478volume118

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Q92835742Understanding biochemical processes in the presence of sub-diffusive behavior of biomolecules in solution and living cellscites workP2860

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