Abstract is: Ian Tomlinson FRS FMedSci is a director of the Institute of Cancer and Genomic Sciences at the University of Birmingham.
| human | Q5 |
| P2070 | Fellow of the Royal Society ID | 14131 |
| P8446 | Gateway to Research person ID | C68CD318-44D7-4513-B052-152D9FD9BA49 |
| P227 | GND ID | 102193870X |
| P2671 | Google Knowledge Graph ID | /g/11h8bs0tv8 |
| P213 | ISNI | 0000000135347694 |
| P549 | Mathematics Genealogy Project ID | 240608 |
| P496 | ORCID iD | 0000-0003-3037-1470 |
| P1153 | Scopus author ID | 7103338177 |
| P214 | VIAF ID | 316463491 |
| P4789 | Who's Who UK ID | U292883 |
| P166 | award received | Fellow of the Royal Society | Q15631401 |
| Fellow of the Academy of Medical Sciences | Q24081923 | ||
| Fellow of the Royal College of Pathologists | Q30337212 | ||
| P185 | doctoral student | Trevor Graham | Q103015578 |
| Lisa Willis | Q103015603 | ||
| Christopher Hornsby | Q103015649 | ||
| P734 | family name | Tomlinson | Q21450746 |
| Tomlinson | Q21450746 | ||
| Tomlinson | Q21450746 | ||
| P101 | field of work | colorectal cancer | Q188874 |
| P735 | given name | Ian | Q18336315 |
| Ian | Q18336315 | ||
| P463 | member of | Royal Society | Q123885 |
| P106 | occupation | researcher | Q1650915 |
| P21 | sex or gender | male | Q6581097 |
| Q56675475 | 'Toxgnostics': an unmet need in cancer medicine |
| Q36016386 | 11q13 is a susceptibility locus for hormone receptor positive breast cancer |
| Q35871567 | 19p13.1 is a triple-negative-specific breast cancer susceptibility locus |
| Q38325322 | 7q deletion mapping and expression profiling in uterine fibroids. |
| Q37169873 | 9q31.2-rs865686 as a susceptibility locus for estrogen receptor-positive breast cancer: evidence from the Breast Cancer Association Consortium |
| Q37005064 | A Common Variant at the 14q32 Endometrial Cancer Risk Locus Activates AKT1 through YY1 Binding |
| Q28709909 | A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts |
| Q28652720 | A candidate gene study of capecitabine-related toxicity in colorectal cancer identifies new toxicity variants at DPYD and a putative role for ENOSF1 rather than TYMS |
| Q34563854 | A colorectal cancer genome-wide association study in a Spanish cohort identifies two variants associated with colorectal cancer risk at 1p33 and 8p12. |
| Q35755874 | A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer |
| Q53434280 | A comparison of the genetic pathways involved in the pathogenesis of three types of colorectal cancer. |
| Q46046714 | A comparison of the phenotype and genotype in adenomatous polyposis patients with and without a family history |
| Q50645407 | A comprehensive genetic profile of phyllodes tumours of the breast detects important mutations, intra-tumoral genetic heterogeneity and new genetic changes on recurrence. |
| Q37205060 | A comprehensive study of chromosome 16q in invasive ductal and lobular breast carcinoma using array CGH. |
| Q80488916 | A family with juvenile polyposis linked to the BMPR1A locus: cryptic mutation or closely linked gene? |
| Q57078703 | A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21 |
| Q33747778 | A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2. |
| Q29417084 | A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24. |
| Q57319748 | A genome-wide association study of tag SNPs identify five novel colorectal cancer susceptibility loci |
| Q50483571 | A genome-wide association study on copy-number variation identifies a 11q11 loss as a candidate susceptibility variant for colorectal cancer. |
| Q57092250 | A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk |
| Q34327333 | A genome-wide scan of 10 000 gene-centric variants and colorectal cancer risk |
| Q55462775 | A genome-wide scan of 10 000 gene-centric variants and colorectal cancer risk. |
| Q37619303 | A large-scale assessment of two-way SNP interactions in breast cancer susceptibility using 46,450 cases and 42,461 controls from the breast cancer association consortium |
| Q34433744 | A large-scale meta-analysis to refine colorectal cancer risk estimates associated with MUTYH variants |
| Q33465307 | A mitotic recombination map proximal to the APC locus on chromosome 5q and assessment of influences on colorectal cancer risk |
| Q33677191 | A modifying locus for familial adenomatous polyposis may be present on chromosome 1p35-p36 |
| Q92711687 | A network analysis to identify mediators of germline-driven differences in breast cancer prognosis |
| Q35626744 | A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer |
| Q51930741 | A nonlinear mathematical model of cell turnover, differentiation and tumorigenesis in the intestinal crypt. |
| Q83879729 | A novel exon duplication event leading to a truncating germ-line mutation of the APC gene in a familial adenomatous polyposis family |
| Q30581337 | A novel test for gene-ancestry interactions in genome-wide association data |
| Q28272700 | A panoply of errors: polymerase proofreading domain mutations in cancer |
| Q57337215 | A pericentric inversion of chromosome six in a patient with Peutz-Jeghers' syndrome and the use of FISH to localise the breakpoints on a genetic map |
| Q38965170 | A polymorphic enhancer near GREM1 influences bowel cancer risk through differential CDX2 and TCF7L2 binding |
| Q34228309 | A polymorphic p53 response element in KIT ligand influences cancer risk and has undergone natural selection |
| Q104475253 | A sensitive and affordable multiplex RT-qPCR assay for SARS-CoV-2 detection |
| Q28119198 | A serine/threonine kinase gene defective in Peutz-Jeghers syndrome |
| Q34514570 | A study of genomic instability in early preneoplastic colonic lesions. |
| Q35218636 | A systematic review and meta-analysis of somatic and germline DNA sequence biomarkers of esophageal cancer survival, therapy response and stage |
| Q33979369 | A two-phase case-control study for colorectal cancer genetic susceptibility: candidate genes from chromosomal regions 9q22 and 3q22. |
| Q39932292 | APC and the three-hit hypothesis |
| Q47767290 | APC mutation spectrum in ileoanal pouch polyps resembles that of colorectal polyps |
| Q35051664 | APC mutations are sufficient for the growth of early colorectal adenomas |
| Q42604858 | APC mutations in FAP-associated desmoid tumours are non-random but not 'just right'. |
| Q35110017 | APC mutations in sporadic colorectal tumors: A mutational "hotspot" and interdependence of the "two hits" |
| Q94352344 | AT-43MULTI-CENTRE, RANDOMIZED, DOUBLE-BLIND PHASE II STUDY COMPARING CEDIRANIB (AZD2171) PLUS GEFITINIB (IRESSA, ZD1839) WITH CEDIRANIB PLUS PLACEBO IN SUBJECTS WITH RECURRENT/PROGRESSIVE GLIOBLASTOMA |
| Q41263199 | Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche |
| Q38436143 | Aberrant expression of apoptosis proteins and ultrastructural aberrations in uterine leiomyomas from patients with hereditary leiomyomatosis and renal cell carcinoma. |
| Q39743943 | Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status |
| Q57319547 | Abstract P3-08-04: Impact of CYP3A variation on estrone levels and breast cancer risk |
| Q46575022 | Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations |
| Q39359690 | Adjuvant capecitabine plus bevacizumab versus capecitabine alone in patients with colorectal cancer (QUASAR 2): an open-label, randomised phase 3 trial |
| Q52430911 | Adjuvant treatment for POLE proofreading domain-mutant cancers: sensitivity to radiotherapy, chemotherapy, and nucleoside analogs. |
| Q58327512 | Adult Leydig Cell Tumors of the Testis Caused by Germline Fumarate Hydratase Mutations |
| Q39437211 | Age- and Tumor Subtype-Specific Breast Cancer Risk Estimates for CHEK2*1100delC Carriers |
| Q36620205 | Allele loss and mutation screen at the Peutz-Jeghers (LKB1) locus (19p13.3) in sporadic ovarian tumours. |
| Q54561640 | Allele loss in colorectal cancer at the Cowden disease/juvenile polyposis locus on 10q. |
| Q40002286 | Allele loss occurs frequently at hMLH1, but rarely at hMSH2, in sporadic colorectal cancers with microsatellite instability |
| Q57337217 | Allele loss on chromosome 11q and microsatellite instability in malignant melanoma |
| Q42581092 | Allele loss, replication errors and loss of expression of E-cadherin in colorectal cancers |
| Q77364823 | Allelic imbalance analysis of chromosome 16q shows that grade I and grade III invasive ductal breast cancers follow different genetic pathways |
| Q54190005 | Allelic imbalance at the LKB1 (STK11) locus in tumours from patients with Peutz-Jeghers' syndrome provides evidence for a hamartoma-(adenoma)-carcinoma sequence. |
| Q57742283 | Allelic loss at SMAD4 in polyps from juvenile polyposis patients and use of fluorescence in situ hybridization to demonstrate clonal origin of the epithelium |
| Q31160002 | Allelic loss studies do not provide evidence for the "endometriosis-as-tumor" theory |
| Q64258313 | An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance |
| Q33904733 | An ancestral Ashkenazi haplotype at the HMPS/CRAC1 locus on 15q13-q14 is associated with hereditary mixed polyposis syndrome |
| Q90359296 | An evaluation of the clinical utility of a panel of variants in DPYD and ENOSF1 for predicting common capecitabine related toxicities |
| Q36073563 | An intergenic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating IGFBP5 expression |
| Q35883287 | An update on the genetics of colorectal cancer |
| Q35921785 | Analyses of 7,635 Patients with Colorectal Cancer Using Independent Training and Validation Cohorts Show That rs9929218 in CDH1 Is a Prognostic Marker of Survival |
| Q43003884 | Analysis of candidate modifier loci for the severity of colonic familial adenomatous polyposis, with evidence for the importance of the N-acetyl transferases |
| Q34430311 | Analysis of chromosomal instability in human colorectal adenomas with two mutational hits at APC. |
| Q39814868 | Analysis of copy number changes suggests chromosomal instability in a minority of large colorectal adenomas |
| Q35359948 | Analysis of genetic and phenotypic heterogeneity in juvenile polyposis |
| Q40483032 | Analysis of ovarian cancer cell lines using array-based comparative genomic hybridization. |
| Q35447238 | Analysis of somatic molecular changes, clinicopathological features, family history, and germline mutations in colorectal cancer families: evidence for efficient diagnosis of HNPCC and for the existence of distinct groups of non-HNPCC families |
| Q35566216 | Apparent Mendelian inheritance of breast and colorectal cancer: chance, genetic heterogeneity or a new gene? |
| Q59238327 | Are we there yet? |
| Q40534910 | Array comparative genomic hybridization analysis of colorectal cancer cell lines and primary carcinomas |
| Q80975676 | Array-CGH analysis of microsatellite-stable, near-diploid bowel cancers and comparison with other types of colorectal carcinoma |
| Q97070156 | Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers |
| Q64056497 | Association analyses identify 31 new risk loci for colorectal cancer susceptibility |
| Q45979098 | Association analysis identifies 65 new breast cancer risk loci. |
| Q30800931 | Association analysis using next-generation sequence data from publicly available control groups: the robust variance score statistic |
| Q37499529 | Association between CASP8 -652 6N del polymorphism (rs3834129) and colorectal cancer risk: results from a multi-centric study |
| Q37118308 | Association between chromosomal instability and prognosis in colorectal cancer: a meta-analysis |
| Q37684672 | Association of breast cancer risk with genetic variants showing differential allelic expression: Identification of a novel breast cancer susceptibility locus at 4q21. |
| Q37268494 | Association of genetic susceptibility variants for type 2 diabetes with breast cancer risk in women of European ancestry |
| Q35022847 | Associations of breast cancer risk factors with tumor subtypes: a pooled analysis from the Breast Cancer Association Consortium studies |
| Q35532898 | Associations of common variants at 1p11.2 and 14q24.1 (RAD51L1) with breast cancer risk and heterogeneity by tumor subtype: findings from the Breast Cancer Association Consortium |
| Q45403384 | Attenuated familial adenomatous polyposis: results from an international collaborative study |
| Q88742240 | Author Correction: Telomere length and genetics are independent colorectal tumour risk factors in an evaluation of biomarkers in normal bowel |
| Q92093535 | Author Correction: The effects of mutational processes and selection on driver mutations across cancer types |
| Q28468367 | BCL9L Dysfunction Impairs Caspase-2 Expression Permitting Aneuploidy Tolerance in Colorectal Cancer |
| Q44820137 | BMP2/BMP4 colorectal cancer susceptibility loci in northern and southern European populations |
| Q38914005 | BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer |
| Q37002955 | BRCA2 Polymorphic Stop Codon K3326X and the Risk of Breast, Prostate, and Ovarian Cancers |
| Q42049565 | Bcl-2 expression in colorectal tumors: evidence of different pathways in sporadic and ulcerative-colitis-associated carcinomas |
| Q47715267 | Beta-catenin abnormalities and associated insulin-like growth factor overexpression are important in phyllodes tumours and fibroadenomas of the breast |
| Q53390837 | Beta-catenin expression and allelic loss at APC in sporadic colorectal carcinogenesis. |
| Q36586200 | Beta-catenin mutations in cell lines established from human colorectal cancers |
| Q46115524 | Body mass index and breast cancer survival: a Mendelian randomization analysis |
| Q38712111 | Bone morphogenetic protein and Notch signalling crosstalk in poor-prognosis, mesenchymal-subtype colorectal cancer. |
| Q73608628 | Bottom-up histogenesis of colorectal adenomas: origin in the monocryptal adenoma and initial expansion by crypt fission |
| Q100457582 | Breast Cancer Polygenic Risk Score and Contralateral Breast Cancer Risk |
| Q43754455 | Breast cancer dormancy can be maintained by small numbers of micrometastases. |
| Q35940158 | Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170. |
| Q35562912 | Breast cancer susceptibility polymorphisms and endometrial cancer risk: a Collaborative Endometrial Cancer Study |
| Q38690051 | British Society of Gastroenterology position statement on serrated polyps in the colon and rectum |
| Q36615641 | CASP8 variants D302H and -652 6N ins/del do not influence the risk of colorectal cancer in the United Kingdom population |
| Q37138668 | CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer |
| Q54451003 | CD24 is upregulated in inflammatory bowel disease and stimulates cell motility and colony formation. |
| Q46853162 | CDC4 mutations occur in a subset of colorectal cancers but are not predicted to cause loss of function and are not associated with chromosomal instability |
| Q41262162 | CDC4/FBXW7 and the 'just enough' model of tumourigenesis |
| Q43202513 | CDX2 mutations do not account for juvenile polyposis or Peutz-Jeghers syndrome and occur infrequently in sporadic colorectal cancers |
| Q57337219 | CLINICO-PATHOLOGICAL FEATURES AND p53 EXPRESSION IN LEFT-SIDED SPORADIC COLORECTAL CANCERS WITH AND WITHOUT MICROSATELLITE INSTABILITY |
| Q33630773 | COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer. |
| Q91335852 | CRISPR-Cas9 Causes Chromosomal Instability and Rearrangements in Cancer Cell Lines, Detectable by Cytogenetic Methods |
| Q36419325 | CYP19A1 fine-mapping and Mendelian randomization: estradiol is causal for endometrial cancer |
| Q44288178 | CYP3A variation, premenopausal estrone levels, and breast cancer risk |
| Q39012229 | Cancer predisposition syndromes: lessons for truly precision medicine |
| Q53261132 | Cancer. The utility of mouse models in post-GWAS research. |
| Q38257835 | Cancer: evolution within a lifetime |
| Q28385765 | Candidate locus analysis of the TERT-CLPTM1L cancer risk region on chromosome 5p15 identifies multiple independent variants associated with endometrial cancer risk |
| Q28186388 | Carcinogenesis in MYH-associated polyposis follows a distinct genetic pathway |
| Q57320090 | Carney Complex, Peutz-Jeghers Syndrome, Cowden Disease, and Bannayan-Zonana Syndrome Share Cutaneous and Endocrine Manifestations, But Not Genetic Loci |
| Q52185208 | Carney complex, Peutz-Jeghers syndrome, Cowden disease, and Bannayan-Zonana syndrome share cutaneous and endocrine manifestations, but not genetic loci. |
| Q39340083 | Cells lacking the fumarase tumor suppressor are protected from apoptosis through a hypoxia-inducible factor-independent, AMPK-dependent mechanism |
| Q38324266 | Cells with pathogenic biallelic mutations in the human MUTYH gene are defective in DNA damage binding and repair |
| Q50198699 | Chromatin organisation and cancer prognosis: a pan-cancer study. |
| Q33833372 | Chromosomal instability confers intrinsic multidrug resistance. |
| Q36455156 | Chromosomal instability, colorectal cancer and taxane resistance |
| Q37217138 | Chromosome 11q in sporadic colorectal carcinoma: patterns of allele loss and their significance for tumorigenesis |
| Q51673997 | Chromosome 8q23.3 and 11q23.1 variants modify colorectal cancer risk in Lynch syndrome. |
| Q57337209 | Clinical and molecular features of the hereditary mixed polyposis syndrome |
| Q36279825 | Clinical applicability and cost of a 46-gene panel for genomic analysis of solid tumours: Retrospective validation and prospective audit in the UK National Health Service. |
| Q57337210 | Clinical features and molecular analysis of a family with multiple colon tumours and reduced plasminogen activator activity |
| Q81425828 | Clinical features of multiple cutaneous and uterine leiomyomatosis: an underdiagnosed tumor syndrome |
| Q62978110 | Clinical management of hereditary colorectal cancer syndromes |
| Q37328811 | Clinical manifestations of colorectal cancer patients from a large multicenter study in Colombia. |
| Q31027996 | Clinical relevance of DPYD variants c.1679T>G, c.1236G>A/HapB3, and c.1601G>A as predictors of severe fluoropyrimidine-associated toxicity: a systematic review and meta-analysis of individual patient data |
| Q52611832 | Clinically actionable mutation profiles in patients with cancer identified by whole-genome sequencing. |
| Q58104113 | Clonality Assessment and Clonal Ordering of Individual Neoplastic Crypts Shows Polyclonality of Colorectal Adenomas |
| Q39209421 | Cluster-randomised non-inferiority trial comparing DVD-assisted and traditional genetic counselling in systematic population testing for BRCA1/2 mutations |
| Q57319701 | Colorectal Cancer Risk Is Not Associated with Increased Levels of Homozygosity in a Population from the United Kingdom |
| Q28276998 | Colorectal cancer and genetic alterations in the Wnt pathway |
| Q39001975 | Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer |
| Q42857003 | Colorectal carcinomas arising in the hyperplastic polyposis syndrome progress through the chromosomal instability pathway |
| Q28538575 | Colorectal tumors from APC*I1307K carriers principally harbor somatic APC mutations outside the A8 tract |
| Q35047900 | Colorectal tumourigenesis in carriers of the APC I1307K variant: lone gunman or conspiracy? |
| Q40296490 | Combined array-comparative genomic hybridization and single-nucleotide polymorphism-loss of heterozygosity analysis reveals complex changes and multiple forms of chromosomal instability in colorectal cancers |
| Q38940534 | Common Variants Confer Susceptibility to Barrett's Esophagus: Insights from the First Genome-Wide Association Studies |
| Q35891162 | Common breast cancer susceptibility loci are associated with triple-negative breast cancer |
| Q34075491 | Common colorectal cancer risk alleles contribute to the multiple colorectal adenoma phenotype, but do not influence colonic polyposis in FAP. |
| Q39382008 | Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression. |
| Q40034823 | Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk |
| Q39635548 | Common genetic variation contributes significantly to the risk of childhood B-cell precursor acute lymphoblastic leukemia |
| Q35794653 | Common germline polymorphisms associated with breast cancer-specific survival |
| Q34379032 | Common non-synonymous SNPs associated with breast cancer susceptibility: findings from the Breast Cancer Association Consortium |
| Q29417145 | Common variants at 19p13 are associated with susceptibility to ovarian cancer |
| Q34298428 | Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus |
| Q28943395 | Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk |
| Q46595215 | Common variation at the adiponectin locus is not associated with colorectal cancer risk in the UK. |
| Q29417133 | Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk |
| Q31082788 | Comparison of 6q25 breast cancer hits from Asian and European Genome Wide Association Studies in the Breast Cancer Association Consortium (BCAC) |
| Q41916234 | Comprehensive analysis of SMAD4 mutations and protein expression in juvenile polyposis: evidence for a distinct genetic pathway and polyp morphology in SMAD4 mutation carriers |
| Q37023886 | Comprehensive analysis of common mitochondrial DNA variants and colorectal cancer risk |
| Q33842871 | Comprehensive assessment of variation at the transforming growth factor beta type 1 receptor locus and colorectal cancer predisposition |
| Q36026731 | Comprehensive genetic assessment of the ESR1 locus identifies a risk region for endometrial cancer |
| Q34181322 | Confirmation of 5p12 as a susceptibility locus for progesterone-receptor-positive, lower grade breast cancer |
| Q57266799 | Contribution of cyclin d1 (CCND1) and E-cadherin (CDH1) polymorphisms to familial and sporadic colorectal cancer |
| Q57092309 | Contribution of the CHEK2 1100delC variant to risk of multiple colorectal adenoma and carcinoma |
| Q57278898 | Correction: Comparison of 6q25 Breast Cancer Hits from Asian and European Genome Wide Association Studies in the Breast Cancer Association Consortium (BCAC) |
| Q28602609 | Correspondence: SEMA4A variation and risk of colorectal cancer |
| Q46990507 | Corrigendum: Whole-genome sequencing of bladder cancers reveals somatic CDKN1A mutations and clinicopathological associations with mutation burden |
| Q100574211 | Corrigendum: Whole-genome sequencing of bladder cancers reveals somatic CDKN1A mutations and clinicopathological associations with mutation burden |
| Q34994574 | Cost-effectiveness of population screening for BRCA mutations in Ashkenazi jewish women compared with family history-based testing |
| Q37354968 | CpG island methylation is a common finding in colorectal cancer cell lines |
| Q47321577 | Critical research gaps and recommendations to inform research prioritisation for more effective prevention and improved outcomes in colorectal cancer. |
| Q37409157 | Cumulative impact of common genetic variants and other risk factors on colorectal cancer risk in 42,103 individuals |
| Q85658166 | Current morphologic criteria perform poorly in identifying hereditary leiomyomatosis and renal cell carcinoma syndrome-associated uterine leiomyomas |
| Q74620394 | Cyclin D1 is not an essential target of beta-catenin signaling during intestinal tumorigenesis, but it may act as a modifier of disease severity in multiple intestinal neoplasia (Min) mice |
| Q37020817 | DNA copy-number alterations underlie gene expression differences between microsatellite stable and unstable colorectal cancers |
| Q40666348 | DNA microarrays for comparative genomic hybridization based on DOP-PCR amplification of BAC and PAC clones |
| Q52893411 | DNA mismatch repair in lymphoblastoid cells from hereditary non-polyposis colorectal cancer (HNPCC) patients is normal under conditions of rapid cell division and increased mutational load. |
| Q28287769 | DNA polymerase ε and δ exonuclease domain mutations in endometrial cancer |
| Q36839027 | Deciphering the 8q24.21 association for glioma |
| Q37332239 | Deciphering the genetic architecture of low-penetrance susceptibility to colorectal cancer |
| Q50627882 | Deciphering the genetics of hereditary non-syndromic colorectal cancer. |
| Q42817159 | Defects in mismatch repair occur after APC mutations in the pathogenesis of sporadic colorectal tumours |
| Q57337208 | Defects in mismatch repair occur afterAPC mutations in the pathogenesis of sporadic colorectal tumours |
| Q57567601 | Definition of a minimal region of deletion of chromosome 7 in uterine leiomyomas by tiling-path microarray CGH and mutation analysis of known genes in this region |
| Q40383487 | Deletion at chromosome band 20p12.1 in colorectal cancer revealed by high resolution array comparative genomic hybridization |
| Q90763661 | Detailed Molecular and Immune Marker Profiling of Archival Prostate Cancer Samples Reveals an Inverse Association between TMPRSS2:ERG Fusion Status and Immune Cell Infiltration |
| Q33852849 | Detecting low penetrance genes in cancer: the way ahead |
| Q91254556 | Detecting repeated cancer evolution from multi-region tumor sequencing data |
| Q37209240 | Different APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/β-catenin signalling thresholds for tumourigenesis. |
| Q36768782 | Differential clonal evolution in oesophageal cancers in response to neo-adjuvant chemotherapy |
| Q35760908 | Disease severity and genetic pathways in attenuated familial adenomatous polyposis vary greatly but depend on the site of the germline mutation. |
| Q46828694 | Distinct expression profile in fumarate-hydratase-deficient uterine fibroids |
| Q34703122 | Does MSI-low exist? |
| Q33747777 | Down-regulation of serum/glucocorticoid regulated kinase 1 in colorectal tumours is largely independent of promoter hypermethylation |
| Q80418153 | E-cadherin/catenin complex status in solid pseudopapillary tumor of the pancreas |
| Q33245402 | EPHB2 germline variants in patients with colorectal cancer or hyperplastic polyposis |
| Q36922505 | Ectopic expression of P-cadherin correlates with promoter hypomethylation early in colorectal carcinogenesis and enhanced intestinal crypt fission in vivo. |
| Q46856424 | Enrichment of low penetrance susceptibility loci in a Dutch familial colorectal cancer cohort |
| Q42387784 | Erratum to: Genetic Biomarkers of Barrett's Esophagus Susceptibility and Progression to Dysplasia and Cancer: A Systematic Review and Meta-Analysis |
| Q42412214 | Erratum: A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer |
| Q57083824 | Erratum: COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer |
| Q57319395 | Erratum: Corrigendum: Common variants at 19p13 are associated with susceptibility to ovarian cancer |
| Q57244842 | Erratum: Corrigendum: Replication stress links structural and numerical cancer chromosomal instability |
| Q61876948 | Erratum: Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas |
| Q28299100 | Evaluation of PIK3CA mutation as a predictor of benefit from nonsteroidal anti-inflammatory drug therapy in colorectal cancer |
| Q33595844 | Evaluation of association of HNF1B variants with diverse cancers: collaborative analysis of data from 19 genome-wide association studies |
| Q54464773 | Evaluation of variants in the CHEK2, BRIP1 and PALB2 genes in an Irish breast cancer cohort. |
| Q35653910 | Evaluation of variation in the phosphoinositide-3-kinase catalytic subunit alpha oncogene and breast cancer risk |
| Q79353586 | Evidence against a major genetic basis for combined breast and colorectal cancer susceptibility |
| Q56437172 | Evidence for a colorectal cancer susceptibility locus on chromosome 3q21-q24 from a high-density SNP genome-wide linkage scan |
| Q56437148 | Evidence for a colorectal cancer susceptibility locus on chromosome 3q21–q24 from a high-density SNP genome-wide linkage scan |
| Q54660202 | Evidence for an association between compound heterozygosity for germ line mutations in the hemochromatosis (HFE) gene and increased risk of colorectal cancer. |
| Q41532605 | Evidence for genetic association between chromosome 1q loci and predisposition to colorectal neoplasia |
| Q49273548 | Evidence for genetic association between chromosome 1q loci and predisposition to colorectal neoplasia. |
| Q35597084 | Evidence for genetic predisposition to desmoid tumours in familial adenomatous polyposis independent of the germline APC mutation |
| Q56437189 | Evidence of Linkage to Chromosome 9q22.33 in Colorectal Cancer Kindreds from the United Kingdom |
| Q47883253 | Evidence of increased microvessel density and activation of the hypoxia pathway in tumours from the hereditary leiomyomatosis and renal cell cancer syndrome |
| Q35064451 | Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation |
| Q37342144 | Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen-Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation |
| Q57599267 | Evolutionary history of human colitis-associated colorectal cancer |
| Q73883821 | Exclusion of PTEN and 10q22-24 as the susceptibility locus for juvenile polyposis syndrome |
| Q36392466 | Exome sequencing of osteosarcoma reveals mutation signatures reminiscent of BRCA deficiency |
| Q35598109 | Exon 3 beta-catenin mutations are specifically associated with colorectal carcinomas in hereditary non-polyposis colorectal cancer syndrome |
| Q43086071 | Explaining differences in the severity of familial adenomatous polyposis and the search for modifier genes |
| Q35594917 | Explaining variation in familial adenomatous polyposis: relationship between genotype and phenotype and evidence for modifier genes |
| Q90347930 | Exploiting differential Wnt target gene expression to generate a molecular biomarker for colorectal cancer stratification |
| Q56992638 | Exploring causality in the association between circulating 25-hydroxyvitamin D and colorectal cancer risk: a large Mendelian randomisation study |
| Q41670375 | Expression Profiling of Proliferation and Apoptotic Markers along the Adenoma-Carcinoma Sequence in Familial Adenomatous Polyposis Patients |
| Q85076808 | Expression of EGFR, HER2, phosphorylated ERK and phosphorylated MEK in colonic neoplasms of familial adenomatous polyposis patients |
| Q52007591 | Expression of HIF-1alpha, HIF-2alpha (EPAS1), and their target genes in paraganglioma and pheochromocytoma with VHL and SDH mutations. |
| Q37340787 | Expression of Idh1(R132H) in the Murine Subventricular Zone Stem Cell Niche Recapitulates Features of Early Gliomagenesis |
| Q112719456 | Expression of the cancer-associated DNA polymerase ε P286R in fission yeast leads to translesion synthesis polymerase dependent hypermutation and defective DNA replication |
| Q42846581 | Expression profiling in progressive stages of fumarate-hydratase deficiency: the contribution of metabolic changes to tumorigenesis |
| Q50677953 | F-box and WD repeat domain-containing 7 regulates intestinal cell lineage commitment and is a haploinsufficient tumor suppressor. |
| Q34577722 | FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation |
| Q28590336 | FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development |
| Q38888900 | FBXW7-mutated colorectal cancer cells exhibit aberrant expression of phosphorylated-p53 at Serine-15. |
| Q37594336 | FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium |
| Q36147983 | Factors influencing success of clinical genome sequencing across a broad spectrum of disorders |
| Q33758794 | Failure of programmed cell death and differentiation as causes of tumors: some simple mathematical models |
| Q37185985 | Familial adenomatous polyposis and the small bowel: a loco-regional review and current management strategies |
| Q37236216 | Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs). |
| Q36111237 | Fine-Mapping of the 1p11.2 Breast Cancer Susceptibility Locus |
| Q35524465 | Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2. |
| Q61230414 | Fine-mapping of 150 breast cancer risk regions identifies 178 high confidence target genes |
| Q92480972 | Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes |
| Q35056061 | Fine-mapping of colorectal cancer susceptibility loci at 8q23.3, 16q22.1 and 19q13.11: refinement of association signals and use of in silico analysis to suggest functional variation and unexpected candidate target genes |
| Q35063160 | Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk |
| Q39844032 | Fine-scale mapping of 8q24 locus identifies multiple independent risk variants for breast cancer |
| Q36248936 | Fine-scale mapping of the 4q24 locus identifies two independent loci associated with breast cancer risk |
| Q34903062 | Fine-scale mapping of the 5q11.2 breast cancer locus reveals at least three independent risk variants regulating MAP3K1. |
| Q37367871 | Fine-scale mapping of the FGFR2 breast cancer risk locus: putative functional variants differentially bind FOXA1 and E2F1. |
| Q37002930 | Five endometrial cancer risk loci identified through genome-wide association analysis |
| Q33405757 | Five quantitative trait loci control radiation-induced adenoma multiplicity in Mom1R Apc Min/+ mice |
| Q91528378 | Frequency of Pathogenic Germline Variants in CDH1, BRCA2, CHEK2, PALB2, BRCA1, and TP53 in Sporadic Lobular Breast Cancer |
| Q35840995 | Frequency of germline hereditary non-polyposis colorectal cancer gene mutations in patients with multiple or early onset colorectal adenomas |
| Q64065191 | Frequency of pathogenic germline variants in BRCA1, BRCA2, PALB2, CHEK2 and TP53 in ductal carcinoma in situ diagnosed in women under the age of 50 years |
| Q54676197 | From genome to proteome--aim of human proteomics. |
| Q36124728 | Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus |
| Q36742577 | Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers |
| Q34535544 | Further observations on LKB1/STK11 status and cancer risk in Peutz-Jeghers syndrome. |
| Q36555751 | GREM1 germline mutation screening in Ashkenazi Jewish patients with familial colorectal cancer |
| Q38408978 | GWAS meta-analysis of 16 852 women identifies new susceptibility locus for endometrial cancer |
| Q37635792 | General lessons from large-scale studies to identify human cancer predisposition genes |
| Q26786469 | Genetic Biomarkers of Barrett's Esophagus Susceptibility and Progression to Dysplasia and Cancer: A Systematic Review and Meta-Analysis |
| Q37389405 | Genetic Risk Score Mendelian Randomization Shows that Obesity Measured as Body Mass Index, but not Waist:Hip Ratio, Is Causal for Endometrial Cancer |
| Q61644477 | Genetic Susceptibility to Cancer |
| Q36618884 | Genetic aberrations in glioblastoma multiforme: translocation of chromosome 10 in an O-2A-like cell line |
| Q46162485 | Genetic analysis of lobular carcinoma in situ and associated invasive lobular cancer |
| Q73424214 | Genetic and functional analyses of FH mutations in multiple cutaneous and uterine leiomyomatosis, hereditary leiomyomatosis and renal cancer, and fumarate hydratase deficiency |
| Q33863400 | Genetic basis of variation in adenoma multiplicity in ApcMin/+ Mom1S mice |
| Q54453105 | Genetic determinants modulate susceptibility to pregnancy-associated tumourigenesis in a recombinant line of Min mice. |
| Q35881821 | Genetic mapping of hereditary mixed polyposis syndrome to chromosome 6q. |
| Q35109800 | Genetic markers of toxicity from capecitabine and other fluorouracil-based regimens: investigation in the QUASAR2 study, systematic review, and meta-analysis |
| Q37739048 | Genetic modifiers of CHEK2*1100delC-associated breast cancer risk |
| Q54940815 | Genetic overlap between endometriosis and endometrial cancer: evidence from cross-disease genetic correlation and GWAS meta-analyses. |
| Q33711610 | Genetic pathways in colorectal and other cancers |
| Q57337198 | Genetic pathways in colorectal and other cancers |
| Q35925620 | Genetic predisposition to ductal carcinoma in situ of the breast |
| Q35151684 | Genetic predisposition to in situ and invasive lobular carcinoma of the breast |
| Q91362827 | Genetic predisposition to mosaic Y chromosome loss in blood |
| Q61229415 | Genetic predisposition to mosaic Y chromosome loss in blood is associated with genomic instability in other tissues and susceptibility to non-haematological cancers |
| Q37523207 | Genetic prognostic and predictive markers in colorectal cancer |
| Q37229689 | Genetic prognostic markers in colorectal cancer |
| Q26740556 | Genetic susceptibility to Barrett's oesophagus: Lessons from early studies |
| Q57337212 | Genetic testing is important in families with a history suggestive of hereditary non-polyposis colorectal cancer even if the Amsterdam criteria are not fulfilled |
| Q35179897 | Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study |
| Q34378972 | Genetic variation in mitotic regulatory pathway genes is associated with breast tumor grade |
| Q36422109 | Genetic variation in the immunosuppression pathway genes and breast cancer susceptibility: a pooled analysis of 42,510 cases and 40,577 controls from the Breast Cancer Association Consortium |
| Q30000080 | Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent |
| Q58104567 | Genetics of inflammatory bowel disease and associated cancers |
| Q47985907 | Genome-wide allelotyping of 104 Finnish colorectal cancers reveals an excess of allelic imbalance in chromosome 20q in familial cases |
| Q36842233 | Genome-wide association analysis identifies three new breast cancer susceptibility loci |
| Q35996692 | Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer |
| Q37422744 | Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. |
| Q24622610 | Genome-wide association studies identify four ER negative-specific breast cancer risk loci |
| Q34537405 | Genome-wide association studies in oesophageal adenocarcinoma and Barrett's oesophagus: a large-scale meta-analysis |
| Q45068755 | Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci |
| Q95329367 | Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses |
| Q29417135 | Genome-wide association study identifies a common variant associated with risk of endometrial cancer |
| Q36024614 | Genome-wide association study identifies a possible susceptibility locus for endometrial cancer |
| Q64040390 | Genome-wide association study of germline variants and breast cancer-specific mortality |
| Q57214846 | Genome-wide homozygosity signatures and childhood acute lymphoblastic leukemia risk |
| Q47651868 | Genomic instability--the engine of tumorigenesis? |
| Q40296913 | Genomic profiling identifies discrete deletions associated with translocations in glioblastoma multiforme. |
| Q35990970 | Genomic stability and tumorigenesis |
| Q57742277 | Germline APC variants in patients with multiple colorectal adenomas, with evidence for the particular importance of E1317Q |
| Q37594356 | Germline CDH1 mutations in bilateral lobular carcinoma in situ |
| Q42005199 | Germline HNPCC gene variants have little influence on the risk for sporadic colorectal cancer |
| Q33681468 | Germline PTEN mutations in Cowden syndrome-like families. |
| Q90371334 | Germline RET variants underlie a subset of paediatric osteosarcoma |
| Q28286394 | Germline and somatic polymerase ε and δ mutations define a new class of hypermutated colorectal and endometrial cancers |
| Q41356138 | Germline deletions in the tumour suppressor gene FOCAD are associated with polyposis and colorectal cancer development. |
| Q28185113 | Germline deletions of EXO1 do not cause colorectal tumors and lesions which are null for EXO1 do not have microsatellite instability |
| Q42841809 | Germline epigenetic silencing of the tumor suppressor gene PTPRJ in early-onset familial colorectal cancer |
| Q42844768 | Germline epimutations of APC are not associated with inherited colorectal polyposis |
| Q24617520 | Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas |
| Q42854967 | Germline mutations but not somatic changes at the MYH locus contribute to the pathogenesis of unselected colorectal cancers. |
| Q34020502 | Germline mutations in BMPR1A/ALK3 cause a subset of cases of juvenile polyposis syndrome and of Cowden and Bannayan-Riley-Ruvalcaba syndromes |
| Q34115940 | Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer |
| Q43074214 | Germline mutations in the TGF-beta and Wnt signalling pathways are a rare cause of the "multiple" adenoma phenotype |
| Q34503694 | Germline mutations of the LKB1 (STK11) gene in Peutz-Jeghers patients |
| Q30579114 | Germline variants and advanced colorectal adenomas: adenoma prevention with celecoxib trial genome-wide association study |
| Q39530717 | Germline variation in inflammation-related pathways and risk of Barrett's oesophagus and oesophageal adenocarcinoma |
| Q104261158 | Germline variation in the insulin-like growth factor pathway and risk of Barrett's esophagus and esophageal adenocarcinoma |
| Q91524449 | Guidelines for the management of hereditary colorectal cancer from the British Society of Gastroenterology (BSG)/Association of Coloproctology of Great Britain and Ireland (ACPGBI)/United Kingdom Cancer Genetics Group (UKCGG) |
| Q38747962 | HOT mutation screening in human glioblastomas |
| Q34208791 | Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase |
| Q89832983 | Hand-foot syndrome is a biomarker of improved survival following treatment with capecitabine |
| Q36276540 | Height and Breast Cancer Risk: Evidence From Prospective Studies and Mendelian Randomization |
| Q36072197 | Hereditary leiomyomatosis and renal cell cancer (HLRCC): renal cancer risk, surveillance and treatment |
| Q41263488 | Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1. |
| Q45506226 | High-resolution breakpoint analysis provides evidence for the sequence-directed nature of genome rearrangements in hereditary disorders |
| Q94655389 | Histological phenotypic subtypes predict recurrence risk and response to adjuvant chemotherapy in patients with stage III colorectal cancer |
| Q48295820 | Homozygous PMS2 deletion causes a severe colorectal cancer and multiple adenoma phenotype without extraintestinal cancer |
| Q41834410 | How many mutations in a cancer? |
| Q35102646 | Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk |
| Q36859142 | Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer |
| Q57170142 | Identification of nine new susceptibility loci for endometrial cancer |
| Q36014067 | Identification of novel genetic markers of breast cancer survival |
| Q34048230 | Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis |
| Q46103372 | Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer |
| Q97635532 | Image-based consensus molecular subtype (imCMS) classification of colorectal cancer using deep learning |
| Q40310422 | Implications of polygenic risk for personalised colorectal cancer screening |
| Q72999921 | In situ analysis of LKB1/STK11 mRNA expression in human normal tissues and tumours |
| Q100490137 | In-depth clinical and biological exploration of DNA Damage Immune Response (DDIR) as a biomarker for oxaliplatin use in colorectal cancer |
| Q57742300 | Inherited susceptibility to colorectal adenomas and carcinomas: Evidence for a new predisposition gene on 15q14-q22 |
| Q35104068 | Inherited variants in the inner centromere protein (INCENP) gene of the chromosomal passenger complex contribute to the susceptibility of ER-negative breast cancer |
| Q43054561 | Investigation of pathogenic mechanisms in multiple colorectal adenoma patients without germline APC or MYH/MUTYH mutations |
| Q84351352 | Investigation of the Birt-Hogg-Dube tumour suppressor gene (FLCN) in familial and sporadic colorectal cancer |
| Q28658581 | Investigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines |
| Q42266358 | Investigation of the effects of DNA repair gene polymorphisms on the risk of colorectal cancer |
| Q57320064 | Is EXO1 a colon cancer predisposition gene? |
| Q57092215 | KRAS Mutation Is Associated with Lung Metastasis in Patients with Curatively Resected Colorectal Cancer |
| Q24655120 | LKB1 exonic and whole gene deletions are a common cause of Peutz-Jeghers syndrome |
| Q57191573 | Large-Scale Genomic Analyses Link Reproductive Aging to Hypothalamic Signaling, Breast Cancer Susceptibility, and BRCA1-Mediated DNA Repair |
| Q28267893 | Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair |
| Q29416989 | Large-scale genotyping identifies 41 new loci associated with breast cancer risk |
| Q43074074 | Laugier-Hunziker syndrome: an important differential diagnosis for Peutz-Jeghers syndrome |
| Q24313629 | Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation |
| Q73591904 | Linkage analysis of candidate regions for coeliac disease genes |
| Q34020718 | Localization of a gene (MCUL1) for multiple cutaneous leiomyomata and uterine fibroids to chromosome 1q42.3-q43. |
| Q28300857 | Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis |
| Q33540701 | Location in the large bowel influences the APC mutations observed in FAP adenomas |
| Q28255265 | Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia |
| Q35352194 | Loss of Bcl-2 expression correlates with tumour recurrence in colorectal cancer |
| Q34720314 | Loss of expression and promoter methylation of SLIT2 are associated with sessile serrated adenoma formation. |
| Q37030899 | Loss of expression of the double strand break repair protein ATM is associated with worse prognosis in colorectal cancer and loss of Ku70 expression is associated with CIN. |
| Q34733395 | Loss of heterozygosity analysis: practically and conceptually flawed? |
| Q61644468 | Low penetrance breast cancer predisposition SNPs are site specific |
| Q77464963 | Low-level microsatellite instability occurs in most colorectal cancers and is a nonrandomly distributed quantitative trait |
| Q33906257 | Low-penetrance susceptibility variants in familial colorectal cancer |
| Q88197857 | MAJOR-GENE MODELS OF SEXUAL SELECTION UNDER CYCLICAL NATURAL SELECTION |
| Q35764426 | MED12 exon 2 mutations are common in uterine leiomyomas from South African patients. |
| Q50120771 | MED12, TERT promoter and RBM15 mutations in primary and recurrent phyllodes tumours. |
| Q56589268 | MLH1 Germline Epimutations as a Factor in Hereditary Nonpolyposis Colorectal Cancer |
| Q54745600 | MSI-low, a real phenomenon which varies in frequency among cancer types. |
| Q64019009 | Malignant phyllodes tumours show stromal overexpression of c-myc and c-kit |
| Q59759914 | Management and 5-year outcomes in 9938 women with screen-detected ductal carcinoma in situ: the UK Sloane Project |
| Q89882131 | Measuring single cell divisions in human tissues from multi-region sequencing data |
| Q35619996 | Mechanisms of inactivation of mismatch repair genes in human colorectal cancer cell lines: the predominant role of hMLH1. |
| Q37100729 | Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer |
| Q30252873 | Mendelian randomisation implicates hyperlipidaemia as a risk factor for colorectal cancer |
| Q91314341 | Mendelian randomisation: A powerful and inexpensive method for identifying and excluding non-genetic risk factors for colorectal cancer |
| Q98772941 | Mendelian randomization analyses suggest a role for cholesterol in the development of endometrial cancer |
| Q29417081 | Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer |
| Q36333368 | Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1. |
| Q34988292 | Meta-analysis of mismatch repair polymorphisms within the cogent consortium for colorectal cancer susceptibility |
| Q29417032 | Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33 |
| Q35745033 | Methylation changes in the TFAP2E promoter region are associated with BRAF mutation and poorer overall & disease free survival in colorectal cancer. |
| Q34497352 | MicroRNA related polymorphisms and breast cancer risk |
| Q35363901 | Microsatellite instability and the clinicopathological features of sporadic colorectal cancer |
| Q36622463 | Microsatellite-stable diploid carcinoma: a biologically distinct and aggressive subset of sporadic colorectal cancer |
| Q35836669 | Missense mutations in fumarate hydratase in multiple cutaneous and uterine leiomyomatosis and renal cell cancer |
| Q28285094 | Mitochondrial tumour suppressors: a genetic and biochemical update |
| Q39713098 | Modelling the consequences of interactions between tumour cells |
| Q91023539 | Modifiable pathways for colorectal cancer: a mendelian randomisation analysis |
| Q57320094 | Modifier genes in humans: strategies for identification |
| Q35809903 | Molecular analysis of phyllodes tumors reveals distinct changes in the epithelial and stromal components |
| Q35594890 | Molecular characteristics of serrated adenomas of the colorectum |
| Q57078705 | Molecular classification and genetic pathways in hyperplastic polyposis syndrome |
| Q82679775 | Molecular genetic evidence that endometriosis is a precursor of ovarian cancer |
| Q40119519 | Molecular testing for somatic cancer mutations: a survey of current and future testing in UK laboratories |
| Q40087347 | Molecular testing for somatic mutations in common cancers: the views of UK oncologists |
| Q51887591 | Most low-level microsatellite instability in colorectal cancers can be explained without an elevated slippage rate. |
| Q36610621 | Much of the genetic risk of colorectal cancer is likely to be mediated through susceptibility to adenomas |
| Q33722799 | Multilevel genomics of colorectal cancers with microsatellite instability-clinical impact of JAK1 mutations and consensus molecular subtype 1 |
| Q28212369 | Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH |
| Q21144952 | Multiple common susceptibility variants near BMP pathway loci GREM1, BMP4, and BMP2 explain part of the missing heritability of colorectal cancer |
| Q36897003 | Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer |
| Q37619454 | Multiple rare variants in different genes account for multifactorial inherited susceptibility to colorectal adenomas |
| Q73721869 | Multiple ways of silencing E-cadherin gene expression in lobular carcinoma of the breast |
| Q34555860 | Mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRADalpha, and MO25alpha, in Peutz-Jeghers syndrome |
| Q63499786 | Mutation burden and other molecular markers of prognosis in colorectal cancer treated with curative intent: results from the QUASAR 2 clinical trial and an Australian community-based series |
| Q35747921 | Mutation cluster region, association between germline and somatic mutations and genotype-phenotype correlation in upper gastrointestinal familial adenomatous polyposis |
| Q91503301 | Mutational Signature Analysis Reveals NTHL1 Deficiency to Cause a Multi-tumor Phenotype |
| Q34756366 | Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer. |
| Q43202093 | Mutations in Bcl10 are very rare in colorectal cancer |
| Q52182349 | Mutations in DPC4 (SMAD4) cause juvenile polyposis syndrome, but only account for a minority of cases. |
| Q28243075 | Mutations in Exon 1 highlight the role of MED12 in uterine leiomyomas |
| Q45345229 | Mutations in the SMAD4/DPC4 gene in juvenile polyposis |
| Q42801824 | Mutations of the PU.1 Ets domain are specifically associated with murine radiation-induced, but not human therapy-related, acute myeloid leukaemia |
| Q40278413 | Mutations within Wnt pathway genes in sporadic colorectal cancers and cell lines |
| Q54494364 | Myh deficiency enhances intestinal tumorigenesis in multiple intestinal neoplasia (ApcMin/+) mice. |
| Q89125858 | Native American gene continuity to the modern admixed population from the Colombian Andes: Implication for biomedical, population and forensic studies |
| Q64458449 | No Association Between Vitamin D Status and Risk of Barrett's Esophagus or Esophageal Adenocarcinoma: A Mendelian Randomization Study |
| Q30374367 | No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer. |
| Q37079859 | No evidence that protein truncating variants in BRIP1 are associated with breast cancer risk: implications for gene panel testing |
| Q83202618 | Novel MLH1 duplication identified in Colombian families with Lynch syndrome |
| Q39006292 | Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study |
| Q54384796 | Nuclear beta-catenin expression and Wnt signalling: in defence of the dogma. |
| Q24685624 | O(6)-methylguanine methyltransferase in colorectal cancers: detection of mutations, loss of expression, and weak association with G:C>A:T transitions |
| Q73594059 | Optimising methods for determining RER status in colorectal cancers |
| Q46015488 | Oral rapamycin reduces tumour burden and vascularization in Lkb1(+/-) mice. |
| Q28584533 | PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS |
| Q34184024 | PHLDA1 expression marks the putative epithelial stem cells and contributes to intestinal tumorigenesis. |
| Q35739446 | POLE mutations in families predisposed to cutaneous melanoma |
| Q112572520 | Pathology of Tumors Associated With Pathogenic Germline Variants in 9 Breast Cancer Susceptibility Genes |
| Q91072311 | Pattern Recognition Receptor Polymorphisms as Predictors of Oxaliplatin Benefit in Colorectal Cancer |
| Q98906952 | Pervasive chromosomal instability and karyotype order in tumour evolution |
| Q33680045 | Peutz-Jeghers disease: most, but not all, families are compatible with linkage to 19p13.3. |
| Q33679883 | Peutz-Jeghers syndrome |
| Q43986380 | Pharmacogenomics in colorectal cancer: a genome-wide association study to predict toxicity after 5-fluorouracil or FOLFOX administration |
| Q54588344 | Polyclonal origin of colonic adenomas in an XO/XY patient with FAP. |
| Q62583133 | Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes |
| Q34327377 | Polymorphisms and colorectal tumor risk |
| Q36066735 | Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate NRBF2 Expression |
| Q36915870 | Polymorphisms in inflammation pathway genes and endometrial cancer risk |
| Q35042479 | Polymorphisms near TBX5 and GDF7 are associated with increased risk for Barrett's esophagus |
| Q41128157 | Population genetics of tumours. |
| Q34994568 | Population testing for cancer predisposing BRCA1/BRCA2 mutations in the Ashkenazi-Jewish community: a randomized controlled trial |
| Q36583004 | Prediction of breast cancer risk based on profiling with common genetic variants |
| Q102219893 | Prediction of relapse-free survival according to adjuvant chemotherapy and regulator of chromosome condensation 2 (RCC2) expression in colorectal cancer |
| Q43232475 | Pregnancy does not influence colonic polyp multiplicity but may modulate upper gastrointestinal disease in patients with FAP. |
| Q37221493 | Premalignant SOX2 overexpression in the fallopian tubes of ovarian cancer patients: Discovery and validation studies. |
| Q38560298 | Prioritizing rare variants with conditional likelihood ratios |
| Q38614073 | Pro-inflammatory fatty acid profile and colorectal cancer risk: A Mendelian randomisation analysis |
| Q35583987 | Prognostic and predictive biomarkers in resected colon cancer: current status and future perspectives for integrating genomics into biomarker discovery |
| Q39052828 | Prognostic and therapeutic impact of argininosuccinate synthetase 1 control in bladder cancer as monitored longitudinally by PET imaging |
| Q47182054 | Prognostic markers for colorectal cancer; estimating ploidy and stroma |
| Q34994583 | Prognostic significance of POLE proofreading mutations in endometrial cancer. |
| Q39922552 | Promoter hypermethylation leads to decreased APC mRNA expression in familial polyposis and sporadic colorectal tumours, but does not substitute for truncating mutations |
| Q35791897 | Proportion and phenotype of MYH-associated colorectal neoplasia in a population-based series of Finnish colorectal cancer patients |
| Q55508030 | Publisher Correction: Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation. |
| Q53030526 | Putative cis-regulatory drivers in colorectal cancer. |
| Q38287490 | Putative direct and indirect Wnt targets identified through consistent gene expression changes in APC-mutant intestinal adenomas from humans and mice |
| Q36009422 | RAD51B in Familial Breast Cancer |
| Q41058083 | RE: HABP2 G534E Mutation in Familial Nonmedullary Thyroid Cancer |
| Q36058262 | Rare disruptive mutations and their contribution to the heritable risk of colorectal cancer. |
| Q37765721 | Rare genetic variants and the risk of cancer |
| Q28606428 | Re: Role of the oxidative DNA damage repair gene OGG1 in colorectal tumorigenesis |
| Q73798495 | Reciprocity between membranous and nuclear expression of beta-catenin in colorectal tumours |
| Q36265886 | Recurrent Coding Sequence Variation Explains Only A Small Fraction of the Genetic Architecture of Colorectal Cancer |
| Q35247152 | Recurrent chromosomal gains and heterogeneous driver mutations characterise papillary renal cancer evolution |
| Q52526259 | Reduced expression of molecules of the cadherin/catenin complex in the transition from colorectal adenoma to carcinoma. |
| Q35688605 | Refinement of the associations between risk of colorectal cancer and polymorphisms on chromosomes 1q41 and 12q13.13 |
| Q56436732 | Refinement of the basis and impact of common 11q23.1 variation to the risk of developing colorectal cancer |
| Q57092286 | Refining Molecular Analysis in the Pathways of Colorectal Carcinogenesis |
| Q34378542 | Refining the Amsterdam Criteria and Bethesda Guidelines: testing algorithms for the prediction of mismatch repair mutation status in the familial cancer clinic. |
| Q47794811 | Refining the relation between 'first hits' and 'second hits' at the APC locus: the 'loose fit' model and evidence for differences in somatic mutation spectra among patients |
| Q35422960 | Relationship of extreme chromosomal instability with long-term survival in a retrospective analysis of primary breast cancer |
| Q39187683 | Replication stress links structural and numerical cancer chromosomal instability |
| Q34543725 | Replication study of SNP associations for colorectal cancer in Hong Kong Chinese |
| Q26825747 | Replicative DNA polymerase mutations in cancer |
| Q85789296 | Reply to "The classification of intestinal polyposis" |
| Q91855319 | Reply to: "Development of an MSI-positive colon tumor with aberrant DNA methylation in a PPAP patient" |
| Q47137439 | Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution. |
| Q34201905 | SDH mutations in cancer |
| Q57461910 | SERUM- AND GLUCOCORTICOID-INDUCED KINASE SGK1 DIRECTLY PROMOTES THE DIFFERENTIATION OF COLORECTAL CANCER CELLS AND RESTRAINS METASTASIS |
| Q33933528 | SMAD4 mutations in colorectal cancer probably occur before chromosomal instability, but after divergence of the microsatellite instability pathway |
| Q34027111 | Screen for IDH1, IDH2, IDH3, D2HGDH and L2HGDH mutations in glioblastoma |
| Q41983219 | Screening SMAD1, SMAD2, SMAD3, and SMAD5 for germline mutations in juvenile polyposis syndrome |
| Q53010655 | Search for low penetrance alleles for colorectal cancer through a scan of 1467 non-synonymous SNPs in 2575 cases and 2707 controls with validation by kin-cohort analysis of 14 704 first-degree relatives. |
| Q57337207 | Selection, the mutation rate and cancer: Ensuring that the tail does not wag the dog |
| Q21266604 | Sequence changes in predicted promoter elements of STK11/LKB1 are unlikely to contribute to Peutz-Jeghers syndrome |
| Q41183905 | Severe polyposis in Apc(1322T) mice is associated with submaximal Wnt signalling and increased expression of the stem cell marker Lgr5. |
| Q91360697 | Shared Genetic Etiology of Obesity-Related Traits and Barrett's Esophagus/Adenocarcinoma: Insights from Genome-Wide Association Studies |
| Q36977534 | Smooth-muscle myosin mutations in hereditary non-polyposis colorectal cancer syndrome |
| Q52336141 | Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response. |
| Q38839775 | Somatic POLE proofreading domain mutation, immune response, and prognosis in colorectal cancer: a retrospective, pooled biomarker study |
| Q34503041 | Somatic mutations in the Peutz-Jeghers (LKB1/STKII) gene in sporadic malignant melanomas |
| Q46615738 | Survival in stage II/III colorectal cancer is independently predicted by chromosomal and microsatellite instability, but not by specific driver mutations |
| Q38602946 | Systematic meta-analyses and field synopsis of genetic association studies in colorectal adenomas |
| Q30999822 | Systematic search for enhancer elements and somatic allelic imbalance at seven low-penetrance colorectal cancer predisposition loci. |
| Q35633533 | TERC polymorphisms are associated both with susceptibility to colorectal cancer and with longer telomeres. |
| Q36287080 | Target gene mutational pattern in Lynch syndrome colorectal carcinomas according to tumour location and germline mutation |
| Q28586748 | Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway |
| Q92462215 | Targeted next generation sequencing reveals a common genetic pathway for colorectal cancers with chromosomal instability and those with microsatellite and chromosome stability |
| Q50041848 | Telomere length and genetics are independent colorectal tumour risk factors in an evaluation of biomarkers in normal bowel. |
| Q71767501 | Testing candidate loci on chromosomes 1 and 6 for genetic linkage to Peutz-Jeghers' disease |
| Q36021583 | The 8q24 rs6983267G variant is associated with increased thyroid cancer risk |
| Q37484741 | The APC variants I1307K and E1317Q are associated with colorectal tumors, but not always with a family history. |
| Q51795143 | The Apc 1322T mouse develops severe polyposis associated with submaximal nuclear beta-catenin expression. |
| Q49817640 | The BRCA2 c.68-7T > A variant is not pathogenic: A model for clinical calibration of spliceogenicity. |
| Q38331013 | The C-terminus of Apc does not influence intestinal adenoma development or progression |
| Q35597393 | The C/C-13910 genotype of adult-type hypolactasia is associated with an increased risk of colorectal cancer in the Finnish population |
| Q21261429 | The FH mutation database: an online database of fumarate hydratase mutations involved in the MCUL (HLRCC) tumor syndrome and congenital fumarase deficiency |
| Q102323911 | The Glasgow Microenvironment Score associates with prognosis and adjuvant chemotherapy response in colorectal cancer |
| Q36716116 | The HABP2 G534E variant is an unlikely cause of familial non-medullary thyroid cancer. |
| Q40930104 | The HLA system and the analysis of multifactorial genetic disease |
| Q45104999 | The Hunting of the Snark: Whither Genome-Wide Association Studies for Colorectal Cancer? |
| Q97527458 | The MLH1 polymorphism rs1800734 and risk of endometrial cancer with microsatellite instability |
| Q35622053 | The TCA cycle and tumorigenesis: the examples of fumarate hydratase and succinate dehydrogenase. |
| Q47949845 | The TGFBR1*6A/9A polymorphism is not associated with differential risk of breast cancer |
| Q64019020 | The Wnt pathway, epithelial-stromal interactions, and malignant progression in phyllodes tumours |
| Q34094916 | The adenomatous polyposis coli (APC) tumour suppressor--genetics, function and disease. |
| Q73549450 | The androgen receptor exon 1 trinucleotide repeat does not act as a modifier of the age of presentation in breast cancer |
| Q51565310 | The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling. |
| Q84059657 | The continuum model of selection in human tumors: general paradigm or niche product? |
| Q55025035 | The effects of mutational processes and selection on driver mutations across cancer types. |
| Q58238423 | The evolutionary landscape of colorectal tumorigenesis |
| Q71834684 | The frequency and mechanism of loss of heterozygosity on chromosome 11q in breast cancer |
| Q36602699 | The genetics of FAP and FAP-like syndromes |
| Q38786667 | The importance of p53 pathway genetics in inherited and somatic cancer genomes. |
| Q36512253 | The in vivo rate of somatic adenomatous polyposis coli mutation |
| Q35864053 | The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis |
| Q38604664 | The mini-driver model of polygenic cancer evolution |
| Q35854432 | The multiple colorectal adenoma phenotype and MYH, a base excision repair gene |
| Q34410886 | The mutation rate and cancer |
| Q90149797 | The polymorphic variant rs1800734 influences methylation acquisition and allele-specific TFAP4 binding in the MLH1 promoter leading to differential mRNA expression |
| Q42597110 | The role of E-cadherin in low-grade ductal breast tumourigenesis |
| Q38418796 | The role of cell proliferation and crypt fission in adenoma aggressiveness: a comparison of ileoanal pouch and rectal adenomas in familial adenomatous polyposis |
| Q52588708 | The role of inflammation in subventricular zone cancer. |
| Q35594706 | The spectrum of p53 mutations in colorectal adenomas differs from that in colorectal carcinomas. |
| Q33587605 | The stem cell marker CD133 associates with enhanced colony formation and cell motility in colorectal cancer |
| Q44463232 | The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis |
| Q28731755 | Thyroid cancer susceptibility polymorphisms: confirmation of loci on chromosomes 9q22 and 14q13, validation of a recessive 8q24 locus and failure to replicate a locus on 5q24 |
| Q57092293 | Tissue, cell and stage specificity of (epi)mutations in cancers |
| Q55055759 | Translational study identifies XPF and MUS81 as predictive biomarkers for oxaliplatin-based peri-operative chemotherapy in patients with esophageal adenocarcinoma. |
| Q28511450 | Tumor burden and clonality in multiple intestinal neoplasia mouse/normal mouse aggregation chimeras |
| Q39563871 | Tumour recurrence is associated with Jass grouping but not with differences in E-cadherin expression in moderately differentiated Dukes' B colorectal cancers. |
| Q34131230 | Two hits revisited again |
| Q51793796 | Two novel LKB1 mutations in Colombian Peutz-Jeghers syndrome patients. |
| Q24657391 | Unregulated smooth-muscle myosin in human intestinal neoplasia |
| Q52810855 | Urgent improvements needed to diagnose and manage Lynch syndrome. |
| Q38475625 | Use of SSCP analysis to identify germline mutations in HNPCC families fulfilling the Amsterdam criteria |
| Q36656389 | Use of multivariate analysis to suggest a new molecular classification of colorectal cancer. |
| Q38974107 | Validation of Recently Proposed Colorectal Cancer Susceptibility Gene Variants in an Analysis of Families and Patients-a Systematic Review |
| Q35365222 | Variability in the severity of colonic disease in familial adenomatous polyposis results from differences in tumour initiation rather than progression and depends relatively little on patient age. |
| Q71767498 | Variants at the secretory phospholipase A2 (PLA2G2A) locus: analysis of associations with familial adenomatous polyposis and sporadic colorectal tumours |
| Q37367984 | Variation at 2q35 (PNKD and TMBIM1) influences colorectal cancer risk and identifies a pleiotropic effect with inflammatory bowel disease |
| Q34114297 | Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk |
| Q34720547 | What can be learnt about disease progression in breast cancer dormancy from relapse data? |
| Q36988586 | What can we learn from the population incidence of cancer? Armitage and Doll revisited |
| Q34015467 | Whole-gene APC deletions cause classical familial adenomatous polyposis, but not attenuated polyposis or "multiple" colorectal adenomas |
| Q28109367 | Whole-genome methylation analysis of benign and malignant colorectal tumours |
| Q33568623 | Whole-genome sequencing of bladder cancers reveals somatic CDKN1A mutations and clinicopathological associations with mutation burden |
| Q91914289 | Why is cancer not more common? A changing microenvironment may help to explain why, and suggests strategies for anti-cancer therapy |
| Q39927345 | mRNA expression profiling of phyllodes tumours of the breast: identification of genes important in the development of borderline and malignant phyllodes tumours |
| Q37414133 | rs2735383, located at a microRNA binding site in the 3'UTR of NBS1, is not associated with breast cancer risk |
| Ian Tomlinson (scientist) | wikipedia |
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