From Desert to Medicine: A Review of Camel Genomics and Therapeutic Products

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From Desert to Medicine: A Review of Camel Genomics and Therapeutic Products is …
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scholarly articleQ13442814

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P356DOI10.3389/FGENE.2019.00017
P932PMC publication ID6389616
P698PubMed publication ID30838017

P2093author name stringBincy Baby
Amanat Ali
Ranjit Vijayan
P2860cites workInitial sequencing and analysis of the human genomeQ21045365
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Hepatitis C virus envelope proteins bind lactoferrinQ24317643
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Pigs in sequence space: a 0.66X coverage pig genome survey based on shotgun sequencingQ24529105
THE NATURAL-SELECTION THEORY OF ANTIBODY FORMATIONQ24559685
Structure of a nanobody-stabilized active state of the β(2) adrenoceptorQ24597139
Translating the A1C assay into estimated average glucose valuesQ24655833
Properties, production, and applications of camelid single-domain antibody fragmentsQ24676749
Genetic determinants of variability in glycated hemoglobin (HbA(1c)) in humans: review of recent progress and prospects for use in diabetes careQ27026664
A camelid antibody fragment inhibits the formation of amyloid fibrils by human lysozymeQ27641839
Viral infection modulation and neutralization by camelid nanobodiesQ27677064
Camel whey protein enhances diabetic wound healing in a streptozotocin-induced diabetic mouse model: the critical role of β-Defensin-1, -2 and -3Q36755454
GM-CSF enhances tumor invasion by elevated MMP-2, -9, and -26 expressionQ36804843
NFAT5 in cellular adaptation to hypertonic stress - regulations and functional significanceQ36847032
Effectiveness of human, camel, bovine and sheep lactoferrin on the hepatitis C virus cellular infectivity: comparison study.Q36958593
Cellular response to hyperosmotic stressesQ36967681
Deconstructing the mechanisms and consequences of TGF-β-induced EMT during cancer progressionQ37044614
Llama-derived single variable domains (nanobodies) directed against chemokine receptor CXCR7 reduce head and neck cancer cell growth in vivoQ37226145
The regulation of mitochondrial DNA copy number in glioblastoma cellsQ37299449
Clinical value of blocking IL-6 receptorQ37443744
Neural mechanisms subserving central angiotensinergic influences on plasma renin in sheepQ43641683
The double puzzle of diabetesQ43753930
Insulin responsiveness of sheep, ponies, miniature pigs and camels: results of hyperinsulinemic clamps using porcine insulinQ43784651
Molecular analysis of heavy chain-only antibodies of Camelus bactrianusQ44005681
Biological variation of glycohemoglobinQ44044753
Decreased renal cytochrome P450 2C enzymes and impaired vasodilation are associated with angiotensin salt-sensitive hypertension.Q44353823
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Aspects of oxidative stress in children with type 1 diabetes mellitusQ45180847
Metal complexes of bovine lactoferrin inhibit in vitro replication of herpes simplex virus type 1 and 2.Q45756803
Camel milk inhibits inflammatory angiogenesis via downregulation of proangiogenic and proinflammatory cytokines in mice.Q45967191
Gastroprotective and Ulcer Healing Effects of Camel Milk and Urine in HCl/EtOH, Non-steroidal Anti-inflammatory Drugs (Indomethacin), and Water-Restraint Stress-induced Ulcer in RatsQ46248966
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Factors associated with adverse reactions induced by caprylic acid-fractionated whole IgG preparations: comparison between horse, sheep and camel IgGsQ46719871
Analysis of heavy and light chain sequences of conventional camelid antibodies from Camelus dromedarius and Camelus bactrianus speciesQ46944022
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Camelid immunoglobulins and nanobody technology.Q47221693
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Evidence for a correlation between the number of marginal band microtubules and the size of vertebrate erthrocytesQ47335341
Genomic selection in the French Lacaune dairy sheep breed.Q47839285
Genetic diversity and origin of Chinese cattle revealed by mtDNA D-loop sequence variationQ48127560
Formatted anti-tumor necrosis factor alpha VHH proteins derived from camelids show superior potency and targeting to inflamed joints in a murine model of collagen-induced arthritisQ49082819
ADH in regulation of blood osmolality and extracellular fluid volumeQ49161319
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Development and evaluation of a simple and effective real time PCR assay for mitochondrial quantification in racing camelsQ50216774
Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domainQ27679289
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p53 and breast cancer, an updateQ28242379
Single domain antibodies: promising experimental and therapeutic tools in infection and immunityQ28248678
Organic osmolytes as compatible, metabolic and counteracting cytoprotectants in high osmolarity and other stressesQ28263589
Naturally occurring antibodies devoid of light chainsQ28269589
Database analysis of O-glycosylation sites in proteinsQ28346313
Activation of GLUT1 by metabolic and osmotic stress: potential involvement of AMP-activated protein kinase (AMPK)Q28569301
The de novo genome assembly and annotation of a female domestic dromedary of North African originQ28598256
Ancient and modern DNA reveal dynamics of domestication and cross-continental dispersal of the dromedaryQ28601000
Genome sequences of wild and domestic bactrian camelsQ28710411
Llama-derived single domain antibodies to build multivalent, superpotent and broadened neutralizing anti-viral moleculesQ28741431
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CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasisQ29614347
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Weak Genetic Structure in Northern African Dromedary Camels Reflects Their Unique Evolutionary History.Q30379029
Isolation of the new antigen receptor from wobbegong sharks, and use as a scaffold for the display of protein loop librariesQ30724175
Definition of animal breeding goals for sustainable production systemsQ30857665
Single domain camel antibodies: current status.Q31005004
Single domain antibodies derived from dromedary lymph node and peripheral blood lymphocytes sensing conformational variants of prostate-specific antigenQ31117894
Generation of llama single-domain antibodies against methotrexate, a prototypical hapten.Q33258925
Identification of cyclin D1- and estrogen-regulated genes contributing to breast carcinogenesis and progressionQ33267068
Requirement of vimentin filament assembly for beta3-adrenergic receptor activation of ERK MAP kinase and lipolysisQ33270248
Isolation and characterization of anti-FcgammaRIII (CD16) llama single-domain antibodies that activate natural killer cellsQ33309759
Tetrameric and homodimeric camelid IgGs originate from the same IgH locusQ33353298
A novel promiscuous class of camelid single-domain antibody contributes to the antigen-binding repertoireQ33559542
Sequencing, analysis, and annotation of expressed sequence tags for Camelus dromedariusQ33587431
The development of activating and inhibiting camelid VHH domains against human protein kinase C epsilonQ33789694
Screening the anti infectivity potentials of native N- and C-lobes derived from the camel lactoferrin against hepatitis C virus.Q33863096
Preclinical screening of anti-HER2 nanobodies for molecular imaging of breast cancerQ33866799
Radicals and oxidative stress in diabetesQ33900538
Therapeutic applications of whey proteinQ33979888
Global challenges in liver diseaseQ33999114
Molecular markers and their use in animal breedingQ34009549
Interleukin-4 and breast cancerQ34058956
What's new about osmotic regulation of glycerophosphocholineQ34144883
Genetic diversity and population structure of Mongolian domestic Bactrian camels (Camelus bactrianus)Q34228388
Neutralization of human papillomavirus by specific nanobodies against major capsid protein L1.Q34259110
Responses to dehydration in the one-humped camel and effects of blocking the renin-angiotensin systemQ34279890
Potent and broad neutralization of HIV-1 by a llama antibody elicited by immunizationQ34284855
Domestic-animal genomics: deciphering the genetics of complex traitsQ34299462
CXCR4 nanobodies (VHH-based single variable domains) potently inhibit chemotaxis and HIV-1 replication and mobilize stem cellsQ34377450
Generation of single domain antibody fragments derived from camelids and generation of manifold constructsQ34386048
The history of Old World camelids in the light of molecular geneticsQ34520966
Sustained reduction in the incidence of type 2 diabetes by lifestyle intervention: follow-up of the Finnish Diabetes Prevention StudyQ34580894
The molecular genetics of crop domesticationQ34594954
Lactoferrin structure and functionsQ34655613
Invited review: Genomic selection in dairy cattle: progress and challengesQ34928306
Proteomics of old world camelid (Camelus dromedarius): Better understanding the interplay between homeostasis and desert environmentQ34961227
Tumour necrosis factor alpha: a potential target for the therapy of solid tumours.Q35215812
Ethnoveterinary treatments by dromedary camel herders in the Suleiman Mountainous Region in Pakistan: an observation and questionnaire studyQ35575438
Comprehensive analysis of the T-cell receptor beta chain gene in rhesus monkey by high throughput sequencingQ35591194
Foot-and-mouth disease in camelids: a reviewQ35859093
Current treatment of medulloblastoma: recent advances and future challengesQ35924437
Camel milk modulates the expression of aryl hydrocarbon receptor-regulated genes, Cyp1a1, Nqo1, and Gsta1, in murine hepatoma Hepa 1c1c7 cells.Q35937168
Antibody repertoire development in camelidsQ36211248
Camelid Ig V genes reveal significant human homology not seen in therapeutic target genes, providing for a powerful therapeutic antibody platform.Q36214456
Interleukin-10 and the immune response against cancer: a counterpointQ36276594
Prevalence and treatment of hepatitis C virus genotypes 4, 5, and 6.Q36290096
Lactoferrin: a modulator of immune and inflammatory responsesQ36302367
Natural and man-made V-gene repertoires for antibody discovery.Q36401413
Unravelling the complexities of the NF-kappaB signalling pathway using mouse knockout and transgenic models.Q36637897
The major histocompatibility complex in Old World camelids and low polymorphism of its class II genesQ36639417
Metabolomic and elemental analysis of camel and bovine urine by GC-MS and ICP-MS.Q37544283
Nanobodies targeting mouse/human VCAM1 for the nuclear imaging of atherosclerotic lesionsQ37569289
Genetic diversity and phylogeographic structure of Bactrian camels shown by mitochondrial sequence variationsQ37696506
Targeting epidermal growth factor receptor in tumors: from conventional monoclonal antibodies via heavy chain-only antibodies to nanobodies.Q37953782
HbA(1c)--an analyte of increasing importanceQ38019290
A study of the anti-diabetic agents of camel milkQ38023195
The atomic mobility component of protein antigenicityQ38154881
Structural insights and biomedical potential of IgNAR scaffolds from sharksQ38293902
The β-casein in camels: molecular characterization of the CSN2 gene, promoter analysis and genetic variability.Q38306117
Leptin expression correlates with favorable clinicopathologic phenotype and better prognosis in colorectal adenocarcinomaQ38358478
Nanobody Technology: A Versatile Toolkit for Microscopic Imaging, Protein-Protein Interaction Analysis, and Protein Function Exploration.Q38654845
The Growth Inhibitory Potential and Antimetastatic Effect of Camel Urine on Breast Cancer Cells In Vitro and In VivoQ38762581
Nanobodies as therapeutics: big opportunities for small antibodiesQ38808711
The differentiation of camel breeds based on meat measurements using discriminant analysis.Q38865819
Multivalent nanobodies targeting death receptor 5 elicit superior tumor cell killing through efficient caspase inductionQ38931192
Absence of aquaporin-4 water channels from kidneys of the desert rodent Dipodomys merriami merriamiQ39084829
Synthesis, preclinical validation, dosimetry, and toxicity of 68Ga-NOTA-anti-HER2 Nanobodies for iPET imaging of HER2 receptor expression in cancerQ39181509
Effects of water deprivation on urea metabolism in camels, desert sheep and desert goats fed dry desert grassQ39275959
Camel urine components display anti-cancer properties in vitroQ39291305
Cell-penetrating anti-GFAP VHH and corresponding fluorescent fusion protein VHH-GFP spontaneously cross the blood-brain barrier and specifically recognize astrocytes: application to brain imagingQ39325717
Nanobodies targeting the hepatocyte growth factor: potential new drugs for molecular cancer therapyQ39399346
Generation and characterization of a functional Nanobody against the vascular endothelial growth factor receptor-2; angiogenesis cell receptorQ39419733
Respiratory water loss in camelsQ39437563
A biparatopic anti-EGFR nanobody efficiently inhibits solid tumour growth.Q39552974
Camelid genomes reveal evolution and adaptation to desert environmentsQ39604668
Camel urine inhibits the cytochrome P450 1a1 gene expression through an AhR-dependent mechanism in Hepa 1c1c7 cell line.Q39649557
Examination of the activity of camel milk casein against hepatitis C virus (genotype-4a) and its apoptotic potential in hepatoma and hela cell linesQ39701870
Differential Effects of Camel Milk on Insulin Receptor Signaling - Toward Understanding the Insulin-Like Properties of Camel MilkQ40011961
Estimating the future health burden of chronic hepatitis C and human immunodeficiency virus infections in the United StatesQ40249402
Inhibition of herpes simplex virus infection by lactoferrin is dependent on interference with the virus binding to glycosaminoglycansQ40588204
Anti-HSV activity of lactoferricin analogues is only partly related to their affinity for heparan sulfateQ40608355
Efficient tumor targeting by single-domain antibody fragments of camelsQ40650068
Lactoferrin markedly inhibits hepatitis C virus infection in cultured human hepatocytesQ41046371
Phytochemicals: guardians of our healthQ41615449
alpha B-crystallin gene induction and phosphorylation by MKK6-activated p38. A potential role for alpha B-crystallin as a target of the p38 branch of the cardiac stress responseQ41736665
Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylationQ41792404
Regulated expression and ultrastructural localization of galectin-1, a proapoptotic beta-galactoside-binding lectin, during spermatogenesis in rat testis.Q42434910
Mitochondrial diversity and phylogeographic structure of Chinese domestic goatsQ42663660
Perinuclear localization and insulin responsiveness of GLUT4 requires cytoskeletal integrity in 3T3-L1 adipocytesQ42798255
Creatine prevents the inhibition of energy metabolism and lipid peroxidation in rats subjected to GAA administration.Q42911287
Camel lactoferrin markedly inhibits hepatitis C virus genotype 4 infection of human peripheral blood leukocytes.Q43038981
The relationship between glycosylated haemoglobin (HbA1c) and measures of insulin resistance across a range of glucose tolerance.Q51378445
SPECT imaging of joint inflammation with Nanobodies targeting the macrophage mannose receptor in a mouse model for rheumatoid arthritis.Q53119136
[Maintenance and diseases of the camel].Q53950914
Improvement of the antimicrobial and antioxidant activities of camel and bovine whey proteins by limited proteolysis.Q54390213
Unique properties of the camel erythrocyte membrane, II. Organization of membrane proteinsQ55065965
The camel, new challenges for a sustainable developmentQ56670220
Characteristics of the somatic hypermutation in the Camelus dromedarius T cell receptor gamma (TRG) and delta (TRD) variable domainsQ56972578
Response of the renin-aldosterone system in the camel to acute dehydrationQ57142278
In vitro antiviral activity of single domain antibody fragments against poliovirusQ57985799
Unique single‐domain antigen binding fragments derived from naturally occurring camel heavy‐chain antibodiesQ57985848
Genetic Diversity and Differentiation of Dromedarian Camel of IndiaQ58137221
Genetic variants analysis of three dromedary camels using whole genome sequencing dataQ58713539
Body Temperature of the Camel and Its Relation to Water EconomyQ62125676
Bcl-2 Is a Prognostic Marker in Breast Cancer Independently of the Nottingham Prognostic IndexQ64018977
A comprehensive biochemical analysis of the blood of the camel (Camelus dromedarius)Q68309764
Characterization of a camel milk protein rich in proline identifies a new beta-casein fragmentQ69628173
Preliminary studies on camel serum immunoglobulinsQ70471082
Cytochrome P-450-dependent HETEs: profile of biological activity and stimulation by vasoactive peptidesQ71738307
The isolation and characterization of camel (Camelus dromedarius) immunoglobulin classes and subclassesQ72619940
Heat-shock response in camel (Camelus dromedarius) blood cells and adaptation to hyperthermiaQ72752709
Response of one-humped camel (Camelus dromedarius) to intravenous glucagon injection and to infusion of glucose and volatile fatty acids, and the kinetics of glucagon disappearance from the bloodQ73268579
Expression of survivin and its relationship to loss of apoptosis in breast carcinomasQ73404059
Comparative aspects of glucose tolerance in camels, sheep, and poniesQ73557619
Phospholipid- and fatty acid-composition in the erythrocyte membrane of the one-humped camel [Camelus dromedarius] and its influence on vesicle properties prepared from these lipidsQ74260483
ICAM-1 expression and the soluble ICAM-1 level for evaluating the metastatic potential of gastric cancerQ74456044
Immunized camel sera and derived immunoglobulin subclasses neutralizing Androctonus australis hector scorpion toxinsQ75390422
Increased expression of vascular endothelial growth factor is associated with tumor progression in hepatocellular carcinomaQ77321925
Effect of camel milk on residual beta-cell function in recent onset type 1 diabetesQ79826079
Expression of the peptidoglycan recognition protein, PGRP, in the lactating mammary glandQ80489971
Wnt signaling pathway in invasive ductal carcinoma of the breast: relationship between beta-catenin, dishevelled and cyclin D1 expressionQ80862957
Effect of camel milk on glycemic control and insulin requirement in patients with type 1 diabetes: 2-years randomized controlled trialQ84237867
The antiplatelet activity of camel urineQ84794480
Genetic and demographic bottleneck analysis of Indian camel breeds by microsatellite markersQ87609883
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectgenomicsQ222046
BreedsQ4960301
P304page(s)17
P577publication date2019-01-01
P1433published inFrontiers in GeneticsQ2499875
P1476titleFrom Desert to Medicine: A Review of Camel Genomics and Therapeutic Products
P478volume10

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cites work (P2860)
Q92632214A Genome-Wide Association Study Identifies Quantitative Trait Loci Affecting Hematological Traits in Camelus bactrianus
Q90631772Camel Hemorphins Exhibit a More Potent Angiotensin-I Converting Enzyme Inhibitory Activity than Other Mammalian Hemorphins: An In Silico and In Vitro Study
Q90681515Genome Diversity and Signatures of Selection for Production and Performance Traits in Dromedary Camels
Q90157615Old World camels in a modern world - a balancing act between conservation and genetic improvement
Q90567810The Major Histocompatibility Complex of Old World Camels-A Synopsis
Q99559912The global status and genetic characterization of hydatidosis in camels (Camelus dromedarius): a systematic literature review with meta-analysis based on published papers

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