Abstract is: Job Dekker is a Dutch biologist. Dekker is a professor in the Department of Systems Biology, and the Department of Biochemistry and Molecular Biotechnology at the University of Massachusetts Medical School and an Investigator at the Howard Hughes Medical Institute. Dekker studied molecular genetics and biochemistry as an undergraduate at Utrecht University, where he also obtained a Ph.D. in Physiological Chemistry in 1997. During his postdoctoral studies in Nancy Kleckner’s lab at Harvard University, Dekker developed a method, called chromosome conformation capture, for identifying a matrix of the pair-wise interactions between different sites of chromatin and inferring the spatial folding of chromosomes from this information. Dekker's work has led to insights into how genomes are folded in three dimensions, the mechanisms that cells employ to fold chromosomes, and how chromosome folding contributes to gene regulation and chromosome segregation. Awarded the Edward Novitski Prize in 2018, and the Biochemical Society International Award in 2018. Dekker is a member of the National Academy of Sciences (2022), and the National Academy of Medicine (2021).
| human | Q5 |
| P2671 | Google Knowledge Graph ID | /g/11fzb8r6qh |
| P1960 | Google Scholar author ID | qaAebdkAAAAJ |
| P269 | IdRef ID | 176598731 |
| P8189 | National Library of Israel J9U ID | 987007325338405171 |
| P691 | NL CR AUT ID | jcu2014812926 |
| P496 | ORCID iD | 0000-0001-5631-0698 |
| P214 | VIAF ID | 143314608 |
| P166 | award received | Edward Novitski Prize | Q5344653 |
| Fellow of the American Association for the Advancement of Science | Q5442484 | ||
| International Award | Q78284498 | ||
| P69 | educated at | Utrecht University | Q221653 |
| P108 | employer | Howard Hughes Medical Institute | Q1512226 |
| University of Massachusetts Medical School | Q7895715 | ||
| P734 | family name | Dekker | Q267326 |
| Dekker | Q267326 | ||
| Dekker | Q267326 | ||
| P735 | given name | Job | Q2569062 |
| Job | Q2569062 | ||
| P106 | occupation | researcher | Q1650915 |
| P21 | sex or gender | male | Q6581097 |
| P3373 | sibling | Martijn Dekker | Q102273598 |
| Q91106484 | A chromosome folding intermediate at the condensin-to-cohesin transition during telophase |
| Q35162569 | A closer look at long-range chromosomal interactions |
| Q29614326 | A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression |
| Q48216188 | A pathway for mitotic chromosome formation. |
| Q34516833 | Activation of proto-oncogenes by disruption of chromosome neighborhoods. |
| Q36377972 | An encyclopedia of mouse DNA elements (Mouse ENCODE). |
| Q34383700 | Analysis of long-range chromatin interactions using Chromosome Conformation Capture |
| Q34346604 | Architectural protein subclasses shape 3D organization of genomes during lineage commitment |
| Q115779091 | Author Correction: Expanded encyclopaedias of DNA elements in the human and mouse genomes |
| Q115779090 | Author Correction: Perspectives on ENCODE |
| Q91098669 | CTCF sites display cell cycle-dependent dynamics in factor binding and nucleosome positioning |
| Q28201750 | Capturing chromosome conformation |
| Q34020234 | Cell-type-specific long-range looping interactions identify distant regulatory elements of the CFTR gene |
| Q33628389 | Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease |
| Q36104763 | Chromatin interaction analysis reveals changes in small chromosome and telomere clustering between epithelial and breast cancer cells |
| Q35649485 | Chromosome Conformation Capture (3C) in Budding Yeast |
| Q35649496 | Chromosome Conformation Capture Carbon Copy (5C) in Budding Yeast |
| Q28262061 | Chromosome Conformation Capture Carbon Copy (5C): a massively parallel solution for mapping interactions between genomic elements |
| Q93179480 | Cohesin Members Stag1 and Stag2 Display Distinct Roles in Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation |
| Q37358016 | Cohesin-based chromatin interactions enable regulated gene expression within preexisting architectural compartments |
| Q35737747 | Cohesin-dependent globules and heterochromatin shape 3D genome architecture in S. pombe |
| Q28131819 | Comprehensive mapping of long-range interactions reveals folding principles of the human genome |
| Q34670135 | Condensin-driven remodelling of X chromosome topology during dosage compensation. |
| Q22066251 | Defining functional DNA elements in the human genome |
| Q99616929 | Detecting chromatin interactions between and along sister chromatids with SisterC |
| Q33480086 | Determining spatial chromatin organization of large genomic regions using 5C technology |
| Q33471397 | Disease-causing 7.4 kb cis-regulatory deletion disrupting conserved non-coding sequences and their interaction with the FOXL2 promotor: implications for mutation screening |
| Q35607409 | Enhanced yeast one-hybrid assays for high-throughput gene-centered regulatory network mapping. |
| Q33758067 | Epigenetic characteristics of the mitotic chromosome in 1D and 3D. |
| Q21560900 | Evidence for transcript networks composed of chimeric RNAs in human cells |
| Q98164640 | Expanded encyclopaedias of DNA elements in the human and mouse genomes |
| Q34343663 | Exploring the three-dimensional organization of genomes: interpreting chromatin interaction data |
| Q34471294 | From cells to chromatin: capturing snapshots of genome organization with 5C technology |
| Q34504529 | Genomics tools for unraveling chromosome architecture |
| Q34288244 | Hi-C: a comprehensive technique to capture the conformation of genomes |
| Q33575932 | Hi-C: a method to study the three-dimensional architecture of genomes |
| Q31029404 | HiC-Pro: an optimized and flexible pipeline for Hi-C data processing |
| Q39563407 | HiTC: exploration of high-throughput 'C' experiments |
| Q90467864 | Highly structured homolog pairing reflects functional organization of the Drosophila genome |
| Q21061203 | Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project |
| Q112714199 | Inner nuclear protein Matrin-3 coordinates cell differentiation by stabilizing chromatin architecture |
| Q33891295 | Integrating one-dimensional and three-dimensional maps of genomes |
| Q63433322 | Integrative detection and analysis of structural variation in cancer genomes |
| Q34508265 | Invariant TAD Boundaries Constrain Cell-Type-Specific Looping Interactions between Promoters and Distal Elements around the CFTR Locus |
| Q30560716 | Iterative correction of Hi-C data reveals hallmarks of chromosome organization |
| Q99353748 | Large domains of heterochromatin direct the formation of short mitotic chromosome loops |
| Q35796431 | Long-Range Chromatin Interactions |
| Q35871975 | Mapping Nucleosome Resolution Chromosome Folding in Yeast by Micro-C |
| Q34578862 | Mapping networks of physical interactions between genomic elements using 5C technology |
| Q24632695 | Mediator and cohesin connect gene expression and chromatin architecture |
| Q99418941 | Multi-contact 3C reveals that the human genome during interphase is largely not entangled |
| Q33808637 | My5C: web tools for chromosome conformation capture studies |
| Q33693950 | Organization of the mitotic chromosome |
| Q35592856 | Predictive polymer modeling reveals coupled fluctuations in chromosome conformation and transcription |
| Q34581232 | Quantitative analysis of chromosome conformation capture assays (3C-qPCR). |
| Q42709502 | RUNX1 contributes to higher-order chromatin organization and gene regulation in breast cancer cells. |
| Q35649491 | Randomized ligation control for chromosome conformation capture |
| Q42837860 | Reply to Brunet and Doolittle: Both selected effect and causal role elements can influence human biology and disease |
| Q37313665 | SMARCA4 regulates gene expression and higher-order chromatin structure in proliferating mammary epithelial cells |
| Q42255573 | SMC complexes differentially compact mitotic chromosomes according to genomic context |
| Q89557250 | SPEN integrates transcriptional and epigenetic control of X-inactivation |
| Q37418601 | Segmental folding of chromosomes: a basis for structural and regulatory chromosomal neighborhoods? |
| Q58105777 | Single-allele chromatin interactions identify regulatory hubs in dynamic compartmentalized domains |
| Q35874015 | Spatial organization of the mouse genome and its role in recurrent chromosomal translocations |
| Q125341548 | Spatial organization of transcribed eukaryotic genes |
| Q28088652 | Structural and functional diversity of Topologically Associating Domains |
| Q33725284 | Structural organization of the inactive X chromosome in the mouse. |
| Q111149738 | Systematic evaluation of chromosome conformation capture assays |
| Q24595581 | The accessible chromatin landscape of the human genome |
| Q35033742 | The active FMR1 promoter is associated with a large domain of altered chromatin conformation with embedded local histone modifications |
| Q35867154 | The context of gene expression regulation |
| Q90467747 | The genome-wide multi-layered architecture of chromosome pairing in early Drosophila embryos |
| Q29615403 | The long-range interaction landscape of gene promoters |
| Q60921893 | The non-canonical SMC protein SmcHD1 antagonises TAD formation and compartmentalisation on the inactive X chromosome |
| Q34664947 | The three-dimensional folding of the α-globin gene domain reveals formation of chromatin globules |
| Q29300664 | Two ways to fold the genome during the cell cycle: insights obtained with chromosome conformation capture |
| Q35686781 | Yeast one-hybrid assays for gene-centered human gene regulatory network mapping. |
| Q102273598 | Martijn Dekker | sibling | P3373 |
| Job Dekker | wikipedia |
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