Activation of epidermal growth factor receptor inhibits KCNQ2/3 current through two distinct pathways: membrane PtdIns(4,5)P2 hydrolysis and channel phosphorylation

scientific article published on 01 March 2007

Activation of epidermal growth factor receptor inhibits KCNQ2/3 current through two distinct pathways: membrane PtdIns(4,5)P2 hydrolysis and channel phosphorylation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1523/JNEUROSCI.2911-06.2007
P932PMC publication ID6672518
P698PubMed publication ID17344388

P2093author name stringHailin Zhang
Zhiying Zhao
Zhanfeng Jia
Huiling Liang
Boyi Liu
Qingzhong Jia
P2860cites workKCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channelQ22008501
A potassium channel mutation in neonatal human epilepsyQ24320244
Delta opioid activation of the mitogen-activated protein kinase cascade does not require transphosphorylation of receptor tyrosine kinasesQ24804323
Cell signaling by receptor tyrosine kinasesQ27860474
Reconstitution of muscarinic modulation of the KCNQ2/KCNQ3 K(+) channels that underlie the neuronal M currentQ28145290
AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonistsQ28574598
Dual phosphorylations underlie modulation of unitary KCNQ K(+) channels by Src tyrosine kinaseQ28575228
G protein-coupled receptor-induced sensitization of phospholipase C stimulation by receptor tyrosine kinasesQ33911037
Structural requirements for differential sensitivity of KCNQ K+ channels to modulation by Ca2+/calmodulinQ33911083
Modulation and genetic identification of the M channelQ34013683
Neuronal KCNQ potassium channels: physiology and role in disease.Q34185467
The complex and intriguing lives of PIP2 with ion channels and transportersQ34457658
Pathways modulating neural KCNQ/M (Kv7) potassium channelsQ34464180
M current mystery messenger revealed?Q34775744
Comparison of modulation of Kv1.3 channel by two receptor tyrosine kinases in olfactory bulb neurons of rodentsQ34864521
Activation of calcium-dependent potassium channels in mouse [correction of rat] brain neurons by neurotrophin-3 and nerve growth factorQ35967608
Protein kinase C bound with A-kinase anchoring protein is involved in muscarinic receptor-activated modulation of M-type KCNQ potassium channels.Q36041453
Regulation of ion channels by phosphatidylinositol 4,5-bisphosphateQ36142866
Modulation of the Kv1.3 potassium channel by receptor tyrosine kinasesQ36435970
Calmodulin mediates Ca2+-dependent modulation of M-type K+ channelsQ36447189
Bradykinin inhibits M current via phospholipase C and Ca2+ release from IP3-sensitive Ca2+ stores in rat sympathetic neuronsQ36513808
Endocytosis as a mechanism for tyrosine kinase-dependent suppression of a voltage-gated potassium channel.Q37496878
Bradykinin excites rat sympathetic neurons by inhibition of M current through a mechanism involving B2 receptors and G alpha q/11.Q38299056
Role of EGF receptor transactivation in phosphoinositide 3-kinase-dependent activation of MAP kinase by GPCRsQ40416265
PKC-delta sensitizes Kir3.1/3.2 channels to changes in membrane phospholipid levels after M3 receptor activation in HEK-293 cells.Q40429831
Tyrosine kinase inhibition: an approach to drug developmentQ40613606
Rap2B-dependent stimulation of phospholipase C-epsilon by epidermal growth factor receptor mediated by c-Src phosphorylation of RasGRP3.Q40886547
Acute suppression of inwardly rectifying Kir2.1 channels by direct tyrosine kinase phosphorylation.Q40988684
Tyrosine phosphorylation of the Kv1.3 potassium channelQ41221181
The neurotrophic action and signalling of epidermal growth factorQ41357971
Activation of Mitogen‐Activated Protein Kinase by Epidermal Growth Factor in Hippocampal Neurons and Neuronal Cell LinesQ41525625
Substance P inhibits the M-current in bullfrog sympathetic neuronesQ41898679
Luteinizing hormone-releasing factor and muscarinic agonists act on the same voltage-sensitive K+-current in bullfrog sympathetic neuronesQ42135955
Maximal epidermal growth-factor-induced cytosolic phospholipase A2 activation in vivo requires phosphorylation followed by an increased intracellular calcium concentration.Q42192141
Opposite actions of brain-derived neurotrophic factor and neurotrophin-3 on firing features and ion channel composition of murine spiral ganglion neurons.Q42517558
Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by GbetagammaQ42544747
Activation of expressed KCNQ potassium currents and native neuronal M-type potassium currents by the anti-convulsant drug retigabine.Q43683699
Arachidonic acid metabolites as mediators of somatostatin-induced increase of neuronal M-currentQ44006618
Recovery from muscarinic modulation of M current channels requires phosphatidylinositol 4,5-bisphosphate synthesisQ44092262
Ceramide, a putative second messenger for nerve growth factor, modulates the TTX-resistant Na(+) current and delayed rectifier K(+) current in rat sensory neuronsQ44180890
Subunit-specific modulation of KCNQ potassium channels by Src tyrosine kinase.Q44270181
PIP(2) activates KCNQ channels, and its hydrolysis underlies receptor-mediated inhibition of M currentsQ44386912
Experiments to test the role of phosphatidylinositol 4,5-bisphosphate in neurotransmitter-induced M-channel closure in bullfrog sympathetic neurons.Q44495444
Modulation of M-current by intracellular Ca2+.Q44964619
Possible role of phosphatidylinositol 4,5 bisphosphate in luteinizing hormone releasing hormone-mediated M-current inhibition in bullfrog sympathetic neuronsQ45173059
Relationship between membrane phosphatidylinositol-4,5-bisphosphate and receptor-mediated inhibition of native neuronal M channels.Q46412703
Cholinergic suppression of KCNQ channel currents enhances excitability of striatal medium spiny neurons.Q46644376
Characteristic interactions with phosphatidylinositol 4,5-bisphosphate determine regulation of kir channels by diverse modulatorsQ47448312
Nerve growth factor decreases potassium currents and alters repetitive firing in rat sympathetic neuronsQ47851915
P2Y2 nucleotide receptors expressed heterologously in sympathetic neurons inhibit both N-type Ca2+ and M-type K+ currents.Q47892716
Muscarinic M1 receptors activate phosphoinositide turnover and Ca2+ mobilisation in rat sympathetic neurones, but this signalling pathway does not mediate M-current inhibition.Q52142288
Localization of immunoreactive epidermal growth factor receptor in neonatal and adult rat hippocampus.Q52220965
Muscarinic suppression of a novel voltage-sensitive K+ current in a vertebrate neuroneQ59066538
Intracellular calcium directly inhibits potassium M channels in excised membrane patches from rat sympathetic neuronsQ70901383
Angiotensin II inhibits calcium and M current channels in rat sympathetic neurons via G proteinsQ71629123
On the role of arachidonic acid in M-current modulation by muscarine in bullfrog sympathetic neuronsQ72816644
BDNF, NT-3 and NGF induce distinct new Ca2+ channel synthesis in developing hippocampal neuronsQ73167519
Tyrosine phosphorylation modulates current amplitude and kinetics of a neuronal voltage-gated potassium channelQ73731933
Receptor-induced transient reduction in plasma membrane PtdIns(4,5)P2 concentration monitored in living cellsQ74344711
P433issue10
P304page(s)2503-2512
P577publication date2007-03-01
P1433published inJournal of NeuroscienceQ1709864
P1476titleActivation of epidermal growth factor receptor inhibits KCNQ2/3 current through two distinct pathways: membrane PtdIns(4,5)P2 hydrolysis and channel phosphorylation
P478volume27

Reverse relations

cites work (P2860)
Q34055806Activation of the Cl- channel ANO1 by localized calcium signals in nociceptive sensory neurons requires coupling with the IP3 receptor
Q33744493Depolarization increases phosphatidylinositol (PI) 4,5-bisphosphate level and KCNQ currents through PI 4-kinase mechanisms
Q83672757Direct or indirect regulation of calcium-activated chloride channel by calcium
Q39101509Divalent cations modulate TMEM16A calcium-activated chloride channels by a common mechanism.
Q42524127Genistein inhibits voltage-gated sodium currents in SCG neurons through protein tyrosine kinase-dependent and kinase-independent mechanisms
Q36201938Multifaceted modulation of K+ channels by protein-tyrosine phosphatase ε tunes neuronal excitability
Q36667893NGF inhibits M/KCNQ currents and selectively alters neuronal excitability in subsets of sympathetic neurons depending on their M/KCNQ current background
Q30519202Reactive oxygen species are second messengers of neurokinin signaling in peripheral sensory neurons
Q35068102Redox and nitric oxide-mediated regulation of sensory neuron ion channel function
Q30500677Stargazin-related protein γ₇ is associated with signalling endosomes in superior cervical ganglion neurons and modulates neurite outgrowth
Q37064702The C-terminus of Kv7 channels: a multifunctional module.
Q41446747The anticonvulsant retigabine suppresses neuronal KV2-mediated currents
Q35888782p75 and TrkA signaling regulates sympathetic neuronal firing patterns via differential modulation of voltage-gated currents