Sequence analysis of the mannose-binding lectin (MBL2) gene reveals a high degree of heterozygosity with evidence of selection

scientific article published on 01 September 2004

Sequence analysis of the mannose-binding lectin (MBL2) gene reveals a high degree of heterozygosity with evidence of selection is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1005420491
P356DOI10.1038/SJ.GENE.6364116
P698PubMed publication ID15306844

P50authorJames TaylorQ42322786
P2093author name stringChanock SJ
Foster CB
Yeager M
Bernig T
Staats B
P2860cites workA second serine protease associated with mannan-binding lectin that activates complementQ24311275
Structural basis of the polymorphism of human complement components C4A and C4B: gene size, reactivity and antigenicity.Q24531858
Complex signatures of natural selection at the Duffy blood group locusQ24561910
Active conservation of noncoding sequences revealed by three-way species comparisonsQ24623668
Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancersQ24625794
Genetics and the population history of EuropeQ24633591
The human mannose-binding protein gene. Exon structure reveals its evolutionary relationship to a human pulmonary surfactant gene and localization to chromosome 10Q24681840
A New Statistical Method for Haplotype Reconstruction from Population DataQ27860495
The structure of haplotype blocks in the human genomeQ27860500
MEGA2: molecular evolutionary genetics analysis softwareQ27860788
MicroRNAs: genomics, biogenesis, mechanism, and functionQ27861070
High frequencies in African and non-African populations of independent mutations in the mannose binding protein geneQ28118760
Intensely punctate meiotic recombination in the class II region of the major histocompatibility complexQ28190352
Mannose-binding lectin polymorphisms in clinical tuberculosisQ28203157
A map of human genome sequence variation containing 1.42 million single nucleotide polymorphismsQ28203288
On the number of segregating sites in genetical models without recombinationQ28206543
Crossover clustering and rapid decay of linkage disequilibrium in the Xp/Yp pseudoautosomal gene SHOXQ28207843
The mannan-binding lectin pathway of complement activation: biology and disease associationQ28214987
The human ortholog of rhesus mannose-binding protein-A gene is an expressed pseudogene that localizes to chromosome 10Q28264648
Differential recognition of obligate anaerobic bacteria by human mannose-binding lectinQ28367585
Molecular determinants of oligomer formation and complement fixation in mannose-binding proteinsQ28575621
Structure of human steroid 21-hydroxylase genesQ28646488
A comparison of bayesian methods for haplotype reconstruction from population genotype dataQ29547566
VISTA : visualizing global DNA sequence alignments of arbitrary lengthQ29614270
DnaSP version 3: an integrated program for molecular population genetics and molecular evolution analysisQ29615363
Linkage disequilibrium in the human genomeQ29616097
Evolution of the mammalian MHC: natural selection, recombination, and convergent evolutionQ33630613
Association of mannose-binding lectin gene heterogeneity with severity of lung disease and survival in cystic fibrosisQ33857510
Determination of ancestral alleles for human single-nucleotide polymorphisms using high-density oligonucleotide arraysQ33864868
The 3' untranslated region of messenger RNA: A molecular 'hotspot' for pathology?Q33903996
Assessing the performance of the haplotype block model of linkage disequilibriumQ33906300
Adjusting the focus on human variationQ33945651
Mannan-binding lectin enhances susceptibility to visceral leishmaniasisQ34008749
Gene conversion and different population histories may explain the contrast between polymorphism and linkage disequilibrium levelsQ34020571
Sequence variation and linkage disequilibrium in the human T-cell receptor beta (TCRB) locusQ34044334
Lower-than-expected linkage disequilibrium between tightly linked markers in humans suggests a role for gene conversionQ34044608
A dynamic programming algorithm for haplotype block partitioningQ34063575
Human genome sequence variation and the influence of gene history, mutation and recombinationQ34142742
Linkage disequilibrium and allele-frequency distributions for 114 single-nucleotide polymorphisms in five populationsQ34146133
Intense and highly localized gene conversion activity in human meiotic crossover hot spotsQ34287628
Haplotype structure and population genetic inferences from nucleotide-sequence variation in human lipoprotein lipaseQ34386645
Population genomics: a bridge from evolutionary history to genetic medicineQ34416664
Mannose-binding lectin gene polymorphisms are associated with major infection following allogeneic hemopoietic stem cell transplantation.Q34621964
Using genetic variation to study immunomodulationQ34750497
SNP500Cancer: a public resource for sequence validation and assay development for genetic variation in candidate genesQ34922555
Structural and functional aspects of complement activation by mannose-binding protein.Q34978572
AVID: A global alignment programQ35023871
SNP and haplotype variation in the human genomeQ35114507
Anti-microbial activities of mannose-binding lectinQ35187396
Haplotype blocks and linkage disequilibrium in the human genomeQ35191477
Patterns of Human Genetic Diversity: Implications for Human Evolutionary History and DiseaseQ35550637
Impact of mannose-binding lectin on susceptibility to infectious diseases.Q35582450
Haplotype and linkage disequilibrium architecture for human cancer-associated genesQ35806728
Association of mutations in mannose binding protein gene with childhood infection in consecutive hospital seriesQ36244208
Host defense molecule polymorphisms influence the risk for immune-mediated complications in chronic granulomatous diseaseQ37388319
Haplotype structure, LD blocks, and uneven recombination within the LRP5 gene.Q40952708
The collectins in innate immunityQ41053677
The Gly-54-->Asp allelic form of human mannose-binding protein (MBP) fails to bind MBP-associated serine proteaseQ42160405
Association of mannose-binding lectin gene variation with disease severity and infections in a population-based cohort of systemic lupus erythematosus patients.Q43848180
Mannan-binding lectin in the sub-Saharan HIV and tuberculosis epidemicsQ43953062
Lack of mannose-binding lectin-A enhances survival in a mouse model of acute septic peritonitisQ44149324
Mannose-binding lectin plasma levels and gene polymorphisms in Plasmodium falciparum malariaQ44164008
Enhancement of complement activation and opsonophagocytosis by complexes of mannose-binding lectin with mannose-binding lectin-associated serine protease after binding to Staphylococcus aureusQ44172221
A comprehensive haplotype analysis of CYP19 and breast cancer risk: the Multiethnic CohortQ44307819
Restricted polymorphism of the mannose-binding lectin gene of indigenous AustraliansQ46733770
Mannose-binding protein B allele confers protection against tuberculous meningitisQ46869254
DNA variability of human genes.Q46876583
Mutations in the human mannose-binding protein gene: frequencies in several population groupsQ46896178
Defining haplotype blocks and tag single-nucleotide polymorphisms in the human genomeQ47313992
Characterization of human serum mannan-binding protein promoterQ47906897
Sequence variation in the human angiotensin converting enzymeQ47964948
DNA sequence diversity in a 9.7-kb region of the human lipoprotein lipase geneQ48036374
Binding of mannan-binding protein to various bacterial pathogens of meningitisQ50147158
Disease-associated mutations in human mannose-binding lectin compromise oligomerization and activity of the final protein.Q51829664
Further evidence for role of a promoter variant in the TNFRSF6 gene in Alzheimer disease.Q51951518
Blocks of limited haplotype diversity revealed by high-resolution scanning of human chromosome 21.Q52051237
A new frequent allele is the missing link in the structural polymorphism of the human mannan-binding proteinQ56702159
Chromosome-wide distribution of haplotype blocks and the role of recombination hot spotsQ56879657
A first-generation linkage disequilibrium map of human chromosome 22Q56879659
Juxtaposed regions of extensive and minimal linkage disequilibrium in human Xq25 and Xq28Q57232777
Increased frequency of homozygosity of abnormal mannan-binding-protein alleles in patients with suspected immunodeficiencyQ63728163
Molecular basis of opsonic defect in immunodeficient childrenQ68303831
Cytoplasmic regulation of mRNA function: The importance of the 3′ untranslated regionQ72088073
Mannose binding protein gene mutations associated with unusual and severe infections in adultsQ72135612
Mannose-binding lectin is a component of innate mucosal defense against Cryptosporidium parvum in AIDSQ73130760
Association of functional mutant homozygotes of the mannose binding protein gene with susceptibility to pulmonary tuberculosis in IndiaQ73488670
Variation is the spice of lifeQ73594237
Evolution of introns and exons of class II major histocompatibility complex genes of vertebratesQ73922623
Differential binding of mannose-binding lectin to respiratory pathogens in cystic fibrosisQ73923265
Deficiency of mannose-binding lectin and burden of infection in children with malignancy: a prospective studyQ74446395
Association between deficiency of mannose-binding lectin and severe infections after chemotherapyQ74446408
Direct measurement of the male recombination fraction in the human beta-globin hot spotQ77584232
Molecular Evolutionary GeneticsQ104203812
P433issue6
P921main subjectheterozygosityQ124059385
P304page(s)461-476
P577publication date2004-09-01
P1433published inGenes and ImmunityQ15745246
P1476titleSequence analysis of the mannose-binding lectin (MBL2) gene reveals a high degree of heterozygosity with evidence of selection
P478volume5

Reverse relations

cites work (P2860)
Q81318250An analysis of genetic variation across the MBL2 locus in Dutch Caucasians indicates that 3' haplotypes could modify circulating levels of mannose-binding lectin
Q38913656Association of a new mannose-binding lectin variant with severe malaria in Gabonese children
Q38320019Association of mannose-binding lectin gene (MBL2) polymorphisms with rheumatoid arthritis in an Indian cohort of case-control samples
Q36481104Challenges of SNP genotyping and genetic variation: its future role in diagnosis and treatment of cancer
Q30350759Effects of natural selection on interpopulation divergence at polymorphic sites in human protein-coding Loci
Q38335440Evolution of the mannose-binding lectin gene in primates.
Q92666194Exploring association between MBL2 gene polymorphisms and the occurrence of clinical blackwater fever through a case-control study in Congolese children
Q35330085Extreme high prevalence of a defective mannose-binding lectin (MBL2) genotype in native South American West Andean populations.
Q37642585From evolutionary genetics to human immunology: how selection shapes host defence genes
Q33401966Genetic and other factors determining mannose-binding lectin levels in American Indians: the Strong Heart Study
Q37144998Genetic polymorphisms of mannose-binding lectin do not influence placental malaria but are associated with preterm deliveries
Q33799136Genome-wide association study SNPs in the human genome diversity project populations: does selection affect unlinked SNPs with shared trait associations?
Q37209510Haplotype specific-sequencing reveals MBL2 association with asymptomatic Plasmodium falciparum infection
Q38164341If there is an evolutionary selection pressure for the high frequency of MBL2 polymorphisms, what is it?
Q36232275Increased plasma mannose binding lectin levels are associated with bronchiolitis obliterans after lung transplantation
Q37184715Independent effects of genetic variations in mannose-binding lectin influence the course of HIV disease: the advantage of heterozygosity for coding mutations
Q33359581Intriguing balancing selection on the intron 5 region of LMBR1 in human population
Q21090770Lectin-dependent enhancement of Ebola virus infection via soluble and transmembrane C-type lectin receptors
Q27486245MBL2and Hepatitis C Virus Infection among Injection Drug Users
Q35153921Mannose binding lectin and susceptibility to rheumatoid arthritis in Brazilian patients and their relatives.
Q34170265Mannose-binding lectin 2 polymorphisms do not influence frequency or type of infection in adults with chemotherapy induced neutropaenia
Q36361610Mannose-binding lectin and its genetic variants.
Q33577516Phylogenetic nomenclature and evolution of mannose-binding lectin (MBL2) haplotypes
Q27001032Population genetic tools for dissecting innate immunity in humans
Q25257137SNP500Cancer: a public resource for sequence validation, assay development, and frequency analysis for genetic variation in candidate genes
Q34393517Serum mannose-binding lectin concentration, but not genotype, is associated with Clostridium difficile infection recurrence: a prospective cohort study
Q34400153The MBL2 'LYQA secretor' haplotype is an independent predictor of postoperative myocardial infarction in whites undergoing coronary artery bypass graft surgery
Q57191722The Role of Complement Activating Collectins and Associated Serine Proteases in Patients With Hematological Malignancies, Receiving High-Dose Chemotherapy, and Autologous Hematopoietic Stem Cell Transplantations (Auto-HSCT)
Q61798413The association of mannose binding lectin genotype and immune response to Chlamydia pneumoniae: The Strong Heart Study
Q34991781The lectin pathway of complement and rheumatic heart disease.
Q27692121Toll-like receptors (TLRs) and mannan-binding lectin (MBL): on constant alert in a hostile environment
Q33939617Variant G57E of Mannose Binding Lectin Associated with Protection against Tuberculosis Caused by Mycobacterium africanum but not by M. tuberculosis

Search more.