Taxol Induces Brk-dependent Prosurvival Phenotypes in TNBC Cells through an AhR/GR/HIF-driven Signaling Axis

scientific article published on 10 July 2018

Taxol Induces Brk-dependent Prosurvival Phenotypes in TNBC Cells through an AhR/GR/HIF-driven Signaling Axis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1158/1541-7786.MCR-18-0410
P932PMC publication ID6214723
P698PubMed publication ID29991529

P50authorJohn A CidlowskiQ62823441
Tiffany N SeagrovesQ73088022
Carlos Perez KerkvlietQ89507017
Kathryn L SchwertfegerQ91244526
Carol A LangeQ101563783
Julie H. OstranderQ117074347
Tarah M. Regan AndersonQ117074442
P2093author name stringYan Peng
Ganesh V Raj
Shihong Ma
Raisa I Krutilina
Taylor M Helle
P2860cites workHypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tensionQ24307473
Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillinQ24318315
Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factorQ24564124
Modifications to glucocorticoid and progesterone receptors alter cell fate in breast cancerQ26772892
Anoikis molecular pathways and its role in cancer progressionQ26852158
Microarray analysis reveals glucocorticoid-regulated survival genes that are associated with inhibition of apoptosis in breast epithelial cellsQ44783902
Hypoxia-inducible factor 1 mediates intermittent hypoxia-induced migration of human breast cancer MDA-MB-231 cellsQ47109212
NCCN Guidelines Insights: Breast Cancer, Version 1.2017.Q47579286
EMT, cell plasticity and metastasis.Q53666394
Decreased androgen receptor expression is associated with distant metastases in patients with androgen receptor-expressing triple-negative breast carcinoma.Q54481449
Characterization of 2,3,7,8-tetrachlorodibenzofuran-dependent suppression and AH receptor pathway gene expression in the developing mouse mammary glandQ77409978
Hypoxia-inducible factor 1alpha is closely linked to an aggressive phenotype in breast cancerQ81100723
Overexpression of hypoxia-inducible factor HIF-1alpha predicts early relapse in breast cancer: retrospective study in a series of 745 patientsQ81682235
Dexamethasone decreases xenograft response to Paclitaxel through inhibition of tumor cell apoptosisQ83995323
A perspective on cancer cell metastasisQ28307891
Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapiesQ29617680
2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Related Halogenated Aromatic Hydrocarbons: Examination of the Mechanism of ToxicityQ29618527
Breast tumor kinase (protein tyrosine kinase 6) regulates heregulin-induced activation of ERK5 and p38 MAP kinases in breast cancer cellsQ33283847
Posttranslationally modified progesterone receptors direct ligand-specific expression of breast cancer stem cell-associated gene programsQ33568421
PTK6 Regulates IGF-1-Induced Anchorage-Independent SurvivalQ33644326
Brk/PTK6 signaling in normal and cancer cell modelsQ33690176
Malignant transformation of mammary epithelial cells by ectopic overexpression of the aryl hydrocarbon receptorQ33804702
HIF-1α-independent hypoxia-induced rapid PTK6 stabilization is associated with increased motility and invasionQ34036107
Endogenous kynurenines as targets for drug discovery and developmentQ34156448
Breast tumor kinase and extracellular signal-regulated kinase 5 mediate Met receptor signaling to cell migration in breast cancer cellsQ34173535
PTK6/BRK is expressed in the normal mammary gland and activated at the plasma membrane in breast tumorsQ34227580
Phosphorylated and sumoylation-deficient progesterone receptors drive proliferative gene signatures during breast cancer progressionQ34304234
Breast tumor kinase (Brk/PTK6) is a mediator of hypoxia-associated breast cancer progression.Q34912116
An integrated genomics approach identifies drivers of proliferation in luminal-subtype human breast cancerQ34989075
Analysis of tumor environmental response and oncogenic pathway activation identifies distinct basal and luminal features in HER2-related breast tumor subtypesQ35558105
Ligand-independent phosphorylation of the glucocorticoid receptor integrates cellular stress pathways with nuclear receptor signalingQ35598838
Progesterone receptors upregulate Wnt-1 to induce epidermal growth factor receptor transactivation and c-Src-dependent sustained activation of Erk1/2 mitogen-activated protein kinase in breast cancer cellsQ35642132
Brk/PTK6 sustains activated EGFR signaling through inhibiting EGFR degradation and transactivating EGFRQ35888553
Refinement of Triple-Negative Breast Cancer Molecular Subtypes: Implications for Neoadjuvant Chemotherapy Selection.Q36054418
PPARγ isoforms differentially regulate metabolic networks to mediate mouse prostatic epithelial differentiation.Q36211459
Nuclear hormone receptor degradation and gene transcription: an updateQ36219014
A TDO2-AhR signaling axis facilitates anoikis resistance and metastasis in triple-negative breast cancer.Q36244860
Activation of the glucocorticoid receptor is associated with poor prognosis in estrogen receptor-negative breast cancerQ36445441
Brk/PTK6 cooperates with HER2 and Src in regulating breast cancer cell survival and epithelial-to-mesenchymal transitionQ36677706
Hsp90 Inhibition Results in Glucocorticoid Receptor Degradation in Association with Increased Sensitivity to Paclitaxel in Triple-Negative Breast CancerQ36679783
Breast Tumor Kinase (Brk/PTK6) Is Induced by HIF, Glucocorticoid Receptor, and PELP1-Mediated Stress Signaling in Triple-Negative Breast CancerQ36693131
A randomized phase I trial of nanoparticle albumin-bound paclitaxel with or without mifepristone for advanced breast cancer.Q37056571
Anoikis resistance and tumor metastasisQ37199998
Activation of the aryl hydrocarbon receptor during different critical windows in pregnancy alters mammary epithelial cell proliferation and differentiationQ37303870
Brk protects breast cancer cells from autophagic cell death induced by loss of anchorage.Q37316549
Dexamethasone induces docetaxel and cisplatin resistance partially through up-regulating Krüppel-like factor 5 in triple-negative breast cancerQ37706950
Clinical and mechanistic aspects of glucocorticoid-induced chemotherapy resistance in the majority of solid tumorsQ40182922
Prognostic and predictive factors in breast cancer by immunohistochemical analysis.Q40866567
Progesterone induces adult mammary stem cell expansionQ42471079
Estrogen receptor, progesterone receptor, and glucocorticoid receptor expression in normal breast tissue, breast in situ carcinoma, and invasive breast cancerQ43252129
P4510describes a project that usesImageJQ1659584
P433issue11
P921main subjectpaclitaxelQ423762
P304page(s)1761-1772
P577publication date2018-07-10
P1433published inMolecular Cancer ResearchQ2751014
P1476titleTaxol Induces Brk-dependent Prosurvival Phenotypes in TNBC Cells through an AhR/GR/HIF-driven Signaling Axis
P478volume16

Reverse relations

cites work (P2860)
Q94481933Glucocorticoid receptors are required effectors of TGFβ1-induced p38 MAPK signaling to advanced cancer phenotypes in triple-negative breast cancer
Q90643576Protein tyrosine kinase 6 signaling in prostate cancer
Q90630036Steroid Receptors as MAPK Signaling Sensors in Breast Cancer: Let the Fates Decide

Search more.