Protein tyrosine kinase 6 signaling in prostate cancer

scientific article published on 25 February 2020

Protein tyrosine kinase 6 signaling in prostate cancer is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID7076292
P698PubMed publication ID32211448

P2093author name stringAngela L Tyner
Wanian M Alwanian
P2860cites workRegulation of the nonreceptor tyrosine kinase Brk by autophosphorylation and by autoinhibitionQ24301621
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Protein tyrosine kinase 6 directly phosphorylates AKT and promotes AKT activation in response to epidermal growth factorQ28115391
Brk is coamplified with ErbB2 to promote proliferation in breast cancerQ28115616
Brk/Protein tyrosine kinase 6 phosphorylates p27KIP1, regulating the activity of cyclin D-cyclin-dependent kinase 4Q28115769
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Expression of the BRK tyrosine kinase in mammary epithelial cells enhances the coupling of EGF signalling to PI 3-kinase and Akt, via erbB3 phosphorylationQ28140199
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Brk, Srm, Frk, and Src42A Form a Distinct Family of Intracellular Src-Like Tyrosine KinasesQ28202022
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Exon-intron structure of the human PTK6 gene demonstrates that PTK6 constitutes a distinct family of non-receptor tyrosine kinaseQ28283456
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The alternative splice variant of protein tyrosine kinase 6 negatively regulates growth and enhances PTK6-mediated inhibition of β-cateninQ30155592
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Cytoplasmic retention of protein tyrosine kinase 6 promotes growth of prostate tumor cellsQ34659926
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PTK6 inhibition promotes apoptosis of Lapatinib-resistant Her2(+) breast cancer cells by inducing Bim.Q35834635
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HER2 and EGFR Overexpression Support Metastatic Progression of Prostate Cancer to Bone.Q38735527
Targeting BRK-Positive Breast Cancers with Small-Molecule Kinase InhibitorsQ38739711
MicroRNA-187, a downstream effector of TGFβ pathway, suppresses Smad-mediated epithelial-mesenchymal transition in colorectal cancerQ38798884
RSK promotes prostate cancer progression in bone through ING3, CKAP2, and PTK6-mediated cell survivalQ38959778
PTK6 activation at the membrane regulates epithelial-mesenchymal transition in prostate cancerQ39125642
Protein tyrosine kinase 6 protects cells from anoikis by directly phosphorylating focal adhesion kinase and activating AKTQ39268132
Characterisation and chromosome mapping of the human non receptor tyrosine kinase gene, brkQ41087231
Whole-genome and Transcriptome Sequencing of Prostate Cancer Identify New Genetic Alterations Driving Disease ProgressionQ42691638
PTK6 regulates growth and survival of endocrine therapy-resistant ER+ breast cancer cellsQ45494068
PTEN is a protein phosphatase that targets active PTK6 and inhibits PTK6 oncogenic signaling in prostate cancer.Q45904675
PTEN loss and activation of K-RAS and β-catenin cooperate to accelerate prostate tumourigenesisQ47406034
EMT in cancerQ47736873
PTEN Loss Promotes Intratumoral Androgen Synthesis and Tumor Microenvironment Remodeling via Aberrant Activation of RUNX2 in Castration-Resistant Prostate CancerQ49788391
Clinical implications of PTEN loss in prostate cancerQ49818398
Deep Phosphotyrosine Proteomics by Optimization of Phosphotyrosine Enrichment and MS/MS ParametersQ51156471
Gene expression alterations in prostate cancer predicting tumor aggression and preceding development of malignancyQ51596197
The long tail of oncogenic drivers in prostate cancer.Q52611753
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Genomic correlates of clinical outcome in advanced prostate cancer.Q64912433
Taxol Induces Brk-dependent Prosurvival Phenotypes in TNBC Cells through an AhR/GR/HIF-driven Signaling AxisQ89507021
MicroRNA-214 targets PTK6 to inhibit tumorigenic potential and increase drug sensitivity of prostate cancer cellsQ91665901
EMT and Cancer: More Than Meets the EyeQ91823867
Loss of PTEN Expression Detected by Fluorescence Immunohistochemistry Predicts Lethal Prostate Cancer in Men Treated with ProstatectomyQ92616203
Vemurafenib Inhibits Active PTK6 in PTEN-null Prostate Tumor CellsQ92707257
P433issue1
P304page(s)1-8
P577publication date2020-02-25
P13046publication type of scholarly workreview articleQ7318358
P1433published inAmerican journal of clinical and experimental urologyQ27725737
P1476titleProtein tyrosine kinase 6 signaling in prostate cancer
P478volume8

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