In utero exposure to maternal diabetes impairs nephron progenitor differentiation

scientific article published on 11 September 2019

In utero exposure to maternal diabetes impairs nephron progenitor differentiation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1152/AJPRENAL.00204.2019
P698PubMed publication ID31509011

P50authorJacqueline HoQ90057493
P2093author name stringZhenwei Gong
Sunder Sims-Lucas
Radhika Muzumdar
Débora M Cerqueira
Elina Mukherjee
Andrew J Bodnar
Shelby L Hemker
Corynn Appolonia
Daniella M Ortiz
Favour O Oladipupo
P2860cites workCited1 is a bifunctional transcriptional cofactor that regulates early nephronic patterningQ24300488
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
Altered ureteric branching morphogenesis and nephron endowment in offspring of diabetic and insulin-treated pregnancyQ27335350
Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanismQ28114789
Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3betaQ28505773
Wnt/beta-catenin signaling regulates nephron induction during mouse kidney developmentQ28506499
Osr1 acts downstream of and interacts synergistically with Six2 to maintain nephron progenitor cells during kidney organogenesisQ28506958
Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4Q28508296
Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital systemQ28511083
Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney developmentQ28590640
Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney developmentQ28592487
Cited1 and Cited2 are differentially expressed in the developing kidney but are not required for nephrogenesisQ28593339
Six2 and Wnt regulate self-renewal and commitment of nephron progenitors through shared gene regulatory networksQ28594605
The number of fetal nephron progenitor cells limits ureteric branching and adult nephron endowmentQ30580163
Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosisQ33556248
Stereologic methods and their application in kidney researchQ33610683
Hypertension reduces soluble guanylyl cyclase expression in the mouse aorta via the Notch signaling pathwayQ33683635
Microarrays and RNA-Seq identify molecular mechanisms driving the end of nephron productionQ33843926
Leptin- and leptin receptor-deficient rodent models: relevance for human type 2 diabetesQ33846858
Post-weaning diet determines metabolic risk in mice exposed to overnutrition in early lifeQ33994482
Prenatal risk factors for childhood CKDQ34103405
The use of animal models in diabetes researchQ34255921
Sall1 maintains nephron progenitors and nascent nephrons by acting as both an activator and a repressorQ34427626
Renal stromal miRNAs are required for normal nephrogenesis and glomerular mesangial survival.Q34496903
Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesisQ34673674
Diabetes mellitus and birth defectsQ34803469
SMG1 identified as a regulator of Parkinson's disease-associated alpha-synuclein through siRNA screeningQ35035515
Integrated β-catenin, BMP, PTEN, and Notch signalling patterns the nephronQ35111241
Mutual antagonism of Wilms' tumor 1 and β-catenin dictates podocyte health and diseaseQ35124213
Notch pathway activation can replace the requirement for Wnt4 and Wnt9b in mesenchymal-to-epithelial transition of nephron stem cellsQ35208718
Bridging of beta-catenin and glycogen synthase kinase-3beta by axin and inhibition of beta-catenin-mediated transcriptionQ35977699
The effect of intrauterine growth retardation on the development of renal nephronsQ36090328
Maternal Fat Feeding Augments Offspring Nephron Endowment in Mice.Q36108900
Superoxide Dismutase 1 In Vivo Ameliorates Maternal Diabetes Mellitus-Induced Apoptosis and Heart Defects Through Restoration of Impaired Wnt SignalingQ36199977
Myocardin-like protein 2 regulates TGFβ signaling in embryonic stem cells and the developing vasculature.Q36215741
Behaviour of CD11b-Positive Cells in an Animal Model of Laser-Induced Choroidal NeovascularisationQ36250660
Maternal diabetes induces congenital heart defects in mice by altering the expression of genes involved in cardiovascular developmentQ36330450
Maternal diabetes modulates renal morphogenesis in offspringQ36662130
Role for compartmentalization in nephron progenitor differentiationQ36712738
Prepregnancy care and the prevention of fetal malformations in the pregnancy complicated by diabetesQ36992779
The metastasis suppressor, N-myc downregulated gene 1 (NDRG1), is a prognostic biomarker for human colorectal cancerQ36997381
High-resolution gene expression analysis of the developing mouse kidney defines novel cellular compartments within the nephron progenitor populationQ37356678
D-glucose-induced dysmorphogenesis of embryonic kidneyQ37361743
Mapping of murine diabetogenic gene mody on chromosome 7 at D7Mit258 and its involvement in pancreatic islet and beta cell development during the perinatal periodQ37381891
Chronic hyperglycemia predisposes to exaggerated inflammatory response and leukocyte dysfunction in Akita mice.Q37415343
Advances in early kidney specification, development and patterningQ37424512
Notch signaling promotes nephrogenesis by downregulating Six2.Q37425842
Deletion of Frs2alpha from the ureteric epithelium causes renal hypoplasiaQ37430764
Effect of maternal diabetes on the embryo, fetus, and children: congenital anomalies, genetic and epigenetic changes and developmental outcomesQ38382091
Bim gene dosage is critical in modulating nephron progenitor survival in the absence of microRNAs during kidney developmentQ38818046
Micropatterned coculture of primary human hepatocytes and supportive cells for the study of hepatotropic pathogens.Q38818466
Semiautomated quantitative image analysis of glomerular immunohistochemistry markers desmin, vimentin, podocin, synaptopodin and WT-1 in acute and chronic rat kidney disease modelsQ38931612
Early organogenesis of the kidneyQ39611879
High glucose promotes nascent nephron apoptosis via NF-kappaB and p53 pathwaysQ39641751
Cessation of renal morphogenesis in miceQ40007459
Severe congenital anomalies of the kidney and urinary tract: epidemiology can inform ethical decision-makingQ40519492
The endoplasmic reticulum stress response is stimulated through the continuous activation of transcription factors ATF6 and XBP1 in Ins2+/Akita pancreatic beta cells.Q40581298
The molecular basis of embryonic kidney developmentQ41122012
Maternal diabetes mellitus and congenital anomalies of the kidney and urinary tract (CAKUT) in the childQ41572347
Maternal nutrition, fetal nutrition, and disease in later lifeQ41588886
Eya1 interacts with Six2 and Myc to regulate expansion of the nephron progenitor pool during nephrogenesisQ42029713
MiR-31 promotes mammary stem cell expansion and breast tumorigenesis by suppressing Wnt signaling antagonistsQ42380563
Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron.Q43213014
Outcomes in type 1 diabetic pregnancies: a nationwide, population-based studyQ45161554
Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidneyQ45178758
Epigenetic mechanisms underlying maternal diabetes-associated risk of congenital heart disease.Q46302040
Global quantification of tissue dynamics in the developing mouse kidneyQ46360772
Proinsulin lacking the A7-B7 disulfide bond, Ins2Akita, tends to aggregate due to the exposed hydrophobic surface.Q46819707
Diet-induced obesity in female mice leads to offspring hyperphagia, adiposity, hypertension, and insulin resistance: a novel murine model of developmental programmingQ46845260
WT1 controls antagonistic FGF and BMP-pSMAD pathways in early renal progenitorsQ46899493
Notch transactivates Rheb to maintain the multipotency of TSC-null cellsQ47303044
Notch is required for the formation of all nephron segments and primes nephron progenitors for differentiationQ47428777
Cloning and expression of apical membrane water channel of rat kidney collecting tubuleQ48133572
Transcriptional regulatory control of mammalian nephron progenitors revealed by multi-factor cistromic analysis and genetic studies.Q48149649
Natriuretic Peptide Receptor Guanylyl Cyclase-A in Podocytes is Renoprotective but Dispensable for Physiologic Renal FunctionQ49204372
Conserved and Divergent Molecular and Anatomic Features of Human and Mouse Nephron PatterningQ49959864
Endothelial marker-expressing stromal cells are critical for kidney formationQ50201268
Maternal obesity increases the risk of metabolic disease and impacts renal health in offspringQ50421794
Maternal glucose intolerance reduces offspring nephron endowment and increases glomerular volume in adult offspring.Q50479688
Trends in incidence of diabetes in pregnancy and serious perinatal outcomes: a large, population-based study in Ontario, Canada, 1996-2010.Q51243598
MiR-181b targets Six2 and inhibits the proliferation of metanephric mesenchymal cells in vitro.Q51782148
Nephron formation adopts a novel spatial topology at cessation of nephrogenesis.Q51852105
Neural tube defects in embryos of diabetic mice: role of the Pax-3 gene and apoptosis.Q52193997
Evidence that elevated glucose causes altered gene expression, apoptosis, and neural tube defects in a mouse model of diabetic pregnancy.Q52537166
Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice.Q54246553
Developmental origins of health and disease.Q55527277
A Prospective Study of the Risk of Congenital Defects Associated with Maternal Obesity and Diabetes MellitusQ59591411
GSK3 suppression upregulates β-catenin and c-Myc to abrogate KRas-dependent tumorsQ59794151
Human intrauterine renal growth expressed in absolute number of glomeruli assessed by the disector method and Cavalieri principleQ70180580
Adverse effects of hyperglycemia on kidney development in rats: in vivo and in vitro studiesQ73117360
A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant miceQ73303112
Augmented and accelerated nephrogenesis in TGF-beta2 heterozygous mutant miceQ80813439
Maternal diabetes and renal agenesis/dysgenesisQ84734577
Maternal diabetes modulates kidney formation in murine progeny: the role of hedgehog interacting protein (HHIP)Q88138798
Loss of miR-17~92 results in dysregulation of Cftr in nephron progenitorsQ92155409
P433issue5
P304page(s)F1318-F1330
P577publication date2019-09-11
P1433published inAmerican Journal of Physiology - Renal PhysiologyQ2610177
P1476titleIn utero exposure to maternal diabetes impairs nephron progenitor differentiation
P478volume317

Search more.