Increased apolipoprotein C3 drives cardiovascular risk in type 1 diabetes

scientific article published on 11 July 2019

Increased apolipoprotein C3 drives cardiovascular risk in type 1 diabetes is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1172/JCI127308
P932PMC publication ID6763229
P698PubMed publication ID31295146

P50authorBaohai ShaoQ37370740
Jenny E KanterQ52684544
Rebecca A. HaeuslerQ75273899
Karin E. BornfeldtQ87887672
John E HokansonQ89513456
Janet K Snell-BergeonQ107143200
Masami Shimizu-AlbergineQ125299270
Farah KramerQ125299327
P2093author name stringJay W Heinecke
Gregory L Kinney
Shelley Barnhart
Mark J Graham
Rosanne M Crooke
Karol Bomsztyk
Tomas Vaisar
Daniel Mar
Clarence R Manuel
P2860cites workInhibitory effects of C apolipoproteins from rats and humans on the uptake of triglyceride-rich lipoproteins and their remnants by the perfused rat liverQ24300330
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The crucial roles of apolipoproteins E and C-III in apoB lipoprotein metabolism in normolipidemia and hypertriglyceridemiaQ26864682
Why Is Apolipoprotein CIII Emerging as a Novel Therapeutic Target to Reduce the Burden of Cardiovascular Disease?Q28077776
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Transcriptional activation of apolipoprotein CIII expression by glucose may contribute to diabetic dyslipidemiaQ28565000
Antisense oligonucleotide inhibition of apolipoprotein C-III reduces plasma triglycerides in rodents, nonhuman primates, and humansQ28575302
Skyline: an open source document editor for creating and analyzing targeted proteomics experimentsQ30080030
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Loss-of-function mutations in APOC3 and risk of ischemic vascular diseaseQ34425444
Very-Low-Density Lipoprotein-Associated Apolipoproteins Predict Cardiovascular Events and Are Lowered by Inhibition of APOC-III.Q34551430
Parallel reaction monitoring (PRM) and selected reaction monitoring (SRM) exhibit comparable linearity, dynamic range and precision for targeted quantitative HDL proteomicsQ34654305
Association between 7 years of intensive treatment of type 1 diabetes and long-term mortalityQ35012749
Aggressive very low-density lipoprotein (VLDL) and LDL lowering by gene transfer of the VLDL receptor combined with a low-fat diet regimen induces regression and reduces macrophage content in advanced atherosclerotic lesions in LDL receptor-deficienQ35088381
Mechanism of hypertriglyceridemia in human apolipoprotein (apo) CIII transgenic mice. Diminished very low density lipoprotein fractional catabolic rate associated with increased apo CIII and reduced apo E on the particlesQ35608640
Common genetic variation in the promoter of the human apo CIII gene abolishes regulation by insulin and may contribute to hypertriglyceridemiaQ35767718
Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis through acyl-CoA synthetase 1.Q35849515
A Cluster of Proteins Implicated in Kidney Disease Is Increased in High-Density Lipoprotein Isolated from Hemodialysis SubjectsQ36257138
Type 1 diabetes promotes disruption of advanced atherosclerotic lesions in LDL receptor-deficient mice.Q36883079
Does Elevated Glucose Promote Atherosclerosis? Pros and ConsQ37083092
A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotectionQ37171168
ApoCIII-enriched LDL in type 2 diabetes displays altered lipid composition, increased susceptibility for sphingomyelinase, and increased binding to biglycanQ37317424
Diabetes and atherosclerosis: is there a role for hyperglycemia?Q37333371
Update on cardiovascular outcomes at 30 years of the diabetes control and complications trial/epidemiology of diabetes interventions and complications studyQ37403220
Relationship of glycated albumin to blood glucose and HbA1c values and to retinopathy, nephropathy, and cardiovascular outcomes in the DCCT/EDIC studyQ37403310
Diabetes and diabetes-associated lipid abnormalities have distinct effects on initiation and progression of atherosclerotic lesionsQ37486465
Lipoprotein physiology in nondiabetic and diabetic states. Relationship to atherogenesisQ37548758
Hyperglycemia promotes myelopoiesis and impairs the resolution of atherosclerosisQ37711215
Cholesterol efflux: a novel regulator of myelopoiesis and atherogenesis.Q38053137
Hypercholesterolemia links hematopoiesis with atherosclerosis.Q38066291
Insulin resistance and hyperglycaemia in cardiovascular disease developmentQ38198953
Insulin stimulates hepatic low density lipoprotein receptor-related protein 1 (LRP1) to increase postprandial lipoprotein clearanceQ38360290
A human APOC3 missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein levelsQ38616263
Recommendation on Design, Execution, and Reporting of Animal Atherosclerosis Studies: A Scientific Statement From the American Heart AssociationQ38669204
ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors.Q39614082
The relationship of blood glucose with cardiovascular disease is mediated over time by traditional risk factors in type 1 diabetes: the DCCT/EDIC studyQ40121355
Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinityQ40244307
Mortality and Cardiovascular Disease in Type 1 and Type 2 DiabetesQ40246024
Foxo1 mediates insulin action on apoC-III and triglyceride metabolism.Q40301333
Targeting APOC3 in the familial chylomicronemia syndromeQ41731850
Neutrophil-derived S100 calcium-binding proteins A8/A9 promote reticulated thrombocytosis and atherogenesis in diabetesQ42180113
Effect of type 1 diabetes on the gender difference in coronary artery calcification: a role for insulin resistance? The Coronary Artery Calcification in Type 1 Diabetes (CACTI) StudyQ43435231
Antisense Inhibition of Apolipoprotein C-III in Patients with HypertriglyceridemiaQ46112189
Apolipoprotein C-III inhibits triglyceride hydrolysis by GPIHBP1-bound LPL.Q46300109
Inflammatory stimuli induce acyl-CoA thioesterase 7 and remodeling of phospholipids containing unsaturated long (≥C20)-acyl chains in macrophages.Q46381890
Aggravated restenosis and atherogenesis in ApoCIII transgenic mice but lack of protection in ApoCIII knockouts: the effect of authentic triglyceride-rich lipoproteins with and without ApoCIII.Q46702771
FoxO transcription factors are required for hepatic HDL-cholesterol clearanceQ50163221
Antisense-Mediated Lowering of Plasma Apolipoprotein C-III by Volanesorsen Improves Dyslipidemia and Insulin Sensitivity in Type 2 Diabetes.Q51716105
Multi-dimensional Transcriptional Remodeling by Physiological Insulin In Vivo.Q64957324
Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related proteinQ68819183
Metabolism of C-apolipoproteins: kinetics of C-II, C-III1 and C-III2, and VLDL-apolipoprotein B in normal and hyperlipoproteinemic subjectsQ71045910
Acute phase reactants of mice. I. Isolation of serum amyloid P-component (SAP) and its induction by a monokineQ71606610
Transcriptional regulation of the apoC-III gene by insulin in diabetic mice: correlation with changes in plasma triglyceride levelsQ72575250
ApoC-III content of apoB-containing lipoproteins is associated with binding to the vascular proteoglycan biglycanQ78432641
Metabolic Karma-The Atherogenic Legacy of Diabetes: The 2017 Edwin Bierman Award LectureQ88426325
Effects of APOC3 Heterozygous Deficiency on Plasma Lipid and Lipoprotein MetabolismQ90724347
ApoC-III ASO promotes tissue LPL activity in the absence of apoE-mediated TRL clearanceQ92050948
PIXUL-ChIP: integrated high-throughput sample preparation and analytical platform for epigenetic studiesQ92709500
Serum apolipoproteins and apolipoprotein-defined lipoprotein subclasses: a hypothesis-generating prospective study of cardiovascular events in T1DQ92774530
P921main subjecttype-1 diabetesQ124407
P304page(s)4165-4179
P577publication date2019-07-11
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleIncreased apolipoprotein C3 drives cardiovascular risk in type 1 diabetes
P478volume130

Reverse relations

cites work (P2860)
Q99593566A New Treatment Strategy for Diabetic Dyslipidemia?
Q96818381Metformin Decreases Insulin Resistance in Type 1 Diabetes Through Regulating p53 and RAP2A in vitro and in vivo
Q89967822Monocytes and Macrophages as Protagonists in Vascular Complications of Diabetes
Q90539112Remnants of the Triglyceride-Rich Lipoproteins, Diabetes, and Cardiovascular Disease

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