Novel fibrillar structure in the inversin compartment of primary cilia revealed by 3D single-molecule superresolution microscopy

scientific article published on 02 January 2020

Novel fibrillar structure in the inversin compartment of primary cilia revealed by 3D single-molecule superresolution microscopy is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1091/MBC.E19-09-0499
P932PMC publication ID7202064
P698PubMed publication ID31895004

P50authorWilliam E. MoernerQ1387059
P2093author name stringPeter K Jackson
Petar N Petrov
Anna-Karin Gustavsson
Henrietta W Bennett
Camille A Bayas
Nancie Mooney
P2860cites workAn ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary ciliumQ24297497
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Loss of nephrocystin-3 function can cause embryonic lethality, Meckel-Gruber-like syndrome, situs inversus, and renal-hepatic-pancreatic dysplasiaQ24315070
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The canonical Wnt signaling pathway is not involved in renal cyst development in the kidneys of inv mutant mice.Q51890954
Localization of Inv in a distinctive intraciliary compartment requires the C-terminal ninein-homolog-containing region.Q51945543
The left-right determinant Inversin is a component of node monocilia and other 9+0 cilia.Q52107835
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Inner lumen proteins stabilize doublet microtubules in cilia and flagellaQ64117068
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A homozygous mutation in INVS causing juvenile nephronophthisis with abnormal reactivity of the Wnt/beta-catenin pathwayQ84960994
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Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia ExcisionQ93104331
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Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determinationQ28188363
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Targeting of Nphp3 to the primary cilia is controlled by an N-terminal myristoylation site and coiled-coil domainsQ28511875
Nek8 regulates the expression and localization of polycystin-1 and polycystin-2Q28513278
NIMA-related kinases defective in murine models of polycystic kidney diseases localize to primary cilia and centrosomesQ28591960
The Rilp-like proteins Rilpl1 and Rilpl2 regulate ciliary membrane content.Q28592935
Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathwaysQ29614619
Inversin relays Frizzled-8 signals to promote proximal pronephros developmentQ30497559
The Nek8 protein kinase, mutated in the human cystic kidney disease nephronophthisis, is both activated and degraded during ciliogenesisQ30505167
Mechanosignaling between central apparatus and radial spokes controls axonemal dynein activityQ30573286
Three-dimensional, single-molecule fluorescence imaging beyond the diffraction limit by using a double-helix point spread functionQ33408484
Beyond 9+0: noncanonical axoneme structures characterize sensory cilia from protists to humansQ34072213
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Ciliopathies: an expanding disease spectrumQ34626170
The nphp-2 and arl-13 genetic modules interact to regulate ciliogenesis and ciliary microtubule patterning in C. elegansQ34679993
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Defects in ciliary localization of Nek8 is associated with cystogenesis.Q34735000
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Novel NEK8 Mutations Cause Severe Syndromic Renal Cystic Dysplasia through YAP DysregulationQ35954123
Superresolution Pattern Recognition Reveals the Architectural Map of the Ciliary Transition ZoneQ36056355
Polarity and asymmetry in the arrangement of dynein and related structures in the Chlamydomonas axonemeQ36205308
Loss of the ciliary kinase Nek8 causes left-right asymmetry defectsQ36509302
Quantitative multicolor subdiffraction imaging of bacterial protein ultrastructures in three dimensionsQ36690739
ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3Q37205532
A guide to super-resolution fluorescence microscopyQ37774153
Phosphorylation-dependent Akt-Inversin interaction at the basal body of primary cilia.Q38768808
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Three-Dimensional Localization of Single Molecules for Super-Resolution Imaging and Single-Particle TrackingQ39115388
The Invs gene encodes a microtubule-associated proteinQ40542271
The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary BaseQ41412960
NEK8 links the ATR-regulated replication stress response and S phase CDK activity to renal ciliopathiesQ41883398
Expression analyses and interaction with the anaphase promoting complex protein Apc2 suggest a role for inversin in primary cilia and involvement in the cell cycleQ44241922
Super-resolution microscopy reveals that disruption of ciliary transition-zone architecture causes Joubert syndromeQ46168591
Palmitoylation of the ciliary GTPase ARL13b is necessary for its stability and its role in cilia formation.Q47894086
Cloning of inv, a gene that controls left/right asymmetry and kidney development.Q48021550
3D single-molecule super-resolution microscopy with a tilted light sheetQ48276744
P433issue7
P304page(s)619-639
P577publication date2020-01-02
P1433published inMolecular Biology of the CellQ2338259
P1476titleNovel fibrillar structure in the inversin compartment of primary cilia revealed by 3D single-molecule superresolution microscopy
P478volume31

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Q100506990Super-resolution Microscopy with Single Molecules in Biology and Beyond-Essentials, Current Trends, and Future Challengescites workP2860