Single-cell RNA-seq identifies a reversible mesodermal activation in abnormally specified epithelia of p63 EEC syndrome

scientific article published on 14 August 2019

Single-cell RNA-seq identifies a reversible mesodermal activation in abnormally specified epithelia of p63 EEC syndrome is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1073/PNAS.1908180116
P1325external data available at URLhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE120107
P932PMC publication ID6717277
P698PubMed publication ID31413199

P50authorFuchou TangQ67596532
Huiqing ZhouQ88086036
P2093author name stringQuan Xu
Qingqing Li
Willem M R van den Akker
Isabelle Petit
Eduardo Soares
Simon J van Heeringen
Yuxuan Zheng
Jieqiong Qu
Daniel Aberdam
Henriette H M Raeven
Karina O Brandao
P2860cites workThe p63 gene in EEC and other syndromesQ24679311
Embryonic stem cell lines derived from human blastocystsQ27861010
Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndromeQ28146059
APR-246/PRIMA-1(MET) rescues epidermal differentiation in skin keratinocytes derived from EEC syndrome patients with p63 mutationsQ28284341
p63 Is essential for the proliferative potential of stem cells in stratified epitheliaQ28300720
ΔNp63 is an ectodermal gatekeeper of epidermal morphogenesisQ28508449
p63 is essential for regenerative proliferation in limb, craniofacial and epithelial developmentQ28587664
p63 is a p53 homologue required for limb and epidermal morphogenesisQ28588206
Lentiviral vector design and imaging approaches to visualize the early stages of cellular reprogramming.Q30499307
Normalization of RNA-seq data using factor analysis of control genes or samplesQ30844396
Nuclear reprogramming to a pluripotent state by three approachesQ33980410
p63 identifies keratinocyte stem cellsQ34707172
Generation of keratinocytes from normal and recessive dystrophic epidermolysis bullosa-induced pluripotent stem cells.Q35008203
Differential binding of fibroblast growth factor-2 and -7 to basement membrane heparan sulfate: comparison of normal and abnormal human tissuesQ35764272
Suramin blocks interaction between human FGF1 and FGFR2 D2 domain and reduces downstream signaling activity.Q36069722
Impaired epithelial differentiation of induced pluripotent stem cells from ectodermal dysplasia-related patients is rescued by the small compound APR-246/PRIMA-1MET.Q36598086
p63-associated disorders.Q36708708
Control of keratinocyte proliferation and differentiation by p63.Q36723013
p63, cell adhesion and survivalQ36734639
p63-expressing cells are the stem cells of developing prostate, bladder, and colorectal epitheliaQ36855105
The alpha/beta carboxy-terminal domains of p63 are required for skin and limb development. New insights from the Brdm2 mouse which is not a complete p63 knockout but expresses p63 gamma-like proteinsQ37423576
Single-cell analysis of mixed-lineage states leading to a binary cell fate choice.Q37510607
Induced multipotency in adult keratinocytes through down-regulation of ΔNp63 or DGCR8.Q37571123
Basal cell signaling by p63 controls luminal progenitor function and lactation via NRG1.Q37632537
Recent Updates on Development of Drug Molecules for Human African TrypanosomiasisQ38806890
EGFR signaling upregulates expression of microsomal prostaglandin E synthase-1 in cancer cells leading to enhanced tumorigenicityQ39443547
A role for the cytoskeleton in STAT5 activation in MCF7 human breast cancer cells stimulated with EGF.Q40269333
The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cellsQ41861103
Suramin and heparin: aspecific inhibitors of mesoderm induction in the Xenopus laevis embryoQ41929399
Characterization and Endocytic Internalization of Epith-2 Cell Surface Glycoprotein during the Epithelial-to-Mesenchymal Transition in Sea Urchin EmbryosQ42031129
Valproic acid inhibits angiogenesis in vitro and in vivoQ44772882
Suramin promotes proliferation and scattering of renal epithelial cellsQ46440352
Master regulatory role of p63 in epidermal development and diseaseQ47286853
Highly multiplexed and strand-specific single-cell RNA 5' end sequencingQ47936785
A Modular Platform for Differentiation of Human PSCs into All Major Ectodermal LineagesQ50196912
Valproic acid sensitizes metformin-resistant human renal cell carcinoma cells by upregulating H3 acetylation and EMT reversal.Q52718768
Identification of the tumour transition states occurring during EMT.Q53693953
Single-Cell Transcriptomic Analysis of Cardiac Differentiation from Human PSCs Reveals HOPX-Dependent Cardiomyocyte MaturationQ57025426
Single Cell and Open Chromatin Analysis Reveals Molecular Origin of Epidermal Cells of the SkinQ57294154
Retinoic acid and BMP4 cooperate with p63 to alter chromatin dynamics during surface epithelial commitmentQ58611498
Suramin is a Potent Inhibitor of Vascular Endothelial Growth Factor. A Contribution to the Molecular Basis of its Antiangiogenic ActionQ59261165
TFAP2C- and p63-Dependent Networks Sequentially Rearrange Chromatin Landscapes to Drive Human Epidermal Lineage CommitmentQ64117626
Fibroblasts change spreading capability and mechanical properties in a direct interaction with keratinocytes in conditions mimicking wound healingQ88578070
P4510describes a project that usescell cultureQ189082
P433issue35
P921main subjectectrodactyly–ectodermal dysplasia–cleft syndromeQ5334319
RNA sequencingQ2542347
single-cell RNA-seqQ18409577
single cell transcriptomicsQ105406038
P304page(s)17361-17370
P577publication date2019-08-14
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleSingle-cell RNA-seq identifies a reversible mesodermal activation in abnormally specified epithelia of p63 EEC syndrome
P478volume116

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