| scholarly article | Q13442814 |
| P2093 | author name string | Gary M Wildey | |
| Philip H Howe | |||
| Xiao-Jun Qi | |||
| P2860 | cites work | Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor | Q22009126 |
| 14-3-3 inhibits Bad-induced cell death through interaction with serine-136 | Q24291932 | ||
| Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis | Q24296925 | ||
| Bim: a novel member of the Bcl-2 family that promotes apoptosis | Q24532974 | ||
| JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis | Q24554008 | ||
| Proapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activity | Q24675444 | ||
| The structure of a Bcl-xL/Bim fragment complex: implications for Bim function | Q27642185 | ||
| Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery | Q27860586 | ||
| Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms | Q28137802 | ||
| The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex | Q28141249 | ||
| Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1 | Q28142184 | ||
| BAD Ser-155 phosphorylation regulates BAD/Bcl-XL interaction and cell survival | Q28145685 | ||
| Gene structure alternative splicing, and chromosomal localization of pro-apoptotic Bcl-2 relative Bim | Q28201672 | ||
| FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines | Q28207468 | ||
| Direct addition of BimL to mitochondria does not lead to cytochrome c release | Q28208417 | ||
| Molecular cloning and characterization of six novel isoforms of human Bim, a member of the proapoptotic Bcl-2 family | Q28208950 | ||
| Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis | Q28212224 | ||
| The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2 | Q28216784 | ||
| Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt | Q28255373 | ||
| Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release | Q28567073 | ||
| Nerve growth factor (NGF) down-regulates the Bcl-2 homology 3 (BH3) domain-only protein Bim and suppresses its proapoptotic activity by phosphorylation | Q28576927 | ||
| Cellular survival: a play in three Akts | Q29547806 | ||
| BCL-2 family members and the mitochondria in apoptosis | Q29614427 | ||
| Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase | Q29620235 | ||
| Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1). | Q33606105 | ||
| Constitutive synthesis of interleukin-3 by leukaemia cell line WEHI-3B is due to retroviral insertion near the gene | Q34378250 | ||
| Ten years of protein kinase B signalling: a hard Akt to follow | Q34432885 | ||
| Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins | Q34612753 | ||
| The proapoptotic BH3-only protein bim is expressed in hematopoietic, epithelial, neuronal, and germ cells | Q35745742 | ||
| FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity | Q36324207 | ||
| Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity. | Q37593642 | ||
| Downregulation of Bim, a proapoptotic relative of Bcl-2, is a pivotal step in cytokine-initiated survival signaling in murine hematopoietic progenitors | Q39457731 | ||
| Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim. | Q40323778 | ||
| Identification of a DEF-type docking domain for extracellular signal-regulated kinases 1/2 that directs phosphorylation and turnover of the BH3-only protein BimEL. | Q40454938 | ||
| Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells. | Q40462629 | ||
| MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol | Q40537978 | ||
| Extracellular signal-regulated kinases 1/2 are serum-stimulated "Bim(EL) kinases" that bind to the BH3-only protein Bim(EL) causing its phosphorylation and turnover | Q40606380 | ||
| Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function. | Q40626751 | ||
| Phosphorylation of the pro-apoptotic protein Bim in lymphocytes is associated with protection from apoptosis | Q40647484 | ||
| Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim. | Q40662652 | ||
| Smad3 potentiates transforming growth factor beta (TGFbeta )-induced apoptosis and expression of the BH3-only protein Bim in WEHI 231 B lymphocytes | Q40663965 | ||
| Activation of ERK1/2 by deltaRaf-1:ER* represses Bim expression independently of the JNK or PI3K pathways | Q40666435 | ||
| Phosphoinositide 3-kinase-dependent regulation of interleukin-3-induced proliferation: involvement of mitogen-activated protein kinases, SHP2 and Gab2. | Q40808389 | ||
| Protein kinase C theta and epsilon promote T-cell survival by a rsk-dependent phosphorylation and inactivation of BAD. | Q40856361 | ||
| FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons | Q42918105 | ||
| Bcl-XL protects BimEL-induced Bax conformational change and cytochrome C release independent of interacting with Bax or BimEL. | Q44116154 | ||
| JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis | Q44485247 | ||
| BH3-only Bcl-2 family members are coordinately regulated by the JNK pathway and require Bax to induce apoptosis in neurons | Q74338796 | ||
| Dissociation of apoptosis from proliferation, protein kinase B activation, and BAD phosphorylation in interleukin-3-mediated phosphoinositide 3-kinase signaling | Q77206625 | ||
| Suppression of transforming growth factor-beta-induced apoptosis through a phosphatidylinositol 3-kinase/Akt-dependent pathway | Q77463961 | ||
| Interleukin-6 inhibits transforming growth factor-beta-induced apoptosis through the phosphatidylinositol 3-kinase/Akt and signal transducers and activators of transcription 3 pathways | Q78101665 | ||
| P433 | issue | 2 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | phosphorylation | Q242736 |
| apoptotic process | Q14599311 | ||
| P304 | page(s) | 813-23 | |
| P577 | publication date | 2006-01-13 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic function | |
| P478 | volume | 281 |
| Q28742388 | 14-3-3theta protects against neurotoxicity in a cellular Parkinson's disease model through inhibition of the apoptotic factor Bax |
| Q24658236 | 14-3-3zeta mediates resistance of diffuse large B cell lymphoma to an anthracycline-based chemotherapeutic regimen |
| Q36089926 | 8‑bromo‑7‑methoxychrysin induces apoptosis by regulating Akt/FOXO3a pathway in cisplatin‑sensitive and resistant ovarian cancer cells |
| Q92686162 | Activation of hedgehog signaling associates with early disease progression in chronic lymphocytic leukemia |
| Q34568683 | Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells |
| Q37163727 | Akt1 is the principal Akt isoform regulating apoptosis in limiting cytokine concentrations. |
| Q52607535 | Akt2: a critical regulator of cardiomyocyte survival and metabolism. |
| Q36973814 | Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy |
| Q42173208 | Alternative splicing of Bim and Erk-mediated Bim(EL) phosphorylation are dispensable for hematopoietic homeostasis in vivo. |
| Q39028687 | Anoikis and EMT: Lethal "Liaisons" during Cancer Progression |
| Q26852158 | Anoikis molecular pathways and its role in cancer progression |
| Q34786462 | Antitumor activity of S116836, a novel tyrosine kinase inhibitor, against imatinib-resistant FIP1L1-PDGFRα-expressing cells |
| Q39343288 | Arsenic induces apoptosis in myoblasts through a reactive oxygen species-induced endoplasmic reticulum stress and mitochondrial dysfunction pathway |
| Q40302263 | B-RAF and PI-3 kinase signaling protect melanoma cells from anoikis |
| Q36388507 | B7-H1 limits the entry of effector CD8(+) T cells to the memory pool by upregulating Bim |
| Q35539267 | BIM and other BCL-2 family proteins exhibit cross-species conservation of function between zebrafish and mammals |
| Q28756824 | BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations |
| Q28478390 | BIM-mediated AKT phosphorylation is a key modulator of arsenic trioxide-induced apoptosis in cisplatin-sensitive and -resistant ovarian cancer cells |
| Q36228193 | Bcl-xl does not have to bind Bax to protect T cells from death |
| Q37566240 | Bid: a Bax-like BH3 protein. |
| Q34047415 | Bim nuclear translocation and inactivation by viral interferon regulatory factor |
| Q35063113 | Bim protein degradation contributes to cisplatin resistance |
| Q33648236 | Bim, Bak, and Bax regulate osteoblast survival |
| Q36508651 | Bim, a proapoptotic protein, up-regulated via transcription factor E2F1-dependent mechanism, functions as a prosurvival molecule in cancer. |
| Q24309169 | BimL directly neutralizes Bcl-xL to promote Bax activation during UV-induced apoptosis |
| Q37684405 | Blocking downstream signaling pathways in the context of HDAC inhibition promotes apoptosis preferentially in cells harboring mutant Ras. |
| Q36483749 | Broad targeting of resistance to apoptosis in cancer. |
| Q45204023 | CD80 Expressed by CD8+ T Cells Contributes to PD-L1-Induced Apoptosis of Activated CD8+ T Cells. |
| Q41839747 | Caveolin-1 abrogates TGF-β mediated hepatocyte apoptosis |
| Q36655944 | Cell survival and apoptosis signaling as therapeutic target for cancer: marine bioactive compounds |
| Q48254812 | Changes in cIAP2, survivin and BimEL expression characterize the switch from autophagy to apoptosis in prolonged starvation. |
| Q42601087 | Competition for growth factors: a lot more death with a little less Aktion. |
| Q34666165 | Concurrent inhibition of PI3K and mTORC1/mTORC2 overcomes resistance to rapamycin induced apoptosis by down-regulation of Mcl-1 in mantle cell lymphoma |
| Q34176924 | Contrasting patterns of Bim induction and neuroprotection in Bim-deficient mice between hippocampus and neocortex after status epilepticus. |
| Q37109227 | Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia. |
| Q37251728 | Cotargeting survival signaling pathways in cancer |
| Q89013204 | Critical role for the Tsc1-mTORC1 pathway in β-cell mass in Pdx1-deficient mice |
| Q37693083 | Crossing paths: interactions between the cell death machinery and growth factor survival signals |
| Q36516796 | Crosstalk between Bcl-2 family and Ras family small GTPases: potential cell fate regulation? |
| Q28591851 | Cyclic-AMP-dependent protein kinase A regulates apoptosis by stabilizing the BH3-only protein Bim |
| Q24319111 | Differential 14-3-3 affinity capture reveals new downstream targets of phosphatidylinositol 3-kinase signaling |
| Q37038490 | Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance |
| Q35058356 | Discovery and development of small molecule SHIP phosphatase modulators |
| Q28564949 | Egr-1 transactivates Bim gene expression to promote neuronal apoptosis |
| Q37111125 | Essential and overlapping functions for mammalian Argonautes in microRNA silencing |
| Q42059865 | FAM83A and FAM83B: candidate oncogenes and TKI resistance mediators |
| Q39248446 | FGFR4 signaling couples to Bim and not Bmf to discriminate subsets of alveolar rhabdomyosarcoma cells. |
| Q39437671 | Flavokawain B induces apoptosis of human oral adenoid cystic cancer ACC-2 cells via up-regulation of Bim and down-regulation of Bcl-2 expression |
| Q33925625 | Flavokawain B, a kava chalcone, induces apoptosis via up-regulation of death-receptor 5 and Bim expression in androgen receptor negative, hormonal refractory prostate cancer cell lines and reduces tumor growth |
| Q35880072 | Follicle-stimulating hormone regulates pro-apoptotic protein Bcl-2-interacting mediator of cell death-extra long (BimEL)-induced porcine granulosa cell apoptosis |
| Q36661222 | Gefitinib-resistance is related to BIM expression in non-small cell lung cancer cell lines |
| Q34609961 | Glucocorticoid-mediated repression of the oncogenic microRNA cluster miR-17~92 contributes to the induction of Bim and initiation of apoptosis |
| Q42959233 | Heat shock preconditioning protects against ER stress-induced apoptosis through the regulation of the BH3-only protein BIM. |
| Q36236465 | Helicobacter pylori CagA Suppresses Apoptosis through Activation of AKT in a Nontransformed Epithelial Cell Model of Glandular Acini Formation |
| Q33598008 | High BIM mRNA levels are associated with longer survival in advanced gastric cancer |
| Q34299388 | Human herpesvirus 8 interferon regulatory factor-mediated BH3-only protein inhibition via Bid BH3-B mimicry |
| Q37444403 | Hyperlipidemia Alters Regulatory T Cell Function and Promotes Resistance to Tolerance Induction Through Costimulatory Molecule Blockade |
| Q28484877 | Hypoxia-induced modulation of apoptosis and BCL-2 family proteins in different cancer cell types |
| Q55368829 | IL-4 enhances survival of in vitro-differentiated mouse basophils through transcription-independent signaling downstream of PI3K. |
| Q24299252 | Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection |
| Q61133333 | Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin |
| Q54379896 | In vivo activation of the PI3K-Akt pathway in mouse beta cells by the EGFR mutation L858R protects against diabetes. |
| Q37416799 | Induction of Akt activity by chemotherapy confers acquired resistance |
| Q36026392 | Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas |
| Q43485482 | Induction of Bim limits cytokine-mediated prolonged survival of neutrophils |
| Q33674608 | Inhibition by anandamide of 6-hydroxydopamine-induced cell death in PC12 cells. |
| Q92372459 | Inhibition of SYK or BTK augments venetoclax sensitivity in SHP1-negative/BCL-2-positive diffuse large B-cell lymphoma |
| Q30389323 | Intrinsically disordered proteins in bcl-2 regulated apoptosis. |
| Q37510693 | Involvement of Akt in neurite outgrowth |
| Q40082360 | Juxtacrine activation of epidermal growth factor (EGF) receptor by membrane-anchored heparin-binding EGF-like growth factor protects epithelial cells from anoikis while maintaining an epithelial phenotype |
| Q28830062 | Knockdown of GSK3β increases basal autophagy and AMPK signalling in nutrient-laden human aortic endothelial cells |
| Q51785654 | Lactoferrin attenuates fatty acid-induced lipotoxicity via Akt signaling in hepatocarcinoma cells. |
| Q34241131 | Lipid Signaling in T-Cell Development and Function |
| Q35990714 | MEK1/2 inhibitors potentiate UCN-01 lethality in human multiple myeloma cells through a Bim-dependent mechanism |
| Q37699351 | MicroRNA-214 protects against hypoxia/reoxygenation induced cell damage and myocardial ischemia/reperfusion injury via suppression of PTEN and Bim1 expression |
| Q37504699 | Molecular and cellular mechanisms of CLL: novel therapeutic approaches. |
| Q36804432 | Multifaceted targeting in cancer: the recent cell death players meet the usual oncogene suspects |
| Q35953074 | Mutation in Osteoactivin Promotes Receptor Activator of NFκB Ligand (RANKL)-mediated Osteoclast Differentiation and Survival but Inhibits Osteoclast Function |
| Q37794795 | Myc: Maestro of MicroRNAs |
| Q28578213 | Nerve growth factor blocks thapsigargin-induced apoptosis at the level of the mitochondrion via regulation of Bim |
| Q38936710 | Novel Approaches to Apoptosis-Inducing Therapies |
| Q35901096 | Novel effects of simvastatin on uterine fibroid tumors: in vitro and patient-derived xenograft mouse model study |
| Q33695021 | Osteolytic bone metastasis is hampered by impinging on the interplay among autophagy, anoikis and ossification |
| Q39653523 | PI3K inhibitors prime neuroblastoma cells for chemotherapy by shifting the balance towards pro-apoptotic Bcl-2 proteins and enhanced mitochondrial apoptosis |
| Q88728607 | Phosphorylation alters Bim-mediated Mcl-1 stabilization and priming |
| Q24631299 | Phosphorylation of Puma modulates its apoptotic function by regulating protein stability |
| Q62817621 | Pro-apoptotic Bim suppresses breast tumor cell metastasis and is a target gene of SNAI2 |
| Q50676792 | Prosurvival and proapoptotic intracellular signaling in rat spiral ganglion neurons in vivo after the loss of hair cells. |
| Q24322936 | RACK1 and CIS mediate the degradation of BimEL in cancer cells |
| Q38244964 | Radiation-induced signaling pathways that promote cancer cell survival (review). |
| Q33840360 | Rational combination of dual PI3K/mTOR blockade and Bcl-2/-xL inhibition in AML. |
| Q37431048 | Reactive oxygen species in cancer |
| Q46045421 | Redox regulation of anoikis resistance of metastatic prostate cancer cells: key role for Src and EGFR-mediated pro-survival signals |
| Q40015294 | Redox regulation of anoikis: reactive oxygen species as essential mediators of cell survival. |
| Q26781203 | Regulation of Bim in Health and Disease |
| Q38619242 | Regulation of antiapoptotic and cytoprotective pathways in colonic epithelial cells in ulcerative colitis |
| Q33825096 | Role for the proapoptotic factor BIM in mediating imatinib-induced apoptosis in a c-KIT-dependent gastrointestinal stromal tumor cell line |
| Q34966603 | Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging |
| Q24645668 | Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance |
| Q37865381 | Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy. |
| Q37339049 | Runx1 is a co-activator with FOXO3 to mediate transforming growth factor beta (TGFbeta)-induced Bim transcription in hepatic cells |
| Q34762275 | S6 kinase 2 promotes breast cancer cell survival via Akt. |
| Q36488905 | SDF-1α degrades whereas glycoprotein 120 upregulates Bcl-2 interacting mediator of death extralong isoform: implications for the development of T cell memory |
| Q34016493 | SOD3 decreases ischemic injury derived apoptosis through phosphorylation of Erk1/2, Akt, and FoxO3a. |
| Q35082400 | Sequential dosing in chemosensitization: targeting the PI3K/Akt/mTOR pathway in neuroblastoma |
| Q42474267 | Shifting the balance of mitochondrial apoptosis: therapeutic perspectives |
| Q27027778 | Signaling cross-talk in the resistance to HER family receptor targeted therapy |
| Q36891596 | T cell Bim levels reflect responses to anti-PD-1 cancer therapy. |
| Q36946967 | TGF beta-mediated BIM expression and apoptosis are regulated through SMAD3-dependent expression of the MAPK phosphatase MKP2 |
| Q33696388 | TGF-beta-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEI |
| Q90594555 | Targeting AKT for cancer therapy |
| Q92372864 | Targeting Degradation of EGFR through the Allosteric Site Leads to Cancer Cell Detachment-Promoted Death |
| Q40154931 | Targeting the RAF/MEK/ERK, PI3K/AKT and p53 pathways in hematopoietic drug resistance. |
| Q34173253 | Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR pathway |
| Q37420518 | The BH3-only protein Bim plays a critical role in leukemia cell death triggered by concomitant inhibition of the PI3K/Akt and MEK/ERK1/2 pathways |
| Q54274892 | The PI3K/AKT/mTOR interactive pathway. |
| Q24616946 | The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation |
| Q38418344 | The apoptotic effect of simvastatin via the upregulation of BIM in nonsmall cell lung cancer cells |
| Q89144664 | The dynamic and stress-adaptive signaling hub of 14-3-3: emerging mechanisms of regulation and context-dependent protein-protein interactions |
| Q52601427 | The role of the cell-matrix interface in aging and its interaction with the renin-angiotensin system in the aged vasculature. |
| Q38902037 | The siRNA cocktail targeting interleukin 10 receptor and transforming growth factor-β receptor on dendritic cells potentiates tumour antigen-specific CD8(+) T cell immunity |
| Q37240022 | The von Hippel-Lindau protein sensitizes renal carcinoma cells to apoptotic stimuli through stabilization of BIM(EL). |
| Q37662408 | The zebrafish as a model organism for the study of apoptosis. |
| Q37837732 | Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways. |
| Q35320797 | Transforming growth factor beta (TGFbeta)-induced apoptosis: the rise & fall of Bim |
| Q49166966 | Truncated protein tyrosine phosphatase receptor type O suppresses AKT signaling through IQ motif containing GTPase activating protein 1 and confers sensitivity to bortezomib in multiple myeloma |
| Q35824228 | Tumor-Associated Endothelial Cells Promote Tumor Metastasis by Chaperoning Circulating Tumor Cells and Protecting Them from Anoikis |
| Q24656277 | Ubiquitin-proteasome system as a modulator of cell fate |
| Q36325477 | Vanadate prevents glucocorticoid-induced apoptosis of osteoblasts in vitro and osteocytes in vivo |
| Q24300375 | Vimentin is a novel AKT1 target mediating motility and invasion |
| Q41561734 | mTOR pathway activation is a favorable prognostic factor in human prostate adenocarcinoma. |
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