| scholarly article | Q13442814 |
| P2093 | author name string | Philip H Howe | |
| Barbara A Hocevar | |||
| Celine Prunier | |||
| P2860 | cites work | SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor | Q22008583 |
| The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway | Q22009096 | ||
| Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction | Q22254170 | ||
| The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway | Q24291279 | ||
| Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton | Q24294845 | ||
| Disabled-2 (Dab2) is required for transforming growth factor beta-induced epithelial to mesenchymal transition (EMT) | Q24296708 | ||
| JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain | Q24308838 | ||
| TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase | Q24310066 | ||
| Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription | Q24311810 | ||
| TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction | Q24312956 | ||
| A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3 | Q24320233 | ||
| Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin | Q24532029 | ||
| XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway | Q24533501 | ||
| Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor | Q24534474 | ||
| The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling | Q24540545 | ||
| Synergistic cooperation of TFE3 and smad proteins in TGF-beta-induced transcription of the plasminogen activator inhibitor-1 gene | Q24596458 | ||
| Smads bind directly to the Jun family of AP-1 transcription factors | Q24685193 | ||
| Crystal structures of the Dab homology domains of mouse disabled 1 and 2 | Q27641511 | ||
| A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket | Q27735488 | ||
| Mechanisms of TGF-beta signaling from cell membrane to the nucleus | Q27860785 | ||
| A system for stable expression of short interfering RNAs in mammalian cells | Q27860875 | ||
| ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-beta signaling | Q28139205 | ||
| Signal transduction by the JNK group of MAP kinases | Q28142592 | ||
| Transmembrane crosstalk between the extracellular matrix--cytoskeleton crosstalk | Q28206345 | ||
| Smad-dependent and Smad-independent pathways in TGF-beta family signalling | Q28208250 | ||
| Wnt activates the Tak1/Nemo-like kinase pathway | Q28244920 | ||
| Activation of the hematopoietic progenitor kinase-1 (HPK1)-dependent, stress-activated c-Jun N-terminal kinase (JNK) pathway by transforming growth factor beta (TGF-beta)-activated kinase (TAK1), a kinase mediator of TGF beta signal transduction | Q28247729 | ||
| New insights into TGF-beta-Smad signalling | Q28260517 | ||
| Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction | Q28271470 | ||
| SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase | Q28364720 | ||
| Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2 | Q28511063 | ||
| Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2 | Q28511801 | ||
| A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure | Q28588921 | ||
| Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor beta | Q28608955 | ||
| PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo | Q28609356 | ||
| The transforming growth factor-beta family | Q29615948 | ||
| Transcriptional control by the TGF-beta/Smad signaling system | Q29618985 | ||
| TGF-beta signaling and the fibrotic response | Q29620099 | ||
| A transcriptional partner for MAD proteins in TGF-beta signalling | Q29622823 | ||
| Matrix survival signaling: from fibronectin via focal adhesion kinase to c-Jun NH(2)-terminal kinase | Q30175136 | ||
| JNK, cytoskeletal regulator and stress response kinase? A Drosophila perspective | Q33536856 | ||
| TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway | Q33890533 | ||
| TAK1 participates in c-Jun N-terminal kinase signaling during Drosophila development | Q33963111 | ||
| Fibronectin at a glance | Q34150530 | ||
| JNK initiates a cytokine cascade that causes Pax2 expression and closure of the optic fissure | Q35965299 | ||
| Regulation of fibronectin biosynthesis by dexamethasone, transforming growth factor beta, and cAMP in human cell lines | Q36218968 | ||
| Activation of distinct alpha5beta1-mediated signaling pathways by fibronectin's cell adhesion and matrix assembly domains | Q36255267 | ||
| Smad3/AP-1 interactions control transcriptional responses to TGF-beta in a promoter-specific manner | Q38299529 | ||
| C-Jun-NH2-terminal kinase mediates expression of connective tissue growth factor induced by transforming growth factor-beta1 in human lung fibroblasts | Q38354405 | ||
| Molecular biology of fibronectin | Q39844004 | ||
| Transforming growth factor beta activation of p44mapk in proliferating cultures of epithelial cells | Q41357904 | ||
| Disruption of basal JNK activity differentially affects key fibroblast functions important for wound healing. | Q42440701 | ||
| Extracellular signal-regulated kinase and the small GTP-binding protein, Rac, contribute to the effects of transforming growth factor-beta1 on gene expression | Q42811037 | ||
| JNK signaling pathway is required for efficient wound healing in Drosophila | Q43169362 | ||
| Functional characterization of transforming growth factor beta signaling in Smad2- and Smad3-deficient fibroblasts | Q43550271 | ||
| The role of the Drosophila TAK homologue dTAK during development. | Q47070752 | ||
| Activin/inhibin beta B subunit gene disruption leads to defects in eyelid development and female reproduction. | Q52218306 | ||
| Regulation of the expression of a secreted acidic protein rich in cysteine (SPARC) in human fibroblasts by transforming growth factor beta. Comparison of transcriptional and post-transcriptional control with fibronectin and type I collagen | Q52237150 | ||
| Targeted disruption in murine cells reveals variable requirement for Smad4 in transforming growth factor beta-related signaling. | Q52537703 | ||
| Evidence for a role of Rho-like GTPases and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in transforming growth factor beta-mediated signaling | Q71984903 | ||
| Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription | Q73280041 | ||
| A dominant negative TAK1 inhibits cellular fibrotic responses induced by TGF-beta | Q73668163 | ||
| Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-beta-induced gene expression | Q78239880 | ||
| P433 | issue | 27 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | Disabled 2, mitogen-responsive phosphoprotein | Q21982744 |
| disability | Q12131 | ||
| P304 | page(s) | 25920-7 | |
| P577 | publication date | 2005-07-08 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | Disabled-2 (Dab2) mediates transforming growth factor beta (TGFbeta)-stimulated fibronectin synthesis through TGFbeta-activated kinase 1 and activation of the JNK pathway | |
| P478 | volume | 280 |
| Q99638028 | A potential therapeutic effect of catalpol in Duchenne muscular dystrophy revealed by binding with TAK1 |
| Q99572116 | Activation of GPR120 in podocytes ameliorates kidney fibrosis and inflammation in diabetic nephropathy |
| Q50100726 | Analysis of Combined Transcriptomes Identifies Gene Modules that Differentially Respond to Pathogenic Stimulation of Vascular Smooth Muscle and Endothelial Cells |
| Q33590950 | Clathrin mediates integrin endocytosis for focal adhesion disassembly in migrating cells |
| Q39013673 | Dab2 inhibits the cholesterol-dependent activation of JNK by TGF-β |
| Q38856672 | Disabled homolog 2 is required for migration and invasion of prostate cancer cells |
| Q34363558 | Disabled-2 downregulation promotes epithelial-to-mesenchymal transition |
| Q35221856 | Disabled-2 heterozygous mice are predisposed to endometrial and ovarian tumorigenesis and exhibit sex-biased embryonic lethality in a p53-null background |
| Q38896934 | Disabled-2: A modular scaffold protein with multifaceted functions in signaling |
| Q54521340 | EHD2 shuttles to the nucleus and represses transcription. |
| Q37541507 | Endocytic proteins in the regulation of nuclear signaling, transcription and tumorigenesis |
| Q28076375 | Endocytosis and Physiology: Insights from Disabled-2 Deficient Mice |
| Q42320799 | Endocytosis and membrane receptor internalization: implication of F-BAR protein Carom |
| Q30418853 | Engulfment protein GULP is regulator of transforming growth factor-β response in ovarian cells |
| Q34028615 | Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter. |
| Q37175879 | FSHD region gene 1 (FRG1) is crucial for angiogenesis linking FRG1 to facioscapulohumeral muscular dystrophy-associated vasculopathy |
| Q36342172 | Genistein alleviates pressure overload-induced cardiac dysfunction and interstitial fibrosis in mice |
| Q34434655 | Hormonal induction and roles of Disabled-2 in lactation and involution |
| Q35178270 | Hypoxia increases the abundance but not the assembly of extracellular fibronectin during epithelial cell transdifferentiation |
| Q93166926 | Hypoxia-Induced Epithelial-Mesenchymal Transition in Cancers: HIF-1α and Beyond |
| Q92810128 | JNK Pathway Mediates Low Oxygen Level Induced Epithelial-Mesenchymal Transition and Stemness Maintenance in Colorectal Cancer Cells |
| Q28395890 | Jun N-terminal kinase 1 regulates epithelial-to-mesenchymal transition induced by TGF-beta1 |
| Q33804105 | Mechanisms of the epithelial-mesenchymal transition by TGF-beta |
| Q34568457 | Negative regulation of the endocytic adaptor disabled-2 (Dab2) in mitosis |
| Q37044600 | Noncanonical TGF-β signaling during mammary tumorigenesis |
| Q57182551 | Pharmacological inhibition of autophagy by 3-MA attenuates hyperuricemic nephropathy |
| Q30439818 | Protein phosphatase 2A is a negative regulator of transforming growth factor-beta1-induced TAK1 activation in mesangial cells |
| Q33594982 | Putative tumour-suppressor gene DAB2 is frequently down regulated by promoter hypermethylation in nasopharyngeal carcinoma |
| Q24311541 | Quantitative proteomics identifies a Dab2/integrin module regulating cell migration |
| Q27023146 | Regulation of autophagy by TGF-β: emerging role in kidney fibrosis |
| Q37045195 | Requirement for protein kinase A in the phosphorylation of the TGFβ receptor-interacting protein km23-1 as a component of TGFβ downstream effects |
| Q37392558 | Role of p38 MAP Kinase Signal Transduction in Solid Tumors |
| Q35213019 | Signaling mechanisms of the epithelial-mesenchymal transition |
| Q28079488 | Switching Roles of TGF-β in Cancer Development: Implications for Therapeutic Target and Biomarker Studies |
| Q93095702 | TAB2 c.1398dup variant leads to haploinsufficiency and impairs extracellular matrix homeostasis |
| Q40725613 | TAK1 is a key modulator of the profibrogenic phenotype of human ileal myofibroblasts in Crohn's disease |
| Q37410310 | TGF-beta signal transduction in chronic kidney disease |
| Q26824337 | TGF-β signaling via TAK1 pathway: role in kidney fibrosis |
| Q36468657 | TGF-β-activated kinase-1: New insights into the mechanism of TGF-β signaling and kidney disease |
| Q41280741 | TGFbeta-induced RhoA activation and fibronectin production in mesangial cells require caveolae |
| Q39155151 | Targeting TGF-β Signaling for Therapeutic Gain |
| Q54349833 | The aldosterone receptor antagonist spironolactone prevents peritoneal inflammation and fibrosis. |
| Q37040558 | The pathophysiology of epithelial-mesenchymal transition induced by transforming growth factor-beta in normal and malignant mammary epithelial cells |
| Q36338683 | The regulation of cell-cell adhesion during epithelial-mesenchymal transition, motility and tumor progression |
| Q35079607 | Therapeutic targets for treating fibrotic kidney diseases |
| Q39464875 | Tissue transglutaminase links TGF-β, epithelial to mesenchymal transition and a stem cell phenotype in ovarian cancer |
| Q37372277 | Transforming growth factor-beta (TGF-beta1) activates TAK1 via TAB1-mediated autophosphorylation, independent of TGF-beta receptor kinase activity in mesangial cells |
| Q37098304 | Transforming growth factor-beta signaling and ubiquitinators in cancer. |
| Q28588905 | Type II Transforming Growth Factor-β Receptor Recycling Is Dependent upon the Clathrin Adaptor Protein Dab2 |
| Q90059126 | USP1 deubiquitinates Akt to inhibit PI3K-Akt-FoxO signaling in muscle during prolonged starvation |
| Q43156994 | c-Jun N-terminal kinase 1 is required for the development of pulmonary fibrosis |
| Q42066518 | c-Jun N-terminal kinase 1 promotes transforming growth factor-β1-induced epithelial-to-mesenchymal transition via control of linker phosphorylation and transcriptional activity of Smad3. |
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