| P50 | author | Reinhard Georg Lührmann | Q1317944 |
| | Herbert Waldmann | Q1609256 |
| | Cindy L Will | Q63134178 |
| | Berthold Kastner | Q63134443 |
| | Henning Urlaub | Q28037184 |
| P2093 | author name string | Anzhalika Sidarovich | |
| | Dmitry E Agafonov | |
| | Javier Ceballos | |
| | Maria M Anokhina | |
| | Penghui Bao | |
| | Sonja Sievers | |
| | Timur Samatov | |
| P2860 | cites work | A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro | Q22010663 |
| | Structural basis of pre-mRNA splicing. | Q53378420 |
| | U2–U6 RNA folding reveals a group II intron-like domain and a four-helix junction | Q57080150 |
| | Identification of SAP155 as the Target of GEX1A (Herboxidiene), an Antitumor Natural Product | Q57228552 |
| | An efficient continuous flow approach to furnish furan-based biaryls | Q58200371 |
| | Interactions of small nuclear RNA's with precursor messenger RNA during in vitro splicing | Q64378031 |
| | The U5 and U6 small nuclear RNAs as active site components of the spliceosome | Q64383669 |
| | Site-specific cross-linking of mammalian U5 snRNP to the 5' splice site before the first step of pre-mRNA splicing | Q67510685 |
| | U5 snRNA interacts with exon sequences at 5′ and 3′ splice sites | Q67753779 |
| | Four yeast spliceosomal proteins (PRP5, PRP9, PRP11, and PRP21) interact to promote U2 snRNP binding to pre-mRNA | Q70495958 |
| | Non-thiol farnesyltransferase inhibitors: N-(4-tolylacetylamino-3-benzoylphenyl)-3-arylfurylacrylic acid amides | Q80546376 |
| | A subset of human 35S U5 proteins, including Prp19, function prior to catalytic step 1 of splicing | Q24294927 |
| | Molecular architecture of the human Prp19/CDC5L complex | Q24300574 |
| | Cwc2 and its human homologue RBM22 promote an active conformation of the spliceosome catalytic centre | Q24301865 |
| | Phosphorylation of spliceosomal protein SAP 155 coupled with splicing catalysis | Q24316022 |
| | An evolutionarily conserved U5 snRNP-specific protein is a GTP-binding factor closely related to the ribosomal translocase EF-2. | Q24318957 |
| | The human U5-200kD DEXH-box protein unwinds U4/U6 RNA duplices in vitro | Q24323409 |
| | The 65 and 110 kDa SR-related proteins of the U4/U6.U5 tri-snRNP are essential for the assembly of mature spliceosomes | Q24534416 |
| | SMNrp is an essential pre-mRNA splicing factor required for the formation of the mature spliceosome | Q24535039 |
| | A novel U2 and U11/U12 snRNP protein that associates with the pre-mRNA branch site. | Q24535663 |
| | New connections between splicing and human disease | Q27005815 |
| | Structure of the yeast U2/U6 snRNA complex | Q27677233 |
| | Crystal structure of a group II intron in the pre-catalytic state | Q27678382 |
| | Structure of a yeast spliceosome at 3.6-angstrom resolution | Q27701867 |
| | The 3.8 Å structure of the U4/U6.U5 tri-snRNP: Insights into spliceosome assembly and catalysis | Q27703519 |
| | Molecular architecture of the human U4/U6.U5 tri-snRNP | Q27704181 |
| | Structure of a yeast activated spliceosome at 3.5 Å resolution | Q27721209 |
| | Structure of a yeast catalytic step I spliceosome at 3.4 Å resolution | Q27721261 |
| | Cryo-EM structure of the spliceosome immediately after branching | Q27722247 |
| | Molecular architecture of the Saccharomyces cerevisiae activated spliceosome | Q27727737 |
| | Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei | Q27860728 |
| | RNA unwinding in U4/U6 snRNPs requires ATP hydrolysis and the DEIH-box splicing factor Brr2 | Q27930438 |
| | Spliceosome activation by PRP2 ATPase prior to the first transesterification reaction of pre-mRNA splicing | Q27931041 |
| | Progression through the spliceosome cycle requires Prp38p function for U4/U6 snRNA dissociation | Q27933924 |
| | Mechanical devices of the spliceosome: motors, clocks, springs, and things | Q27938081 |
| | The Prp19p-associated complex in spliceosome activation | Q27938109 |
| | Rearrangement of competing U2 RNA helices within the spliceosome promotes multiple steps in splicing | Q27939473 |
| | A new generation of the IMAGIC image processing system | Q28131751 |
| | The spliceosome: design principles of a dynamic RNP machine | Q28131809 |
| | A novel base-pairing interaction between U2 and U6 snRNAs suggests a mechanism for the catalytic activation of the spliceosome | Q28201291 |
| | Design and synthesis of natural product derivatives with selective and improved cytotoxicity based on a sesquiterpene scaffold | Q38786173 |
| | Evidence for substrate-specific requirement of the splicing factor U2AF(35) and for its function after polypyrimidine tract recognition by U2AF(65). | Q39449313 |
| | Sudemycins, novel small molecule analogues of FR901464, induce alternative gene splicing | Q39587350 |
| | A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity | Q39633161 |
| | The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing | Q39934103 |
| | Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA. | Q40104313 |
| | Multiple protein-protein interactions converging on the Prp38 protein during activation of the human spliceosome | Q40206494 |
| | The portal protein of bacteriophage SPP1: a DNA pump with 13-fold symmetry. | Q40872452 |
| | A novel U2-U6 snRNA structure is necessary for mammalian mRNA splicing | Q41354468 |
| | An RNA switch at the 5' splice site requires ATP and the DEAD box protein Prp28p | Q41607972 |
| | GraFix: sample preparation for single-particle electron cryomicroscopy | Q41623539 |
| | Investigation of N-aryl-3-alkylidenepyrrolinones as potential Niemann-Pick type C disease therapeutics | Q41843908 |
| | Remodeling of U2-U6 snRNA helix I during pre-mRNA splicing by Prp16 and the NineTeen Complex protein Cwc2 | Q42118082 |
| | Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin A | Q42146150 |
| | Molecular architecture of zinc chelating small molecules that inhibit spliceosome assembly at an early stage | Q42288523 |
| | Selective inhibition of topoisomerase I and various steps of spliceosome assembly by diospyrin derivatives | Q42643933 |
| | Mechanistic insights from reversible splicing catalysis | Q42953067 |
| | Protein localisation by electron microscopy reveals the architecture of the yeast spliceosomal B complex | Q43119935 |
| | SR proteins escort the U4/U6.U5 tri-snRNP to the spliceosome | Q43205783 |
| | Intramolecular reactions of alkynes with furans and electron rich arenes catalyzed by PtCl2: the role of platinum carbenes as intermediates. | Q44431843 |
| | Exon definition complexes contain the tri-snRNP and can be directly converted into B-like precatalytic splicing complexes | Q46044906 |
| | Establishment of broadly applicable reaction conditions for the palladium-catalyzed direct arylation of heteroatom-containing aromatic compounds | Q46126944 |
| | Phosphorylation of human PRP28 by SRPK2 is required for integration of the U4/U6-U5 tri-snRNP into the spliceosome | Q46634476 |
| | Post-transcriptional spliceosomes are retained in nuclear speckles until splicing completion | Q46686083 |
| | Cyplecksins are covalent inhibitors of the pleckstrin homology domain of cytohesin | Q48030138 |
| | An unusual chemical reactivity of Sm site adenosines strongly correlates with proper assembly of core U snRNP particles | Q48925671 |
| | Small nuclear ribonucleoprotein remodeling during catalytic activation of the spliceosome | Q50336089 |
| | Isolation of an active step I spliceosome and composition of its RNP core | Q50336090 |
| | Splicing factor SF3b as a target of the antitumor natural product pladienolide | Q50672786 |
| | Use of multivariate statistics in analysing the images of biological macromolecules | Q52745385 |
| | Splicing regulation at the second catalytic step by Sex-lethal involves 3' splice site recognition by SPF45 | Q28217970 |
| | Bright, color-tunable fluorescent dyes in the Vis/NIR region: establishment of new "tailor-made" multicolor fluorophores based on borondipyrromethene | Q28305408 |
| | Multivariate statistical classification of noisy images (randomly oriented biological macromolecules). | Q30412687 |
| | RNA structure analysis of human spliceosomes reveals a compact 3D arrangement of snRNAs at the catalytic core | Q30556912 |
| | SPF30 is an essential human splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome | Q33944960 |
| | Characterization of purified human Bact spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis | Q34146146 |
| | Psoromic acid derivatives: a new family of small-molecule pre-mRNA splicing inhibitors discovered by a stage-specific high-throughput in vitro splicing assay | Q34159087 |
| | Semiquantitative proteomic analysis of the human spliceosome via a novel two-dimensional gel electrophoresis method | Q34181884 |
| | Spliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formation | Q34246700 |
| | Resolution of the mammalian E complex and the ATP-dependent spliceosomal complexes on native agarose mini-gels | Q34362249 |
| | RNA catalyses nuclear pre-mRNA splicing | Q34382976 |
| | Small-molecular inhibitors of Ca²⁺-induced mitochondrial permeability transition (MPT) derived from muscle relaxant dantrolene | Q34425740 |
| | The anti-tumor drug E7107 reveals an essential role for SF3b in remodeling U2 snRNP to expose the branch point-binding region | Q34626756 |
| | Evidence for a group II intron-like catalytic triplex in the spliceosome | Q34641230 |
| | A high-throughput splicing assay identifies new classes of inhibitors of human and yeast spliceosomes | Q34774635 |
| | A novel mechanism for Prp5 function in prespliceosome formation and proofreading the branch site sequence | Q34800010 |
| | Stalling of spliceosome assembly at distinct stages by small-molecule inhibitors of protein acetylation and deacetylation | Q34887390 |
| | Single-molecule analysis of protein-free U2-U6 snRNAs | Q35010846 |
| | The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome | Q35014709 |
| | Identification of small molecule inhibitors of pre-mRNA splicing | Q35301222 |
| | U2 toggles iteratively between the stem IIa and stem IIc conformations to promote pre-mRNA splicing | Q35720890 |
| | The Natural Product N-Palmitoyl-l-leucine Selectively Inhibits Late Assembly of Human Spliceosomes | Q35789105 |
| | A quantitative high-throughput in vitro splicing assay identifies inhibitors of spliceosome catalysis | Q35826664 |
| | The yeast PRP19 protein is not tightly associated with small nuclear RNAs, but appears to associate with the spliceosome after binding of U2 to the pre-mRNA and prior to formation of the functional spliceosome | Q36676911 |
| | Gel electrophoretic isolation of splicing complexes containing U1 small nuclear ribonucleoprotein particles | Q36783515 |
| | Single molecule analysis reveals reversible and irreversible steps during spliceosome activation | Q37042668 |
| | Evidence for a base-pairing interaction between U6 small nuclear RNA and 5' splice site during the splicing reaction in yeast | Q37316124 |
| | The mechanism of the second step of pre-mRNA splicing | Q37947529 |
| | Pre-mRNA splicing in disease and therapeutics | Q38028093 |
| | The spliceosome as a target of novel antitumour drugs | Q38057608 |
| | Stable tri-snRNP integration is accompanied by a major structural rearrangement of the spliceosome that is dependent on Prp8 interaction with the 5' splice site | Q38296438 |
| | Modulation of alternative splicing with chemical compounds in new therapeutics for human diseases | Q38308005 |
| | Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Å resolution | Q38584680 |
| | RNA mis-splicing in disease | Q38642996 |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | spliceosome | Q915868 |
| P577 | publication date | 2017-03-16 | |
| P1433 | published in | eLife | Q2000008 |
| P1476 | title | Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation. | |
| P478 | volume | 6 | |