Iron at the interface of immunity and infection

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Iron at the interface of immunity and infection is …
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scholarly articleQ13442814

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P356DOI10.3389/FPHAR.2014.00152
P932PMC publication ID4100575
P698PubMed publication ID25076907
P5875ResearchGate publication ID264394576

P50authorGuenter WeissQ42254473
Manfred NairzQ56816089
P2093author name stringEgon Demetz
David Haschka
P2860cites workTumour necrosis factor alpha regulates iron transport and transporter expression in human intestinal epithelial cellsQ80489412
Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPSQ81734651
Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalizationQ24310115
IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidinQ24568204
Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogensQ24630289
ER stress controls iron metabolism through induction of hepcidinQ24630714
Siderophore biosynthesis but not reductive iron assimilation is essential for Aspergillus fumigatus virulenceQ24647631
Natural resistance to infection with intracellular pathogens: the Nramp1 protein is recruited to the membrane of the phagosomeQ24670206
Mechanisms of mammalian iron homeostasisQ27010510
Iron overload favors the elimination of Leishmania infantum from mouse tissues through interaction with reactive oxygen and nitrogen speciesQ27305261
Iron traffics in circulation bound to a siderocalin (Ngal)–catechol complexQ27662810
Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase proteinQ28214986
Ferritin, iron homeostasis, and oxidative damageQ28216801
Two to tango: regulation of Mammalian iron metabolismQ28287034
Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal EnvironmentQ28487339
Nramp transfection transfers Ity/Lsh/Bcg-related pleiotropic effects on macrophage activation: influence on oxidative burst and nitric oxide pathwaysQ28511331
A mammalian siderophore synthesized by an enzyme with a bacterial homolog involved in enterobactin productionQ28511945
Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injuryQ28591880
Nramp1 promotes efficient macrophage recycling of iron following erythrophagocytosis in vivoQ28593895
Ferritin, iron homeostasis, and oxidative damage1,2 1Guest Editor: Mario Comporti 2This article is part of a series of reviews on “Iron and Cellular Redox Status.” The full list of papers may be found on the homepage of the journal.Q29399399
Nitric oxide and the immune responseQ29617591
Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating ironQ29619561
Iron and its relation to immunity and infectious diseaseQ30978515
Iron transport into mycobacterium avium-containing phagosomes from an Nramp1(Gly169)-transfected RAW264.7 macrophage cell line.Q31996280
Quercetin interferes with iron metabolism in Leishmania donovani and targets ribonucleotide reductase to exert leishmanicidal activityQ33320399
Increased serum hepcidin and alterations in blood iron parameters associated with asymptomatic P. falciparum and P. vivax malariaQ33529583
Iron chelation therapy for malaria: a reviewQ33537442
Salmonella enterica serovar Typhi impairs CD4 T cell responses by reducing antigen availabilityQ33603033
Regulation of mammalian siderophore 2,5-DHBA in the innate immune response to infectionQ33702939
Combinatorial effects of malaria season, iron deficiency, and inflammation determine plasma hepcidin concentration in African childrenQ33714721
Nramp1: a link between intracellular iron transport and innate resistance to intracellular pathogens.Q33782048
Iron release from macrophages after erythrophagocytosis is up-regulated by ferroportin 1 overexpression and down-regulated by hepcidinQ33818360
Taming the elephant: Salmonella biology, pathogenesis, and preventionQ33877264
Rescuing iron-overloaded macrophages by conservative relocation of the accumulated metalQ38649814
Effect of iron chelation therapy on recovery from deep coma in children with cerebral malariaQ39029074
Iron acquisition by Mycobacterium tuberculosis residing within myeloid dendritic cellsQ39344560
Interferon-gamma limits the availability of iron for intramacrophage Salmonella typhimurium.Q39968051
The anemia of chronic disordersQ40052338
Effect of provision of daily zinc and iron with several micronutrients on growth and morbidity among young children in Pakistan: a cluster-randomised trialQ40106335
The iron efflux protein ferroportin regulates the intracellular growth of Salmonella entericaQ40290550
Iron ERRs with SalmonellaQ40443127
Serum neopterin, interleukin-4, and interleukin-6 concentrations in cerebral malaria patients and the effect of iron chelation therapy.Q40672934
Regulatory interactions between iron and nitric oxide metabolism for immune defense against Plasmodium falciparum infection.Q40813924
Regulation of iron metabolism in murine J774 macrophages: role of nitric oxide-dependent and -independent pathways following activation with gamma interferon and lipopolysaccharideQ40926865
Central role of transcription factor NF-IL6 for cytokine and iron-mediated regulation of murine inducible nitric oxide synthase expression.Q40956310
Functional requirement of the hypoxia-responsive element in the activation of the inducible nitric oxide synthase promoter by the iron chelator desferrioxamineQ41110961
Pathways for the regulation of macrophage iron metabolism by the anti-inflammatory cytokines IL-4 and IL-13.Q41143770
Iron regulates nitric oxide synthase activity by controlling nuclear transcriptionQ41447238
Modulation of iron metabolism in monocyte cell line U937 by inflammatory cytokines: changes in transferrin uptake, iron handling and ferritin mRNA.Q41513908
Iron modulates interferon-gamma effects in the human myelomonocytic cell line THP-1Q41621241
Nitric oxide and salmonella pathogenesisQ42100653
Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: community-based, randomised, placebo-controlled trialQ42170063
Inverse agonist of estrogen-related receptor γ controls Salmonella typhimurium infection by modulating host iron homeostasisQ42222690
Iron supplementation in HIV-infected Malawian children with anemia: a double-blind, randomized, controlled trial.Q42275870
TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogensQ42741793
Role of iron homeostasis in trypanosomiasis-associated anemiaQ43410557
Nramp1 functionality increases inducible nitric oxide synthase transcription via stimulation of IFN regulatory factor 1 expressionQ43664582
Iron overload alters innate and T helper cell responses to Candida albicans in mice.Q43705216
Decreased susceptibility to Plasmodium falciparum infection in pregnant women with iron deficiencyQ43944520
Role of IL-10 for induction of anemia during inflammationQ44092330
Labile plasma iron in iron overload: redox activity and susceptibility to chelationQ44477026
Pathways for the regulation of interferon-gamma-inducible genes by iron in human monocytic cells.Q44529298
Scrutinizing the mechanisms underlying the induction of anemia of inflammation through GPI-mediated modulation of macrophage activation in a model of African trypanosomiasis.Q46352622
Tuberculosis and iron overload in Africa: a review.Q46697838
Biosynthesis and IroC-dependent export of the siderophore salmochelin are essential for virulence of Salmonella enterica serovar TyphimuriumQ46808987
Dysregulated monocyte iron homeostasis and erythropoietin formation in patients with anemia of chronic diseaseQ46909992
Iron fortification and malaria risk in childrenQ47835970
Metabolic adaptation to tissue iron overload confers tolerance to malariaQ48025726
Modulatory potential of iron chelation therapy on nitric oxide formation in cerebral malariaQ48035061
Regulation of reticuloendothelial iron transporter MTP1 (Slc11a3) by inflammationQ48853976
Nramp1-functionality increases iNOS expression via repression of IL-10 formationQ50058295
The co-ordinated regulation of iron homeostasis in murine macrophages limits the availability of iron for intracellular Salmonella typhimuriumQ50072262
A physiological model to study iron recycling in macrophages.Q50758548
Regulation of iron homeostasis in anemia of chronic disease and iron deficiency anemia: diagnostic and therapeutic implications.Q51764368
Role of iron in T cell activation: Th1 clones differ from TH2 clones in their sensitivity to inhibition of DNA synthesis caused by IGG mabs against the transferrin receptor and the iron chelator deferoxamineQ54298211
Iron trafficking and metabolism in macrophages: contribution to the polarized phenotypeQ56942373
Ferroportin-encapsulated nanoparticles reduce infection and improve immunity in mice infected with Leishmania majorQ58836346
Autocrine formation of hepcidin induces iron retention in human monocytesQ58876413
Hepcidin regulation by innate immune and infectious stimuliQ59401841
Metallobiology of host–pathogen interactions: an intoxicating new insightQ62801421
Association of pulmonary tuberculosis with increased dietary ironQ74442113
Hereditary hemochromatosis results in decreased iron acquisition and growth by Mycobacterium tuberculosis within human macrophagesQ79234100
Understanding the multiple functions of Nramp1.Q33887474
Regulation of transferrin receptor expression and ferritin content in human mononuclear phagocytes. Coordinate upregulation by iron transferrin and downregulation by interferon gammaQ33893144
Salmonella typhimurium IroN and FepA proteins mediate uptake of enterobactin but differ in their specificity for other siderophoresQ33992252
Role of iron in Nramp1-mediated inhibition of mycobacterial growth.Q34000686
Biosynthesis of nitric oxide activates iron regulatory factor in macrophagesQ34059787
Iron status predicts treatment failure and mortality in tuberculosis patients: a prospective cohort study from Dar es Salaam, TanzaniaQ34273983
Nutritional immunity: transition metals at the pathogen-host interfaceQ34288184
Hereditary hemochromatosis--a new look at an old diseaseQ34324340
Divalent-metal transport by NRAMP proteins at the interface of host-pathogen interactionsQ34341978
Host-mediated regulation of superinfection in malariaQ34356504
Anemia of chronic disease.Q34401570
Microbial siderophore-mediated transportQ34526524
Erythropoietin contrastingly affects bacterial infection and experimental colitis by inhibiting nuclear factor-κB-inducible immune pathwaysQ34544348
Iron and immunity: a double-edged sword.Q34557043
Host iron redistribution as a risk factor for incident tuberculosis in HIV infection: an 11-year retrospective cohort studyQ34566723
Iron and microbial infectionQ34650077
Iron availability and infectionQ34803576
Iron and the anemia of chronic disease.Q34966625
Low hepcidin levels in severely anemic malawian children with high incidence of infectious diseases and bone marrow iron deficiencyQ35067289
Nifedipine affects the course of Salmonella enterica serovar Typhimurium infection by modulating macrophage iron homeostasisQ35164461
Iron deficiency and anemia predict mortality in patients with tuberculosisQ35677249
Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammationQ35804433
Iron deficiency protects against severe Plasmodium falciparum malaria and death in young childrenQ35845332
Hepcidin is the major predictor of erythrocyte iron incorporation in anemic African childrenQ35955702
The iron chelator deferasirox protects mice from mucormycosis through iron starvationQ35960985
The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflammation and cancerQ35996059
Iron metabolism and toxicityQ35998155
The Deferasirox-AmBisome Therapy for Mucormycosis (DEFEAT Mucor) study: a randomized, double-blinded, placebo-controlled trialQ36058200
Oxidative stress fuels Trypanosoma cruzi infection in miceQ36068270
Anemia of chronic disease: pathophysiology and laboratory diagnosisQ36080048
Slc11a1 (Nramp1) impairs growth of Salmonella enterica serovar typhimurium in macrophages via stimulation of lipocalin-2 expressionQ36091290
Lipocalin 2 deficiency dysregulates iron homeostasis and exacerbates endotoxin-induced sepsis.Q36140013
Slc11a1 limits intracellular growth of Salmonella enterica sv. Typhimurium by promoting macrophage immune effector functions and impairing bacterial iron acquisition.Q36305784
Antimicrobial actions of the NADPH phagocyte oxidase and inducible nitric oxide synthase in experimental salmonellosis. II. Effects on microbial proliferation and host survival in vivoQ36368755
Repression of SPI2 transcription by nitric oxide-producing, IFNgamma-activated macrophages promotes maturation of Salmonella phagosomesQ36402842
Nitric oxide and oxidative stress (H2O2) control mammalian iron metabolism by different pathwaysQ36560913
Iron uptake controls the generation of Leishmania infective forms through regulation of ROS levelsQ36603547
Iron depletion limits intracellular bacterial growth in macrophagesQ36787471
Nitric oxide-mediated regulation of ferroportin-1 controls macrophage iron homeostasis and immune function in Salmonella infectionQ36822684
The iron export protein ferroportin 1 is differentially expressed in mouse macrophage populations and is present in the mycobacterial-containing phagosome.Q36838527
Neutrophil gelatinase-associated lipocalin and interleukin-10 regulate intramacrophage Chlamydia pneumoniae replication by modulating intracellular iron homeostasisQ36852751
On risks and benefits of iron supplementation recommendations for iron intake revisitedQ36909917
Iron in infection and immunityQ36913895
Iron overload and immunityQ36923159
Iron and citrate export by a major facilitator superfamily pump regulates metabolism and stress resistance in Salmonella TyphimuriumQ37031868
Lipocalin 2 deactivates macrophages and worsens pneumococcal pneumonia outcomesQ37052936
Probiotic bacteria reduce salmonella typhimurium intestinal colonization by competing for ironQ37118020
Iron in innate immunity: starve the invadersQ37157743
Lipocalin 2 is required for pulmonary host defense against Klebsiella infectionQ37257477
Bone morphogenetic protein signaling is impaired in an HFE knockout mouse model of hemochromatosisQ37376502
Absence of functional Hfe protects mice from invasive Salmonella enterica serovar Typhimurium infection via induction of lipocalin-2.Q37398323
Lipocalin-2 resistance confers an advantage to Salmonella enterica serotype Typhimurium for growth and survival in the inflamed intestineQ37401782
Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in miceQ37403137
Leishmania donovani depletes labile iron pool to exploit iron uptake capacity of macrophage for its intracellular growthQ37414550
Transition metal ions at the crossroads of mucosal immunity and microbial pathogenesisQ37511583
Leishmania-mediated inhibition of iron export promotes parasite replication in macrophages.Q37534221
Iron metabolism in trypanosomatids, and its crucial role in infectionQ37691483
Neutrophils are a source of gamma interferon during acute Salmonella enterica serovar Typhimurium colitisQ37713277
The struggle for iron - a metal at the host-pathogen interface.Q37801985
Divergent modulation of Chlamydia pneumoniae infection cycle in human monocytic and endothelial cells by iron, tryptophan availability and interferon gammaQ37852650
The receptor that tames the innate immune responseQ37970027
Hepcidin and the iron-infection axisQ38058767
Anaemia in inflammatory rheumatic diseasesQ38059457
The complex interplay of iron metabolism, reactive oxygen species, and reactive nitrogen species: insights into the potential of various iron therapies to induce oxidative and nitrosative stress.Q38137617
Translational regulation via iron-responsive elements by the nitric oxide/NO-synthase pathwayQ38316713
Cytokine-mediated regulation of iron transport in human monocytic cellsQ38358858
Effect of iron fortification on malaria incidence in infants and young children in Ghana: a randomized trialQ38445196
P304page(s)152
P577publication date2014-07-16
P1433published inFrontiers in PharmacologyQ2681208
P1476titleIron at the interface of immunity and infection
P478volume5

Reverse relations

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