Reversion and T cell escape mutations compensate the fitness loss of a CD8+ T cell escape mutant in their cognate transmitted/founder virus

scientific article

Reversion and T cell escape mutations compensate the fitness loss of a CD8+ T cell escape mutant in their cognate transmitted/founder virus is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2014PLoSO...9j2734S
P356DOI10.1371/JOURNAL.PONE.0102734
P8608Fatcat IDrelease_5xr7twugdfhnfj5377vmbj7mqu
P932PMC publication ID4100905
P698PubMed publication ID25028937
P5875ResearchGate publication ID263972683

P50authorAndrew James McMichaelQ21165187
Tanmoy BhattacharyaQ55414889
Alan S. PerelsonQ55719625
P2093author name stringHui Li
Feng Gao
Hongshuo Song
Shilpa S Iyer
Bhavna Hora
Kevin Wiehe
Michael K P Liu
Nilu Goonetilleke
P2860cites workVariable fitness impact of HIV-1 escape mutations to cytotoxic T lymphocyte (CTL) responseQ21131580
X-ray structures of the hexameric building block of the HIV capsidQ27655910
Structure of the HIV-1 Full-Length Capsid Protein in a Conformationally Trapped Unassembled State Induced by Small-Molecule BindingQ27666307
Mature HIV-1 capsid structure by cryo-electron microscopy and all-atom molecular dynamicsQ27678383
ROSETTA3: an object-oriented software suite for the simulation and design of macromoleculesQ28914720
HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapyQ29616404
Transmission of HIV-1 CTL escape variants provides HLA-mismatched recipients with a survival advantageQ33325923
Molecular evolution of human immunodeficiency virus type 1 upon transmission between human leukocyte antigen disparate donor-recipient pairsQ33344499
Timing constraints of in vivo gag mutations during primary HIV-1 subtype C infectionQ33515034
Transmission of single HIV-1 genomes and dynamics of early immune escape revealed by ultra-deep sequencingQ33680395
Relationship between functional profile of HIV-1 specific CD8 T cells and epitope variability with the selection of escape mutants in acute HIV-1 infectionQ33828583
Dynamics and timing of in vivo mutations at Gag residue 242 during primary HIV-1 subtype C infectionQ33907924
Impaired replication capacity of acute/early viruses in persons who become HIV controllersQ33963989
Selective escape from CD8+ T-cell responses represents a major driving force of human immunodeficiency virus type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolutionQ34092644
Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodiesQ34114798
Early selection in Gag by protective HLA alleles contributes to reduced HIV-1 replication capacity that may be largely compensated for in chronic infectionQ34295972
Translating HIV sequences into quantitative fitness landscapes predicts viral vulnerabilities for rational immunogen designQ34334803
Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1Q34545760
Progression to AIDS in South Africa is associated with both reverting and compensatory viral mutationsQ34841789
Rapid reversion of sequence polymorphisms dominates early human immunodeficiency virus type 1 evolutionQ35634318
Generation of transmitted/founder HIV-1 infectious molecular clones and characterization of their replication capacity in CD4 T lymphocytes and monocyte-derived macrophagesQ35826158
Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infectionQ35947590
Early low-titer neutralizing antibodies impede HIV-1 replication and select for virus escapeQ36000736
Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replicationQ36315510
Escape and compensation from early HLA-B57-mediated cytotoxic T-lymphocyte pressure on human immunodeficiency virus type 1 Gag alter capsid interactions with cyclophilin A.Q36315572
Impact of immune escape mutations on HIV-1 fitness in the context of the cognate transmitted/founder genomeQ36394656
Intersubtype differences in the effect of a rare p24 gag mutation on HIV-1 replicative fitnessQ36414578
Vertical T cell immunodominance and epitope entropy determine HIV-1 escapeQ36497283
TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infectionQ36513955
Transmission of HIV-1 Gag immune escape mutations is associated with reduced viral load in linked recipientsQ36639954
Frequent and variable cytotoxic-T-lymphocyte escape-associated fitness costs in the human immunodeficiency virus type 1 subtype B Gag proteinsQ36759719
HIV-1 conserved-element vaccines: relationship between sequence conservation and replicative capacityQ36827382
Marked epitope- and allele-specific differences in rates of mutation in human immunodeficiency type 1 (HIV-1) Gag, Pol, and Nef cytotoxic T-lymphocyte epitopes in acute/early HIV-1 infectionQ36898637
HLA-associated alterations in replication capacity of chimeric NL4-3 viruses carrying gag-protease from elite controllers of human immunodeficiency virus type 1.Q37033250
HLA-associated clinical progression correlates with epitope reversion rates in early human immunodeficiency virus infectionQ37051649
Genetic identity, biological phenotype, and evolutionary pathways of transmitted/founder viruses in acute and early HIV-1 infectionQ37273158
The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infectionQ37273195
Evolution of HLA-B*5703 HIV-1 escape mutations in HLA-B*5703-positive individuals and their transmission recipientsQ37273283
Impact of HLA in mother and child on disease progression of pediatric human immunodeficiency virus type 1 infectionQ37356088
Primary infection by a human immunodeficiency virus with atypical coreceptor tropismQ38631923
HLA-B57/B*5801 human immunodeficiency virus type 1 elite controllers select for rare gag variants associated with reduced viral replication capacity and strong cytotoxic T-lymphocyte [corrected] recognitionQ41966337
Evolution of HIV-1 in an HLA-B*57-positive patient during virologic escape.Q44082963
HIV evolution: CTL escape mutation and reversion after transmissionQ47211742
Detection of minor drug-resistant populations by parallel allele-specific sequencing.Q54563995
Evolution and transmission of stable CTL escape mutations in HIV infectionQ56880602
Viral replication capacity as a correlate of HLA B57/B5801-associated nonprogressive HIV-1 infectionQ80819695
P275copyright licenseCreative Commons CC0 LicenseQ6938433
P6216copyright statuscopyrighted, dedicated to the public domain by copyright holderQ88088423
P433issue7
P407language of work or nameEnglishQ1860
P304page(s)e102734
P577publication date2014-07-16
P1433published inPLOS OneQ564954
P1476titleReversion and T cell escape mutations compensate the fitness loss of a CD8+ T cell escape mutant in their cognate transmitted/founder virus
P478volume9

Reverse relations

cites work (P2860)
Q41919990A strongly selected mutation in the HIV-1 genome is independent of T cell responses and neutralizing antibodies.
Q59356540Antisense-Derived HIV-1 Cryptic Epitopes Are Not Major Drivers of Viral Evolution during the Acute Phase of Infection
Q32183405Immunologic and Virologic Mechanisms for Partial Protection from Intravenous Challenge by an Integration-Defective SIV Vaccine
Q42680526Patterns and rates of viral evolution in HIV-1 subtype B infected females and males
Q34686014Preexisting compensatory amino acids compromise fitness costs of a HIV-1 T cell escape mutation
Q37464540Transmission of Multiple HIV-1 Subtype C Transmitted/founder Viruses into the Same Recipients Was not Determined by Modest Phenotypic Differences
Q26798040What do mathematical models tell us about killing rates during HIV-1 infection?

Search more.