Topological and functional properties of the small GTPases protein interaction network

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Topological and functional properties of the small GTPases protein interaction network is …
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P819ADS bibcode2012PLoSO...744882D
P356DOI10.1371/JOURNAL.PONE.0044882
P932PMC publication ID3441499
P698PubMed publication ID23028658
P5875ResearchGate publication ID231815002

P50authorAnna DelpratoQ42306009
P2860cites workRac and Rho GTPases in cancer cell motility controlQ21245504
An automated method for finding molecular complexes in large protein interaction networksQ21284295
The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42Q22254751
The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutationsQ24302236
Structural basis for Rab11-mediated recruitment of FIP3 to recycling endosomesQ24305088
Rab and Arl GTPase family members cooperate in the localization of the golgin GCC185.Q24310137
The Fas-FADD death domain complex structure unravels signalling by receptor clusteringQ24312945
Raf family kinases: old dogs have learned new tricksQ24316181
Distinct roles of RalA and RalB in the progression of cytokinesis are supported by distinct RalGEFsQ24337038
STRING: known and predicted protein-protein associations, integrated and transferred across organismsQ24558597
A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signalingQ24599676
The 'invisible hand': regulation of RHO GTPases by RHOGDIsQ24606819
The STRING database in 2011: functional interaction networks of proteins, globally integrated and scoredQ24607390
The GTP/GDP cycling of rho GTPase TCL is an essential regulator of the early endocytic pathwayQ24607678
Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPasesQ24630460
Phosphotyrosine interactome of the ErbB-receptor kinase familyQ24672516
Regulation of CD95/Fas signaling at the DISCQ26824629
Rho kinase proteins--pleiotropic modulators of cell survival and apoptosisQ27023537
Emergence of Scaling in Random NetworksQ27037290
Structural Basis and Mechanism of Autoregulation in 3-Phosphoinositide-Dependent Grp1 Family Arf GTPase Exchange FactorsQ27649147
Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteinsQ27686798
The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factorsQ27860467
A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiaeQ27860755
Rab proteins as membrane organizersQ27860861
A signalling cascade involving PKC, Src and Cdc42 regulates podosome assembly in cultured endothelial cells in response to phorbol esterQ46921342
Functional and topological characterization of protein interaction networksQ47866212
Path lengths in protein-protein interaction networks and biological complexity.Q47977288
A duplication growth model of gene expression networksQ48615306
Computing topological parameters of biological networksQ51900389
Network growth models and genetic regulatory networksQ51944109
From fragile X mental retardation protein to Rac1 GTPase: new insights from Fly CYFIP.Q51948131
The ran GTPase regulates mitotic spindle assemblyQ52535025
An ARF6/Rab35 GTPase cascade for endocytic recycling and successful cytokinesisQ53193713
Scale-free networks with an exponent less than twoQ60575130
The product of the human c-erbB-2 gene: a 185-kilodalton glycoprotein with tyrosine kinase activityQ70141373
Chromatin-independent nuclear envelope assembly induced by Ran GTPase in Xenopus egg extractsQ73827307
Dynamic models of gene expression and classificationQ77494643
Differential molecular interactions of beta-catenin and plakoglobin in adhesion, signaling and cancerQ77565725
The Miro GTPases: at the heart of the mitochondrial transport machineryQ37450067
Polarized endocytic transport: the roles of Rab11 and Rab11-FIPs in regulating cell polarityQ37554102
Network biology: understanding the cell's functional organizationQ27861027
The small GTP-binding protein rac regulates growth factor-induced membrane rufflingQ27861063
Collective dynamics of 'small-world' networksQ27861064
Ypt32 recruits the Sec4p guanine nucleotide exchange factor, Sec2p, to secretory vesicles; evidence for a Rab cascade in yeastQ27931218
A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCzeta signaling and cell transformationQ28139572
Rab8B GTPase and junction dynamics in the testisQ28183730
The Fas signaling pathway: more than a paradigmQ28201953
A developmentally regulated ARF-like 5 protein (ARL5), localized to nuclei and nucleoli, interacts with heterochromatin protein 1Q28213144
beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosisQ28215045
RAS oncogenes: weaving a tumorigenic webQ28250360
An Eps homology (EH) domain protein that binds to the Ral-GTPase target, RalBP1Q28256262
The function of GRB2 in linking the insulin receptor to Ras signaling pathwaysQ28259867
Dexamethasone Rapidly Induces a Novel Ras Superfamily Member-related Gene in AtT-20 CellsQ28260734
Localization and function of Arf family GTPasesQ28263465
Isolation of a transforming sequence from a human bladder carcinoma cell lineQ28264736
Fyn: a novel molecular target in cancerQ28273098
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctionsQ28587668
Roles of BLOC-1 and adaptor protein-3 complexes in cargo sorting to synaptic vesiclesQ28594620
Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membraneQ28647586
Error and attack tolerance of complex networksQ29547268
Network motifs: simple building blocks of complex networksQ29547340
Small GTP-binding proteinsQ29547372
Mitochondrial membrane permeabilization in cell deathQ29547425
Cytoscape 2.8: new features for data integration and network visualizationQ29547471
ARF proteins: roles in membrane traffic and beyondQ29618078
The GTP-binding protein Ran/TC4 is required for protein import into the nucleusQ29620192
The small GTPase rab5 functions as a regulatory factor in the early endocytic pathwayQ29620272
p120-Ras GTPase activating protein (RasGAP): a multi-interacting protein in downstream signalingQ30157461
Ras history: The saga continuesQ30404024
Regulation of Arf activation: the Sec7 family of guanine nucleotide exchange factorsQ30444535
Active Arf6 recruits ARNO/cytohesin GEFs to the PM by binding their PH domains.Q30444590
The ADP ribosylation factor nucleotide exchange factor ARNO promotes beta-arrestin release necessary for luteinizing hormone/choriogonadotropin receptor desensitizationQ30454394
Different polycomb group CBX family proteins associate with distinct regions of chromatin using nonhomologous protein sequencesQ30484141
Downregulation of the Ras-mitogen-activated protein kinase pathway by the EphB2 receptor tyrosine kinase is required for ephrin-induced neurite retractionQ31813080
Human RAS superfamily proteins and related GTPasesQ33689727
Ras and calcium signaling pathways converge at Raf1 via the Shoc2 scaffold proteinQ33721174
Bid: a Bax-like BH3 protein.Q37566240
The dynamic Rab11-FIPsQ37597377
RalGDS family members couple Ras to Ral signalling and that's not all.Q37755616
Multistep and multitask Bax activationQ37780011
Regulation of calcium channels by RGK proteins.Q37800791
Dynamics of the Rho-family small GTPases in actin regulation and motilityQ37823095
The FERM family proteins in cancer invasion and metastasisQ37825218
The diverse roles of Rac signaling in tumorigenesisQ37863400
Structure-Function Relationships of the G Domain, a Canonical Switch MotifQ37889983
Rho protein crosstalk: another social network?Q37933751
Ubiquitination: Added complexity in Ras and Rho family GTPase functionQ37965170
RhoA GTPase regulates radiation-induced alterations in endothelial cell adhesion and migration.Q39457528
DA-Raf1, a competent intrinsic dominant-negative antagonist of the Ras-ERK pathway, is required for myogenic differentiationQ39739826
Type II cadherin ectodomain structures: implications for classical cadherin specificity.Q40300083
ATR activation necessary but not sufficient for p53 induction and apoptosis in hydroxyurea-hypersensitive myeloid leukemia cellsQ40356550
Ezrin function is required for ROCK-mediated fibroblast transformation by the Net and Dbl oncogenesQ40370592
Rab24 is an atypical member of the Rab GTPase family. Deficient GTPase activity, GDP dissociation inhibitor interaction, and prenylation of Rab24 expressed in cultured cellsQ40902023
Farnesyl transferase inhibitors induce apoptosis of Ras-transformed cells denied substratum attachment.Q41127508
Isoform-specific differences between Rap1A and Rap1B GTPases in the formation of endothelial cell junctionsQ42812157
Fyn kinase controls FcepsilonRI receptor-operated calcium entry necessary for full degranulation in mast cells.Q43204073
Duplication models for biological networks.Q46098622
Ras and Rho GTPases: a family reunionQ34073399
Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c.Q34139321
Kinase- and phosphatase-anchoring proteins: harnessing the dynamic duo.Q34141952
Human-tumor-derived cell lines contain common and different transforming genesQ34245850
Gene duplication and the properties of biological networksQ34293758
Novel specificities emerge by stepwise duplication of functional modules.Q34408286
Physiological Substrates of cAMP-Dependent Protein KinaseQ34466019
Signaling role of Cdc42 in regulating mammalian physiologyQ34509197
RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survivalQ34571216
Using graph theory to analyze biological networksQ35005792
Perturbation of cytoskeleton dynamics by the opposing effects of Rac1 and Rac1bQ35049674
Arfophilins are dual Arf/Rab 11 binding proteins that regulate recycling endosome distribution and are related to Drosophila nuclear falloutQ35161159
Conservation and evolution of gene coexpression networks in human and chimpanzee brainsQ35215128
Transforming activity of human tumor DNAsQ35426142
Live and let die: regulatory mechanisms in Fas-mediated apoptosis.Q35538226
Regulation of actin dynamics by WASP family proteinsQ35560916
Involvement of 14-3-3 proteins in the second epidermal growth factor-induced wave of Rac1 activation in the process of cell migration.Q35604332
ARF family G proteins and their regulators: roles in membrane transport, development and disease.Q35632439
The Rac effector p67phox regulates phagocyte NADPH oxidase by stimulating Vav1 guanine nucleotide exchange activityQ35641633
Fas death receptor signalling: roles of Bid and XIAP.Q35657414
Mitogen-activated protein kinases in apoptosis regulationQ35743118
The importance of bottlenecks in protein networks: correlation with gene essentiality and expression dynamicsQ35753717
Sin3a is essential for the genome integrity and viability of pluripotent cellsQ35907694
Evidence for a dual role for TC4 protein in regulating nuclear structure and cell cycle progressionQ36234292
The RGK family of GTP-binding proteins: regulators of voltage-dependent calcium channels and cytoskeleton remodelingQ36478004
Regulation of the phagocyte NADPH oxidase by Rac GTPaseQ36598790
Phagocytosis-coupled activation of the superoxide-producing phagocyte oxidase, a member of the NADPH oxidase (nox) familyQ36627802
Hubba: hub objects analyzer--a framework of interactome hubs identification for network biologyQ36749291
Rho kinase in the regulation of cell death and survivalQ36755421
Novel insights from adaptor protein 3 complex deficiencyQ36968537
Inhibition of NF-kappaB activity by IkappaBbeta in association with kappaB-RasQ37012573
Ral GTPases and cancer: linchpin support of the tumorigenic platformQ37064855
Rho GTPases of the RhoBTB subfamily and tumorigenesisQ37094102
The SWI/SNF complex and cancerQ37398568
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesCytoscapeQ3699942
P433issue9
P407language of work or nameEnglishQ1860
P304page(s)e44882
P577publication date2012-09-13
P1433published inPLOS OneQ564954
P1476titleTopological and functional properties of the small GTPases protein interaction network
P478volume7

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cites work (P2860)
Q30384681A Systematic Analysis of Candidate Genes Associated with Nicotine Addiction.
Q39089032Artemisinin rewires the protein interaction network in cancer cells: network analysis, pathway identification, and target prediction
Q34107063Bioinformatic Analysis of Differential Protein Expression in Calu-3 Cells Exposed to Carbon Nanotubes
Q28115399E-cadherin interactome complexity and robustness resolved by quantitative proteomics
Q57296600Genomic analysis of RNA-Seq and sRNA-Seq data identifies potential regulatory sRNAs and their functional roles in Staphylococcus aureus
Q39294242IQGAP1 is a key node within the small GTPase network
Q33557400Identification of candidate miRNA biomarkers from miRNA regulatory network with application to prostate cancer
Q36183157In silico identification of essential proteins in Corynebacterium pseudotuberculosis based on protein-protein interaction networks
Q38447168Network analysis and cross species comparison of protein-protein interaction networks of human, mouse and rat cytochrome P450 proteins that degrade xenobiotics.
Q64268816Novel Prognostic Markers in Triple-Negative Breast Cancer Discovered by MALDI-Mass Spectrometry Imaging
Q36545796Preclinical model in HCC: the SGK1 kinase inhibitor SI113 blocks tumor progression in vitro and in vivo and synergizes with radiotherapy
Q36820419Roles of rho GTPases in intracellular transport and cellular transformation.
Q37727820SGK1 affects RAN/RANBP1/RANGAP1 via SP1 to play a critical role in pre-miRNA nuclear export: a new route of epigenomic regulation
Q35048071Sharp bounds and normalization of Wiener-type indices
Q37617010Small GTPases of the Ras superfamily regulate intestinal epithelial homeostasis and barrier function via common and unique mechanisms.
Q24564171The G protein-coupled receptor heterodimer network (GPCR-HetNet) and its hub components
Q97643136Topological and system-level protein interaction network (PIN) analyses to deduce molecular mechanism of curcumin

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