ERM proteins and NF2 tumor suppressor: the Yin and Yang of cortical actin organization and cell growth signaling

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ERM proteins and NF2 tumor suppressor: the Yin and Yang of cortical actin organization and cell growth signaling is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1016/S0955-0674(01)00300-3
P698PubMed publication ID11792551
P5875ResearchGate publication ID11565282

P50authorAlexis GautreauQ48371975
Daniel LouvardQ33231567
P2093author name stringMonique Arpin
P2860cites workThe TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase RhoQ22254081
CD95 (APO-1/Fas) linkage to the actin cytoskeleton through ezrin in human T lymphocytes: a novel regulatory mechanism of the CD95 apoptotic pathwayQ24598098
Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domainQ24598762
Regulation of F-actin binding to platelet moesin in vitro by both phosphorylation of threonine 558 and polyphosphatidylinositidesQ24645681
Ezrin, a plasma membrane-microfilament linker, signals cell survival through the phosphatidylinositol 3-kinase/Akt pathwayQ24648522
ERM (ezrin/radixin/moesin)-based molecular mechanism of microvillar breakdown at an early stage of apoptosisQ24676652
Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail associationQ24678197
Regulation of the neurofibromatosis type 2 tumor suppressor protein, merlin, by adhesion and growth arrest stimuliQ42830999
Molecular characterization of a new ALK translocation involving moesin (MSN-ALK) in anaplastic large cell lymphomaQ43580523
Ezrin interacts with focal adhesion kinase and induces its activation independently of cell-matrix adhesionQ43684842
Mutations in transcript isoforms of the neurofibromatosis 2 gene in multiple human tumour typesQ48181670
A dual involvement of the amino-terminal domain of ezrin in F- and G-actin binding.Q54560172
Ezrin-dependent promotion of glioma cell clonogenicity, motility, and invasion mediated by BCL-2 and transforming growth factor-beta2.Q55474355
Interdomain interaction of merlin isoforms and its influence on intermolecular binding to NHE-RFQ73195911
Altered expression of the ERM proteins in lung adenocarcinomaQ73226522
Unopposed phosphatase action initiates ezrin dysfunction: a potential mechanism for anoxic injuryQ73644657
In vivo functional analysis of ezrin during mouse blastocyst formationQ73800309
Interdomain binding mediates tumor growth suppression by the NF2 gene productQ73934607
Merlin differentially associates with the microtubule and actin cytoskeletonQ74257128
The membrane-microfilament linker ezrin is involved in the formation of the immunological synapse and in T cell activationQ77307336
Phosphorylation of moesin by rho-associated kinase (Rho-kinase) plays a crucial role in the formation of microvilli-like structuresQ77696515
High levels of ezrin expressed by human pancreatic adenocarcinoma cell lines with high metastatic potentialQ77754238
Increased expression of the NF2 tumor suppressor gene product, merlin, impairs cell motility, adhesionand spreadingQ77946287
Morphogenic effects of ezrin require a phosphorylation-induced transition from oligomers to monomers at the plasma membraneQ24683879
Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domainQ27622801
The 2.7 A crystal structure of the activated FERM domain of moesin: an analysis of structural changes on activationQ27632553
Protein phosphatase 2C inactivates F-actin binding of human platelet moesinQ28144127
Exclusion of CD43 from the immunological synapse is mediated by phosphorylation-regulated relocation of the cytoskeletal adaptor moesinQ28208110
The NF2 interactor, hepatocyte growth factor-regulated tyrosine kinase substrate (HRS), associates with merlin in the "open" conformation and suppresses cell growth and motilityQ28210273
The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44Q28363493
The neurofibromatosis 2 protein product merlin selectively binds F-actin but not G-actin, and stabilizes the filaments through a lateral associationQ28365540
Ezrin is a downstream effector of trafficking PKC-integrin complexes involved in the control of cell motilityQ28366134
The Nf2 tumor suppressor gene product is essential for extraembryonic development immediately prior to gastrulationQ28504969
ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapseQ28507578
Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumorsQ28510087
Schwann cell hyperplasia and tumors in transgenic mice expressing a naturally occurring mutant NF2 proteinQ30500623
Radixin is involved in lamellipodial stability during nerve growth cone motilityQ30629181
Hierarchy of merlin and ezrin N- and C-terminal domain interactions in homo- and heterotypic associations and their relationship to binding of scaffolding proteins EBP50 and E3KARP.Q31655533
Cytoskeletal rearrangement during migration and activation of T lymphocytesQ33650492
ERM-Merlin and EBP50 protein families in plasma membrane organization and functionQ34059680
Phosphorylation of threonine 558 in the carboxyl-terminal actin-binding domain of moesin by thrombin activation of human plateletsQ34369147
Suppression of radixin and moesin alters growth cone morphology, motility, and process formation in primary cultured neuronsQ36255600
Direct involvement of ezrin/radixin/moesin (ERM)-binding membrane proteins in the organization of microvilli in collaboration with activated ERM proteinsQ36256564
Ezrin is an effector of hepatocyte growth factor-mediated migration and morphogenesis in epithelial cellsQ36268138
Ezrin promotes morphogenesis of apical microvilli and basal infoldings in retinal pigment epitheliumQ36326132
Mutagenesis of the phosphatidylinositol 4,5-bisphosphate (PIP(2)) binding site in the NH(2)-terminal domain of ezrin correlates with its altered cellular distributionQ36326421
RhoA-dependent phosphorylation and relocalization of ERM proteins into apical membrane/actin protrusions in fibroblastsQ38610718
Ezrin function is required for ROCK-mediated fibroblast transformation by the Net and Dbl oncogenesQ40370592
Ezrin, a membrane-cytoskeletal linking protein, is involved in the process of invasion of endometrial cancer cellsQ40902115
Impairment of cell adhesion by expression of the mutant neurofibromatosis type 2 (NF2) genes which lack exons in the ERM-homology domainQ41001855
Ezrin immunoreactivity is associated with increasing malignancy of astrocytic tumors but is absent in oligodendrogliomasQ42757022
Rho- and rac-dependent assembly of focal adhesion complexes and actin filaments in permeabilized fibroblasts: an essential role for ezrin/radixin/moesin proteinsQ42796333
Activation of ERM proteins in vivo by Rho involves phosphatidyl-inositol 4-phosphate 5-kinase and not ROCK kinasesQ42809055
The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling.Q42823880
P433issue1
P921main subjectcell growthQ189159
P304page(s)104-109
P577publication date2002-02-01
P1433published inCurrent Opinion in Cell BiologyQ13505682
P1476titleERM proteins and NF2 tumor suppressor: the Yin and Yang of cortical actin organization and cell growth signaling
P478volume14

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