Ezrin regulates E-cadherin-dependent adherens junction assembly through Rac1 activation

scientific article

Ezrin regulates E-cadherin-dependent adherens junction assembly through Rac1 activation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1091/MBC.E02-07-0410
P932PMC publication ID165106
P698PubMed publication ID12802084

P50authorAlexis GautreauQ48371975
Daniel LouvardQ33231567
P2093author name stringMonique Arpin
Laurence Del Maestro
Philippe Pujuguet
P2860cites workDirect involvement of ezrin/radixin/moesin (ERM)-binding membrane proteins in the organization of microvilli in collaboration with activated ERM proteinsQ36256564
NH2-terminal deletion of beta-catenin results in stable colocalization of mutant beta-catenin with adenomatous polyposis coli protein and altered MDCK cell adhesionQ36258529
Ezrin is an effector of hepatocyte growth factor-mediated migration and morphogenesis in epithelial cellsQ36268138
Induction of cell scattering by expression of beta1 integrins in beta1-deficient epithelial cells requires activation of members of the rho family of GTPases and downregulation of cadherin and catenin functionQ36313391
Hyaluronic acid (HA) binding to CD44 activates Rac1 and induces lamellipodia outgrowthQ36326315
Mutagenesis of the phosphatidylinositol 4,5-bisphosphate (PIP(2)) binding site in the NH(2)-terminal domain of ezrin correlates with its altered cellular distributionQ36326421
Perturbation of cell adhesion and microvilli formation by antisense oligonucleotides to ERM family membersQ36534860
Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinaseQ38330900
Activation of the small GTPase Rac is sufficient to disrupt cadherin-dependent cell-cell adhesion in normal human keratinocytesQ38489431
RAC1 regulates adherens junctions through endocytosis of E-cadherinQ38689476
Ezrin function is required for ROCK-mediated fibroblast transformation by the Net and Dbl oncogenesQ40370592
Rac1 orientates epithelial apical polarity through effects on basolateral laminin assemblyQ40782515
Cadherin engagement regulates Rho family GTPasesQ40791943
Inhibition of invasion of epithelial cells by Tiam1-Rac signalingQ41075588
Regulation of cell-cell adhesion by rac and rho small G proteins in MDCK cellsQ41075647
Rho regulates association of both the ERM family and vinculin with the plasma membrane in MDCK cellsQ41116431
ICAM-2 redistributed by ezrin as a target for killer cellsQ41183913
Regulation of receptor-mediated endocytosis by Rho and Rac.Q41185352
Translocation of activated Rho from the cytoplasm to membrane ruffling area, cell-cell adhesion sites and cleavage furrowsQ41326729
Microinjected antibodies against the cytoplasmic domain of vesicular stomatitis virus glycoprotein block its transport to the cell surfaceQ42567664
Rho- and rac-dependent assembly of focal adhesion complexes and actin filaments in permeabilized fibroblasts: an essential role for ezrin/radixin/moesin proteinsQ42796333
Recruitment and activation of Rac1 by the formation of E-cadherin-mediated cell-cell adhesion sitesQ43592674
Soluble ezrin purified from placenta exists as stable monomers and elongated dimers with masked C-terminal ezrin-radixin-moesin association domainsQ70801487
Delineation of the Cdc42/Rac-binding domain of p21-activated kinaseQ74588214
The membrane-microfilament linker ezrin is involved in the formation of the immunological synapse and in T cell activationQ77307336
The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase RhoQ22254081
Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding siteQ24617964
Regulation of F-actin binding to platelet moesin in vitro by both phosphorylation of threonine 558 and polyphosphatidylinositidesQ24645681
Recycling of E-cadherin: a potential mechanism for regulating cadherin dynamicsQ24651967
Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail associationQ24678197
Moesin interacts with the cytoplasmic region of intercellular adhesion molecule-3 and is redistributed to the uropod of T lymphocytes during cell polarizationQ24683747
Morphogenic effects of ezrin require a phosphorylation-induced transition from oligomers to monomers at the plasma membraneQ24683879
Rho GTPases and the actin cytoskeletonQ27860579
A kinase-regulated PDZ-domain interaction controls endocytic sorting of the beta2-adrenergic receptorQ28145098
Exclusion of CD43 from the immunological synapse is mediated by phosphorylation-regulated relocation of the cytoskeletal adaptor moesinQ28208110
Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G proteinQ28248311
Interaction of radixin with Rho small G protein GDP/GTP exchange protein DblQ28277746
ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapseQ28507578
The Small GTPases Rho and Rac Are Required for the Establishment of Cadherin-dependent Cell–Cell ContactsQ29042060
Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeletonQ29620156
ERM proteins and NF2 tumor suppressor: the Yin and Yang of cortical actin organization and cell growth signalingQ34495193
Selective alterations in biosynthetic and endocytic protein traffic in Madin-Darby canine kidney epithelial cells expressing mutants of the small GTPase Rac1.Q34672405
Activation of cdc42, rac, PAK, and rho-kinase in response to hepatocyte growth factor differentially regulates epithelial cell colony spreading and dissociationQ34712138
Spatio-temporal regulation of Rac1 localization and lamellipodia dynamics during epithelial cell-cell adhesionQ36015668
Ezrin contains cytoskeleton and membrane binding domains accounting for its proposed role as a membrane-cytoskeletal linkerQ36232246
Ezrin NH2-terminal domain inhibits the cell extension activity of the COOH-terminal domainQ36235486
Ezrin oligomers are major cytoskeletal components of placental microvilli: a proposal for their involvement in cortical morphogenesis.Q36236171
Effects of regulated expression of mutant RhoA and Rac1 small GTPases on the development of epithelial (MDCK) cell polarityQ36256216
P4510describes a project that usesImageQuantQ112270642
P433issue5
P304page(s)2181-2191
P577publication date2003-02-06
P1433published inMolecular Biology of the CellQ2338259
P1476titleEzrin regulates E-cadherin-dependent adherens junction assembly through Rac1 activation
P478volume14

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