Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site

scientific article published on August 1, 1995

Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1091/MBC.6.8.1061
P953full work available at URLhttps://europepmc.org/articles/pmc301263?pdf=render
https://europepmc.org/articles/PMC301263
https://europepmc.org/articles/PMC301263?pdf=render
P3181OpenCitations bibliographic resource ID4914082
P932PMC publication ID301263
P698PubMed publication ID7579708
P5875ResearchGate publication ID15618841

P2093author name stringA. Bretscher
R. Gary
P2860cites workF-actin binding site masked by the intramolecular association of vinculin head and tail domainsQ24309102
Ezrin has properties to self-associate at the plasma membraneQ24312441
Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2Q24313491
Moesin: a member of the protein 4.1-talin-ezrin family of proteinsQ24314954
Heterotypic and homotypic associations between ezrin and moesin, two putative membrane-cytoskeletal linking proteinsQ24564097
Purification of an 80,000-dalton protein that is a component of the isolated microvillus cytoskeleton, and its localization in nonmuscle cellsQ24681337
Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activationQ28131755
A gene family consisting of ezrin, radixin and moesin. Its specific localization at actin filament/plasma membrane association sitesQ28202167
cDNA cloning and sequencing of the protein-tyrosine kinase substrate, ezrin, reveals homology to band 4.1Q28261183
Rous sarcoma virus transforming protein lacking myristic acid phosphorylates known polypeptide substrates without inducing transformationQ28609965
High-Efficiency Cloning of Full-Length cDNAQ29618285
Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membraneQ29618478
The role of cytoskeleton in organizing growth cones: a microfilament-associated growth cone component depends upon microtubules for its localizationQ30442300
A single amino acid change in Raf-1 inhibits Ras binding and alters Raf-1 functionQ30454014
Both p21ras and pp60v-src are required, but neither alone is sufficient, to activate the Raf-1 kinaseQ30454103
Cloning and characterisation of an immunodominant major surface antigen of Echinococcus multilocularisQ33290612
Moesin, ezrin, and p205 are actin-binding proteins associated with neutrophil plasma membranesQ34446936
Cytovillin, a microvillar Mr 75,000 protein. cDNA sequence, prokaryotic expression, and chromosomal localizationQ35887992
Rapid phosphorylation and reorganization of ezrin and spectrin accompany morphological changes induced in A-431 cells by epidermal growth factorQ36219929
Ezrin contains cytoskeleton and membrane binding domains accounting for its proposed role as a membrane-cytoskeletal linkerQ36232246
Ezrin NH2-terminal domain inhibits the cell extension activity of the COOH-terminal domainQ36235486
ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletonsQ36382880
Radixin is a novel member of the band 4.1 familyQ36532958
Perturbation of cell adhesion and microvilli formation by antisense oligonucleotides to ERM family membersQ36534860
The ezrin-like family of tyrosine kinase substrates: receptor-specific pattern of tyrosine phosphorylation and relationship to malignant transformation.Q36781301
Microfilament Structure and Function in the Cortical CytoskeletonQ37132256
An anti-Ras function of neurofibromatosis type 2 gene product (NF2/Merlin).Q38304298
The secretion-stimulated 80K phosphoprotein of parietal cells is ezrin, and has properties of a membrane cytoskeletal linker in the induced apical microvilliQ41081966
Deregulation of genes encoding microfilament-associated proteins during Fos-induced morphological transformationQ41371021
Ligation of CD4 surface antigen induces rapid tyrosine phosphorylation of the cytoskeletal protein ezrinQ41456900
Structural diversity of band 4.1 superfamily members.Q41458167
Moesin, like ezrin, colocalizes with actin in the cortical cytoskeleton in cultured cells, but its expression is more variable.Q41556812
Indirect association of ezrin with F-actin: isoform specificity and calcium sensitivityQ42053540
Ezrin has a COOH-terminal actin-binding site that is conserved in the ezrin protein familyQ42720142
Cytovillin and other microvillar proteins of human choriocarcinoma cellsQ44569520
Radixin is a component of hepatocyte microvilli in situQ46381117
A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressorQ48129277
Mutations in transcript isoforms of the neurofibromatosis 2 gene in multiple human tumour typesQ48181670
Identification of ezrin as an 81-kDa tyrosine-phosphorylated protein in T cellsQ67899144
Microvillus-specific Mr 75,000 plasma membrane protein of human choriocarcinoma cellsQ68162689
Characterization of a chemically homogeneous tumor antigen from a methylcholanthrene-induced sarcoma, Meth AQ69598291
A structural model of human erythrocyte protein 4.1.Q71300747
Ezrin is concentrated in the apical microvilli of a wide variety of epithelial cells whereas moesin is found primarily in endothelial cellsQ72572435
Raf: the holy grail of Ras biology?Q75293018
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectmicrofilament proteinsQ76708328
P304page(s)1061-75
P577publication date1995-08-01
P1433published inMolecular Biology of the CellQ2338259
P1476titleEzrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site
P478volume6

Reverse relations

cites work (P2860)
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Q45771218An MBoC Favorite: Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site
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Q42810844Expression level, subcellular distribution and rho-GDI binding affinity of merlin in comparison with Ezrin/Radixin/Moesin proteins
Q48262377Expression of ezrin and moesin in primary breast carcinoma and matched lymph node metastases.
Q40157152Expression of the cytoskeleton linker protein ezrin in human cancers
Q33591167Ezrin activation by LOK phosphorylation involves a PIP2-dependent wedge mechanism.
Q27324986Ezrin and moesin are required for efficient T cell adhesion and homing to lymphoid organs
Q40380183Ezrin controls the macromolecular complexes formed between an adapter protein Na+/H+ exchanger regulatory factor and the cystic fibrosis transmembrane conductance regulator
Q47952810Ezrin directly interacts with AQP2 and promotes its endocytosis.
Q37682332Ezrin expression and cell survival regulation in colorectal cancer
Q40370592Ezrin function is required for ROCK-mediated fibroblast transformation by the Net and Dbl oncogenes
Q28251491Ezrin induces long-range interdomain allostery in the scaffolding protein NHERF1
Q36369093Ezrin interacts with S100A4 via both its N- and C-terminal domains.
Q43684842Ezrin interacts with focal adhesion kinase and induces its activation independently of cell-matrix adhesion
Q24532065Ezrin is a cyclic AMP-dependent protein kinase anchoring protein
Q36268138Ezrin is an effector of hepatocyte growth factor-mediated migration and morphogenesis in epithelial cells
Q37263199Ezrin mediates tethering of the gamma-aminobutyric acid transporter GAT1 to actin filaments via a C-terminal PDZ-interacting domain.
Q36236171Ezrin oligomers are major cytoskeletal components of placental microvilli: a proposal for their involvement in cortical morphogenesis.
Q43880965Ezrin oligomers are the membrane-bound dormant form in gastric parietal cells
Q39611457Ezrin promotes actin assembly at the phagosome membrane and regulates phago-lysosomal fusion.
Q35153735Ezrin regulates E-cadherin-dependent adherens junction assembly through Rac1 activation
Q35322212Ezrin regulates NHE3 translocation and activation after Na+-glucose cotransport.
Q35827509Ezrin regulates microvillus morphogenesis by promoting distinct activities of Eps8 proteins.
Q28729756Ezrin ubiquitylation by the E3 ubiquitin ligase, WWP1, and consequent regulation of hepatocyte growth factor receptor activity
Q24648522Ezrin, a plasma membrane-microfilament linker, signals cell survival through the phosphatidylinositol 3-kinase/Akt pathway
Q35684785Ezrin, radixin, and moesin are phosphorylated in response to 2-methoxyestradiol and modulate endothelial hyperpermeability
Q28588034Ezrin-radixin-moesin (ERM)-binding phosphoprotein 50 organizes ERM proteins at the apical membrane of polarized epithelia
Q24676628Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2
Q35775396Ezrin/radixin/moesin proteins and Rho GTPase signalling in leucocytes
Q28506649FERM domain containing protein 7 interacts with the Rho GDP dissociation inhibitor and specifically activates Rac1 signaling
Q39272171FLT3-driven redox-modulation of Ezrin regulates leukaemic cell migration
Q36374372Fluorescent ligand-directed co-localization of the parathyroid hormone 1 receptor with the brush-border scaffold complex of the proximal tubule reveals hormone-dependent changes in ezrin immunoreactivity consistent with inactivation
Q40432756G protein-coupled receptor kinase 2-mediated phosphorylation of ezrin is required for G protein-coupled receptor-dependent reorganization of the actin cytoskeleton
Q37032810Genetic variations and polymorphisms in the ezrin gene are associated with age-related cataract
Q31655533Hierarchy of merlin and ezrin N- and C-terminal domain interactions in homo- and heterotypic associations and their relationship to binding of scaffolding proteins EBP50 and E3KARP.
Q46102053High turnover of ezrin T567 phosphorylation: conformation, activity, and cellular function
Q36125047Homotypic receptor-receptor interactions regulating Eph signaling
Q42516001IGF-I regulates HT1080 fibrosarcoma cell migration through a syndecan-2/Erk/ezrin signaling axis.
Q47934778Identification and functional analysis of the ezrin-binding site in the hyaluronan receptor, CD44.
Q24678695Identification of EBP50: A PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family
Q24291083Identification of EPI64, a TBC/rabGAP domain-containing microvillar protein that binds to the first PDZ domain of EBP50 and E3KARP
Q61918725Identification of a novel Ezrin-binding site in syndecan-2 cytoplasmic domain
Q24291502Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins
Q22254021Identification of a novel member of the chloride intracellular channel gene family (CLIC5) that associates with the actin cytoskeleton of placental microvilli
Q43426756Identification of moesin as NKCC2-interacting protein and analysis of its functional role in the NKCC2 apical trafficking
Q36149269Immune synapse formation requires ZAP-70 recruitment by ezrin and CD43 removal by moesin
Q53379260Increased ezrin expression and activation by CDK5 coincident with acquisition of the senescent phenotype.
Q42810938Inhibition of NF-kappaB activation by merlin
Q24296241Inhibition of T cell activation by cyclic adenosine 5'-monophosphate requires lipid raft targeting of protein kinase A type I by the A-kinase anchoring protein ezrin
Q39744299Initiation of malignancy by duodenal contents reflux and the role of ezrin in developing esophageal squamous cell carcinoma
Q30732369Insight into the molecular basis of pathogen abundance: group A Streptococcus inhibitor of complement inhibits bacterial adherence and internalization into human cells
Q53902140Interaction between two isoforms of the NF2 tumor suppressor protein, merlin, and between merlin and ezrin, suggests modulation of ERM proteins by merlin.
Q30443779Interaction of ezrin with the novel guanine nucleotide exchange factor PLEKHG6 promotes RhoG-dependent apical cytoskeleton rearrangements in epithelial cells
Q38197313Interactions between Epac1 and ezrin in the control of endothelial barrier function.
Q34021307Interleukin-7 compartmentalizes its receptor signaling complex to initiate CD4 T lymphocyte response
Q36431740Juxtanodin is an intrinsically disordered F-actin-binding protein
Q36789915Kindlin-2 directly binds actin and regulates integrin outside-in signaling
Q29615144LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity
Q22004003Layilin, a novel talin-binding transmembrane protein homologous with C-type lectins, is localized in membrane ruffles
Q90183565Light-responsive microRNA miR-211 targets Ezrin to modulate lysosomal biogenesis and retinal cell clearance
Q53075204Lipid binding promotes the open conformation and tumor-suppressive activity of neurofibromin 2.
Q24555712Listeria monocytogenes exploits ERM protein functions to efficiently spread from cell to cell
Q36323012Local ERM activation and dynamic growth cones at Schwann cell tips implicated in efficient formation of nodes of Ranvier
Q36455890Local phosphocycling mediated by LOK/SLK restricts ezrin function to the apical aspect of epithelial cells
Q48236413Merlin links to the cAMP neuronal signaling pathway by anchoring the RIbeta subunit of protein kinase A.
Q35880377Merlin: a tumour suppressor with functions at the cell cortex and in the nucleus.
Q42547381Mode of Ezrin-Membrane Interaction as a Function of PIP2 Binding and Pseudophosphorylation
Q47251104Moesin is involved in polarity maintenance and cortical remodelling during asymmetric cell division.
Q54106494Moesin, the major ERM protein of lymphocytes and platelets, differs from ezrin in its insensitivity to calpain.
Q39693467Moesin-induced signaling in response to lipopolysaccharide in macrophages
Q34189987Molecular analysis of microscopic ezrin dynamics by two-photon FRAP.
Q28241032Molecular conformation of the full-length tumor suppressor NF2/Merlin--a small-angle neutron scattering study
Q38204110Molecular insights into NF2/Merlin tumor suppressor function
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Q37058655Molecular mechanisms of cell-cell spread of intracellular bacterial pathogens
Q24683879Morphogenic effects of ezrin require a phosphorylation-induced transition from oligomers to monomers at the plasma membrane
Q46758062Mutational and immunohistochemical analysis of ezrin-, radixin-, moesin (ERM) molecules in epilepsy-associated glioneuronal lesions
Q35563136NF2: the wizardry of merlin
Q90323753NaPi-IIa interacting partners and their (un)known functional roles
Q64076170Neutrophil Cell Shape Change: Mechanism and Signalling during Cell Spreading and Phagocytosis
Q28508442Normal development of mice and unimpaired cell adhesion/cell motility/actin-based cytoskeleton without compensatory up-regulation of ezrin or radixin in moesin gene knockout
Q28273758Open conformation of ezrin bound to phosphatidylinositol 4,5-bisphosphate and to F-actin revealed by neutron scattering
Q28277373Organizing the cell cortex: the role of ERM proteins
Q24298277PACE-1, a novel protein that interacts with the C-terminal domain of ezrin
Q38609066Phosphatidylinositol 4,5-bisphosphate alters the number of attachment sites between ezrin and actin filaments: a colloidal probe study
Q28255119Phosphatidylinositol 4,5-bisphosphate clusters the cell adhesion molecule CD44 and assembles a specific CD44-Ezrin heterocomplex, as revealed by small angle neutron scattering
Q24676944Phosphoinositide binding and phosphorylation act sequentially in the activation mechanism of ezrin
Q36119138Phosphorylation and activity of the tumor suppressor Merlin and the ERM protein Moesin are coordinately regulated by the Slik kinase
Q45965376Phosphorylation of ezrin/radixin/moesin (ERM) protein in spinal microglia following peripheral nerve injury and lysophosphatidic acid administration.
Q34369147Phosphorylation of threonine 558 in the carboxyl-terminal actin-binding domain of moesin by thrombin activation of human platelets
Q42830032Phosphorylation-independent membrane relocalization of ezrin following association with Dbl in vivo
Q24337035Plasmodium vivax inhibits erythroid cell growth through altered phosphorylation of the cytoskeletal protein ezrin
Q51805729Pleiotropic function of ezrin in human metastatic melanomas.
Q48507439Preso regulation of dendritic outgrowth through PI(4,5)P2-dependent PDZ interaction with βPix
Q48726985Protein phosphorylation in response to PDGF stimulation in cultured neurons and astrocytes
Q33252911Pseudomonas aeruginosa ExoS ADP-ribosyltransferase inhibits ERM phosphorylation
Q36345022Quantitative analysis of the binding of ezrin to large unilamellar vesicles containing phosphatidylinositol 4,5 bisphosphate.
Q24305375Radixin assembles cAMP effectors Epac and PKA into a functional cAMP compartment: role in cAMP-dependent cell proliferation
Q38151846Re-defining ERM function in lymphocyte activation and migration
Q24671083Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway
Q24645681Regulation of F-actin binding to platelet moesin in vitro by both phosphorylation of threonine 558 and polyphosphatidylinositides
Q58545180Regulation of actin-based apical structures on epithelial cells
Q52778774Regulation of cell proliferation and adhesion by means of a novel region of drosophila merlin interacting with Sip1.
Q33536481Regulation of cortical structure by the ezrin-radixin-moesin protein family
Q37428401Regulation of expression of microvillus membrane proteins by estrogen in baboon fetal ovarian oocytes
Q28283727Regulation of ezrin localization by Rac1 and PIPK in human epithelial cells
Q40172193Regulation of focal adhesion kinase by its amino-terminal domain through an autoinhibitory interaction
Q46639710Reorganization of actin cytoskeleton by FRIED, a Frizzled-8 associated protein tyrosine phosphatase
Q38325656Replacement of threonine 558, a critical site of phosphorylation of moesin in vivo, with aspartate activates F-actin binding of moesin. Regulation by conformational change
Q48382402Rho kinase activates ezrin-radixin-moesin (ERM) proteins and mediates their function in cortical neuron growth, morphology and motility in vitro
Q24678197Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association
Q38610718RhoA-dependent phosphorylation and relocalization of ERM proteins into apical membrane/actin protrusions in fibroblasts
Q24303641Rocks: multifunctional kinases in cell behaviour
Q35633077Self-masking in an intact ERM-merlin protein: an active role for the central alpha-helical domain
Q58195107Sequential binding of ezrin and moesin to L-selectin regulates monocyte protrusive behaviour during transendothelial migration
Q28283023Serine 518 phosphorylation modulates merlin intramolecular association and binding to critical effectors important for NF2 growth suppression
Q34566715Shaping the intestinal brush border
Q42442394Shifts in cellular localization of moesin in normal oral epithelium, oral epithelial dysplasia, verrucous carcinoma and oral squamous cell carcinoma
Q41099634Signal transduction and actin filament organization
Q33748611Sip1, the Drosophila orthologue of EBP50/NHERF1, functions with the sterile 20 family kinase Slik to regulate Moesin activity
Q27939303Sla2p is associated with the yeast cortical actin cytoskeleton via redundant localization signals
Q40016536Slik Sterile-20 kinase regulates Moesin activity to promote epithelial integrity during tissue growth
Q35213087Slik and the receptor tyrosine kinase Breathless mediate localized activation of Moesin in terminal tracheal cells
Q33943320Small molecule inhibitors of ezrin inhibit the invasive phenotype of osteosarcoma cells.
Q24301774Spatial recruitment and activation of the Fes kinase by ezrin promotes HGF-induced cell scattering
Q40476423Src phosphorylates ezrin at tyrosine 477 and induces a phosphospecific association between ezrin and a kelch-repeat protein family member.
Q33914506Src-dependent ezrin phosphorylation in adhesion-mediated signaling
Q73089628Stimulation of Rho GDI release by ERM proteins
Q27651819Structural Basis for CD44 Recognition by ERM Proteins
Q24682640Structural analysis of Drosophila merlin reveals functional domains important for growth control and subcellular localization
Q27644609Structural basis for type II membrane protein binding by ERM proteins revealed by the radixin-neutral endopeptidase 24.11 (NEP) complex
Q27640373Structural basis of adhesion-molecule recognition by ERM proteins revealed by the crystal structure of the radixin-ICAM-2 complex
Q24598762Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain
Q24313074Structure of dimerized radixin FERM domain suggests a novel masking motif in C-terminal residues 295-304
Q27622801Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain
Q27639959Structure of the active N-terminal domain of Ezrin. Conformational and mobility changes identify keystone interactions
Q30431490Structure-function relationships in the ezrin family and the effect of tumor-associated point mutations in neurofibromatosis 2 protein
Q35362918Tailor-made ezrin actin binding domain to probe its interaction with actin in-vitro
Q27932330The COOH-terminal domain of Myo2p, a yeast myosin V, has a direct role in secretory vesicle targeting
Q24314977The ERM proteins interact with the HOPS complex to regulate the maturation of endosomes
Q28363493The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44
Q36184681The NHERF2 sequence adjacent and upstream of the ERM-binding domain affects NHERF2-ezrin binding and dexamethasone stimulated NHE3 activity.
Q35652619The Na+/H+ Exchanger-3 (NHE3) Activity Requires Ezrin Binding to Phosphoinositide and Its Phosphorylation
Q52731433The PP1 phosphatase flapwing regulates the activity of Merlin and Moesin in Drosophila.
Q22254081The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho
Q35241607The activation of ezrin-radixin-moesin proteins is regulated by netrin-1 through Src kinase and RhoA/Rho kinase activities and mediates netrin-1-induced axon outgrowth
Q37297700The calcineurin homologous protein-1 increases Na(+)/H(+) -exchanger 3 trafficking via ezrin phosphorylation
Q47859501The carboxyl-terminal region of EBP50 binds to a site in the amino-terminal domain of ezrin that is masked in the dormant molecule
Q35887294The co-workers of actin filaments: from cell structures to signals
Q33329717The cytoskeletal linker protein moesin: decreased levels in Wiskott-Aldrich syndrome platelets and identification of a cleavage pathway in normal platelets
Q42860390The cytoskeletal protein ezrin regulates EC proliferation and angiogenesis via TNF-alpha-induced transcriptional repression of cyclin A.
Q30428648The ezrin protein family: membrane-cytoskeleton interactions and disease associations
Q38368921The ezrin-radixin-moesin family of proteins in the regulation of B-cell immune response
Q40689657The focal adhesion kinase amino-terminal domain localises to nuclei and intercellular junctions in HEK 293 and MDCK cells independently of tyrosine 397 and the carboxy-terminal domain
Q44505297The lower cell density of leaf parenchyma in the Arabidopsis thaliana mutant lcd1-1 is associated with increased sensitivity to ozone and virulent Pseudomonas syringae
Q28576784The nuclear receptor hepatocyte nuclear factor 4alpha acts as a morphogen to induce the formation of microvilli
Q24315599The parathyroid hormone 1 receptor directly binds to the FERM domain of ezrin, an interaction that supports apical receptor localization and signaling in LLC-PK1 cells
Q37504826The protective role of MLCP-mediated ERM dephosphorylation in endotoxin-induced lung injury in vitro and in vivo
Q28354232The protein 4.1, ezrin, radixin, moesin (FERM) domain of Drosophila Coracle, a cytoplasmic component of the septate junction, provides functions essential for embryonic development and imaginal cell proliferation
Q36253132The role of FAS to ezrin association in FAS-mediated apoptosis
Q28199313The role of the CD44/ezrin complex in cancer metastasis
Q37395713The scaffold protein PDZK1 undergoes a head-to-tail intramolecular association that negatively regulates its interaction with EBP50.
Q37387020Three determinants in ezrin are responsible for cell extension activity
Q47144215Trafficking Ion Transporters to the Apical Membrane of Polarized Intestinal Enterocytes.
Q64253417Two Sides of the Coin: Ezrin/Radixin/Moesin and Merlin Control Membrane Structure and Contact Inhibition
Q24321386Two independent domains of hDlg are sufficient for subcellular targeting: the PDZ1-2 conformational unit and an alternatively spliced domain
Q73635476Tyrosine Phosphorylation of Moesin in Arachidonic Acid-Stimulated Human Platelets
Q42839207Universal absence of merlin, but not other ERM family members, in schwannomas.
Q42198362p38MAPK, Rho/ROCK and PKC pathways are involved in influenza-induced cytoskeletal rearrangement and hyperpermeability in PMVEC via phosphorylating ERM.

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