Ezrin contains cytoskeleton and membrane binding domains accounting for its proposed role as a membrane-cytoskeletal linker

scientific article

Ezrin contains cytoskeleton and membrane binding domains accounting for its proposed role as a membrane-cytoskeletal linker is …
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scholarly articleQ13442814

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P356DOI10.1083/JCB.120.1.129
P932PMC publication ID2119498
P698PubMed publication ID8416983
P5875ResearchGate publication ID277445894

P50authorDaniel LouvardQ33231567
P2093author name stringTurunen O
Vaheri A
Arpin M
Algrain M
P2860cites workMoesin: a member of the protein 4.1-talin-ezrin family of proteinsQ24314954
Molecular cloning of protein 4.1, a major structural element of the human erythrocyte membrane skeletonQ24627974
A new protein of adhesion plaques and ruffling membranesQ24681303
Purification of an 80,000-dalton protein that is a component of the isolated microvillus cytoskeleton, and its localization in nonmuscle cellsQ24681337
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Q25938983
High-efficiency transformation of mammalian cells by plasmid DNAQ27860469
A gene family consisting of ezrin, radixin and moesin. Its specific localization at actin filament/plasma membrane association sitesQ28202167
cDNA cloning and sequencing of the protein-tyrosine kinase substrate, ezrin, reveals homology to band 4.1Q28261183
An interaction between vinculin and talinQ28268200
Interaction of plasma membrane fibronectin receptor with talin--a transmembrane linkageQ28285095
Sequence and domain structure of talinQ28302349
Characterization of an integral membrane glycoprotein associated with the microfilaments of pig intestinal microvilli.Q30827211
Cloning and characterisation of an immunodominant major surface antigen of Echinococcus multilocularisQ33290612
Cytovillin, a microvillar Mr 75,000 protein. cDNA sequence, prokaryotic expression, and chromosomal localizationQ35887992
The protein-tyrosine kinase substrate, p81, is homologous to a chicken microvillar core proteinQ36214322
Rapid phosphorylation and reorganization of ezrin and spectrin accompany morphological changes induced in A-431 cells by epidermal growth factorQ36219929
In vivo analysis of functional domains from villin and gelsolinQ36531081
Radixin is a novel member of the band 4.1 familyQ36532958
Microfilament Structure and Function in the Cortical CytoskeletonQ37132256
The secretion-stimulated 80K phosphoprotein of parietal cells is ezrin, and has properties of a membrane cytoskeletal linker in the induced apical microvilliQ41081966
Redistribution of Mr 75,000 plasma membrane protein, cytovillin, into newly formed microvilli in herpes simplex and Semliki Forest virus infected human embryonal fibroblastsQ42034414
Microtubules containing detyrosinated tubulin are less dynamicQ42054726
Microinjected antibodies against the cytoplasmic domain of vesicular stomatitis virus glycoprotein block its transport to the cell surfaceQ42567664
Immunofluorescent and immunochemical evidence for the expression of cytovillin in the microvilli of a wide range of cultured human cellsQ43502563
Villin induces microvilli growth and actin redistribution in transfected fibroblasts.Q52486999
Interactions between protein 4.1 and band 3. An alternative binding site for an element of the membrane skeleton.Q52496321
Glycophorin is linked by band 4.1 protein to the human erythrocyte membrane skeletonQ59070174
Microvillus-specific Mr 75,000 plasma membrane protein of human choriocarcinoma cellsQ68162689
Ezrin immunoreactivity in neuron subpopulations: cellular distribution in relation to cytoskeletal proteins in sensory neuronsQ68340441
Identification of the functional site of erythrocyte protein 4.1 involved in spectrin-actin associationsQ70017486
Epidermal growth factor induces rapid tyrosine phosphorylation of proteins in A431 human tumor cellsQ72638520
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectcytoskeletonQ154626
P1104number of pages11
P304page(s)129-139
P577publication date1993-01-01
P1433published inJournal of Cell BiologyQ1524550
P1476titleEzrin contains cytoskeleton and membrane binding domains accounting for its proposed role as a membrane-cytoskeletal linker
P478volume120

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cites work (P2860)
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Q38485099Entry of the two infectious forms of vaccinia virus at the plasma membane is signaling-dependent for the IMV but not the EEV.
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Q42827339Ezrin expression in stromal cells of capillary hemangioblastoma. An immunohistochemical survey of brain tumors.
Q40370592Ezrin function is required for ROCK-mediated fibroblast transformation by the Net and Dbl oncogenes
Q36007635Ezrin functionality and hypothermic preservation injury in LLC-PK1 cells
Q42720142Ezrin has a COOH-terminal actin-binding site that is conserved in the ezrin protein family
Q42757022Ezrin immunoreactivity is associated with increasing malignancy of astrocytic tumors but is absent in oligodendrogliomas
Q28251491Ezrin induces long-range interdomain allostery in the scaffolding protein NHERF1
Q43684842Ezrin interacts with focal adhesion kinase and induces its activation independently of cell-matrix adhesion
Q27335547Ezrin interacts with the SARS coronavirus Spike protein and restrains infection at the entry stage
Q28366134Ezrin is a downstream effector of trafficking PKC-integrin complexes involved in the control of cell motility
Q36268138Ezrin is an effector of hepatocyte growth factor-mediated migration and morphogenesis in epithelial cells
Q36236171Ezrin oligomers are major cytoskeletal components of placental microvilli: a proposal for their involvement in cortical morphogenesis.
Q43880965Ezrin oligomers are the membrane-bound dormant form in gastric parietal cells
Q34187445Ezrin phosphorylation on tyrosine 477 regulates invasion and metastasis of breast cancer cells
Q36326132Ezrin promotes morphogenesis of apical microvilli and basal infoldings in retinal pigment epithelium
Q35153735Ezrin regulates E-cadherin-dependent adherens junction assembly through Rac1 activation
Q35322212Ezrin regulates NHE3 translocation and activation after Na+-glucose cotransport.
Q24617964Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site
Q28729756Ezrin ubiquitylation by the E3 ubiquitin ligase, WWP1, and consequent regulation of hepatocyte growth factor receptor activity
Q39149877Ezrin, Radixin, and Moesin (ERM) proteins function as pleiotropic regulators of human immunodeficiency virus type 1 infection
Q24648522Ezrin, a plasma membrane-microfilament linker, signals cell survival through the phosphatidylinositol 3-kinase/Akt pathway
Q36850394Ezrin, radixin and moesin are possible auto-immune antigens in rheumatoid arthritis
Q55474355Ezrin-dependent promotion of glioma cell clonogenicity, motility, and invasion mediated by BCL-2 and transforming growth factor-beta2.
Q30502773Ezrin-mediated apical integrity is required for intestinal homeostasis
Q24676628Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2
Q28566506Flotillin-mediated endocytic events dictate cell type-specific responses to semaphorin 3A
Q36320446Fluid shear triggers microvilli formation via mechanosensitive activation of TRPV6
Q24297509Functional activities and cellular localization of the ezrin, radixin, moesin (ERM) and RING zinc finger domains in MIR
Q34145489Functional analysis of the neurofibromatosis type 2 protein by means of disease-causing point mutations
Q24672551Functional binding interaction identified between the axonal CAM L1 and members of the ERM family
Q50720587Functional differences between cardiac and renal isoforms of the rat Na+-Ca2+ exchanger NCX1 expressed in Xenopus oocytes.
Q40432756G protein-coupled receptor kinase 2-mediated phosphorylation of ezrin is required for G protein-coupled receptor-dependent reorganization of the actin cytoskeleton
Q42831434Gem associates with Ezrin and acts via the Rho-GAP protein Gmip to down-regulate the Rho pathway
Q30497357Glucose-induced ERM protein activation and translocation regulates insulin secretion
Q28574426Hepatocyte growth factor-induced Ras activation requires ERM proteins linked to both CD44v6 and F-actin
Q24564097Heterotypic and homotypic associations between ezrin and moesin, two putative membrane-cytoskeletal linking proteins
Q46102053High turnover of ezrin T567 phosphorylation: conformation, activity, and cellular function
Q37375853Hypoxia increases human keratinocyte motility on connective tissue.
Q24522393I-SceI-induced gene replacement at a natural locus in embryonic stem cells
Q41183913ICAM-2 redistributed by ezrin as a target for killer cells
Q47934778Identification and functional analysis of the ezrin-binding site in the hyaluronan receptor, CD44.
Q35534383Identification and molecular cloning of a 67-kilodalton protein in Schistosoma japonicum homologous to a family of actin-binding proteins.
Q35247857Identification of Drosophila cytoskeletal proteins by induction of abnormal cell shape in fission yeast
Q36011467Identification of F-actin as the dynamic hub in a microbial-induced GTPase polarity circuit.
Q61918725Identification of a novel Ezrin-binding site in syndecan-2 cytoplasmic domain
Q34316029Identification of the protein 4.1 binding interface on glycophorin C and p55, a homologue of the Drosophila discs-large tumor suppressor protein
Q24795269Imaging of dynamic changes of the actin cytoskeleton in microextensions of live NIH3T3 cells with a GFP fusion of the F-actin binding domain of moesin
Q44444318Immunodetection of the microvillous cytoskeleton molecules villin and ezrin in the parasitophorous vacuole wall of Cryptosporidium parvum (Protozoa: Apicomplexa).
Q28593765In vivo, villin is required for Ca(2+)-dependent F-actin disruption in intestinal brush borders
Q42053540Indirect association of ezrin with F-actin: isoform specificity and calcium sensitivity
Q40235602Inhibition of the hyaluronan-CD44 interaction by merlin contributes to the tumor-suppressor activity of merlin
Q39869313Integrating receptor signal inputs that influence small Rho GTPase activation dynamics at the immunological synapse
Q41625262Interaction of cytoskeletal proteins with membrane lipids.
Q71823591Interdomain Interactions of Radixin in Vitro
Q34693039Internalization of Met requires the co-receptor CD44v6 and its link to ERM proteins.
Q40386859Involvement of ezrin/moesin in de novo actin assembly on phagosomal membranes
Q40684840Isolation and characterization of an aggresome determinant in the NF2 tumor suppressor
Q40239600Isolation of bright aggregate fluctuations in a multipopulation image correlation spectroscopy system using intensity subtraction
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Q30670358Localized activation of m-calpain in human umbilical vein endothelial cells upon hypoxia
Q24537500MYO1A (brush border myosin I) dynamics in the brush border of LLC-PK1-CL4 cells
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Q73115347Membrane-bound ezrin is involved in B-cell receptor-mediated signaling: potential role of an ITAM-like ezrin motif
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Q30418770Merlin/ERM proteins establish cortical asymmetry and centrosome position
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Q30834940Micro-scale chromophore-assisted laser inactivation of nerve growth cone proteins
Q89666602MicroRNA-183 in Cancer Progression
Q40409326Microvillus assembly. Not actin alone
Q41914993Mifepristone increases mRNA translation rate, triggers the unfolded protein response, increases autophagic flux, and kills ovarian cancer cells in combination with proteasome or lysosome inhibitors.
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Q33293043Modulation of cellular mechanics during osteogenic differentiation of human mesenchymal stem cells
Q47251104Moesin is involved in polarity maintenance and cortical remodelling during asymmetric cell division.
Q34446936Moesin, ezrin, and p205 are actin-binding proteins associated with neutrophil plasma membranes
Q54106494Moesin, the major ERM protein of lymphocytes and platelets, differs from ezrin in its insensitivity to calpain.
Q26744973Molecular Mechanisms for cAMP-Mediated Immunoregulation in T cells - Role of Anchored Protein Kinase A Signaling Units
Q36235682Molecular dissection of radixin: distinct and interdependent functions of the amino- and carboxy-terminal domains
Q24683879Morphogenic effects of ezrin require a phosphorylation-induced transition from oligomers to monomers at the plasma membrane
Q36326421Mutagenesis of the phosphatidylinositol 4,5-bisphosphate (PIP(2)) binding site in the NH(2)-terminal domain of ezrin correlates with its altered cellular distribution
Q39691830Mutant actins demonstrate a role for unpolymerized actin in control of transcription by serum response factor
Q30576322Myosin IIB and F-actin control apical vacuolar morphology and histamine-induced trafficking of H-K-ATPase-containing tubulovesicles in gastric parietal cells
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Q30160335PALS1 specifies the localization of ezrin to the apical membrane of gastric parietal cells
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Q40617807Phosphatidylserine externalization and membrane blebbing are involved in the nonclassical export of FGF1
Q24676944Phosphoinositide binding and phosphorylation act sequentially in the activation mechanism of ezrin
Q42526764Phosphorylation of a K+ channel alpha subunit modulates the inactivation conferred by a beta subunit. Involvement of cytoskeleton
Q45965376Phosphorylation of ezrin/radixin/moesin (ERM) protein in spinal microglia following peripheral nerve injury and lysophosphatidic acid administration.
Q34369147Phosphorylation of threonine 558 in the carboxyl-terminal actin-binding domain of moesin by thrombin activation of human platelets
Q42830032Phosphorylation-independent membrane relocalization of ezrin following association with Dbl in vivo
Q34448492Polarized distribution of actin isoforms in gastric parietal cells
Q39147018Protein-protein interaction network of celiac disease
Q38969786Proteomic analysis of CD44(+) and CD44(-) gastric cancer cells
Q30496716Radixin deficiency causes deafness associated with progressive degeneration of cochlear stereocilia
Q30629181Radixin is involved in lamellipodial stability during nerve growth cone motility
Q48570454Real-time imaging of actin filaments in the zebrafish oocyte and embryo
Q24671083Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway
Q24645681Regulation of F-actin binding to platelet moesin in vitro by both phosphorylation of threonine 558 and polyphosphatidylinositides
Q37428401Regulation of expression of microvillus membrane proteins by estrogen in baboon fetal ovarian oocytes
Q28283727Regulation of ezrin localization by Rac1 and PIPK in human epithelial cells
Q38325656Replacement of threonine 558, a critical site of phosphorylation of moesin in vivo, with aspartate activates F-actin binding of moesin. Regulation by conformational change
Q36106076Restoration of Na+/H+ exchanger NHE3-containing macrocomplexes ameliorates diabetes-associated fluid loss
Q40855892Retention of prominin in microvilli reveals distinct cholesterol-based lipid micro-domains in the apical plasma membrane.
Q24296619Rho GTPases have diverse effects on the organization of the actin filament system
Q42796333Rho- and rac-dependent assembly of focal adhesion complexes and actin filaments in permeabilized fibroblasts: an essential role for ezrin/radixin/moesin proteins
Q24678197Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association
Q58700844Role of Ezrin Phosphorylation in HIV-1 Replication
Q58123524Role of cyclic AMP-dependent protein kinases in human villous cytotrophoblast differentiation
Q41037971Schwannomin: new insights into this member of the band 4.1 superfamily
Q48075368Screening for germ-line mutations in the NF2 gene
Q34566715Shaping the intestinal brush border
Q41961340Sonic hedgehog induces angiogenesis via Rho kinase-dependent signaling in endothelial cells.
Q37134443Sp1 and AP-1 regulate expression of the human gene VIL2 in esophageal carcinoma cells
Q24301774Spatial recruitment and activation of the Fes kinase by ezrin promotes HGF-induced cell scattering
Q37737387Spatiotemporal control of cyclic AMP immunomodulation through the PKA-Csk inhibitory pathway is achieved by anchoring to an Ezrin-EBP50-PAG scaffold in effector T cells
Q34431639Specific binding of HIV-1 envelope protein gp120 to the structural membrane proteins ezrin and moesin
Q37385292Specific release of membrane-bound annexin II and cortical cytoskeletal elements by sequestration of membrane cholesterol
Q33914506Src-dependent ezrin phosphorylation in adhesion-mediated signaling
Q60921949Steroidal glycoalkaloids from target cytoskeletal proteins: an analysis
Q24682640Structural analysis of Drosophila merlin reveals functional domains important for growth control and subcellular localization
Q24598762Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain
Q30431490Structure-function relationships in the ezrin family and the effect of tumor-associated point mutations in neurofibromatosis 2 protein
Q36736649Subtractive hybridization cloning of novel genes differentially expressed during intestinal development
Q52337636TGFβ and IGF1R signaling activate protein kinase A through differential regulation of ezrin phosphorylation in colon cancer cells.
Q35362918Tailor-made ezrin actin binding domain to probe its interaction with actin in-vitro
Q42771059The Drosophila lethal(2)giant larvae tumor suppressor protein forms homo-oligomers and is associated with nonmuscle myosin II heavy chain
Q24314977The ERM proteins interact with the HOPS complex to regulate the maturation of endosomes
Q33395671The FERM and PDZ domain-containing protein tyrosine phosphatases, PTPN4 and PTPN3, are both dispensable for T cell receptor signal transduction
Q39612709The Joubert Syndrome Protein Inpp5e Controls Ciliogenesis by Regulating Phosphoinositides at the Apical Membrane
Q36184681The NHERF2 sequence adjacent and upstream of the ERM-binding domain affects NHERF2-ezrin binding and dexamethasone stimulated NHE3 activity.
Q35652619The Na+/H+ Exchanger-3 (NHE3) Activity Requires Ezrin Binding to Phosphoinositide and Its Phosphorylation
Q36149204The actin cytoskeleton as a sensor and mediator of apoptosis
Q35241607The activation of ezrin-radixin-moesin proteins is regulated by netrin-1 through Src kinase and RhoA/Rho kinase activities and mediates netrin-1-induced axon outgrowth
Q37297700The calcineurin homologous protein-1 increases Na(+)/H(+) -exchanger 3 trafficking via ezrin phosphorylation
Q33329717The cytoskeletal linker protein moesin: decreased levels in Wiskott-Aldrich syndrome platelets and identification of a cleavage pathway in normal platelets
Q42860390The cytoskeletal protein ezrin regulates EC proliferation and angiogenesis via TNF-alpha-induced transcriptional repression of cyclin A.
Q30428648The ezrin protein family: membrane-cytoskeleton interactions and disease associations
Q40689657The focal adhesion kinase amino-terminal domain localises to nuclei and intercellular junctions in HEK 293 and MDCK cells independently of tyrosine 397 and the carboxy-terminal domain
Q41017187The involvement of calpain-dependent proteolysis of the tumor suppressor NF2 (merlin) in schwannomas and meningiomas
Q39910582The mechanisms used by enteropathogenic Escherichia coli to control filopodia dynamics
Q40602468The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis
Q77307336The membrane-microfilament linker ezrin is involved in the formation of the immunological synapse and in T cell activation
Q34406752The properties of the protein tyrosine phosphatase PTPMEG.
Q28354232The protein 4.1, ezrin, radixin, moesin (FERM) domain of Drosophila Coracle, a cytoplasmic component of the septate junction, provides functions essential for embryonic development and imaginal cell proliferation
Q39018803The proteome of the differentiating mesencephalic progenitor cell line CSM14.1 in vitro
Q24296013The role of ezrin-associated protein network in human sperm capacitation
Q28586327The zebrafish band 4.1 member Mir is involved in cell movements associated with gastrulation
Q36096812The zebrafish goosepimples/myosin Vb mutant exhibits cellular attributes of human microvillus inclusion disease.
Q37387020Three determinants in ezrin are responsible for cell extension activity
Q47144215Trafficking Ion Transporters to the Apical Membrane of Polarized Intestinal Enterocytes.
Q27307288Tunneling nanotubes provide a unique conduit for intercellular transfer of cellular contents in human malignant pleural mesothelioma
Q42833405Two variants of the rat brain sodium-driven chloride bicarbonate exchanger (NCBE): developmental expression and addition of a PDZ motif
Q30914948Tyrosine phosphorylation and cellular redistribution of ezrin in MDCK cells treated with pervanadate
Q35584126Understanding micrometastatic disease and Anoikis resistance in ewing family of tumors and osteosarcoma
Q61829605Upregulation of the cytoskeletal-associated protein Moesin in the neointima of coronary arteries after balloon angioplasty: a new marker of smooth muscle cell migration?
Q30009048p120RasGAP Protein Mediates Netrin-1 Protein-induced Cortical Axon Outgrowth and Guidance

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