Robust Salmonella metabolism limits possibilities for new antimicrobials.

scientific article

Robust Salmonella metabolism limits possibilities for new antimicrobials. is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1040351681
P356DOI10.1038/NATURE04616
P698PubMed publication ID16541065
P5875ResearchGate publication ID7237732

P50authorThomas F. MeyerQ2423758
P2093author name stringMatthias Mann
Matthias Selbach
Daniel Becker
Matthias Ballmaier
Dirk Bumann
Claudia Rollenhagen
P2860cites workComparison of genome degradation in Paratyphi A and Typhi, human-restricted serovars of Salmonella enterica that cause typhoidQ22122046
Complete genome sequence of Salmonella enterica serovar Typhimurium LT2Q22122369
Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18Q22122370
From genetic footprinting to antimicrobial drug targets: examples in cofactor biosynthetic pathwaysQ24539226
Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18Q24554266
EcoCyc: a comprehensive database resource for Escherichia coliQ24796847
Functional profiling of the Saccharomyces cerevisiae genomeQ27860544
Mass spectrometry-based proteomicsQ28182890
Typhoid and paratyphoid feverQ28269252
The large-scale organization of metabolic networksQ29547498
Genome-scale models of microbial cells: evaluating the consequences of constraintsQ29616789
A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosisQ29617342
Functional cartography of complex metabolic networksQ30481006
Selection analyses of insertional mutants using subgenic-resolution arraysQ30760746
Examination of Salmonella gene expression in an infected mammalian host using the green fluorescent protein and two-colour flow cytometryQ30828698
Large-scale identification of essential Salmonella genes by trapping lethal insertionsQ33199163
Metabolic functions of duplicate genes in Saccharomyces cerevisiaeQ33224556
Differences in gene content between Salmonella enterica serovar Enteritidis isolates and comparison to closely related serovars Gallinarum and Dublin.Q34048325
Lipid biosynthesis as a target for antibacterial agentsQ34395560
Animal models of Salmonella infections: enteritis versus typhoid fever.Q34469859
Salmonella enterica highly expressed genes are disease specificQ34491811
Exploiting genomics, genetics and chemistry to combat antibiotic resistance.Q35140829
Antibacterial research and development in the 21(st) Century--an industry perspective of the challengesQ35903226
A millennium update on pediatric diarrheal illness in the developing worldQ36095978
Novel target sites in bacteria for overcoming antibiotic resistanceQ36159533
A mouse model for S. typhimurium-induced enterocolitisQ36248020
Identification of Salmonella functions critical for bacterial cell division within eukaryotic cellsQ40445651
Unravelling the biology of macrophage infection by gene expression profiling of intracellular Salmonella entericaQ43533379
Optimization of GFP levels for analyzing Salmonella gene expression during an infectionQ50109216
Recombinant avirulent Salmonella vaccine strains with stable maintenance and high level expression of cloned genes in vivoQ50196578
P433issue7082
P407language of work or nameEnglishQ1860
P304page(s)303-307
P577publication date2006-03-01
P1433published inNatureQ180445
P1476titleRobust Salmonella metabolism limits possibilities for new antimicrobials
P478volume440

Reverse relations

cites work (P2860)
Q37071956(15)N{(31)P} REDOR NMR studies of the binding of phosphonate reaction intermediate analogues to Saccharomyces cerevisiae lumazine synthase
Q35940889A Comparison of the ATP Generating Pathways Used by S. Typhimurium to Fuel Replication within Human and Murine Macrophage and Epithelial Cell Lines
Q34547091A community effort towards a knowledge-base and mathematical model of the human pathogen Salmonella Typhimurium LT2
Q37424840A link between gut community metabolism and pathogenesis: molecular hydrogen-stimulated glucarate catabolism aids Salmonella virulence
Q35325775A metaproteomics approach to elucidate host and pathogen protein expression during catheter-associated urinary tract infections (CAUTIs).
Q38668518A novel antimicrobial approach based on the inhibition of zinc uptake in Salmonella enterica.
Q30974252A proteomic view of an important human pathogen--towards the quantification of the entire Staphylococcus aureus proteome
Q35176370Absolute quantification of microbial proteomes at different states by directed mass spectrometry
Q41042251Acidic pH sensing in the bacterial cytoplasm is required for Salmonella virulence
Q40495826Alternative fluorescent labeling strategies for characterizing gram-positive pathogenic bacteria: Flow cytometry supported counting, sorting, and proteome analysis of Staphylococcus aureus retrieved from infected host cells
Q34018578Amino acid recognition and gene regulation by riboswitches.
Q37887170Antibiotic treatment of CF lung disease: from bench to bedside
Q38049352Antibiotic-resistant bacteria: a challenge for the food industry.
Q33301096Antimicrobial drug resistance of Salmonella enterica serovar typhi in asia and molecular mechanism of reduced susceptibility to the fluoroquinolones
Q36757725Antimicrobial resistance and virulence: a successful or deleterious association in the bacterial world?
Q59042634Application of Molecular Approaches for Understanding Foodborne Salmonella Establishment in Poultry Production
Q94561463Aspartate semialdehyde dehydrogenase inhibition suppresses the growth of the pathogenic fungus Candida albicans
Q33131299Assessing the Metabolic Diversity of Streptococcus from a Protein Domain Point of View
Q38695278At the crossroads: communication of bacteria-containing vacuoles with host organelles.
Q37899789Biochemistry of the non-mevalonate isoprenoid pathway
Q91890032Blocks in Tricarboxylic Acid Cycle of Salmonella enterica Cause Global Perturbation of Carbon Storage, Motility, and Host-Pathogen Interaction
Q42279950Both thiamine uptake and biosynthesis of thiamine precursors are required for intracellular replication of Listeria monocytogenes
Q21089623Capnocytophaga canimorsus: a human pathogen feeding at the surface of epithelial cells and phagocytes
Q28289781Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells
Q50537803Combined action of the type IV secretion effector proteins BepC and BepF promotes invasome formation of Bartonella henselae on endothelial and epithelial cells
Q48171420Combined chemical genetics and data-driven bioinformatics approach identifies receptor tyrosine kinase inhibitors as host-directed antimicrobials
Q34158566Complete proteome of a quinolone-resistant Salmonella Typhimurium phage type DT104B clinical strain
Q27323145Comprehensive assignment of roles for Salmonella typhimurium genes in intestinal colonization of food-producing animals
Q24649162Constraint-based analysis of metabolic capacity of Salmonella typhimurium during host-pathogen interaction
Q28552763Core Proteomic Analysis of Unique Metabolic Pathways of Salmonella enterica for the Identification of Potential Drug Targets
Q40567992Correlating Drug-Target Kinetics and In vivo Pharmacodynamics: Long Residence Time Inhibitors of the FabI Enoyl-ACP Reductase
Q28252916Crystal structure of a type III pantothenate kinase: insight into the mechanism of an essential coenzyme A biosynthetic enzyme universally distributed in bacteria
Q38261033Defining the metabolic requirements for the growth and colonization capacity of Campylobacter jejuni
Q33874236Development of ELISAs for diagnosis of acute typhoid fever in Nigerian children.
Q37143551Differential quantitative proteomics of Porphyromonas gingivalis by linear ion trap mass spectrometry: non-label methods comparison, q-values and LOWESS curve fitting
Q47385425Distinguishing between metabolically active and dormant bacteria on paper.
Q44480719Do targets limit antibiotic discovery?
Q48220585Drugging tRNA aminoacylation.
Q24285722Dual RNA-seq unveils noncoding RNA functions in host–pathogen interactions
Q40046693During infection of epithelial cells Salmonella enterica serovar Typhimurium undergoes a time-dependent transcriptional adaptation that results in simultaneous expression of three type 3 secretion systems
Q49587782Dysbiosis-Associated Change in Host Metabolism Generates Lactate to Support Salmonella Growth
Q26774700Elucidating Host-Pathogen Interactions Based on Post-Translational Modifications Using Proteomics Approaches
Q34240776Evolution of variation in presence and absence of genes in bacterial pathways
Q34388303Extensive in vivo resilience of persistent Salmonella
Q55397646Few Differences in Metabolic Network Use Found Between Salmonella enterica Colonization of Plants and Typhoidal Mice.
Q21131360Fructose-asparagine is a primary nutrient during growth of Salmonella in the inflamed intestine
Q89965574Functional Inhibition of Host Histone Deacetylases (HDACs) Enhances in vitro and in vivo Anti-mycobacterial Activity in Human Macrophages and in Zebrafish
Q64980329Functional expansion of a TCA cycle operon mRNA by a 3' end-derived small RNA.
Q37718885Functional single-cell analyses: flow cytometry and cell sorting of microbial populations and communities
Q42111680Genetic determinants of resistance to fusidic acid among clinical bacteremia isolates of Staphylococcus aureus
Q41871341Genetic screening for bacterial mutants in liquid growth media by fluorescence-activated cell sorting.
Q34172679Genome scanning for conditionally essential genes in Salmonella enterica Serotype Typhimurium
Q37256563Glucose and glycolysis are required for the successful infection of macrophages and mice by Salmonella enterica serovar typhimurium.
Q34302315Glycerol supplementation enhances L. reuteri's protective effect against S. Typhimurium colonization in a 3-D model of colonic epithelium
Q34286388High-throughput comparison of gene fitness among related bacteria
Q33395856Histoplasma capsulatum proteome response to decreased iron availability
Q34889881Host hydrogen rather than that produced by the pathogen is important for Salmonella enterica serovar Typhimurium virulence
Q34305317Human genome-wide RNAi screen for host factors that modulate intracellular Salmonella growth
Q38243324Identification of Protective Antigens for Vaccination against Systemic Salmonellosis
Q30424877Identification of a common immune signature in murine and human systemic Salmonellosis
Q50072446Identification of host-induced pathogen genes by differential fluorescence induction reporter systems
Q33845728Identification of metabolic pathways essential for fitness of Salmonella Typhimurium in vivo
Q36949434Identification of the genetic basis for clinical menadione-auxotrophic small-colony variant isolates of Staphylococcus aureus
Q37719739Identifying potential therapeutic targets of methicillin-resistant Staphylococcus aureus through in vivo proteomic analysis
Q34456080Immunity to intracellular Salmonella depends on surface-associated antigens
Q34495624Immunological characterization of a gidA mutant strain of Salmonella for potential use in a live-attenuated vaccine
Q36993458In vitro and in vivo validation of ligA and tarI as essential targets in Staphylococcus aureus
Q33610279In vivo IFN-γ secretion by NK cells in response to Salmonella typhimurium requires NLRC4 inflammasomes
Q39568172In vivo and in silico determination of essential genes of Campylobacter jejuni.
Q30489356Inducing optimal substitution between antibiotics under open access to the resource of antibiotic susceptibility
Q35109868Innate immune activation during Salmonella infection initiates extramedullary erythropoiesis and splenomegaly
Q30480219Integrated network reconstruction, visualization and analysis using YANAsquare.
Q33530403Integration of 'omics' data: does it lead to new insights into host-microbe interactions?
Q31066785Integration of omics data: how well does it work for bacteria?
Q35409022Intestinal inflammation allows Salmonella to use ethanolamine to compete with the microbiota
Q38663493Intracellular Salmonella metabolism.
Q27322699Intraspecies competition for niches in the distal gut dictate transmission during persistent Salmonella infection
Q37897209Investigating pathogen biology at the level of the proteome
Q33870965Isolation of F. novicida-Containing Phagosome from Infected Human Monocyte Derived Macrophages.
Q39042382Labeling of the pathogenic bacterium Staphylococcus aureus with gold or ferric oxide-core nanoparticles highlights new capabilities for investigation of host-pathogen interactions
Q34429033Live attenuated S. Typhimurium vaccine with improved safety in immuno-compromised mice
Q38090511Lysine biosynthesis in microbes: relevance as drug target and prospects for β-lactam antibiotics production.
Q26865681Mass spectrometry-based proteomic approaches to study pathogenic bacteria-host interactions
Q30439892Mass spectrometry-based proteomics and its application to studies of Porphyromonas gingivalis invasion and pathogenicity
Q33597003Mass spectrometry-based quantitative proteomic analysis of Salmonella enterica serovar Enteritidis protein expression upon exposure to hydrogen peroxide
Q55448576Methionine biosynthesis and transport are functionally redundant for the growth and virulence of Salmonella Typhimurium.
Q35804589Mlc regulation of Salmonella pathogenicity island I gene expression via hilE repression
Q40460667Model-driven discovery of synergistic inhibitors against E. coli and S. enterica serovar Typhimurium targeting a novel synthetic lethal pair, aldA and prpC
Q27306197Modification of Salmonella Typhimurium motility by the probiotic yeast strain Saccharomyces boulardii
Q46248137Molecular evolution of an oligomeric biocatalyst functioning in lysine biosynthesis
Q46778188Motility allows S. Typhimurium to benefit from the mucosal defence
Q38325342Mycobacterial proteomics: analysis of expressed proteomes and post-translational modifications to identify candidate virulence factors
Q35831206N-acetylglucosamine-6-phosphate deacetylase (NagA) of Listeria monocytogenes EGD, an essential enzyme for the metabolism and recycling of amino sugars.
Q36596234NAD+ utilization in Pasteurellaceae: simplification of a complex pathway.
Q26827940Network-based approaches in drug discovery and early development
Q37329167New trends in pharmacogenomic strategies against resistance development in microbial infections
Q35068795Non-essential genes form the hubs of genome scale protein function and environmental gene expression networks in Salmonella enterica serovar Typhimurium
Q36358643Novel approaches to developing new antibiotics for bacterial infections
Q34903245Novel classes of antibiotics or more of the same?
Q40149893Novel targets for antibiotics in Staphylococcus aureus
Q36239332O-Nucleoside, S-nucleoside, and N-nucleoside probes of lumazine synthase and riboflavin synthase
Q42729379Orthogonal alkynyl amino acid reporter for selective labeling of bacterial proteomes during infection.
Q34697874Parallel exploitation of diverse host nutrients enhances Salmonella virulence.
Q34389664Polyfunctional CD4+ T cell responses to immunodominant epitopes correlate with disease activity of virulent Salmonella
Q33745572Postgenomic strategies in antibacterial drug discovery.
Q38452362Protein turnover analysis in Salmonella Typhimurium during infection by dynamic SILAC, Topograph, and quantitative proteomics
Q47160568Proteogenomics in Aid of Host-Pathogen Interaction Studies: A Bacterial Perspective
Q37895209Proteome analysis of host-pathogen interactions: Investigation of pathogen responses to the host cell environment
Q34884343Proteomes of host cell membranes modified by intracellular activities of Salmonella enterica
Q35745541Proteomic Analyses of Intracellular Salmonella enterica Serovar Typhimurium Reveal Extensive Bacterial Adaptations to Infected Host Epithelial Cells
Q58572049Proteomic Profiling of During Host Infection Using Bio-Orthogonal Noncanonical Amino Acid Tagging (BONCAT)
Q40222325Proteomic comparison between Salmonella Typhimurium and Salmonella Typhi
Q37274847Proteomic investigation of the time course responses of RAW 264.7 macrophages to infection with Salmonella enterica
Q64099626Proteomics of intracellular Salmonella enterica reveals roles of Salmonella pathogenicity island 2 in metabolism and antioxidant defense
Q28080622Purification and proteomics of pathogen-modified vacuoles and membranes
Q40198592Quantitative proteomic analysis of host epithelial cells infected by Salmonella enterica serovar Typhimurium.
Q46859773Reactive oxygen species are the major antibacterials against Salmonella Typhimurium purine auxotrophs in the phagosome of RAW 264.7 cells
Q30592724Reconciling a Salmonella enterica metabolic model with experimental data confirms that overexpression of the glyoxylate shunt can rescue a lethal ppc deletion mutant
Q35046832Revisiting the host as a growth medium
Q36313529Riboflavin biosynthesis is associated with assimilatory ferric reduction and iron acquisition by Campylobacter jejuni
Q28082931Salmonella as a model for non-cognate Th1 cell stimulation
Q90701291Salmonella enterica Requires Lipid Metabolism Genes To Replicate in Proinflammatory Macrophages and Mice
Q42145025Salmonella enterica: a surprisingly well-adapted intracellular lifestyle
Q35026100Salmonella-how a metabolic generalist adopts an intracellular lifestyle during infection
Q28504981Salmonella-induced mucosal lectin RegIIIβ kills competing gut microbiota
Q35865404Shotgun proteomics of bacterial pathogens: advances, challenges and clinical implications
Q33864950Staphylococcus aureus physiological growth limitations: insights from flux calculations built on proteomics and external metabolite data
Q27675312Structural Characterization of Inhibitors with Selectivity against Members of a Homologous Enzyme Family
Q40165154Structural basis for competitive inhibition of 3,4-dihydroxy-2-butanone-4-phosphate synthase from Vibrio cholerae.
Q27008867Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review
Q41832574Subpopulation-specific metabolic pathway usage in mixed cultures as revealed by reporter protein-based 13C analysis
Q35935855Superessential reactions in metabolic networks
Q34620058Target identification and validation for anthelmintic discovery
Q27677435Tetrahydrodipicolinate N-Succinyltransferase and Dihydrodipicolinate Synthase from Pseudomonas aeruginosa: Structure Analysis and Gene Deletion
Q58066651The Importance of Virulence Prediction and Gene Networks in Microbial Risk Assessment
Q37074020The In Vitro Redundant Enzymes PurN and PurT Are Both Essential for Systemic Infection of Mice in Salmonella enterica Serovar Typhimurium
Q36855715The Salmonella pathogenicity island 13 contributes to pathogenesis in streptomycin pre-treated mice but not in day-old chickens
Q37666798The antigenome: from protein subunit vaccines to antibody treatments of bacterial infections?
Q42641021The conservation and evolutionary modularity of metabolism
Q35029271The francisella tularensis proteome and its recognition by antibodies
Q40416060The infectious intracellular lifestyle of Salmonella enterica relies on the adaptation to nutritional conditions within the Salmonella-containing vacuole
Q38095672The lumazine synthase/riboflavin synthase complex: shapes and functions of a highly variable enzyme system
Q24651695The neglected role of antibody in protection against bacteremia caused by nontyphoidal strains of Salmonella in African children
Q36505887The salmonella transcriptome in lettuce and cilantro soft rot reveals a niche overlap with the animal host intestine
Q34248983The transcriptional landscape and small RNAs of Salmonella enterica serovar Typhimurium.
Q55465441The treatment of enteric fever.
Q33318131Three factors underlying incorrect in silico predictions of essential metabolic genes
Q35730742Toward a Systemic Understanding of Listeria monocytogenes Metabolism during Infection
Q37517328Tracking the dynamics of salmonella specific T cell responses
Q83644737Trade-offs between efficiency and robustness in bacterial metabolic networks are associated with niche breadth
Q33334019Transgenic, fluorescent Leishmania mexicana allow direct analysis of the proteome of intracellular amastigotes
Q34977328Tryptophan synthase: a mine for enzymologists
Q37828117Understanding and engineering of microbial cells based on proteomics and its conjunction with other omics studies
Q37325143Use of high-throughput mass spectrometry to elucidate host-pathogen interactions in Salmonella
Q39035296Using bacterial genomes and essential genes for the development of new antibiotics
Q38070780Viable screening targets related to the bacterial cell wall.
Q41837872YjhS (NanS) is required for Escherichia coli to grow on 9-O-acetylated N-acetylneuraminic acid
Q34777635rpoS-Regulated core genes involved in the competitive fitness of Salmonella enterica Serovar Kentucky in the intestines of chickens

Search more.